신원방우황청심원액의 심혈관계에 관한 약효

조태순,이선미,김낙두,허인회,안형수,권광일,박석기,심상호,신대희,박대규 충남대학교 약학대학 의약품개발연구소 1999 藥學論文集 Vol.15 No.-

In order to investigate the pharmacological properties of New Wonbang Woohwangchungsimwon Liquid (NSCL), effects of Wonbang Woohwangchungsimwon Liquid (SCL) and NSCL were compared. In isolated rat aorta, NSCL and SCL showed the relaxation of blood vessels in maximum contractile response to phenylephrine (10^-6M) regardless to intact endothelium or denuded rings of the rat aorta. Furthermore, the presences of the inhibitor of NO synthase and guanylate cyclase did not affect the relaxing effect of NSCL and SCL. NSCL and SCL inhibited the vascular contractions induced by acetylcholine, prostaglandin endoperoxide or peroxide in a dose-dependent manner. In conscious spontaneously hypertensive rats (SHRs), NSCL and SCL significantly decreased heart rate. NSCL and SCL, at high doses, had a negative inotropic effect that was a decrease of left ventricular developed pressure and (-dp/dt)/(+dp/dt) in the isolated perfused rat hearts, and also decreased the contractile force and heart rate in the isolated rat right atria. In excised guinea-pig papillary muscle, NSCL and SCL had no effects on parameters of action potential such as resting membrane potential, action potential amplitude, APD_90 and V_max at low doses, whereas inhibited the cardiac contractility at high doses. These results suggested that NSCL and SCL have weak cardiovascular effects with relaxation of blood vessels and decrease of heart rate, and that this effect is no significant differences between cardiovascular effects of two preparations.

한국산 육서사류(陸棲蛇類)의 조충류 감염상태

조승열,송기원,이순형 중앙대학교 의과대학 의과학연구소 1982 中央醫大誌 Vol.7 No.4

One hundred Korean terrestial snakes,i.e.,7 Elaphe rufodorsata,17 E. dione, 10 Dinodon rufozonatum rufozatum,37 Natrix tigrina lateralis,21 Agkistrodon blomhoffii brevicaudus,6A.calibinosus and 2A. saxatiilis were examined from June 17, 1981 to Jun 1, 1982, to observe the fauna of Korean cestode parasities. They were collected from 13 localities of southern Korea: i.e., Chunseong Gun, Hong-cheon Gun, Hoengseong Gun, Weonseong Gun, Samcheog Gun, Gangweon Do; Namyangju Gun, PAju Gun, Ganghwa Gun, Gyeonggi Do; Youngdong Gun, Jeweon Gun, Chungcheongbug Do; Jangheung Gun, Jeonlanam Do; Sancheong Gun, Gyeongsangam Do and Bugjeju Gun, Jeju Do respectively. The results could be summarized as follows: 1. A total of 61 snakes was found to be infected withsparganum larvae of Spirometra mansoni out of 100 examined. Snakes from 11 localities were infected. By species of snake, N.t. lateralis and A.b. brevicaudus showed the higher infection rates. The mean density was 11.0 per examined snake and 18.1 per infected snake respectively. A. caliginosus and A. saxatilis were new hosts of spatganum in Korea. 2. Trtrathyridium of Mesocestoides sp. was found in one snake, Elaphe rufodorsala collected from ChunSeong Gun, Gangweon Do. A total of 16 tetrathyridia was found at serosa and mesemtery of the snake. The morphology of the larvae was described. This was thr first record of recovery of thtrathyridia in any vertebrate intermediate host in Korea. Elaphe rufodorsata was a new host. 3. proteocephalus japonensis(Yamaguti, 1935) n.comb.(syn.: Ophiotaenia Japonensis Yamaguti, 1935) were found in 10 snakes which were collected from Hongcheon Gun, Weonseong Gun, Namyangju Gun, Paju Gun, Jeweon Gun, and Sancheong Gun repectively. The infected snakes were Agkistrodon blomhoffii brevicaudus, A. caliginosus, A. saxatilis and Natrix tigrina lateralis. The habit was small instetine. The measurement data and morpholigy were described. The preaently observed worms were longer than those of original description and was a difference in mumber of uteerine branches. A. blomhoffii brevicaudus, A. caliginosus, A. saxatilis were new hosts for this protecephalid cestode. Korea was added to list of the locality.

신원방우황청심원의 심혈관계에 관한 약효

조태순,이선미,김낙두,허인회,안형수,권광일,박석기,심상호,신대희,박대규 성균관대학교 약학연구소 1999 成均藥硏論文集 Vol.11 No.-

Abstract-In order to investigate the phamacological properties of New Wonbang Woohwangchungsimwon Pill (NSCH), effects of Wonbang Woohwangchungsimwon Pill (SCH) and NSCH were compared using various experimental models. In rat aorta, NSCH and SCH made the relaxation of blood vessels in maximum contractile response to phenylephrine (10^-6 M) regardless to endothelium containing or denuded rings of the rat aorta. Furthermore, the presence of the inhibitors of NO synthase and guanylate cyclase did not aftect significantly the relaxing effects of NSCH and SCH, NSCH and SCH inhibited the vascular contractions induced by acetylcholine, prostaglandin endoperoxide or peroxide in a dose-dependent manner. In conscious spontaneously hypertensive rats (SHRs). NSCH and SCH decreased significantly heart rate. These, at high doses, had a negative inotropic effect that was a decrease of left ventricular developed pressure and (-dp/dt)/(+dp/dt) in the isolated perfused rat hearts, and also decreased the contractile force and heart rate in the isolated rat right atria. In guinea-pig papillary muscle, these had no effects on parameters of action potential such as action potential amplitude (APA). V_max and resting membrane potential (RMP) at low doses, whereas inhibited the cardiac contractility at high doses. Furthermore, these had a significant inhibitory effects on palpitation of the heart in normotensive rats and SHRs. These results suggest that NSCH and SCH have weak cardiovascular effects, and that there is no significant differences between cardiovascular effects of two preparations.

신원방우황청심원액의 심혈관계에 관한 약효

조태순,이선미,김낙두,허인회,안형수,권광일,박석기,심상호,신대희,박대규 성균관대학교 약학연구소 1999 成均藥硏論文集 Vol.11 No.-

Abstract-In order to investigate the pharmacological properties of New Wonbang Woohwangchungsimwon Liquid (NSCL), effects of Wonbang Woohwangchungsimwon Liquid (SCL) and NSCL were compared. In isolated rat aorta, NSCL and SCL showed the relaxation of blood vessels in maximum contractile response to phenylephrine (10^-6 M) regardless to intact endothelium or denuded rings of the rat aorta. Furthermore, the presences of the inhibitor of NO synthase and guanylate cyclase did not affect the relaxing effect of NSCL and SCL. NSCL and SCL inhibited the vascular contractions induced by acetylcholine, prostaglandin endoperoxide or peroxide in a dose-dependent manner. In conscious spontaneously hypertensive rats (SHRs), NSCL and SCL significantly decreased heart rate. NSCL and SCL, at high doses, had a negative inotropic effect that was a decrease of left ventricular developed pressure and (-dp/dt)/(+dp/dt) in the isolated perfused rat hearts, and also decreased the contractile force and heart rate in the isolated rat right atria. In excised guinea-pig papillary muscle, NSCL and SCL had no effects on parameters of action potential such as resting membrane potential, action potential amplitude, APD_90 and V_max at low doses, whereas inhibited the cardiac contractility at high doses. These results suggested that NSCL and SCL have weak cardiovascular effects with relaxation of blood vessels and decrease of heart rate, and that this effect is no significant differences between cardiovascular effects of two preparations.

신우황청심원액의 심혈관계에 관한 약효연구

조태순,이선미,김낙두,허인회,안형수,권광일,박석기,심상호,신대희,박대규 충남대학교 약학대학 의약품개발연구소 1997 藥學論文集 Vol.13 No.-

In order to investigate the pharmacological properties of New Woohwangchungsimwon Liquid (NCL), efects of Woohwangchungsimwon Liquid (CL) and NCL were compared. In isolated rat aorta, NCL and CL showed the relaxation of blood vessels in maximum contractile response to phenylephrine (10^6M) without regard to intact endothelium or denuded rings of the rat aorta. Furthemore, the presences of the inhibitor of NO synthase and guanylate cyclase did not affect the relaxation of NCL and CL. NCL and CL inhibited the vascular contractions induced by acetylcholine, prostaglandin endoperoxide or peroxide in a dosedependent manner. In conscious spontaneously hypertensive rats (SHRs), NCL and CL significantly decreased heart rate. NCL and CL, at high doses, had a negative inotropic effect that was a decrease of LVDP and (-dp/dt)/(+dp/dt) in the isolated perfused rat hearts, and also decreased the contractile force and heart rate in the isolated rat right atria. In excised guinea-pig papillary muscle, NCL and CL had no efects on parameters of action potential at low doses, whereas inhibited the cardiac contractility at high doses. These results suggested that NCL and CL have weak cardiovascular effects with relaxation of blood vessels and decrease of heart rate, and that this effect is no significant differences between two preparations.

항생제 혼합 시멘트 정을 이용한 장관골 감염성 불유합의 이단계 치료

조세현,정순택,박형빈,황선철,하용찬,황인환 대한골절학회 2004 대한골절학회지 Vol.17 No.4

목적: 장관골 감염성 불유합의 치료 시 항생제 혼합 시멘트 정을 이용한 이단계 재건술의 결과를 분석하고자 한다. 대상 및 방법: 1998년 1월부터 2002년 9월까지 장관골 감염성 불유합으로 이단계 재건 수술을 받은 41예 (대퇴골 26예, 경골 15예)를 대상으로 하였다. 일단계 수술에서는 광범위한 변연 절제술, 부골 제거 및 세척술과 기존 고정 장치의 제거 또는 외고정 장치로의 교환을 시행한 후 시공 (dead space)과 불유합 주변 연부조직 내 항생제 혼합 시멘트 정을 삽입하였다. 임상적 감염 증상이 호전된 평균 8.7주 (3주~32주) 후 이단계 재건술로서 Ⅰ군은 내고정 장치 (금속판 5예, 골수강내 금속정 8예), Ⅱ군은 외고정 장치 (Ilizarov 25예, Monofixator 3예)로 각각 고정하고 17예에서는 골내 이동술이나 골 연장술을 시행하였다. 양군 모두 필요한 경우 골 이식과 시멘트 정의 교환을 추가하였다. 추시 기간은 16개월에서 최장 71개월로 평균 45개월 이었다. 치료 결과는 골유합 기간 및 Paley 방법에 의한 방사선상 골유합 상태와 하지 기능으로 평가하였다. 결과: Ⅰ군 13예 전부와 Ⅱ군 28예 중 26예에서 감염의 치료와 골유합을 얻었다. 이단계 재건술 후 골 이식술, 골 소파술, 외고정 핀 교환과 각변형 교정술, 피부 이식 또는 근육 피판 회전술 등의 보조적 시술이 Ⅰ군은 평균 2회, Ⅱ군은 평균 6.2회 추가되었다. 평균 골유합 기간은 Ⅰ군이 19.3주이고 Ⅱ군이 23.1주로 내고정군이 더 빨랐다. 방사선상 Paley 골유합 상태는 Ⅰ군이 우수 8예, 양호 5예이었고, Ⅱ군이 우수 18예, 양호 7예, 보통 1예, 불량 2예 이었다 (p=0.492). 기능적 결과는 Ⅰ군에서 우수 6예, 양호 6예, 보통 1예 이었고, Ⅱ군에서는 우수 10예, 양호 13예, 보통 3예, 불량 2예 이었다 (p=0.267). 결론: 항생제 혼합 시멘트 정의 골수염 치료 효과가 관찰되었으며, 감염이 호전된 후 내고정 장치로 교환해 준 군이 외고정을 유지한 군에 비하여 추가 수술 횟수가 적고, 골유합 기간도 빨랐다. Purpose: To evaluate treatment results between internal na external fixation groups in two-stage reconstruction of infected nonunion of long bones using antibiotics-impregnated cement beads. Materials and Methods: In the first stage, preexisting hardwares were removed and radical debridement was done. The dead space was filled with antibiotics -impregnated cement beads and the nonunion sits was immobilized by external fixation, cast or skeletal traction. In the second stage, all cases were divided into two groups; the nonunion was fixed by internal fixation in group Ⅰ versus external fixation in group Ⅱ. The intervening period between the first and second stage was average 8.7 weeks (range, 3~23 weeks). Results: The follow-up period was average 45 months (range, 16~71 months). Infection control and bone union were achieved in all 13 cases of group Ⅰ. Infection recurred in two of 28 cases in group Ⅱ, one underwent above-knee amputation and the other case was lost in follow-up. The mean number of supportive operations including repeated curettage, augmentation and change of infected pins, angular correction, and soft tissue flap was average 2 and 6.2 times respectively in group Ⅰ and group Ⅱ. Bony union period was average 19.3 and 23.1 weeks in each group. According to Paley's classification, group Ⅰ was similar to group Ⅱ in bony and functional result (p>0.05). Conclusion: Antibiotics-impregnated cement beads provided positive effect on infection control. Internal fixation group showed less number of additional operations and earlier bony union than external fixation group.

Information Technology의 기존 관광산업에 대한 영향 및 향후 Trend에 대한 전망 : 사이버여행사 수익모델을 중심으로 Profit Model of Cyber Travel Agency

조현준,나윤중,임형순,엄서호 한국문화관광학회 2001 문화관광연구 Vol.3 No.1

IT has an influence on the travel agency as chance and threat. The purpose of this study is to find what profit model of cyber travel agency. Ernst&Young's five business profit models that are based on target audience and transaction focus is selected to evaluated existing model of cyber travel agency. Those are off-line facilitator, gateway, context provider, commerce destination, online exchange. The result of this study show that there is no specific profit model in domestic cyber and on-offline travel agencies. Just Portal cyber travel agencies abroad have a few profit model. They have online exchange model, which are various target audience and abound provide contents.

地方大學으로서의 濟州大學의 高等敎育 改革에 關한 硏究

趙文富,金永和,李淳珩 제주대학 1975 논문집 Vol.7 No.1

The role of education is to create a man of ability for development of the nation and society in Korea. The function of the study in the university for a developing country has been repeated a vicious circle by being the financial destitution. But we must find a way out of such vicious circle difficulties, reforming the higher education in the university, and develop the knowledge industry in the developing country. To reform the higher education, a university education, we need the necessary reforming personnels, the financial resources and the governmental consideration etc.. And the president with the necessary reforming personnels must display his ability of leadership, plan for the educational reform in the university and carry out the plan. In the case of Jeju National University, the reforming preconditions, personnels, financial and political etc., are not so good. We need to train and secure the necessary reforming personnels and ensure the financial preconditions and expect to do the governmental consideration. So We want to be enacted the special bedget in the National Assembly. And then the above various problems shall be planned for the eductional reform in the university, and the president of the university with them shall try to perform the reforming plan.

폭풍발생에 따른 해안단면변화에 관한 수치해석

표순보,조원철,이보형,이홍식 중앙대학교 기술과학연구소 1998 기술과학연구소 논문집 Vol.28 No.-

폭풍발생에 다른 해안단면의 변화를 예측하는 것은 해안선 변화에 대한 종합적인 대책을 수립하는데 있어 중요한 역할을 한다. 해안단면변화는 주로 해빈의 유사이송에 에 의해 발생되나, 유사이송은 유사의 입경, 수면상승높이, 쇄파고 등 많은 요소들에 의해 복합적으로 작용하기 때문에 현재에도 정확한 예측이 어려운 실정이다. 본 논문에서는 해안단면에서의 평형에너지소산개념을 수치모델에 도입하여 폭풍발생에 따른 안층방향의 해안단면변화와 해빈침식에 대하여 분석하여 보았다. 안층방향의 해안단면변화와 해빈침식은 평형단면 파라미터, 유사이송률 파라미터, 수면상승높이에 의해 크게 영향을 받음을 알 수 있다. A numerical model is applied for predicting variation of the beach profile and beach erosion during storms. Equation of sediment continuity and dynamic equation, governing on-offshore sediment transport due to a disequilibrium of wave energy dissipation, are used in the model. During a storm, the beach profile evolves to a form where the depth at the surf zone is related to the distance seaward of the waterline. In general, variation of the beach profile is found to be sensitive to the equilibrium profile parameter, the sediment transport rate parameter and the elevated water level. Also, the model response characteristics in the simulation of beach erosion show a lag between the maximum storm surge elevation and the maximum erosion.

천연 생약복합추출물이 Streptozotocin 유발 당뇨성 흰쥐의 장기무게 및 혈당내성에 미치는 효과

박형래,조정순 명지대학교 자연과학연구소 2006 자연과학논문집 Vol.25 No.-

상엽, 지황, 산약, 구기자 및 황기 등 5가지 천연복합추출의 일반성분 분석의 결과 100g 당 325 kcal이었으며, 수분함량 7.4%, 조지발 0.3g, 탄수화물 66.1g, 회분 11.7g이었다. 무기질 중 칼슘은 1503.96 mg, 칼륨은 2510.27 mg, 철분 9.68 mg, 소디움 1.20 mg이었다. streptozotocin(STZ)으로 당뇨를 유발시킨 흰쥐에 5가지 천연복합추출물(BG515)를 12주간 경구 투여한 후 다음과 같은 결과를 얻었다. 체중변화에서 실험군 모두에서 정상군에 비하여 유의적으로 낮은 체중증가를 나타냈었으며 BG515-4군에서 가장 낮은 체중증가 경향을 나타내었다. 평균 1일 식이섭취량 비교에서 STZ-control군을 포함한 실험군 모두에서 정상군에 비하여 현저한 증가를 나타내었으며 STZ-control군 및 천연복합물질 BG-515 투여군 사이에는 유의적인 차이는 없었다. 평균 1일 음수량 비교에서 당뇨가 유발된 STZ-control군을 포함한 실험군 모두에서 정상군에 비하여 6배 정도의 높은 음수량을 나타내었다. 신장과 간, 폐 및 심장조직의 중량은 STZ-control군을 포함한 실험군 모두에서 실험 전 기간에 걸쳐 정상군에 비해 상대적 중량이 유의적으로 높게 나타났으며 췌장의 중량도 정상군에 비해 실험군 모두에서 유의적인 증가를 나타내었으며, 비장의 중량은 정상군을 포함한 모든 실험군에서 비슷한 경향을 나타내었다. 천연복합물질의 섭취가 당뇨쥐의 내당능에 미치는 영향을 관찰한 경과 정상군의 경우 15분 후에 혈당이 최고치에 달하였고 90분 후에는 다시 공복 시 혈당수분으로 회복되었고 STZ-control군에서는 혈당이 60분 후에 최고치에 이르렀고 120분 후에도 공복 시 혈당치보다 현저히 높은 수준에 머물렀다. BG515-1군, BG515-2군 및 BG515-4군에서는 30분대에 가장 높은 수준에 달하였으며 120분 후에는 현저하게 감소되어 거의 공복전의 수준에 도달하였고 BG515-2군에서 가장 좋은 내당능 효과를 보였다. This study was designed to investigate natural medicinal plants-extracts (BG515), which are multi extracts of Mori Folium, Rehmannia glutinosa Liboschitz, Dioscorea japonica, Lycii fructus, and Astragalus Radix on blood glucose level and lipid metabolism in streptozotocin induced diabetic rats. The contents of carbohydrate in the natural medicinal plants extracts was 66.1g, crude protein was 14.5g, crude fat was 0.3g, ash was 11.7g, moisture was 7.4% per 100g edible portion. The contents of calcium in BG515 was 1503.96 mg, phosphorus was 468.31 mg, iron was 9.6 mg, sodium was 1.20 mg, and potassium was 2510.27 mg per 100g. 35 Male Sprague-Dawley (SD) rats weighing 150-170g each (6 weeks old) were randomly divided into one control (Group A) and 4 STZ-induced diabetic groups and subjected to one of the following treatment for 12 weeks. Group A and B were fed on basal diets and Group C, D and E received same diets as group A and B but additionally supplemented 150 mg/kg, 300 mg/kg, and 600 mg/kg of BG515 orally for 12 weeks, respectively. Diabetes of Group B, C, D and E were induced by intravenous injection of 45 mg/kg body weight of STZ in sodium citrate buffer (pH 4.5) via tail vein, respectively. Diabetic rats including BG515 administered groups showed the lower weight gain compared to the normal rats. but weight loss in STZ-control group is much stronger than BG515 groups. There were significant increases of feed-and drinking water consumption in all STZ-treated diabetic rats including BG515 administered groups compared to normal group. Especially, drinking water consumption in STZ-groups is increased with six fold in compare with control group. In BG515 -2 groups, showed the best of glucose challenge in normal and diabetic rats fed experimental diets.