퇴행성 슬관절염에 대한 제통단의 안정성과 효능 임상연구

서병관,류성룡,강중원,안경애,이상훈,최도영,김건식,이두익,이윤호,이재동 EAST-WEST MEDICAL RESEARCH INSTITUTE KYUNG HEE UNI 2005 東西醫學硏究所 論文集 Vol.2005 No.-

Objectives : In order to investigate the efficacy and safety of the newly developed herbal medicine Jetongdan, a placebo-controlled randomized clinical trial of patients with osteoarthriotis of the knee was undertaken. Methods : Data were obtained from 80 patients with OA of the knee. After the enrollment, they were asked to answer a disease-specific questionnaire (Western Ontario and McMaster Universities (WOMAC) OA index) and analyzed with the erythrocyte sedimentation rate (ESR) in order to evaluate the efficacy of Jetongdan, and analyzed for aspartate transaminase (AST) level, alanine transminase (ALT) level, blood urea mitrogen (BUN) level, and creatinine (Cr) level in order to evaluate the safety of Jetongdan. Results : The liver function and renal function did not deteriorate after treatment with Jetongdan. Composite WOMAC score and physical function subscale was improved, but pain subscale, stiffness subscale, and ESR were not improved by Jetongdan. This was possibly because the baseline characteristics of the two groups were not homogenized after randomization. Conclusions : Jetongdan could be a promising treatment option for osteoarthritis of the knee. Further study in a larger population with appropriate severity grades is recommended.

장간막정맥혈전증 1예

서경원,이상호 고신대학교 의과대학 2009 고신대학교 의과대학 학술지 Vol.24 No.2

Mesenteric venous thrombosis is a rare disease accounting for 5-15%. MVT is generally difficult to diagnose and can be fatal because of delayed diagnosis and treatment. A case of extensive thrombosis of the mesenteric vein was diagnosed early and successfully treated in a 70-year-old female who was admitted to hospital because of bloody diarrhea and abdominal pain. Computed tomography(CT) showed remarkable thickening of the bowel walls and extensive thrombosis of superior mesenteric vein. Because intestinal infarction and peritonitis was seen, emergency operation was done and catheter-directed thrombectomy through mesenteric vein was successfully performed. She discharged without any complications.

농구 선수의 만성 슬개건염

서경호,서경묵,김성원,김백곤,송인섭 大韓再活醫學會 1998 Annals of Rehabilitation Medicine Vol.22 No.6

화상처리에 의한 주행 차선인식 알고리즘

서경호,김태효,박영석 경남대학교 정보통신연구소 1999 연구논문집 Vol.1 No.-

본 논문에서는 화상처리를 이용하여 고속도로에 그어진 차선을 정확하게 검출할 수 있는 알고리즘을 제안하고 이를 시험하였다. 본 알고리즘은 전 처리과정이 없이 원화상을 제안한 경사형 마스크에 의해 처리된다. 실험은 고속도로를 주행하면서 비데오 카메라로 영상을 녹화하였고, 이 영상을 Capture Board로 디지털영상으로 변환하여 본 알고리즘에 적용하였다. 차선검출 과정에서 좌측 및 우측 차선을 검출하기 위한 2개의 경사형 마스크를 사용하므로서 부분적 그림자 및 조도의 변화로 인한 경계선이 희미한 차선의 경우도 효과적으로 검출할 수 있음을 확인할 수 있었다. In this paper, we proposed and tested an algorithm which the road lane on express way can exactly be detected and recognized using image processing. This algorithm has no use for pre-processing, and the original image is directly processed by the two RAMP MASKs. In the experiment, we recorded the test images by a video camera while we were in driving. The recorded images were converted to digital images by the image capture board and applied the algorithm. In order to detect the left and right lanes, the two RAMP MASKs were used respectively. In the result, we confirmed that this algorithm can effectively detect the road lanes although the boundary line of both lanes have no clear due to partial shadows or variation of light.

퇴행성 슬관절염 환자의 증상 중증도 지표와 DITI의 상관성 연구

서병관,류성룡,강중원,안경애,이재동,최도영,김건식,이두익,이윤호,이상훈 EAST-WEST MEDICAL RESEARCH INSTITUTE KYUNG HEE UNI 2005 東西醫學硏究所 論文集 Vol.2005 No.-

Objectives : To investigate the applicability of thermography as severity measurement in the patients with osteoarthritis (OA) of the knee. Methods : Data were obtained from 80 patiens with OA of the knee. They were asked to answer two disease-specific questionnaire (Western Ontario and McMaster Universities (WOMAC) OA index, Lequesne's Functional Index (LFI)), one generic instrument (Korean Health Assessment Questionnaire (KHAQ)), VAS in order to assess the severity of disease, quality of life, degree of pain and taken thermography in standardized environment. Results : The thermal difference between ipsilateral side and contralaterla side of lateral aspect of knee was correlated with that of medial aspect of knee, and the thermal difference of anterior thigh was correlated with that of lateral, medial aspect of knee and patella region. Age, duration of disease, duration of morning stiffness, sex, crepitus, and painful side of knee were not correlated with the thermal differences of each region. LFI, WOMAC, WOMAC pain subscale, WOMAC stiffness subscale, WOMAC physical function, KHAQ,, VAS were not correlated with the thermal differences of each region. Conclusion : Further study on the thermography on OA of the knee in population with appropriate severity grade and the standardization of analysis of thermographic data were recommended.

위암환자에서 수술 전 내시경생검 조직검사와 수술 후 조직검사의 변동

서경원,이상호 고신대학교 의과대학 2009 고신대학교 의과대학 학술지 Vol.24 No.2

Background : This study was carried out in order to investigate the discrepancy between the histology obtained through the preoperative endoscopic biopsy and post operative resection. Methods :To analyse the factors affecting the discrepancy 280 cases, in 270 gastric adenocarcinoma patients who underwent surgical operation in this hospital since 1st August, 2004, to 31st July 2005, were subjected to present study. Histologic types were categorized into well-differentiated tubular(WD-T), moderately-differentiated tubular(MD-T), poor-differentiated tubular(PD-T), signet ring cell carcinoma, and papillary adenocarcinoma(Pap). The data is gender, tumor marker, concordance of pathologist, tumor location, T and N factor, and stage in this study Results : From the cases exhibiting WD-T, MD-T, PD-T, and SRC in endoscopic biopsy,52.9%, 60.4%,38.9% and 65.6%, respectively, showed the same pathology in resected specimen. The sensitivity was analysed as 70.3%, 52.9%, 26.9%, 80% respectively. For the statistically significant factors affecting the pathologic discrepancy, male patient showed higher discrepancy. In this cases, the discrepancy rate of gender is 49% in male, 34% in female patients with elevated CEA level had higher discrepancy. And that is statistically significant factors affecting the pathologic discrepancy. However, Patients with elevated CA19-9 levels also showed higher discrepancy, but no significance. Also, There is no difference about discrepancy according to concordance of pathologists who reported histologic biopsy, in the preoperation and postoperation. When discrepancy was presented, 44.9% was reported in accord case, 44.2% was reported in discord case with respect to pathologist. As for the discrepancy following the location of tu or, data showed less discrepancy, in cases where tumor was located at the lower 1/3, but this showed no significance. In the change of pathologic results based on T,N factor, It showed no significance.but, it is noticeable in mucosal, submucosal cancer that was reported 32.2% and 57.4% present rate of discrepancy, patients with elevated stage had higher discrepancy, but this showed no significance. Conclusions : The statistically significantly factors that affected the pathologic discrepancy were gender, and rise in CEA level. Mucosal and submucosal cancer showed discrepancy in 32.5% and 57.4% respectively, and further study is thought to be necessary. Also, further retrospective study with more cases is thought be needed for early gastric adenocarcinoma

교원효소로 유발된 랫드 대뇌 출혈병변의 병리학적 관찰

서일복,소경순,김광호,김영석 世明대학교 한의학연구소 1998 韓醫學硏究所 論文集 Vol.1 No.-

This study was carried out to characterized the hemorrhagic lesion sof the collagenase induced hemorrhagic stroke in rats. Fifty three Sprague-Dawley male rats were divided into two group. Group Ⅰ was served as model animals for hemorrhagic stroke, which were infused with 2㎕ saline containing 0.5unit collagenase(type Ⅶ) into the caudaate nuclei. Group Ⅱ was served as control animals, which were infused with 2㎕ saline only into the caudate nuclei. Six heaks of the rats of group Ⅰ were sacrificed at 30 min, 1, 5, 24 hours, 2, 5, 10 days after the infusion , and 3 heads of rats were sacrificed at 15 days after the infusion. Two heads of the rats of group Ⅱ were sacrificed at 30min, 1,5, 24 hours after the infusion. The brains of the rats were removed and examined grossly and histopathologically. Grossly, pin point sized or linear hemorrhage were occurred at 30minutes and the hemorrhagic lesions extended to 5mm in diameter at 24 hours. After then the hemorrhagic lesions faded gradually. Histopathologically, extended hemorrhage with degeneration of brain parenchyma were observed at 5 hours. Large area of malacia were observed at 24 hours. At 5 days, proliferation of astrocytes, proliferation of newly formed capillaries, and infiltration of lipid laden macrophages were seen at the periphery of the area of malacia. At 15 days, most of the area of malacia were replaced by granulation tissue. These observations may be useful parameters for the screening of therapeutic drugs using collagenase induced hemorrhagic stroke animal model.

CTX-M형 ESBL 생성 비장티푸스성 살모넬라의 특성

박순호,서일혜,안정열,박필환,김경희,송영희,김정은 대한감염학회 2010 감염과 화학요법 Vol.42 No.1

Background: Extended-spectrum ß-lactamase (ESBL)-producing Salmonella have been increasingly reported worldwide. ESBL-producing Salmonella is of particular concern since children cannot be treated with quinolones. This study was conducted to determine the phenotypic and genetic characteristics of ESBL-producing Salmonella in a tertiary hospital. Materials and Methods: Four clinical ESBL-producing isolates of non-typhoidal Salmonella were collected during 2001 to 2009. Antimicrobial susceptibility was determined by disk diffusion test and VITEK-II system. ESBL production was tested by ESBL phenotypic confirmatory test. TEM, SHV, CTX-M1, CTX-M2, CTX-M8, and CTX-M9 type ESBL genes were detected by PCR amplification, and PCR products were subjected to direct sequencing Results: Phenotypic confirmatory test showed that 4 of the 300 non-typhoidal Salmonella isolates were ESBL-producing: 3 S. Enteritidis and 1 S. Typhimurium. All 4 isolates were recovered during the past 1 year period. All 3 S. Enteritidis harbored CTX-M-15, while the S. Typhimurium harbored CTX-M-14. All CTX-M-15-producing S. Enteritidis isolates showed resistance both to cefotaxime and ceftazidime, while the CTX-M-14-producing S. Enteritidis were resistant only to cefotaxime. Conclusions: ESBL-producing nontyphoidal Salmonella has emerged recently and the type of ESBL has switched from TEM and SHV to CTX-M.

하악 무치악 부위의 임플란트 이식을 위한 전산화단층촬영 영상의 비교 평가

선경훈,정호걸,박혁,박창서,김기덕 대한구강악안면방사선학회 2009 Imaging Science in Dentistry Vol.39 No.1

Purpose : The purpose of this study was to evaluate the clinical usefulness of the recently developed multi-detector computed tomography and cone beam computed tomography in pre-operative implant evaluation, by comparing them with the single detector computed tomography, already confirmed for accuracy in this area. Materials and Methods : Five partially edentulous dry human mandibles, with 1×1 mm gutta percha cones, placed in 5 mm intervals posterior to the mental foramen on each side of the buccal part of the mandible, were used in this study. They were scanned as follows: 1) Single detector computed tomography: slice thickness 1 mm, 200 mA, 120 kV 2) Multi-detector computed tomography: slice thickness 0.75 mm, 250 mA, 120 kV 3) Cone beam computed tomography: 15 mAs, 120 kV Axial images acquired from three computed tomographies were transferred to personal computer, and then reformatted cross-sectional images were generated using V-Implant 2.0 (CyberMed Inc., Seoul, Korea) software. Among the cross-sectional images of the gutta percha cone, placed in the buccal body of the mandible, the most precise cross section was selected as the measuring point and the distance from the most superior border of the mandibular canal to the alveolar crest was measured and analyzed 10 times by a dentist. Results : There were no significant intraobserver differences in the distance from the most superior border of the mandibular canal to the alveolar crest (p>0.05). There were no significant differences among single detector computed tomography, multi-detector computed tomography and cone beam computed tomography in the distance from the most superior border of the mandibular canal to the alveolar crest (p>0.05). Conclusion : Multi-detector computed tomography and cone beam computed tomography are clinically useful in the evaluation of pre-operative site for mandibular dental implants, with consideration for radiation exposure dose and scanning time.

GHP용 천연가스 엔진의 희박 연소 특성에 관한 연구

李珉湖,李焌瑞,車京玉 明知大學校 産業技術硏究所 2004 産業技術硏究所論文集 Vol.23 No.-

Lean burn in natural gas spark ignition engine is the effective way to achieve energy saving and low emission effects. The keys techniques for the lean burn considered as followings ; test technique for intake port performance, measurement and analysis of in-cylinder air motion, flame propagation measurement, and finding correlation between fluid motion and flame speed. In other advanced countries, these techniques had been fully developed and have been applying to engine production, but the domestic technology and/or know-how for lean burn engine design are not enough. This study aims to develope fundamental key techniques for the lean burn in natural gas engine for GHP. The techniques in this study include intake port design (SCV) and test method. Experimental is applied to investigate the effects of swirl control valves to improve the engine performance and emission, efficiency in a DOHC natural gas engine using the GHP engine.