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Risk factors of HSIL in women with ASC-H: Indications for direct conization
( Hye-yon Cho ),( Min Sun Kyeong ),( Jung Bae Kang ),( Kyu-sang Kyeong ),( Myunghwa Lee ),( Seungho Kim ),( Sujin Kim ),( Yaesol Kim ) 대한산부인과학회 2022 대한산부인과학회 학술대회 Vol.108 No.-
Objective: To identify risk factors of HSIL and cervical cancer in women with ASC-H Methods: A retrospective chart review of 155 patients who had ASC-H and underwent conization between 2013 and 2022. Clinical factors (age, parity, body weight, height, medical history, prior history of abdominal surgery, and complete blood counts within 1week of conization), and pathologic results (type of HPV infection, punch biopsy results, and pathologic reports of conization) are recruited. Results: Total 122 women diagnosed as HSIL (≥CIN2) by punch biopsy or conization. Women with HSIL was significantly correlated with younger age (<45 years old), non-multiparity, non-menopause, no prior abdominal surgery, high-risk HPV infection, and higher neutrophil to lymphocyte (NLR) ratio (≥ 2.0) than those without HSIL (<CIN2). Multiple logistic regression revealed that high-risk HPV infection (Hazard ratio 4.709; 95% Confidence interval 1.541~14.391; P= 0.007) and no prior abdominal history (Hazard ratio 4.047; 95% CI (1.409~11.628; P= 0.009) were high risk factors for HSIL in women with ASC-H. Conclusion: Direct conization might be preferred when women with ASC-H also have high-risk HPV infection and no history of abdominal surgery.
( Hye Yon Cho ),( Min Sun Kyung ),( Jeong Bae Kang ),( Pong Rim Jang ) 대한산부인과학회 2014 대한산부인과학회 학술대회 Vol.100 No.-
목적: : This study was aimed to evaluate the efficacy of HE4, and risk of ovarian malignancy algorithm (ROMA) in discrimination of ovarian cancer from benign disease, by comparing to CA125. 방법: Prospectively, serum from 68 women with ovarian mass was obtained prior to surgery. For control group, serum from 79 normal populations without ovarian mass was also obtained. The HE4 and CA125 data were registered and evaluated separately, and ROMA was calculated for each sample. 결과: Total 49 patients with benign ovarian tumor, and 20 patients with ovarian cancer were evaluated. Median serum levels of HE4, CA125, and ROMA in patients with ovarian cancer were significantly higher than those with benign ovarian tumor and normal populations (p< 0.0001). In ROC curve analysis for patients with pelvic masses, AUC for HE4 and ROMA seems superior to CA125 alone, but it was not statistically significant. However, sub-analysis showed that negative predictive value (62.5% vs. 85.4%) and positive predictive value (70.0% vs. 75.0%) for CA125 were lower than that for combination of HE4 and ROMA. 결론: Our data suggested that the HE4 and ROMA algorithm were not superior to CA125 as an independent diagnostic tool for epithelial ovarian cancer. However, combination of HE4 and ROMA algorithm can be a better tool than CA125, in distinction of ovarian cancer from benign disease.
( Hye-yon Cho ),( Ryeobin Lee ),( Ye Hyon Park ),( Tae-yeem Lee ),( Sung-taek Park ),( Sung-ho Park ),( Jeong Bae Kang ),( Pong Rheem Jang ),( Min Sun Kyung ) 대한산부인과학회 2016 대한산부인과학회 학술대회 Vol.102 No.-
목적: To investigate the impact of laparoscopic hysterectomy (LH) on ovarian reserve by comparing changes of serum anti-Mullerian hormone (AMH) levels following LH (study group) and laparoscopic myomectomy (LM; control group). 방법: Serum AMH levels were measured pre-operatively (AMH0), 7 days (AMH1), 2 months (AMH2), and 6 months (AMH3) after LH and LM in 40 premenopausal women (LOC=20; LM=20). Changes of AMH were compared between two groups. 결과: Total 40 women included in this study (LOC=20; LM=20). At postoperative 6 months, 35 women checked AMH3. On the baseline data analysis, mean age was younger in LM group compared to LH group (p= 0.031). Parity and BMI was similar in both groups. AMH0 was similar in both groups (2.4 ± 2.72 in LM vs. 1.5 ± 3.52 in LH, p= 0.370). Also, AMH1, AMH2, and AMH3 were not different between the two groups. A rate of a significant decrease of AMH (more than 50% decrease compared to AMH0) at postoperative 6 months was not different between the two groups. 결론: Serum AMH levels were not significantly decreased after LH compared to LM, which suggests that LH may have no adverse effects on ovarian reserve comparing to LM. A long-term study of AMH levels is required.
( Hye Yon Cho ),( Yoon Ha Kim ),( Jong Woon Kim ),( Sun Joo Choi ),( Tae Bok Song ) 대한산부인과학회 2010 Journal of Womens Medicine Vol.3 No.4
Primary retroperitoneal mucinous cystadenomas (PRMCs) are very rare and difficult to diagnose before operation. Also the histogenesis of PRMC is unclear. We present a case report of a 30-year-old woman with PRMC in 15 weeks and 3 days of pregnancy. The ultrasound examination showed a 13×9×6 cm sized cystic tumor of the left ovary. The tumor revealed to be the cystic mass localized in the left retroperitoneum after exploratory larparotomy. This is the first case to report PRMC in pregnancy. Preoperative diagnosis of PRMC is very difficult, because the cystic mass of women in the pelvic cavity was usually ovarian mass. When confronted with cystic mass in pelvic cavity, we have to include the retroperitoneal mass in the list of differential diagnosis.
( Hye Yon Cho ),( Sung Ho Park ),( Hong Bae Kim ) 대한산부인과학회 2010 Journal of Womens Medicine Vol.3 No.1
Vaginal evisceration with abdominal viscera following hysterectomy is very uncommon complication. However, total laparoscopic hysterectomy (TLH) seems to be higher risk than other hysterectomy routes. Minimizing the use of electrothermal instruments and meticulous, full-thickness closure during vaginal vault procedure in TLH will decrease the risk. But if a vaginal vault prolapse occurs unfortunately, a delayed absorbable polydioxanone suture like PDS will be benefit in closing vaginal vault. In most of these cases, healing of vaginal vault is good by one time of repair and recurrence is rare. We experience a case of 48-year-old woman who presented repetitive vaginal evisceration after TLH. Therefore, we report this case with relevant literatures. Surgeons should consider advising women who underwent TLH regarding the slow and steady resumption of the first sexual intercourse postoperatively, particularly patients having highly sexual activity and high risk of wound-healing.