A Type-2 Fuzzy Logic Ensemble SVM Classifier based on Feature Weighting

Weiping Huang,Ziyang Wang,Qinghua Chi,Jun Liang 보안공학연구지원센터 2016 International Journal of Signal Processing, Image Vol.9 No.2

THE OPPORTUNITY AND CHALLENGE IN NORTHEAST ASIA

Huang Weiping 한국동북아학회 1996 한국동북아논총 Vol.1 No.2

Northeast-asian economic cooperation because of the regional high speed economic growth has been taken the attention of the world, in this region there are economic supper power - Japan and three of the Four Dragons - Korea, Hongkong and Taiwan, of course, others as China, Far-east Russia, also play the very important role in the regional cooperation. In this regional cooperation, main characteristic is the supplement and movement of the capital, technology, labour, and other resources in order to get the optimum allocation and combination of the factors. The forerunners and leading powers of the cooperation in this region is NIEs in the near future but not the developed countries as the cooperation in European EEC. Korea is one of the forerunners and leading powers, Beijing-seoul Axis will be the center of the cooperation at the first step in Northease - Asian region, for the sake of Japan`s low gesture in the cooperation both by the government and the business circle. Recently, neither Seoul nor Beijing could be the SOLO (unique) leader of the regional cooperation. At the second step, if possible, Beijing - Seoul - Tokyo Axis will be formed, the cooperation will develop far, one could say, starting the cooperation depends on NIEs in this region, but developing the cooperation will much on the participation by Japan. The relation between Korea and China would be shown as the competition within the framework of cooperation, competition is the motive force for the cooperation, and will take place in the aspects of trade, investment, technology, market expansion, and other resources introduced. The future of cooperation would certainly be bright, but the States, Japan also have their own benefit and interest in the region, in this case, they have the great effective influences on Northeast-Asian regional economic cooperation, the cooperation should be open to them especially to Japan.

Experimental Study on the Effect of Boundary Layer on High-Speed Train Aerodynamic Forces Measurement

Zhixiang Huang,Weiping Zeng,Jie Gai,Hanjie Huang 대한토목학회 2021 KSCE JOURNAL OF CIVIL ENGINEERING Vol.25 No.5

The influences of boundary layer thickness on the aerodynamic characteristics of a high-speed train head car were investigated with an 1:8 scaled model in an 8 m × 6 m wind tunnel at CARDC. Boundary layer thicknesses at different positions on the ballast surface were measured under the wind velocity range of 40 to 70 m/s and the Reynolds number range of 1.25 × 106 to 2.19 × 106. It was found that the effect of Reynolds number on the head car was small. The boundary layer thickness increased significantly along the ballast and decreased gradually with the increase of the wind velocity. A linearly fitted model was employed to calculate the boundary layer thickness under different wind velocities. The changing patterns of the drag and lift force coefficients with the boundary layer thickness were complex. The drag and lift coefficients increased by 5.57% and 21.97% respectively, when the boundary layer thickness was larger than 118 mm. The effects of boundary layer on lift coefficients were more prominent than on the drag coefficients.

Effects of neutron irradiation on densities and elastic properties of aggregate-forming minerals in concrete

Weiping Zhang,Hui Liu,Yong Zhou,Kaixing Liao,Ying Huang Korean Nuclear Society 2023 Nuclear Engineering and Technology Vol.55 No.6

The aggregate-forming minerals in concrete undergo volume swelling and microstructure change under neutron irradiation, leading to degradation of physical and mechanical properties of the aggregates and concrete. A comprehensive investigation of volume change and elastic property variation of major aggregate-forming minerals is still lacking, so molecular dynamics simulations have been employed in this paper to improve the understanding of the degradation mechanisms. The results demonstrated that the densities of the selected aggregate-forming minerals of similar atomic structure and chemical composition vary in a similar trend with deposited energy due to the similar amorphization mechanism. The elastic tensors of all silicate minerals are almost isotropic after saturated irradiation, while those of irradiated carbonate minerals remain anisotropic. Moreover, the elastic modulus ratio versus density ratio of irradiated minerals is roughly following the density-modulus scaling relationship. These findings could further provide basis for predicting the volume and elastic properties of irradiated concrete aggregates in nuclear facilities.

MBNL3 Acts as a Target of miR-302e to Facilitate Cell Proliferation, Invasion and Angiogenesis of Gastric Adenocarcinoma via AKT/VEGFA Pathway

( Weiping Tang ),( Can Huang ),( Bing Jiang ),( Junjun Lin ),( Yecai Lu ) 한국미생물생명공학회 2024 Journal of microbiology and biotechnology Vol.34 No.7

Gastric adenocarcinoma (GAC) is a common, malignant type of tumor in human, and is accompanied with higher mortality. Muscleblind-like 3 (MBNL3) was found to be a pivotal participator in aggravating this cancer’s progression. However, the regulatory effects of MBNL3 on GAC development have not been investigated. We therefore sought to study the functions of MBNL3 in GAC progression. In this study, it was demonstrated that MBNL3 exhibited higher expression, and GAC patients with higher MBNL3 expression had poor prognosis. Overexpression of MBNL3 facilitated, and knockdown of MBNL3 suppressed cell proliferation, invasion, and angiogenesis in GAC. Further experiments showed that miR-302e targets MBNL3. Rescue assays then uncovered that the miR-302e/MBNL3 axis aggravated GAC progression. In addition, MBNL3 activated the AKT/VEGFA pathway, and the suppressive regulatory impacts of MBNL3 knockdown on GAC cell proliferation, invasion, and angiogenesis could be rescued after 740 Y-P treatment. Through in vivo assay, it was proved that MBNL3 accelerated tumor growth in vivo. In conclusion, MBNL3 acted as a target of miR-302e to facilitate cell proliferation, invasion, and angiogenesis of gastric adenocarcinoma through the AKT/ VEGFA pathway. Our findings illustrate that MBNL3 may be an available bio-target for GAC treatment.

Successful Treatment of Psychiatric Symptoms after Traumatic Brain Injury Using Deep Brain Stimulation to the Anterior Limb of Internal Capsule-Nucleus Accumbens

Bin Zhou,Weiping Kuang,Hongxing Huang,Yong Zhu,Xiaofeng Chen,Liang Li,Ping Yang 대한정신약물학회 2020 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.18 No.4

Psychiatric symptoms are common after traumatic brain injury (TBI), and some patients have poor drug therapeutic efficacy. We report a successfully treated case of psychiatric symptoms after TBI using deep brain stimulation (DBS) to the anterior limb of internal capsule (ALIC)-nucleus accumbens (NAc) in a 76-year-old woman. The patient suffered from auditory hallucination, mood changes, and insomnia caused by TBI. Psychological test assessment showed the scores of Hamilton Anxiety Scale, Hamilton Depression Scale and Positive and Negative Syndrome Scale were 30, 35, and 96 respectively. Head magnetic resonance imaging scan showed right temporal lobe encephalomalacia. Head magnetic resonance spectroscopy (MRS) showed bilateral basal ganglia choline increased relatively. After DBS to the ALIC-NAc, the target parameters were adjusted. The psychiatric symptoms were completely improved and the result of head MRS was normal in the end. The current report declares that DBS is reversible, adjustable and safe in the treatment of psychiatric symptoms caused by TBI. DBS to the ALIC-NAc should be considered as a possible treatment choice once a patient showed psychiatric symptoms after TBI.

Dispersion mechanisms of Arabic gum in the preparation of ultrafine silver powder

Yingfen Li,Weiping Gan,Xiaogang Liu,Tao Lin,Bei Huang 한국화학공학회 2014 Korean Journal of Chemical Engineering Vol.31 No.8

Finely divided silver micro-spheres were prepared with Arabic gum (AG) as dispersant through the chemicalreaction of AgNO3 and ascorbic acid. AG dispersive mechanisms in the preparation of silver powder are proposed inthe paper. The -COOH and -NH2 groups of AG reacted with Ag+ to form Ag+-AG complexes, followed by the nucleationof silver on AG polymer chains, which yielded silver spheres with an AG protection layer by reducing Ag+-AG complexeswith ascorbic acid. With the steric effect of AG, the prepared silver particles exhibit improved dispersibility. UV-Vis and FTIR spectra confirmed that silver particles were stabilized by AG.

Stigmast-4-en-6β-ol-3-one decreases viability and induces apoptosis and ferroptosis in liver cancer cells by reducing E2F1

Zhiyun Zhang,Jian Wang,Weiping Wan,Zhengchao Shen,Aixue Zuo,Rong Chen,Qinyi Wu,Enli Cai,Feng Huang,Rongping Zhang,Xinan Shi 한국통합생물학회 2023 Animal cells and systems Vol.27 No.1

Hepatocellular carcinoma (HCC) is a frequently occurring malignant gastrointestinal cancer. The 5-year survival rate of HCC is still below 8%, and thus, identifying more effective therapeutic methodsis needed. Here, we evaluated the effects of Stigmast-4-en-6β-ol-3-one (S463) on the viability andcolony formation of liver cancer cells. S463 treatment decreased the viability and inducedapoptosis and ferroptosis in liver cancer cells, and also increased cellular malondialdehyde(MDA) and lipid peroxidation levels. In S463 treated cells, the expression level of Bax wasincreased, and the expression level of GPX4 was reduced, and the cleavage of PARP wasimproved. We also found that S463 treatment downregulated E2F1 and upregulated p53 atboth the mRNA and protein levels. Importantly, rescue experiments revealed thatoverexpression of E2F1 partially restored S463-induced Bax and p53 upregulation and GPX4downregulation and counteracted the S463-induced decrease in cell viability and colonyformation and the S463-induced increase in MDA and lipid peroxidation levels. Our findingssuggest that S463 significantly inhibits viability and colony formation and induces apoptosisand ferroptosis in liver cancer cells via E2F1.

Sparse probabilistic principal component analysis model for plant-wide process monitoring

Jing Zeng,Kangling Liu,Weiping Huang,Jun Liang 한국화학공학회 2017 Korean Journal of Chemical Engineering Vol.34 No.8

In the industrial monitoring process, probabilistic principal component analysis (PPCA) is a popular algorithm for reducing the dimension. However, the principal components (PCs) are not easy to interpret and its preserved number cannot be determined automatically. In this paper, we propose a sparse PPCA (SPPCA) to improve the interpretability by adding a prior and introducing sparsification to the loading matrix of PPCA. An expectation-maximization (EM) algorithm is used to obtain the parameters of the probabilistic formulation, and the dimensionality of the latent variable space can be automatically determined during the iterative process. With the sparse representation, a process monitoring strategy is then developed with the construction of several partial PPCA models. Case studies of SPPCA to a numerical case and Tennessee Eastman (TE) benchmark process demonstrate its feasibility and efficiency.

Asymptotic ruin probabilities for proportional investment under interest force with dominatedly-varying-tailed claims

Yu Chen,,Yin Huang,Weiping Zhang 한국통계학회 2012 Journal of the Korean Statistical Society Vol.41 No.1

We study the asymptotic behavior of the ruin probabilities in the renewal risk model, in which the insurance company is allowed to invest a constant fraction of its wealth in a stock market which is described by a geometric Brownian motion and the remaining wealth in a bond with nonnegative interest force. We give the expression of the wealth process by the Itô formula, and finally we derive the asymptotic behavior of finite-time and infinite-time ruin probabilities in the presence of pairwise quasi-asymptotically independent claims with dominant varying tails for this model. In the particular case of compound Poisson model, explicit asymptotic expressions for the ruin probabilities are given with tails of regular variation, where the relation of the infinite-time ruin probability is the same as Gaier and Grandits (2004). For this case, we give some numerical results to assess the qualities of the asymptotic relations.