萬頃江流域에 있어서 井水中의 弗素含量에 관한 硏究

金完泰,安榮根,申和雨,張賢淑 원광대학교 식품약품안전성연구소 1987 食品藥品安全性硏究 Vol.1 No.-

This study is the survey about Fluorine contents in the well water of area of Mankyung River side and water of Mankyung River. The result of this survey is as followings: The water of well in this area contained 0.5∼1.3ppm and it's average value was about 0.8 ppm. The water from Mankyung River contained 0.8∼0.9ppm and it's average value is 0.87ppm. By the regionally sectional survey the well water of the area of Mankyung River side, the well water of Chun-Ju, Iri, Samye, and Kusan contained 0.5∼0.8ppm, but the well water of Baikku area contained 0.6∼1.3ppm. Especially in Baikku area 63% of well contained 0.6∼1.0ppm and 38% of well contained 1.1∼1.3ppm. From the above results one can conclude that the 38% of well water of the Baikku area is troubled one.

更年1號丸의 抗酸化活性에 對한 硏究

이현숙,남경수,이태균 동국대학교 경주대학 1996 東國論集 Vol.15 No.-

To investigate the antioxidant effects of Gaengnyounilhohwan (GIH), we administrated acetaminophen (500mg/kg, i.P.) that induced hepatic lipid peroxidation to starved mice for 24hrs after pretreatment of GIH for 6 days. And the effects of GIH on the hepatic enzymes(glutathion-S-transferase, superoxide dismutase, glutathion peroxidase and catala se) which participate in lipid peroxidation and glutathion metabolism were investigated. The results were as follows 1. GST(glutathion-S-transferase) activity in the acetaminphen treated group was remarkably reduced compared with saline treated group (control group). However, in the pretreated group of GIH for 6 days GST activity was increased about 2.7 fold. 2. Compared with control group, SOD (superoxide dismutase) activity was decreased by 26.9% in the acetaminophen treated group. On the other hand, in the GIH pretreated group SOD activity was almost recovered to the level of control group. 3. In the acetaminophen treated group, GSH-Px(glutathion peroxidase) activity was decreased by 47.1 % compare with control group. And in the GIH pretreated group. GSH-Px activity was increased about 2 fold and recover to the control group. 4. Catalase activity was also decreased by 23.8% in actamlnophen treated group. However, in the GIH pretreated group, catalase activity was increased above 2 fold compared with control group. 5. In the acetaminophen treated group, malondialdehyde values of plasma and cytosolic fraction were significantly increased compared with control group. However, after the GIH treated group, lipid peroxide formation was decreased by 47% in plasma, and remarkably decreased 3.7 fold in cytosolic fraction. These results suggest that GIH plays a protective role in the formation of acetaminophen induced lipid peroxidation.

뇌졸중 병변 위치에 따른 자세 측정기상의평형 및 자세 조절의 특징

김현숙,이강우,성덕현,황지혜,김태욱 大韓再活醫學會 2000 Annals of Rehabilitation Medicine Vol.24 No.3

임신 중 발견된 대망 종괴 1례

조인숙,김태의,김정식,이해혁,이권해,김희경,남계현 순천향의학연구소 2004 Journal of Soonchunhyang Medical Science Vol.10 No.2

A case of omental mass during Pregnancy Omental cyst is a rare lesion and occur primarily during childhood and young adulthood. When encountered, most of them are benign and intraabdominal masses. It shows a large mass but not palpable and often asymptomatic. The precise diagnosis is made by most commonly at surgery or during pathologic examination. So, we report this case with brief review of literatures.

학교급식의 식재료 공급체계 개선방안

위태석,황대용,최정숙,정현영 한국식품유통학회 2004 食品流通硏究 Vol.21 No.2

This study deals with school food service from the consumption extension of our agricultural products and the maximization of the educational effects point of view. By consuming regional agricultural products for school meals, the dietary life and agricultural education combined knowledge with behavior could be implemented. Therefore, to propel a "Movement of Jisanjiso", regional agricultural structure and marketing structure should be established and the effective support program of central government and autonomy also should be prepared.

원발성 난소 소세포암 2례

조인숙,남계현,김태희,김정식,이해혁,이권해,권계원 순천향의학연구소 2004 Journal of Soonchunhyang Medical Science Vol.10 No.2

Two cases of primary small cell carcinoma of the ovary occurred. One was a case of 43-year-old woman associated with hypercalcemia and the other was a case of 40-year-old woman with pulmonary type. Ovarian small cell carcinoma of the hypercalcemic type have clinicopathological, immunohistochemical, ultrastructural, and flow cytometric features that from differ from those of small cell carcinomas of the pulmonary type. It is important for therapeutic reasons to distinguish these two types of ovarian tumors from each other and from a variety of malignant small cell tumors that ovary primarily or secondarily. So, we reported these cases with a brief review of the concerned literatures.

천연자원의 Cytotoxicity와 Antioxidative activity 검색

김태희,양기숙,이수현 숙명여자대학교 약학연구소 1993 약학논문집-숙명여자대학교 Vol.9 No.-

A preliminary lab experiment was carried out on 29 species of medicinal plants known to be effective anti-cancer agents among the folk medicine. The cytotoxicity of P_(388), L_(1210) leukemia cells, the inhibition rate of its root meritism through the cress seedling assay and the lipid peroxidation test were performed. Potential cytotoxicity on the P_(388) leukemia cells in the Thalictrum aquilegifolium, Lindera obtusiloba and Artemisia annua and the control of cell proliferation in the caulis of Acathopanax chiisanensis against L1 2 I O leukemia cells were observed. In the cress seedling test, the plants such as Pharbitis nil, Artemisia iwayomogi, the caulis of Acanthopanax chiisanensis, Clematis mandshurica and Melandrium firmum showed activity in vincristine 200㎕/㎖ cisplatin 500㎕/㎖ concentration. On the system 1,2-lipid peroxidation, it was found that Artemisia iwayomogi and Artemisia annua exhibited strong antioxidative effect in the homogenate substance of rat liver injured by CC1₄.

생물변환 천연식용색소 생산공정기술 개발 : Ⅰ. 홍화 황색소의 안정성에 미치는 pH 및 온도의 영향 Ⅰ. Effect of pH and Temperature on the Stability of the Yellow Pigment from Carthamus tinctorious L.

홍성현,박성길,이종민,한태룡,백영숙,정인식 경희대학교 생명자원과학연구원 1999 硏究論文集 Vol.20 No.-

홍화로부터 열에 의한 안정성을 검토하였다. 황색소의 분해반응은 산성, 중성, 염기성 조건에서 UV/Vis spectral measurement에 의해 조사되었다. 시간변화에 다른 흡광도를 측정해 본 결과 온도가 상승함에 따라 황색소의 분해되는 정도가 점차적으로 증가하는 것을 확인 할 수 있었다. 40℃에서 황색소의 분해 반감기는 pH3.0, pH7.0, 그리고 pH12.0에서 각각 112.1, 39.3 과 25.3 시간이었다. 이것은 황색소가 pH3.0에서 비교적 더 안정함을 말한다. pH3.0, 7.0 그리고 12.0에서 황색소의 activation energy는 각각 519, 15.0 그리고 12.3 kJ/mol이었다 We investigated thermal stability of yellow pigment from Carthamus tinctorious L. Decomposition reactions of yellow pigment were monitored at acidic, neutral and alkaline conditions by UV/Vis spectral measurement. Decomposition of yellow pigment increased as temperature increased Decomposition half lives of yellow pigment at 40℃ were 112.1 39.3, and 25.3 hrs at pH 3.0 , pH 7.0, and pH 12.0, respectively, indicating that yellow pigment is more stable at pH 3.0. The activation energies of yellow pigment at pH 3.0, pH 7.0, and pH 12.0 were 51.9, 15.0, and 12. 3 kJ/mol, respectively.

하고초의 지질과산화 및 간독성에 미치는 영향

김태희,양기숙,이현아 숙명여자대학교 1995 약학논문집-숙명여자대학교 Vol.11 No.-

Prunella vulgaris L. var. lilachina(Labiatae) is used as herbal remedies for infectious hepatities, cancer, human tuberculosis, bacilliary dysentery. In order to investigate the efficacy of the plant in vitro and in vivo, its fractions were examined antilipid peroxidative activity and therapeutic effect of carbon tetrachloride induced hepatotoxicity in rats. In liver lipid, the lipid peroxidative activity was inhibited significantly by ether and butanol fractions in vitro, also in butanol fraction in vivo (p>0.001). In serum, the antilipid peroxidative activity was increased significantly in chloroform fraction in vivo. Butanol fraction had significantly reduced the elevated level of S-GOT and S-GPT(p<0.001). The liver and lipid weights of CCl_4 administration group tend to increase compared with those of normal group. The administration of each fraction P.O. after CCl_4, S.C., lipid weight tend to reduce, but not significant.

국내에서 발생하고 있는 사람 브루셀라증의 임상적 특성

김연숙,최영실,오원섭,권기태,이혁,이선희,손준성,김신우,장현하,정숙인,고관수,박미연,백경란,송재훈 대한감염학회 2006 감염과 화학요법 Vol.38 No.6

배경 : 2002년 내국인에서의 첫 사람 브루셀라증의 증례 보고 이후 국내에서 사람 브루셀라증이 빠른 증가를 보이고 있다. 이에 연구자들은 국내에서 발생하는 브루셀라증의 임상적 특성을 연구하고자 하였다. 방법 : 2003년부터 2006년 7월까지 7개 대학병원에 내원한 환자들을 대상으로 WHO의 진단기준에 의하여 확진된 브루셀라증 환자들의 의무기록을 후향적으로 조사분석 하였다. 배양된 균은 삼성서울병원에 의뢰하여 16S rRNA 유전자 분석방법을 이용하여 종을 확인하였고, 표준시험관응집검사는 국립보건원에 의뢰하여 시행하였다. 결과 : 34예의 환자들이 브루셀라증으로 확진되었고, 31명이 남자였다. 혈액에서 B. abortus가 증명된 경우가 8예, 표준시험관 응집검사상 의미 있는 항체가 상승을 보인경우가 26예이었다. 환자들은 대부분 축산업관련 종사자였고, 추후 브루셀라증으로 확진된 소와의 직접 접촉을 통해 감염된 것으로 여겨진다. 국내 사람 브루셀라증의 가장 흔한 증상은 발열이었고, 위장관계 합병증이 가장 흔히 동반되었다. 치료로는 doxycycline/rifampicin이 24예의 환자에서 doxycycline/aminoglycoside (streptomycin 혹은 gentamicin)이 10예의 환자에서 6주 이상의 기간 동안 투여되었다. 치료에 반응을 보이지 않는 환자는 없었고, 재발이 1예 있었다. 결론 : 국내에서 발생하는 사람 브루셀라증의 원인균으로 현재까지 분리 동정된 것은 B. abortus이며, 소 브루셀라증의 증가로 인해 인체감염사례가 함께 증가하는 것으로 사료된다. 위험 직업군 종사자들에서 감염된 소와의 직접 접촉을 통해 주로 발생하고 있는 브루셀라증의 임상종상은 국외에서 발생하는 경우와 유사한 양상을 보이고 있으며 치료에 대한 반응은 비교적 좋은 편이긴 하나, 추후 보다 많은 환자들을 대상으로 한 연구가 필요하리라 사료된다. 사람 브루셀라증의 조절을 위해서는 소 브루셀라증의 조절이 필수적이며, 브루셀라증의 조절에 성공한 선진국의 사례를 적극적으로 도입해야 할 것으로 생각된다. Background : Since the first Korean case of human brucellosis was reported in 2002, the incidence of human brucellosis has been rapidly increasing. We performed this study to evaluate the clinical characteristics of human brucellosis occurring in South Korea. Materials and Methods : Demographic features, clinical manifestations, and therapeutic outcomes of cases confirmed as brucellosis according to WHO diagnostic criteria were evaluated. Species of Brucella isolates were identified with 16S rRNA gene sequencing method. Serologic diagnosis was performed with standard tube agglutination test (STA). Results : A total of 34 cases were enrolled from 2003 to 2006 in six hospitals. Eight cases were confirmed with the isolation of Brucella from blood and 26 cases were confirmed with titer of antibodies ≥1:160 by STA. Male (31) was predominant and most of the patients were cattle farmers. The most common transmission route was direct contact with infected or their cattle byproducts. Fever was the most prominent symptom and fatigue followed. Gastrointestinal and musculoskeletal systems were commonly complicated. Patients were treated with doxycycline and rifampin or aminoglycosides for more than 6 weeks. All patients responded well to the therapeutic regimens, but one patient relapsed 10 months after treatment. Conclusion : Brucellosis occurring in Korea has been caused by B. abortus, whose preferred natural host animals are cattle. Korean patients were infected through direct contact with bovine brucellosis. Clinical manifestations of brucellosis were similar to those occurring worldwide. Therapeutic outcomes were good among patients with brucellosis in Korea. In order to prevent human brucellosis, measures to eradicate bovine brucellosis should precede.