무인운전경전철시스템의 효과적 운영을 위한 사업초기단계 SE적용방안

정수영(Su-Young Chung),박수중(Soo-Choong Park),민경세(Kyung-Se Min),전서탁(Seo-Tak Jeon) 한국철도학회 2011 한국철도학회 학술발표대회논문집 Vol.2011 No.10

Recently the demand regarding reliability and safety of the railroad are increased as built to Driverless LRT system. Therefore PM and SE technique is applied for efficient management of a construction business. In case of SE(System Engineering) in domestic most foreign companies are doing to lead but we are under effort for the environment that a domestic company can lead. In this study We emphasize to SE importance of pre-business for operation to be effective of Driveless LRT system and propose about activities in the SE at requirements definitions and requirements analysis steps of a highest level. To achieve this We propose SE Application Methods of Pre-Business regarding assistance process of project planning evaluation and control and risk management.

複合 韓藥劑 淸籬滋坎湯의 抗癌效果 및 作用機轉 糾明

Cho, Kyung-Sam,Kim, Si-Young,Park, Jai-Kyung,Choi, Seung-Hoon,Chung, Se-Young,Yoon, Hwi-Joong 경희대학교 동서의학연구소 1999 INTERNATIONAL SYMPOSIUM ON EAST-WEST MEDICINE Vol.1999 No.1

Kyung Sam Cho¹Si Young Kim¹, Jai Kyung Park²,Seung Hoon Choi³,Se Young Chung⁴, Hwi Joong Yoon¹¹College of Medicine, ²East-West Medical Research Institute, ³College of Oriental Medicine, ⁴College of Pharmacology, Kyung Hee University,Seoul, Korea. The Anti-cancer Effect of Oriental Medicine Chung-Ri-Ja-Gam-Tang in the Mouse with Metastatic Lung Cancer. Proceedings of International Symposium on East-West Medicine, Seoul. 231-243, 1999.-The oriental medicine Chung-Ri-Ja-Gam-Tang is an herbal medicine which has been used for pulmonary diseases and known as having immune stimulatory effects. It has been known effective in lung cancer. So we studied the effects and the mechanisms of this herbal medicine it the mouse with metastatic lung cancer. The metastatic lung cancer of the mouse was produced with melnoma cell line(B16BL/6).5×10□/mouse tumor cells were injected intravenously to the CDF1 mouse via tail vein. The mice were divided 4 groups. The first group was treated with 50mg/kg extract of Chung-Ri-Ja-Gam-Tang per oral for 10 days after cancer cell injection, second group treated with saline after cancer cell injection, the third group with medicine without cancer cell, and the last group with saline only. After 10 days treatments some of the mice were scarificed and the lung and spleen was removed. The survival duration, weight change, the number of metastatic cancer nodule of the lung, the NK cell activity, the capacity of cytokines(INF-γ,INF-α,IL-2) production and the proliferation activities of mouse lymphocytes were measured. The surival times of the group 1 mice were longer and the weight loss was less than the group 2 significantly. The number of the metastatic nodule of the lung were decresed in the group 1 than the group 2. The production of INF-γ,was increase in group 2 than group 3 and 4, IL-2 production was increased in group 1 than group 2,3,4 significantly. There was no difference in TNF- α production and proliferation activity of lymphocyte in each group. The NK cell activity was significantly increased in group 1 than group 2,3,4. We conclude that the Chung-Ri-Ja-Gam-Tang has the effect of increasing the NK cell activity of the CDF1 mouse with metastatic lung cancer(B16BL/6). And it is suggested that the increased production of the IL-2 is the mechanisms of enhanced NK cell activity.

고령자 급성 췌장염의 임상적 고찰

백용한,서정훈,송건훈,이진헌,송시영,정재복,강진경,박인서,이수진 大韓消化器病學會 1998 大韓消化器病學會誌 Vol.32 No.3

좌심실 기능부전을 동반한 만성 관상동맥질환에서 Dobutamine 심초음파의 역할

정보영,임세중,최승혁,고충원,하종원,정남식,유경종,강면식 대한순환기학회 1998 Korean Circulation Journal Vol.28 No.8

高張力鋼熱影響部 微視組織의 類別

鄭世喜,金台永,李聖哲 全北大學校 1979 論文集 Vol.21 No.-

The assessment of the toe HAZ fracture toughness is one of the most troublesome problems to resolve because the fracture toughness depends to a large extent upon microstructural gradients such as variations of the microstructure and the grain size in the HAZ and because such microstructural characteristics are directly influenced by the thermal cycle during welding. The aim of the present study is to classify metallurgically the distribution of the constituents of microstructure in the HAZ by measuring Vickers microhardness. The metallurgical observation and microhardness measurement for the toe HAZ of 60㎏/㎟ low alloy steel, which was submerged are welded as bead-on-plate, were carried out. The experimental results were summarized as follows; There is a linear relationship between the ratio of hardness Hv/(Hv)_M (Hv:Vickers hardness, (Hv)_M : Vickers hardness of 100% martensite) and the area percentage of their structural constituents, and it is independent on chemical composition of materials. It was concluded, consequently, that the transformation behavior for the structure of other 60㎏/㎟ low alloy steel in the HAZ and the ratio of mixture of structural constituents in its every position can be quantitatively classified by the ratio of microhardness Hv/(Hv)_M.

인삼에 있어 변조 장뇌삼 판별에 대하여

정찬문,신주식,이이,장세영 충북대학교 연초연구소 2004 煙草硏究 Vol.19 No.-

시장에서 시판되고 있는 장뇌삼을 재료로 하여 변조 특성 및 이들 변조삼의 진위여부를 판별하고자 그 특성을 조사하였다. 장뇌삼의 변조는 뇌두와 뿌리부위를 주로 변조하는 것으로 나타났다. 뇌두부위는 경흔적수와 수근수를 늘리던가 아니면 뇌두를 장뇌로 변조하였고 뿌리 부위는 지근수 및 지근장을 늘리는 것으로 나타났다. 변조한 뇌두부위의 특징은 먼저 뇌두하단에 있는 동체의 중심주를 요(凹)모양으로 만들고 변조한 뇌두를 철(凸)모양으로 깍아 심지 박듯이 맞추는 것이었다. 또한 각기 다른 인삼의 뇌두를 교묘히 잇대어 장뇌로 만들었고 여기에 수근을 접착하여 오래된 진짜 산삼 형태와 유사하게 변조하였다. 그리고 뿌리부위는 접착면을 절편 자르듯 사선으로 잘라 접착면이 많게 하였고 후에 이들 접착면을 비벼 흔적을 없애는 수법이었다. 변조에 사용된 재료는 인삼 및 출처불명의 약초뿌리를 사용하였고 접착제는 공업용으로 접착성이 강한 것을 사용하였다. For identification of altering methods and distinction of altered long-rhizome ginseng, we studied the properties of long-rhizome ginseng which is being sold in market. Artificial long-rhizome ginsengs were made by modification of rhizomes and roots. Artificial long rhizomes were made by increasing the number of stem vestige root and rhizome root or by modification of rhizome to long-rhizome. Roots were modified by increasing of the number and the length of secondary roots. Artificial long rhizomes were made by carving the rhizome in concave shape and attaching convex shaped modified another rhizome. Those who make artificial ginseng made the altered long-rhizome ginseng looks like real long-aged wild ginseng by elongation of the rhizome by attaching many ginseng rhizomes and attaching of secondary roots. They cut the attaching surface obliquely for increased number of attaching point and removed the vestige by scrubbing the attaching region. They used ginseng, medicinal plant from doubtful origin, and industrial strong adhesives for making altered long-rhizome ginseng.

鋼 熔着金屬의 熱變形脆化에 關한 硏究

鄭世喜,金台永,林載奎,鄭熙敦,朴昌彦 全北大學校 1984 論文集 Vol.26 No.-

The susceptibility of weld metal(AWS, F76-EH14) on hot straining embrittlement has been examined. The sharp notch was machined on the weld metal of 1st bead and on coarse-grained HAZ transformed by next pass. After machining the notch, these specimens were bended at 250℃ to receive the hot straining embrittlement and they were done COD fracture toughness test by the three point bending, and then the change of plastic zone at notch tip was evaluated by microhardness test. The obtained results are summarized as follows. 1. Fracture toughness of weld metal was greater than that of base metal. 2. Fracture toughness of the coarse-grained HAZ was similar to that of weld metal. 3. Hardness of weld metal reheated by next pass was lower than that of weld metal owing to the effect of heat treatment. 4. Plastic deformation of the coarse-grained HAZ was less than that of weld metal.

Berberinephenolbetaine 誘導體合成 및 活性硏究[Ⅲ]

정경옥,김동현,정세영,노영수,김신규 慶熙大學校 1990 論文集 Vol.19 No.-

Nucleophilic additon of allyl magnesium bromide to berberine chloride resulted in the 8-allyl-9, 10-dimethoxy-2, 3-methylenedioxy-13, 13a-dehydroberbine[Ⅰ]. And oxidation of [Ⅰ] with m-chloroperbenzoic acid in a stream of Argon at-20∼-30℃ afforded the 8-allylberberinephenolbetaine [Ⅱ], and cycloaddition of [Ⅱ] with dialkylacetylenedicarboxylate(R; a=CH_3, b=C_2H_5) in THF gave 8-allyl-9, 10-dimethoxy-2, 3-ethylendioxy-13-oxo-8, 14-ethenodimethyldicarboxyberbine[Ⅲ a] and 8-allyl-9, 10-dimethoxy-2, 3-methylenedioxy-13-oxo-8, 14-ethenodiethyl-dicarboxy-berbine[Ⅲb]. Heating of 8, 14-ethenoberbines[Ⅲa and Ⅲb] in ethanol effected smooth isomerization leading to the 3, 4-[benzo(3",4"-dimethoxy)]-1, 8-[dihydre(2',3'-methylenedioxy) naphthalene]-5-allyl-6, 7-dimethylcarboxy-2-oxo-azocine[Ⅳa] and 3, 4-[benzo(3", 4"-dimethoxy)]-1, 8-dihydro(2', 3'-methylenedioxy)naphthalene]-5-allyl-6, 7-diethylcarboxy-2-oxo-azocine[Ⅳb]. Irradiation of berberine chloride in methanol containing rose bengal and sodium methoxide with O_2 stream afforded the 8, 9, 10, 14-tetramethoxy-2, 3-methylenedioxy-13-oxoberberine[Ⅳ], and recrystallization of [Ⅳ] from methanol gave 8-methoxyberberinephenolbetaine[Ⅶ]. And cycloadditon of [Ⅶ] with dimethyl-acetylenedicarboxylate gave 8, 9, 10-trimethoxy-2, 3-methylene-dioxy-13-oxo-8, 14-ethenodimethyldicarboxyberbine[Ⅷ], and heating of [Ⅷ] in ethanol effected smooth isomerization leading to 3, 4-[benzo(3" 4"-dimethoxy)]-1, 8-[dihydro(2',3'-methylene-dioxy) naphthalene]-5-methoxy-6, 7-dimethylcarboxy-2-oxo-azocine[Ⅸ]. The in vitro biological evaluation showed that compounds[Ⅷ] and [Ⅸ] had antibacterial effect against Pseudomonas aeruginosa, and compounds [Ⅰ], [Ⅱ], [Ⅲb] and [Ⅶ] completely had anticancer activity to P-388 mouse lymphocyle leukemia at concentration of 100㎍, and [Ⅰ] almost had anticancer activity at concentration of 20㎍.

그라비아 인쇄업 근로자의 톨루엔 노출수준과 신경행동기능 평가

정수영,강성규,김대성,이세훈 大韓産業醫學會 2004 대한직업환경의학회지 Vol.16 No.2

목적 : 고농도의 톨루엔에 노출될 가능성이 있는 그라비아 인쇄 사업장 5개소를 전정하여 톨루엔 노출 수준과 신경행동학적 기능을 평가하였다. 방법 : 톨루엔의 노출수준을 평가하기 위하여 기중 톨루엔 농도와 요중 마뇨산 농도를 측정하였고 신경행동학적 기능을 평가하기 위하여 컴퓨터 신경행동검사(BARS-K)를 실시하여 147명의 비노출군과 비교하였다. 신경행동검사는 숫자외우기(정순, 역순), 단순반응시간, 손가락 두드리기(우수, 열수), 부호 숫자 짝짓기, 선택주의력(맞은수)에 대해 시행하였다. 결과 : 연구결과는 다음과 같다. 1. 5개 사업장을 대상으로 측정한 기중 톨루엔의 평균 노출수준은 56.7(GSD60.9) ppm 이었고 사업장별 기중 톨루엔 평균농도는 10.5(GSD5.9)~181.9(GSD17.7)ppm로서 사업장에 따라 차이가 있었으며, 100 ppm을 초과하여 노출된 근로자수는 10명이었다. 2. 5개 사업장을 대상으로 측정한 요중 마뇨산의 평균 농도는 1.87(GSD2.06) g/g creatinine 이었고 사업장별 요중 마뇨산 평균농도는 0.31(GSD0.11)~5.14(GSD0.55) g/g creatinine 으로 나타났으며 노동부에서 제시한 요중 마뇨산의 노출한계인 2.5 g/g creatinine를 초과한 근로자수는 14명이었다. 3. 기중 톨루엔 농도와 요중 마뇨산 농도의 상관관계는 r=0.899(p<0.01)로서 유의한 상관성이 있는 것으로 나타났다. 4. 신경행동검사(BARS-K)의 각 검사항목에 대하여 혼란변수의 영향을 통제한 후에도 숫자외우기(정순), 두드리기(우수, 열수), 선택주의력(맞은수) 검사에서 톨루엔 노출군과 비노출군 사이에 통계적으로 유의한 차이를 보였다. 5. 노출군만을 대상으로 연령, 교육정도, 근무기간, 컴퓨터친숙도, 음주 등의 혼란변수를 통제하였을 때 숫자외우기(역순) 검사만이 톨루엔 노출수준에 따라 유의하게 저하되는 검사항목이었고 두드리기(우수) 검사와 선택주의력(맞은수) 검사는 톨루엔 노출수준보다 연령이나, 음주에 의해 더 많이 영향을 받는 것으로 나타났으며, 나머지 검사항목들의 경우 유의한 영향을 미치는 변수가 없었다. 결론 : 이상의 결과로 그라비아 인쇄 사업장의 근로자는 허용기준 내외의 비교적 높은 농도의 톨루엔에 노출되고 있으며, 톨루엔을 포함하는 유기용제 노출로 인한 신경행동학적 수행능력의 저하를 발견할 수 있었다. Objectives: The aims of this study were to investigate the occupational exposure level to toluene among rotogravure printers and neurobehavioral effects among them. Methods: Fifty rotogravure printers and 147 controls participated in this study. Environmental and biological monitoring was performed for the investigation of toluene expo- sure level, and neurobehavioral performance test were performed by using the Behavioral Assessment and Research System with Korean language instructions(J3ARS-K). Results: The major results were as follows; 1. Geometric mean toluene concentrations in the ambient air of 5 rotogravure printing work- places were 10.5 (GSD 5.9)-1181.9 (GSD 17.7), with a grand total of 56.7 (GSD60.9) ppm. 2. The geometric mean urinary hippuric acid level for rotogravure printers of 5 workplaces were 0.31 (GSD 0.11)-5.14 (GSD 0.55), with the grand total of 1.87 (GSD 2.06) g/g creatinine. 3. There was a linear correlation between hippuric acid levels in urine and the exposed toluene in air: urine hippuric acid (g/g creatinine)=0.03 toluene (ppm) + 0.15 ( ~ 0 . 8 9 9 , ~-4.01, n=50). 4. After adjustment for confounders, significant associations were found between toluene exposure and Digit span forwards, Digit span backwards, Tapping preferred hand, Symbol digit and Selective attention trials. Conclusions: 1. Rotogravure printers were occupationally exposed to relatively high concentration to toluene. and their neurobehavioral performances were decreased. 2. The BARS neurobehavioral testing program, which minimizes the use of text in the instructions, was very effective in overcoming the cultural barriers in neurobehavioral testing.

유기용제의 성분분석과 건강영향에 관한 연구

노영만,이세훈,김현욱,이광묵,정치경,이승한 大韓産業醫學會 1993 대한직업환경의학회지 Vol.5 No.1

In order to evaluate the health effects of occupational exposure to organic solvents in workers of automobile manufacturing and car repairing factories, we investigated the component analysis of organic solvents, the concentration of organic solvents in air, biological monitoring, and the neurobehavioral tests of workers. The component analysis of organic solvents was conducted in 2 automobile manufacturing factories(A and C factory) and a car repairing factory(B factory). The concentration of organic solvents in air was measured in painting departments of A and C factories. The biological monitoring was conducted on 191 male workers exposed to organic solvents and 211 controls of A and B factory. The neurobehavioral tests were examined on 105 workers among the subjects studied biological monitoring and 76 male controls. The results were as follows: 1. Eighteen and 9 solvents were identified in paints and thinners of automobile manufacturing factory(A factory). The organic solvents more than 30% in mean assay were m+p-xylene, o-xylene and ethanol in paints, and isobutyl alcohol and m+p-xylene in thinners at A factory. 2. Twenty and 9 solvents were identified in paints and thinners of car repairing factory (B factory). The organic solvents more than 30% in mean assay were m+p-xylene, o-xylene and ethyl acetate in paints and toluene, m+p-xylene and ethyl benzene in thinners at B factory. 3. In automobile manufacturing factory(C factory), 21 solvents were identified and the organic solvents more than 30% in mean assay were toluene, n-propyl benzene and methanol in mixture with paint and thinner. 4. Organic solvents such as isoprpyl acetone, isopropyl pentanone, n-propyl benzne, 1, 3-dihydroxy propane and 1-ethyl-2-methyl benzene, not registered in the TLVs of ACGIH, were detected in paints and thinners. 5. Mean hippuric acid was significantly higher in solvent exposed group than in control group. Mean m+p-methyl hippuric acid was significantly higher in workers of A factory than in those of B factory and mean o-methyl hippuric acid of workers in A factory was significantly higher than that in B factory and control group. 6. m+p-Methyl hippuric acid was significantly related to m+p-xylene. 7. Benton visual perception among neurobehavioral tests was influenced by exposure to organic solvents.