Antimycobacterial Activity of Fusaric Acid from a Mangrove Endophyte and its Metal Complexes

Jia-Hui Pan,Yi Chen,Yu-Hong Huang,Yi-Wen Tao,Jun Wang,Yan Li,Yi Peng,Tao Dong,Xiao-Min Lai,Yong-Cheng Lin 대한약학회 2011 Archives of Pharmacal Research Vol.34 No.7

Due to the increasing prevalence of multidrug-resistant Mycobacterium tuberculosis, there is an urgent need for new antituberculosis drugs that have novel mechanisms of action. As part of our ongoing search for antimycobacterial metabolites from mangrove endophytes, chemical analysis of the active extract of a strain of Fusarium sp. was performed, which led to the isolation of fusaric acid as the predominant constituent. A variety of metal complexes of fusaric acid were prepared. Antimycobacterial assays showed that Cadmium (II) and Copper (II) complexes exhibited potent inhibitory activity against the M. bovis BCG strain [minimum inhibitory concentration (MIC) = 4 μg/mL] and the M. tuberculosis H37Rv strain (MIC = 10 μg/mL), respectively. This is the first report of the antimycobacterial activity of the mangrove Fusarium metabolite and its coordinating metal complexes.

Case-Control Study of Diet in Patients with Cervical Cancer or Precancerosis in Wufeng, a High Incidence Region in China

Jia, Yao,Hu, Ting,Hang, Chuan-Ying,Yang, Ru,Li, Xiong,Chen, Zhi-Lan,Mei, Ye-Dong,Zhang, Qing-Hua,Huang, Ke-Cheng,Xiang, Qun-Ying,Pan, Xiu-Yu,Yan, Yu-Ting,Wang, Xiao-Li,Wang, Shao-Shuai,Hang, Zhou,Tang Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.10

Purpose: To investigate the diet of patients with cervical cancer and precancerosis in the Wufeng area, a high-incidence region in China. Methods: In the case group, 104 patients diagnosed with cervical cancer or cervical intraepithelial neoplasias (CINII/III) were recruited from the Wufeng area. Nine hundred thirty-six healthy women were selected from the same area as the matched controls. A questionnaire, which included questions about general lifestyle conditions, smoking and alcohol status, source of drinking water, green tea intake, and diet in the past year, was presented to all participants. Results: Green tea intake (P=0.022, OR=0.551, 95% CI=0.330-0.919) and vegetable intake (P=0.035, OR=0.896, 95% CI=0.809-0.993) were identified as protective factors against cervical cancer or CINII/III. There was no indication of any associations of other lifestyle factors (smoking status, alcohol status, source of drinking water) or diet (intake of fruit, meat/egg/milk, soybean food, onion/garlic, staple food and pickled food) with cervical cancer. Conclusions: The results suggest that eating more fresh vegetables and drinking more green tea may help to reduce the risk of cervical cancer or CINII/III in people of the Wufeng area.

Tuning the Surface Properties of Graphene Oxide by Surface-Initiated Polymerization of Epoxides: An Efficient Method for Enhancing Gas Separation

Wu, Yu,Jia, Pan,Xu, Linli,Chen, Zhangyan,Xiao, Linhong,Sun, Jinhua,Zhang, Jun,Huang, Yong,Bielawski, Christopher W.,Geng, Jianxin American Chemical Society 2017 ACS APPLIED MATERIALS & INTERFACES Vol.9 No.5

<P>Here, we describe an in situ approach for growing polyepoxides from the surfaces of graphene oxide (GO) using a surface-initiated polymerization reaction. The polymerization methodology is facile and general as a broad range of epoxides carrying various functional groups have been successfully polymerized by simply adding GO powders in the epoxide monomers. The resultant polyepoxide grafted GO are found to show enhanced dispersibility in various common solvents and to exhibit increased d-spacing between the basal planes. In particular, grafting poly(2,3-epoxy-1-propanol) (PEP) to GO results in a composite (i.e., GO-g-PEP) that is dispersible in water and miscible with polyether block amide, i.e., Pebax MH 1657. Preliminary studies have indicated the membranes prepared using Pebax/GO-g-PEP composites exhibit enhanced CO2 permeabilities and selectivities in comparison to H-2, O-2, or N-2. The excellent performance in gas separation is attributed to the layered structure of the GO-g-PEP sheets with enlarged d-spacing and the functional groups present on the PEP chains grafted to the surfaces of GO sheets.</P>

Synthesis, Structures and Properties of Two Metal-organic Frameworks Derived from 3-Nitro-1,2-benzenedicarboxylic Acid

Wen-Jia Xu,Ling-Yu Zhang,Jin-Niu Tang,Dai-Yin Wang,Gang-Hong Pan,Yu Feng 대한화학회 2013 Bulletin of the Korean Chemical Society Vol.34 No.8

Two metal-organic frameworks based on the connectivity co-effect between rigid benzenedicarboxylic acid and bridging ligand have been synthesized [Zn2(3-NO2-bdc)2(4,4'-bpy)2H2O]n (1), [Co(3-NO2-bdc)(4,4'- bpy)H2O]n (2) (where 3-NO2-bdcH2 = 3-nitro-1,2-benzenedicarboxylic acid, 4,4'-bpy = 4,4'-bipyridine). The two novel complexes were characterized by IR spectrum, elemental analysis, fluorescent properties, thermogravimetric analysis, single-crystal X-ray diffraction and powder X-ray diffraction (PXRD). X-ray structure analysis reveals that 1 and 2 are two-dimensional (2D) network structures. Complex 1 and complex 2 belong to triclinic crystal with P-1 space group. The luminescence measurements reveal that two complexes exhibit good fluorescent emissions in the solid state at room temperature. Also, thermal decomposition process and powder X-ray diffraction of complexes were investigated.

Synthesis, Structures and Properties of Two Metal-organic Frameworks Derived from 3-Nitro-1,2-benzenedicarboxylic Acid

Xu, Wen-Jia,Zhang, Ling-Yu,Tang, Jin-Niu,Wang, Dai-Yin,Pan, Gang-Hong,Feng, Yu Korean Chemical Society 2013 Bulletin of the Korean Chemical Society Vol.34 No.8

Two metal-organic frameworks based on the connectivity co-effect between rigid benzenedicarboxylic acid and bridging ligand have been synthesized $[Zn_2(3-NO_2-bdc)_2(4,4'-bpy)_2H_2O]_n$ (1), $[Co(3-NO_2-bdc)(4,4'-bpy)H_2O]_n$ (2) (where $3-NO_2-bdcH_2$ = 3-nitro-1,2-benzenedicarboxylic acid, 4,4'-bpy = 4,4'-bipyridine). The two novel complexes were characterized by IR spectrum, elemental analysis, fluorescent properties, thermogravimetric analysis, single-crystal X-ray diffraction and powder X-ray diffraction (PXRD). X-ray structure analysis reveals that 1 and 2 are two-dimensional (2D) network structures. Complex 1 and complex 2 belong to triclinic crystal with P-1 space group. The luminescence measurements reveal that two complexes exhibit good fluorescent emissions in the solid state at room temperature. Also, thermal decomposition process and powder X-ray diffraction of complexes were investigated.

Dark current suppression of amorphous selenium based photosensors by the ZnO hole blocking layer

Tung-Yuan Yu,Fu-Ming Pan,Cheng-Yi Chang,Tien Hu,Jenn-Fang Chen,Jia-Feng Wang,Jia-Feng Wang,Cheng-Lu Lin,Te-Ming Chen 한국물리학회 2014 Current Applied Physics Vol.14 No.5

To study the influence of defects in the hole blocking layer (HBL) on the dark current of amorphous selenium (a-Se) based photosensors, we prepared ZnO thin films by reactive sputter deposition (RSD) for the use as the HBL of the photosensors. The ZnO HBL layers prepared with different oxygen flow rates were characterized by X-ray photoelectron spectroscopy, Raman scattering analysis and photoluminescence, indicating that the density of oxygen vacancies in the ZnO thin films is significantly affected by the oxygen flow rate. The deep level transient spectroscopy measurement reveals two hole trap levels present in the RSD deposited ZnO thin films; one is at 0.94 eV and the other at 0.24 eV above the valence band edge. The electrical performance of the a-Se photosensor is largely influenced by the amount of oxygen vacancies in the ZnO thin film. The a-Se photosensor with the ZnO HBL of the most oxygen vacancies has the lowest dark current and demonstrates the highest breakdown field.

Adenovirus vector-mediated FAM176A overexpression induces cell death in human H1299 non-small cell lung cancer cells

( Hong Xie ),( Jia Hu ),( Huan Pan ),( Ya Xin Lou ),( Ping Lv ),( Ying Yu Chen ) 생화학분자생물학회 2014 BMB Reports Vol.47 No.2

FAM176A (family with sequence similarity 176 member A) is a novel molecule related to programmed cell death. A decreased expression of FAM176A has been found in several types of human tumors in including lung cancers. In the present study, we investigated the biological activities of FAM176A on the human non-small cell lung cancer cell line H1299 cells. We constructed a recombinant adenovirus 5-FAM176A vector (Ad5-FAM176A) and evaluated the expression and anti-tumor activities in vitro. Cell viability analysis revealed that the adenovirus-mediated increase of FAM176A inhibited the growth of the tumor cells in a dose- and time-dependent manner. This inhibitory effect was mediated by both autophagy and apoptosis that involved caspase activation. In addition, cell cycle analysis suggested that Ad5-FAM176A could induce cell cycle arrest at the G2/M phase, all of which suggested that adenovirus-mediated FAM176A gene transfer might present a new therapeutic approach for lung cancer treatment. [BMB Reports 2014; 47(2): 104-109]

0BTimSim: An Efficient Simulator for Wireless Ad-hoc Networks

Hui Xia,Jia Yu,Guo-Dong Wang,Zhen-Kuan Pan 보안공학연구지원센터 2016 International Journal of Future Generation Communi Vol.9 No.4

With the growth of increasingly complex in wireless ad-hoc networks, performance modeling and evaluation play a crucial part in their design process to ensure successful deployment and exploitation in practice. Compared with the actual implementation (testbeds), simulation has become a valuable tool, which allows studying large scale systems that cannot be built practically. However, most simulators currently used for such networks are intended to evaluate individual routing protocol, which should be extracted from the source code and rewritten in accordance with the simulator’s requirements. Thus, in this paper, we design a new wireless ad-hoc network simulator, called Time Step-based Wireless Ad-hoc Network Simulator (TimSim). It is intended to facilitate the migration of simulation code to real devices via providing useful APIs with real device driver. We use a discrete event processor with time step-based feature as the simulating engine, and the data can be transmitted in bit-level. A unique feature of TimSim is its ability to support the simulation of multi-thread programming. Additionally, we import database access to store the simulation information. Extensive experiments have been conducted to evaluate the efficiency of TimSim. Furthermore, a case study on a real system has been presented to illustrate its practicability.

Fluorescent Nanoparticles for Observing Primo Vascular System Along Sciatic Nerve

Zhao-Feng Jia,Ki-Hoon Eom,Jin-Myung Cha,Jin-Kyu Lee,Zhen-Dong Su,Wen-Hui Yu,Pan Dong Ryu,소광섭,Byung-Cheon Lee 사단법인약침학회 2010 Journal of Acupuncture & Meridian Studies Vol.3 No.3

The primo vascular system was found in the epineurium along the rat sciatic nerve following subcutaneous injection of fluorescent nanoparticles at the Zusanli acupoint (ST-36). Nanoparticles were injected into the primo-vessel near ST-36 and flowed along the sciatic nerve. Fluorescence revealed a structure in the epineurium that was hardly detectable. Images of the isolated sample stained with 4’,6-diamidino-2-phenylindole were captured using confocal microscopy. These images showed the distinctive nuclei distribution and multi-lumen structure of primo-vessels that differentiate them from lymphatic vessels, blood capillaries and nerves. This study demonstrates a new use for nanoparticles in fluorescence reflectance imaging techniques during in vivo imaging of primo-vessels.

상호 관계 기반 자동 이미지 주석 생성

양형정(Hyungjeong Yang),Jia-yu Pan(Jia-yu Pan),Pinar Duygulu(Pinar Duygulu),Christos Falout(Christos Falout) 한국정보과학회 2004 정보과학회논문지 : 소프트웨어 및 응용 Vol.31 No.10

본 논문에서는 상호 관계에 기반한 자동 이미지 주석 생성 방법을 보인다. 새로운 실험 이미지를 위한 자동 주석의 생성은 훈련 데이타 내의 주석과 함께 주어진 이미지들을 이용하여 이미지의 시각적 속성과 텍스트 속성의 상호 관계를 발견해 냄으로 수행된다. 본 논문에서 제시하는 상호 관계 기반 자동주석 생성 모델은 1) 시각적 속성의 적절한 군집화, 2) 시각적 속성과 텍스트 속성의 가중치 부여, 3) 노이즈 제거를 위한 차원 축소 등의 요소를 고려하여 설계 된다. 실험은 680 MB의 Corel 이미지 데이타를 이용하여 각 10개의 데이타 집합에 대해 수행 되었으며, 실험 결과, 시각적 속성과 텍스트 속성에 대한 가중치 부여와 시각적 속성의 적절한 군집화가 모델의 성능을 향상 시키며, 본 논문에서 제시한 상호 관계기반 모델이 기존의 EM을 이용한 자동 주석 생성 모델에 비해 45%의 상대적 성능 향상을 보인다. This paper presents correlation-based automatic image captioning. Given a training set of annotated images, we want to discover correlations between visual features and textual features, so that we can automatically generate descriptive textual features for a new unseen image. We develop models with multiple design alternatives such as 1) adaptively clustering visual features, 2) weighting visual features and textual features, and 3) reducing dimensionality for noise sup-pression. We experiment thoroughly on 10 data sets of various content styles from the Corel image database, about 680MB. The major contributions of this work are: (a) we show that careful weighting visual and textual features, as well as clustering visual features adaptively leads to consistent performance improvements, and (b) our proposed methods achieve a relative improvement of up to 45% on annotation accuracy over the state-of-the-art, EM approach.