기억력 저하를 호소하는 노인들을 대상으로 INM176를 3개월간 임상시험한 후의 치료성적 및 부작용 평가 보고

김지혜,고선규,고효정,권영아,김성환,김재경,김태은,박재우,서민영,송영란,이인수,김도관 大韓神經精神醫學會 2003 신경정신의학 Vol.42 No.2

Objectives : We examined the effects of INM 176 (K-l107) compared with placebo on the cognitive functions of 92 old aged subjects with cognitive impairment. Methods : This was a prospective, 12 week, double-blind, Placebo-controlled clinical trial. The elderly who achieved a score of less than 25 points on the K-MMSE or showed a high risk of Alzheimer's disease from the 7-Minute Neurocognitive Screening Battery were considered to have objective impairment and were selected as subjects for this study. The subjects were randomized to placebo or INM 176 group. The outcome measures were from the Alzheimer's Disease Assessment Scale-cognitive subscale (ADAS-Cog), the Instrumental Activities ofDaily Living (IADL) and the Korean Geriatric Depression Scale (KGDS) and two kinds of computerized priming tests. After setting the total error score in the Alzheimer's Disease Assessment Scale-Cognitive section (ADAS-cog) as the repeated measurement factor, an analysis of variance of the combined factor design was done between the placebo and INM 176 group. Results : The interaction effect of time (pre- and post-trial) and group (placebo and INM 176 group) was significant in the analysis of the ADAS-cog's total error score. The INM 176 group's total error score in the ADAS-cog decreased significantly (p<0.01), whereas the placebo group showed a slight increase. The mean changes in IADL and GDS from baseline scores favored in the INM 176 group than in the placebo group. Outcome changes ofADAS-cog, IADL, KGDS scores during the 12 week clinical trail ofINM 176 and placebo demonstrated favorable responses in the INM176 administered group. Conclusions : This is a preliminary clinical trial result of INM176 as a memory pill. Based on these results, INM176 may be a candidate molecule for the improvement of cognitive functions, including memory, Further clinical trial should demonstrate its efficacy.

거대 난소 종양의 염전 1예

김미영,이해혁,유애리,박정희,이임순,정수호,고은석,레앙소팥,배동한,김태희,이권해 순천향의학연구소 2008 Journal of Soonchunhyang Medical Science Vol.14 No.1

..

유방암과 섬유선종의 방사선학적 소견 : 유방 단순촬영술과 유방 초음파검사 소견의 비교 연구 Studies on mammographic and ultrasonographic findings evaluation

임한혁,최득린,고은석,이혜경,임철완,이상진,홍현숙,최교창,김영화,박재성 순천향의학연구소 1997 Journal of Soonchunhyang Medical Science Vol.3 No.2

Purpose : To evaluate the utility of mammography and ultrasonography in study of morphologic differential diagnosis between malignant and benign mass. Materials and Methods : Average age of patients with breast cancer was 48.4 year-old, and that of fibroadenoma was 29.4 year-old. The equipments used for examination were MF-159 high frequency mammography(Bennet Co.) and Acoustic image 5200S. We evaluated mammographic findings about breast parenchymal pattern, calcification, margin and size of the mass associated tumor nature, and ultrasonographic findings about shape, height and width, internal homogenicity and echo pattern, wall contour, boundary echo, and posterior shadow in breast mass. Thirty-seven of mammographic findings and 34 cases of ultrasonogreaphic findings in pathologically proven breast cancer and 34 case of mammographic findings and 71 cases of ultrasonographic findings in breast fibroadenoma were reviewed retrospectively. Results : In mammographic study, the parenchymal patterns of breast cancer according to Wolfe classification were NI(16.2%), PI(24.3%), P@(37.8%), and DY(21.6%) and those in fibroadenoma were NI(3.1%), Pl(11.7%), P2(35.2%),and DY(50%). Mammographic findings about presence of calcification were as follows; only calcification(16.2%), only mass(51.3%), and mass with calcification(32.5%) in breast cancer, and only mass(91.2%), mass with calcification(8.8%) in fibroadenoma. The features of mass margins were classified as ill-defined margin(45.9%), well-defined(5.4%), and well-defined with partial spiculation(48.6%) in breast cancer and ill-defined(20.5%), well-defined(73.5%), and well-defined with partial spiculation(5.8%) in fibroadenoma. The mass were grouped by size; 1-2cm(37.8%), 2-4cm(45.9%), and 4-6cm(16.3%) in breast cancer and 1-2cm(79.4%), 2-4cm(17.6%), and 4-6cm (3.0%) in fibroadenoma. On ultrasonographic study, the shape of masses in breast cancer were lobulated(82.3%),oval(14.7%), and round(3.0%),and those in fibroadenoma were lobulated(14.0%), oval(57.7%), and round(18.3%). The cases that the height was longer than width were 32.3% in breast cancer and 0% in fibroadenoma. The findings about homogenecity and echo patterns were as follows; hypoechoic(52.9%) and mixed(47.1%) in breast cancer and hypoechoic(2.8%), hypoechoic(63.4%), and mixed(33.8%) in fibroadenoma. The margin of masses were smooth in 85.9% of fibroadenoma, and irregular in 73.6% of breast cancer. The boundary echoes of masses and decreased posterior echo shadow were seen only in 61.8% and 55.9% of breast cancer, respectively. Conclusion: The margin and calcifications are more clearly delineated on mammography but breast cancer and fibroadenoma, both are more commonly developed in dense parenchymal pattern(P2+DY),and there findings are easily obscured in mammography. So ultrasoography is very useful in these masses evaluation, especially amoung young patients.

요골 두 아탈구와 동반된 상완골 내 상과 골절 : 1예 보고 A Case Report

이한용,유기원,정진영,송주현,고해석,강용구,손문익 대한골절학회 2003 대한골절학회지 Vol.16 No.2

주관절 손산 중 상완골 내 상과 골절은 단독으로 혹은 주관절 탈구와 동반되어 발생하는 것이 일반적이다. 저자들은 15세 남자 환자의 좌측 요골 두 아탈구가 동반된 상완골 내 상과 골절을 경험하였다. 도수 정복을 시도하였으나 요골 두 아탈구의 정복을 얻을 수 없어 관혈적 정복술로 치료하엿다. 6개월추시 결과 후휴증이 없는 정상적인 관절 상태를 확인할 수 있었다. 연령, 원인 , 손상 기전으로 분석해 보면 이 동반 손상은 발생하기 매우 어렵고, 문헌 탐색 결과 현재까지 동일한 증례를 찾아볼 수 없었으므로 보고하는 바이다. It has been known that fracture of medial epicondylar apophysis of distal humerus may be isolated of associated with elbow deslocations. We have experienced a case which medial epicondylar fracture of the distal humerus was associated with subluxation of the radial head. Initially, we had tried reduction of subluxated radial head by closed method, but failed. Finally open reduction gad been performed. At 6 month after open reduction, clinical and radiological result were excellent. As it is difficult for those associated injuries to occur simultaneously and the similar cases never have been reported yet, we would like to present this case with a review of the literature.

조혈모세포이식 후 발생한 주폐포자층 폐렴에 대한 고찰

주지현,최정현,이동건,백지연,고윤호,이혜정,김세희,신호진,박윤희,박지영,김유진,신완식,김춘추 대한감염학회 2001 감염 Vol.33 No.4

Background : Pneumocytitis cainii pneumonia (PCP) can occur in immunocompromised hosts especially such as AIDS or cancer patients. Although recent research had focused on PCP in AIDS patients, few studies have described the clinical presentations of PCP in recipients of stem cell transplantation (SCT). We evaluated the clinical manifestations of PCP in SCT patients admitted at St. Mary's hospital, Seoul, Korea. Methods : The medical records of 17 PCP patients undergoing SCT between Feb. 1998 and Feb. 2000 were reviewed. The diagnosis of PCP was confirmed through the demonstration of Pneumocytitis cainii via either cytology of brochoalveolar lavage (BAL) or histological technique of lung biopsy. CMV disease and CMV infection were confirmed by BAL culture and antigenemia respectively . Results : Seventeen patients were all recipients of allogeneic SCT and 7 of 17 patients were performed non-sibling SCT. Patients presented with symptoms including brief period (4 ∼23 days) of fever (76%), dyspnea (70%), cough (64%), and signs such as rare(58.8%), Sixteen patients (94%) had been receiving immunosuppressive agent such as cyclosporine A (64%) or Fk506 (35%) without PCP prophylaxis. Eleven patients (64%) were treated with corticosteroid with mean dose of 16 mg/day prednisolone and mean duration of 4.6 months after post-SCT period. Twelve patients were co-infected with CMV. Another co-infected miCroorganisms were Pseudomonas aeruginosa, Mycobacterium tuberculosis, herpes simplex virus, parainfluenza virus, Average duration of treatment with trimethoprim-sulfamethoxazole (TMP/SMX) was 21 ±9 days. Four patients died, and three of them were related with PCP. Conclusion : PCP developed frequently in patients who were taking immunosuppressive drug due to graft versus host disease or were not taking TMP/SMX prophylaxis. High risk patients showing fever, cough, or dyspnea should be considered to take early bronchoscopic intervention for detection of PCP. When treat for PCP, it also be considered to the possibility of coinfection such as CMV. (Korean J Infect Dis 33:273∼279, 2001)

혈액투석 환자에서 대퇴신경범증으로 발현된 장골근 및 요근 농양 1예

이준상,강동구,신상열,윤재호,조영일,고성은,유영범,전혜정,진춘조,송종오 대한신장학회 2004 대한신장학회잡지 Vol.23 No.1

Chemical Components and Antioxidant Active of Polygonum multiflorum Root Cultivated with Lentinula edodes Mycelals

Young-Woo Koh,Seong-Woo Jin,Hae-Shin Je,Kyung-Je Kim,Seung-Eon Ban,Seung-Bin Im,Sang-Wook Jeong,Jeong-Hoe Moon,Junseok Oh,Jae-Heoi Hong,Tae-Young Park,Kyoungsun Seo 한국버섯학회 2017 버섯 Vol.21 No.2

The purpose of this study was to expand the utility of the Polygonum multiflorum. Also, we fermented P. multiflorum by mushroom mycelial, and analyzed for chemical compositions and biological active of fermented P. multiflorum root. The crude protein content did not show a significant difference between control and fermented P. multiflorum root, crude fat, ash and crude fiber content of fermented P. multiflorum root were lower than control. The content of soluble nitrogen free extract of P. multiflorum root was significantly higher than fermented P. multiflorum root. The major amino acids of P. multiflorum root were determined the arginine. The content of arginine and glutamic acid were 586.67 mg%, and 283.78 mg%, respectively. Sixteen kinds of amino acids were detected in fermented P. multiflorum root, and the major amino acids were determined the arginine and threonine. The total amino acid contents of control and fermented P. multiflorum root were 3,469.03 mg%, and 3,630 mg%, respectively. As the results of antioxidant activity test, the antioxidant capacity of fermented P. multiflorum had a higher than the control. As the mushroom fermentation progresses, it is confirmed that the amino acid content and antioxidant capacity were increased, and it is expected to develop the product using the fermented P. multiflorum using mushroom mycelials.

The burden of symptomatic patients with chronic spontaneous urticaria: a real-world study in Korea

Young-Min Ye,Young-Il Koh,Jeong-Hee Choi,Mi-Ae Kim,Jung-Won Park,Tae-Bum Kim,Young-Hee Nam,Yoon-Seok Chang,Hae-Sim Park 대한내과학회 2022 The Korean Journal of Internal Medicine Vol.37 No.5

Background/Aims: Chronic spontaneous urticaria (CSU) poses a considerable burden both on the quality of life (QoL) of individual patients and on healthcare systems. Real‑world data evaluating the disease burden of CSU are limited in this country. This study evaluated the disease burden and healthcare resource utilization (HRU) among symptomatic CSU patients. Methods: This multicenter, noninterventional, retrospective, and cross-sectional study assessed CSU patients symptomatic for more than 6 months despite step-wise H1-antihistamine medications. Primary outcomes included Urticaria Activity Score over 7 days (UAS7) and Chronic Urticaria QoL scale (CU-QoL). Secondary outcomes included EuroQol 5-Dimension 5-Level (EQ-5D-5L), Dermatology Life Quality Index (DLQI), association of disease activity with QoL, medications used for the past 6 months, and HRU. Results: Five hundred patients with CSU were enrolled. Mean disease duration was 3.7 years. Based on UAS7, 22.2% of patients were in well-controlled status and 31.2%, 28.4%, and 18.2% of them had mild, moderate, and severe disease, respectively. Mean CU-QoL and DLQI scores were 57.5 ± 29.7 and 10.2 ± 7.6, respectively, while the EQ-5D-5L utility score was 0.8 ± 0.2. H1-antihistamines were prescribed to 95% of patients, while omalizumab was prescribed to 33% of patients. Most patients (98%) had outpatient visits in the past 6 months. Negative correlations were noted between UAS7 and CUQoL, EQ-5D-5L, EQ-5D-5L visual analog scale scores, but a positive correlation was noted with DLQI score (p < 0.001 for all). The number of outpatient department visits increased with disease activity (p = 0.001). Conclusions: CSU affects QoL, leading to increased HRU, particularly in patients with severe disease.

요정 모르간(Morgane La Fee) 연구 -모르간 류의 이야기 도식-

고혜영 ( Hae Young Koh ) 건국대학교 동화와번역연구소(구 건국대학교 중원인문연구소) 2010 동화와 번역 Vol.19 No.-

아발론의 요정이며 아더 왕의 누이인 모르간은 아마도 아더 왕의 세계에서 가장 매력적인 인물일 것이다. 그것은 그녀가 고대의 여신을 모델로 하여 만들어진 문학적 인물이며 따라서 고대의 여신의 기억을 우리에게 불러일으키기 때문이다. 요정 모르간은 프랑스 민간에서는 무르그 또는 모르공이라는 이름으로 널리 알려져 있었다. 그러나 문학작품에서 그녀는 1132년이 되어서야 웨일즈 출신의 주교 조프리 오브 몬머스의 라틴어 작품 ??멀린의 생애??에서 처음 등장한다. 이 작품에서 그녀는 전투 중 치명상을 입은 아더 왕을 치유하기 위해 아발론 섬으로 데려가는 호의적인 인물로 나타난다. 아발론 섬은 켈트의 저승으로서 모르간은 여덟 자매들과 함께 이 섬을 통치한다. 그러나 그 후 랑슬로-그라알 연작의 한 작품 ??랑슬로??에서 모르간은 아주 어둡고도 무서운 면모를 보여준다. 연인에게 버림받은 그녀는 한 계곡에 마법을 걸어 연인에게 불실한 모든 기사들이 그곳에 갇혀 있게 한다. 이처럼 해서 그녀는 남성이란 족속의 경박함에 잔인하게 복수하는 것이다. 이러한 모르간의 불귀의 계곡의 이야기는 범세계적인 민담의 이야기 도식을 따르고 있다. 요정이 인간남자를 자신의 왕국으로 데려가 그곳에 머무르게 한다는 이 도식은 그것을 가장 완벽하게 보여주고 있는 인물의 이름을 따서 모르간 류의 이야기 도식이라 부를 수 있겠다. 그런데 이 요정담이 범세계적인 도식에 속하기는 하지만 그것이 기록문학에 들어온 이상 그것이 속한 특정한 시대와 지역에 자리잡게 된다. 따라서 모르간의 전설도 중세의 서구의 지배적 이데올로기, 즉 승려들과 기사들의 이데올로기에 종속되어 기독교화 되었다. 철두철미 이질적인 이 신화를 기독교적인 초자연성과 통합시킬 수 없었던 중세의 승려들은 이 환상적인 세계를 악마화 하게 되는 것이다. Fee d’Avalon, demi-soeur du roi Arthur, Morgane est peut-e??tre le personnage qui exerce le plus de fascination dans le monde arthurien. C’est parce qu’elle est la forme litteraire qui a ete calquee sur une divinite feminine archaique dont elle est la reminiscence lointaine. La fee Morgane est largement repandu dans la tradition populaire francaise, sous le nom de Mourgue ou de Morgon. Mais elle n’apparai??t qu’en 1132 dans le texte latin de la Vita Merlini du clerc gallois Geoffry of Monmouth. La, elle est un personnage benevole qui emmene pour le soigner, le roi Arthur, blesse mortellement dans le bataille, dans l’i??le d’Avalon, vision celtique de l’Autre monde ou elle regne avec huit soeurs. Mais apres dans le texte de Lancelot du cycle Lancelot-Graal, Morgane presente des traits bien sombres et inquietants. Trahie par son amant, elle lance un sortilege sur le val de telle sorte que tout chevalier infidele a sa dame s’y trouve enferme. Ainsi, elle se venge cruellement de la legerete de la gent masculine. L’histoire de Val sans Retour de Morgane reproduit un scheme folklorique universel que l’on qualifie de “morganien”, du nom de celle qui l’illustre le plus parfaitement. Bien que cette histoire feerique releve de scenarios universels, son entree dans la litterature ecrite l’ancre dans un espace-temps deternine. Alors, la legende de Morgane est christianisee et soumise a une ideologie dominante de l’Occident medieval, celle des clercs et des chevaliers. Ne pouvant integrer au surnaturel chretien une mythologie qui lui etait irreductiblement etrangere, les clercs medievaux diaboliserent le monde fantastique.

『동화와번역』 : 『페르스발 로망』 연구 -이름 찾기의 이야기-

고혜영 ( Hae Young Koh ) 건국대학교 동화와번역연구소 2014 동화와 번역 Vol.27 No.-

크레티앵의 로망 『성배이야기 또는 페르스발 로망』에서 명명행위는 이야기 전 체에 구조와 의미를 이루어주는 가장 중요한 사건이라 하겠다. 이야기 주인공은 후 반부에 가서야 명명되며, 처음에 그는 아버지 없이 그저 과부마님의 아들이라 불리 는 이름 없는 순진한 시골소년이다. 그는 어머니의 세계를 떠나 남자들의 세계로 향하는데, 부성상을 향한 이 도정은 자신의 정체성, 즉 이름을 추구하는 도정이다. 처음에는 이름이 없던 소년은 자신이 죽인 적수인 붉은 기사의 이름으로 알려 짐으로써 거짓된 정체성을 얻는다. 그 후 어부왕의 성에서의 시험의 실패 후, 역설 적이게도 그는 웨일즈 인 페르스발이라는 자신의 이름에 대한 계시를 얻게 되어 자신의 고유한 인격을 얻게 된다. 몇몇 부성적 인물들을 거쳐 마지막 부성적 인물 인 외숙인 은자는 그를 성배의 신비로 안내하고 아버지인 신에게 인도한다. 은자 가 알려준 신의 이름은 궁극의 이상적 부성상을 보여주고, 페르스발의 모험은 이 부성상 위에서 끝남으로써, 명명행위의 중요성이 밝혀진다. 명명행위는 이야기 전체의 목적이 되고, 소년이 갖게 되는 여러 이름들은 그의 성격의 점진적 변모를 보여준다. 이처럼 페르스발은 이야기 내내 진화한다. 무지의 상태에 있던 그는 이야기 끝에서, 자신의 경험과 조언자들에 의해 상위의 지식을 얻게 되어 성숙한 인물이 된다. 그리하여 페르스발 이야기는 성장소설의 기원이라 평가되는 것이다. In the romance of Chretien de Troyes, Le Conte du Graal ou le Roman de Perceval, the naming is the most important event which gives structure and meaning to all the story. The hero of the story is named very late, and at the beginning he is a young rustic without name, orphan of father, called only the son of the lady widow. He leaves the maternal world to make his way into the world of men, and this way to the paternal figure coincides with that of searching for an identity, a name. The boy initially without name will be known with the false identity, under the name of the Red Knight, an adversary that he killed. Then, after the failure in the test at the castle of the Fisher King, paradoxically he can get his own individuality with the revelation of his own name, Perceval the Welshman. After several parternal figures, the last one, the hermit, his uncle of the maternal line, initiates him in the mistery of the Grail and leads him to the God the Father. The hermit lets him know the names of God who represents the ultimate figure of the ideal father, on which concludes the Perceval`s adventures, pointing out the vital importance that the act of naming can take. The naming is the object of all the story, and the boy`s different names represent the progressive changes of his caracter. Perceval doesn`t stop progressing throughout the story. At the beginning he is in the stage of complete ignorance, and in the end he attains, through his experiences and the guidance of the advisers, the superior knowledge which makes him a mature person. Thus, the story of Perceval is considered as the origin of the Bildungsroman.