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신현철,윤철호,김종대,정지천,신억섭,허근 한국한의학연구원 1997 한국한의학연구원논문집 Vol.3 No.1
In convulsion state by PTZ in rat, anticonvulsive effect and some γ-aminobutyric acid (GABA)-related mechanisms of Bythus extract in brain was experimented. It was ingibited GABA-T activity, lipid peroxide generation and xanthine oxidase activity as scheduled administration in vitro and vivo. And the content of brain gutathione was increased as scheduled administration in rat. In convulsion state by PTZ of previously managed rat by Buthus extract, onset eime and duration were non-specific changes but recovery time and severity was remarkably reduced. In conclusion speculated that Buthus extract inhibits convulsion by control of GABA content in brain.
주지현,최정현,이동건,백지연,고윤호,이혜정,김세희,신호진,박윤희,박지영,김유진,신완식,김춘추 대한감염학회 2001 감염 Vol.33 No.4
Background : Pneumocytitis cainii pneumonia (PCP) can occur in immunocompromised hosts especially such as AIDS or cancer patients. Although recent research had focused on PCP in AIDS patients, few studies have described the clinical presentations of PCP in recipients of stem cell transplantation (SCT). We evaluated the clinical manifestations of PCP in SCT patients admitted at St. Mary's hospital, Seoul, Korea. Methods : The medical records of 17 PCP patients undergoing SCT between Feb. 1998 and Feb. 2000 were reviewed. The diagnosis of PCP was confirmed through the demonstration of Pneumocytitis cainii via either cytology of brochoalveolar lavage (BAL) or histological technique of lung biopsy. CMV disease and CMV infection were confirmed by BAL culture and antigenemia respectively . Results : Seventeen patients were all recipients of allogeneic SCT and 7 of 17 patients were performed non-sibling SCT. Patients presented with symptoms including brief period (4 ∼23 days) of fever (76%), dyspnea (70%), cough (64%), and signs such as rare(58.8%), Sixteen patients (94%) had been receiving immunosuppressive agent such as cyclosporine A (64%) or Fk506 (35%) without PCP prophylaxis. Eleven patients (64%) were treated with corticosteroid with mean dose of 16 mg/day prednisolone and mean duration of 4.6 months after post-SCT period. Twelve patients were co-infected with CMV. Another co-infected miCroorganisms were Pseudomonas aeruginosa, Mycobacterium tuberculosis, herpes simplex virus, parainfluenza virus, Average duration of treatment with trimethoprim-sulfamethoxazole (TMP/SMX) was 21 ±9 days. Four patients died, and three of them were related with PCP. Conclusion : PCP developed frequently in patients who were taking immunosuppressive drug due to graft versus host disease or were not taking TMP/SMX prophylaxis. High risk patients showing fever, cough, or dyspnea should be considered to take early bronchoscopic intervention for detection of PCP. When treat for PCP, it also be considered to the possibility of coinfection such as CMV. (Korean J Infect Dis 33:273∼279, 2001)
[판례평석] 무의미한 연명치료중단에 대한 환자의 자기결정권 : 대법원 2009. 5. 21. 선고 2009다17417 등을 중심으로
최지윤,김현철 이화여자대학교 생명의료법연구소 2009 생명윤리정책연구 Vol.3 No.2
Recently the Supreme Court in Korea has permitted the withdrawal of lifesustaining treatment of an old dying patient in PVS. The judgment was made on the basis of the patient's right of self-determination. The Court has inferred the patient's presumptive intention from the patient's former statements, religion, character, age and so on, and judged that the right of selfdetermination can be exercised even through the “presumptive intention.” But the patient’s right of self-determination can’t be exercised by the inferred intention for the presumptive intention is a mere hypothesis. If human dignity is generally recognized as an indispensable value of his or her whole life, the withdrawal of life-sustaining treatment should be justified by a patient’s interest for itself.
백지현,박은영,정윤숙,홍재원,채윤태,진성준,최희경,신소연,한상훈,진범식,김창오,최준용,송영구,조남훈,김준명 대한감염학회 2009 감염과 화학요법 Vol.41 No.4
Coccidioidomycosis is a fungal infection that results from inhaling the airborne arthroconidia of the Coccidioides species. It is an endemic disease in the southwest part of North America and rarely diagnosed in Korea. As tourism to endemic areas and the number of immunocompromised patients have been increasing, the incidence of this infection has increased in non-endemic areas. Treatment is usually successful with antifungal agents; however, recurrence is common. It is difficult to decide when to discontinue the antifungal treatment especially in non-endemic areas where doctors are not familiar with the disease. We report a case of recurrent coccidioidomycosis manifesting as osteomyelitis after the treatment of the patient for disseminated coccidioidal infection. The complement fixation test was a useful tool for the assessment of patient response and to evaluate suspected recurrence.
식품영양학 전공자를 위한 인턴십 교육 프로그램 개선방안
주나미,윤지영,김옥선,정현아,박상현,고영주,조기원 한국식생활문화학회 2005 韓國食生活文化學會誌 Vol.20 No.1
This study was conducted to evaluate the effect of current dietetic internship program. The survey sample was dietetic practitioners who were charged with a training for dietetic students. The questionnaire requested information about demographic information, experience of guidance for the dietetic student, self evaluation as trainer, fortification items in university education, and difficulties of the internship program. Data was analyzed using SAS for windows(version 6.12), Descriptive statistics were used such as means. standard deviations. frequency distribution and percentages. Comparison of mean differences was analyzed using t-test and ANOVA. Participants identified how effective the current internship program was. Result indicated that the effectiveness was not high(2.81), and under 29 years old age group, under 6 years work experience group. and contracted foodservice group had positive opinion of the program significantly. Under 29 years old age group, evaluated themselves as a good trainer. The results revealed that respondents wanted to be fortified the practical training courses in school curriculum.
어명근,최지현,최윤국 한국농업정책학회, 한국축산경영학회 2000 농업경영정책연구 Vol.27 No.2
According to the measurement of Revealed Competitive Advantage (RCA) indices, relative competitiveness for grapes, plum, kiwi, pears and apples were higher than any other Chilean agricultural products. Climatic and geological conditions, market oriented agricultural polities as well as the plantational structure and development of processing, marketing and logistic systems for export were the sources of competitiveness of Chilean fruit industry. Export of Chilean fruits toward Korea would steeply increase as Korea-Chile free trade agreements are come into effects. Small-sized Korean fruit farmers should lower the costs and raise the quality of their products. At the same time, they should promote the development of fruit processing industry.
김경수,김기환,김현만,윤지원,강엽 아주대학교 1997 아주의학 Vol.2 No.2
IDDM (Insulin dependent diabetes mellitus) is believed to be an autoimmune disease and characterized by the immune activation against insulin-producing pancreatic beta cell. The identification and characterization of new autoantigens reactive with an activated immune System would heip to elucidate the pathogenic mechanism of this disease. Several autoantigens are trying to apply for diagnosis and prevention of IDDM. The NOD (non obese diabetic) mice have been the best model for studying the pathogenesis of human IDDM. To identify new autoantigens reactive with activated humoral immunity of NOD mice, the lambda gt11 cDNA library was constructed from NOD-derived pancreatic beta cell (MIN6N8a: mouse insulinoma cell) and screened with prediabetic NOD sera. Mine positive dones were selected from 2x10^(5) phage plaques. The 5'-end sequencing and homology searching showed that six clones from nine clones had over 98% sequence homolgy with the retroviral envelope gene. Full sequendng reveated that the cloned gene was a fragment of ecotropic retrovirus (emv-3) envelope gene. To confirm the immunoreactivity of doned retroviral envelope protein, the cloned gene fragment was expressed in an E.coli expression vector System. Western blotting showed that the recombinant envelope protein fragment also reacted with prediabetic NOD sera.
Yoon, Ji-Hyeon,Wei, Shuai,Oh, Deog-Hwan Elsevier 2018 FOOD SCIENCE AND TECHNOLOGY -ZURICH- Vol.94 No.-
<P>A new selective enrichment broth (OSA) was developed for detection of Staphylococcus aureus combined with real-time PCR. Acriflavine, nalidixic acid, potassium tellurite and sodium chloride were added as selective reagents and mannitol, sodium pyruvate, and yeast extract as promoters. The growth of S. aureus (10, 100, 1000 CFU/mL inoculation level) in OSA was superior to that in TSB with 7.5% NaCl (TNaCl). OSA showed a good inhibition ability against 8 strains including 4 Gram-positive and 4 Gram-negative. Further, OSA gave a good recovery of cold-, acid-, and heat-stressed cells comparable to TSBYE but superior to TNaCl. A real-time PCR targeting the nuc gene was developed and the standard curve was established from 9.1 x 10(7) to 9.1 x 10(2) cfu/mL with a high regression coefficient of determination (R-2 = 0.999) and a high amplification efficiency of 96.362%. Using artificially contaminated food samples (kimbap, milk, and spam) with a level of similar to 10 CFU/25 g or mL, OSA better supported the growth of S. aureus and all samples were readily detected after 12 h enrichment by real-time PCR. In summary, OSA was demonstrated as a promising selective enrichment broth for detection of S. aureus combined with real-time PCR with a total assay time of 15 h.</P>