가스메탄/액체산소를 추진제로 이용한 동축인젝터 설계 및 분무 특성

김보연(BoYeon Kim),이양석(YankSuk Lee),박진호(JinHo Park),고영성(YoungSung Ko),김선진(SunJin Kim),김유(Yoo Kim) 한국추진공학회 2010 한국추진공학회 학술대회논문집 Vol.2010 No.11

기체메탄/액체산소를 추진제로 이용한 동축인젝터를 설계하였으며, 전단(기체)/전단(액체)형 인젝터와 전단(기체)/스월(액체)형 인젝터 두 가지로 제작하였다. 수류시험을 통해 두 가지 인젝터의 미립화와 분무특성을 알아보았다. 전단/전단형 인젝터는 물줄기 형태로 분무되고, 전단/스월형 인젝터는 hollow cone형태로 분무되었다. 전단/전단형 인젝터보다 전단/스월형 인젝터의 미립화 성능이 우수하였다. Coaxial injectors using GCH4/LOx as propellants was designed with shear(gas)/shear(liquid) type and shear(gas)/swirl(liquid) type. Spray characteristics were investigated by cold flow test. Spray patterns of the shear/shear and the shear/swirl type injectors were like a spout of water and hollow cone, respectively. Atomization efficiency of the shear/swirl type injector was better than atomization efficiency of the shear/shear type injector.

유스 케이스 기반 요구사항 분석을 통한 리스크 추출 및 우선순위화 연구

김보연 ( Boyeon Kim ),김재승 ( Jaeseung Kim ),박보경 ( Bokyung Park ),손현승 ( Hyunseung Son ),김영철 ( Robert Youngchul Kim ),김우열 ( Woo Yeol Kim ) 한국정보처리학회 2012 한국정보처리학회 학술대회논문집 Vol.19 No.2

기존의 리스크기반 테스팅은 조직, 프로젝트, 제품에만 초점이 맞추어져 있어 소프트웨어 개발에 관련된 리스크 활동은 잘 고려되지 않는다. 본 논문에서는 소트프웨어 개발에 리스크를 적용하고자 유스케이스 기반 리스크 위험도 측정과 우선순위화를 제안한다. 제안한 리스크 위험도 측정방법은 GoRE의 Goal 중요도 매트릭스를 리스크 결정 매트릭스로 확장하고 이를 이용하여 리스크의 위험도를 우선 순위화에 적용한 것이다. 확장한 리스크 결정 매트릭스는 유스 케이스와 요구사항의 연관관계를 파악한 후 고객 중요도를 계산하여 리스크 위험도를 측정하는 방법이다. 이를 통해 소프트웨어 개발 전 리스크 요구사항 고려로 시스템 구축에 도움이 되고자 한다.

과산화수소/케로신 단일 인젝터 설계 및 혼합비에 따른 연소특성

김보연(Boyeon Kim),이양석(Yangsuk Lee),김근철(Geunchul Kim),고영성(Yungsung Ko),김유(Yoo Kim),김선진(Sunjin Kim) 한국추진공학회 2010 한국추진공학회 학술대회논문집 Vol.2010 No.5

본 연구에서는 과산화수소와 케로신을 추진제로 사용하는 로켓 엔진의 혼합비에 따른 연소특성을 파악하기 위해 동축 스월형의 단일 인젝터 로켓엔진을 설계 및 제작하여 연소실험을 수행하였다. 수류실험을 통해 설계/제작된 단일 인젝터의 분무 성능을 검증하였으며, 연소 시험은 혼합비에 따른 연소성능을 특성배기속도로 평가하였다. 연소 시험은 다양한 혼합비에서 성공적으로 수행되었으며, 설계점에서의 연소 효율이 약 95% 이상이었으며 연소실 압력 섭동도 매우 작은 것으로 확인되었다. In this study, a coaxial swirl injector using hydrogen peroxide and kerosene was designed and combustion performance tests were performed to evaluate combustion characteristic according to mixture ratio. Spray characteristic of the injector was verified by cold flow test and combustion performances according to mixture ratio were evaluated by the characteristic exhaust velocity. Test results showed that the combustion efficiency at the design condition was about 95% and the pressure fluctuation was very small.

과산화수소/케로신 점화용 분사기 설계 및 분무특성에 관한 연구

김보연(Boyeon Kim),황오식(Ohsik Hwang),이양석(Yangsuk Lee),고영성(Youngseong Ko),김유(Yoo Kim),김선진(Sunjin Kim) 한국추진공학회 2009 한국추진공학회 학술대회논문집 Vol.2009 No.5

본 연구에서는 케로신/과산화수소 점화용 분사기의 설계/제작하여 분무특성에 관한 연구를 수행하고자 하였으며, 이에 앞서 촉매점화방식으로 적용할 때 가장 적합한 분사기를 설계하고자 하였다. 설계/제작된 분사기를 수류시험을 통해 질량 유량 및 분산각을 측정하였다. 그 결과 케로신의 목표 질량유량(12.88g/s)은 설계 차압과 같은 차압인 3 bar에서 측정되었으며, 이 때 분산각은 40˚임을 확인하였다. 또한 과산화수소의 목표 질량 유량(94.39g/s)은 설계 차압(3 bar) 보다 작은 1 bar에서 측정됨을 확인하였다. This study was performed to design of H2O2/Kerosene catalyst ignition injector and cold flow test to measure the mass flow rate and spray angle. Mass flow rate and spray angle were measured by designed injector through cold flow test. Result of test kerosene mass flow rate was measured 12.88 g/s and 40 deg of spray angle at pressure drop 3 bar as same as design point. And hydrogen peroxide was measured 94.39 g/s at pressure drop 1 bar smaller than design point.

Sorafenib for 9,923 Patients with Hepatocellular Carcinoma: An Analysis from National Health Insurance Claim Data in South Korea

( Sojung Han ),( Do Young Kim ),( Ho Yeong Lim ),( Jung Hwan Yoon ),( Baek-yeol Ryoo ),( Yujeong Kim ),( Kook-hee Kim ),( Boyeon Kim ),( So Young Yi ),( Dong-sook Kim ),( Doyeon Cho ),( Jina Yu ),( Su 대한간학회 2020 춘·추계 학술대회 (KASL) Vol.2020 No.1

Aims: The purpose of this study was to investigate the characteristics, treatment patterns including subsequent treatment and outcomes of sorafenib of whole HCC patients in South Korea. Methods: This is a retrospective, single-arm, and observational study. Data sources came from the national health insurance data. Included patients were those who had been diagnosed as HCC and received sorafenib between 1 July 2008 and 31 December 2014. A total of 9,923 patients were recruited in this study. Results: The mean age of 9,923 patients were 59 years with male predominance (84.6%). The mean HCC-prevalent duration was 663 days (22.1 months). The most common etiology of HCC was hepatitis B (66%). Before sorafenib treatment, 6,669 (67.2%) patients received other kinds of therapies for HCC including transarterial chemoembolization (TACE), resection and radiation therapy. During sorafenib therapy, 1,565 (15.8%) received combined treatment with other modalities. After sorafenib therapy, 2,591 (26.1%) patients received rescue therapies, of which TACE was the most common modality applied in 1,498 (15.1%) patients. The mean duration of sorafenib administration in all the patients was 105.7 days. In 7,159 (72.2%) patients, the initial and mean sorafenib dose were the same. There were 7,023 (70.8%) patients whose initial sorafenib dose was 600-800mg. The survival was longest in patients with recommended starting dose of 800mg, followed by dose reduction to 400mg (15.0 months). The second longest survival was demonstrated in patients with starting dose of 800mg, followed by dose reduction to 400-600mg (9.6 months). A total of 3,591 patients underwent rescue therapy after sorafenib, and the median OS was 14.5 months which were longer than 4.6 months in 7,332 patients who received supportive care after sorafenib. The most commonly applied treatment after sorafenib was TACE (30.8%). Conclusions: Real-life data show that the efficacy of sorafenib seems to be similar with that in clinical trials. Appropriate subsequent therapy after sorafenib might prolong the patient survival.

Comparison of Homologous Recombination Repair Gene Next-Generation Sequencing Analysis in Patients With Metastatic Castration-Resistant Prostate Cancer Between Local and Central Laboratories in Korea

Kim Yoonjung,Park Inho,Kim Boyeon,Choi Yu Jeong,Oh Seoung Chul,Lee Kyung-A 대한진단검사의학회 2023 Annals of Laboratory Medicine Vol.43 No.1

Background: Following success of the phase III PROfound trial, the poly (ADP-ribose) polymerase (PARP) inhibitor olaparib was approved by the US Food and Drug Administration in May 2020 for adult patients with deleterious homologous recombination repair (HRR) gene-mutated metastatic castration-resistant prostate cancer (mCRPC). As locally adopted multigene panel next-generation sequencing (NGS) assays for selecting PARP inhibitor candidates have not been thoroughly evaluated, we compared the analytical performance of the FoundationOne CDx (Foundation Medicine, Inc., Cambridge, MA, USA) (central laboratory) and other NGS assays (local laboratory) with samples from the PROfound trial in Korea. Methods: One hundred PROfound samples (60 HRR mutation [HRRm] cases and 40 non-HRRm cases) were analyzed. The results of HRR gene mutation analysis were compared between the FoundationOne CDx and two other NGS assays [SureSelect Custom Design assay (Agilent Technologies, Inc., Santa Clara, CA, USA) and Oncomine Comprehensive assay (Thermo Fisher Scientific, Inc., Waltham, MA, USA)]. Results: The positive percent agreement for single nucleotide variants (SNVs) and insertion/deletions (indels) between the central laboratory and local laboratory was 98.7%–100.0%. The negative percent agreement and overall percent agreement (OPA) for SNVs and indels between central and local laboratories were both 100%. Compared with that of the FoundationOne CDx assay, the OPA for copy number variations of the Oncomine Comprehensive and SureSelect Custom assays reached 99.8%–100%. Most mCRPC patients harboring a deleterious genetic variant were successfully identified with both local laboratory assays. Conclusions: The NGS approach at a local laboratory showed comparable analytical performance for identifying HRRm status to the FoundationOne CDx assay used at the central laboratory.

A New Approach on Digital Blood Pressure Measurement Method for u-Healthcare Systems

Boyeon Kim,Wenhai Jin,Sung Hoon Woo,Yunseok Chang 보안공학연구지원센터 2015 International Journal of Bio-Science and Bio-Techn Vol.7 No.1

The traditional blood pressure measurement method so called Kortokoff method has to apply strong air pressure on patient’s artery that could give severe damage on artery, and has the problem that method cannot measure the blood pressure in a series or continuously. But recent engineering technology can give new solutions that can solve the problems by using digital sensors and microcomputer. In this paper, we proposed a kind of non-Kortokoff method that can get the blood pressure from patient’s digitalized arterial pulse waveform analysis without air pressure on patient’s artery. This method can check patient’s blood pressure in a series through converting the continuous arterial pulse waveform into the absolute systolic and diastolic values with pre-defined blood pressure mapping equation from experiments. The experimental results showed that the proposed non-Kortokoff blood pressure measurement method has very good accuracy over 95% compare to commercial tonometers in continuous measurement. Also, the proposed non-Kortokoff blood pressure measurement method can be designed and implemented as a small device since it has no mechanical air pressure compartment, and applied on the u-Healthcare service areas very effectively such as a digital blood pressure checker for usual life blood pressure monitoring along with the medical device for home and hospitals.

Physiological function of pumpkin seed fermented extract

Boyeon Park,Haejin Kim,Eunji Lee,Jaemin Seo,Sejin Kim,Kyungyoung Yoon 한국식품영양과학회 2021 한국식품영양과학회 학술대회발표집 Vol.2021 No.10

In this study, we fermented skimmed pumpkin seeds at 55°C for 48 hours using the Bacillus licheniformis SF5-1 strain, then enzyme-treated at 50°C with Flavourzyme and Alcalase, and then each extract was classified into a control group, microbial group, microbial with Flavourzyme group, and microbial with Alcalase group. The total polyphenol content for each experimental group was 11.64, 12.85, 14.62 and 24.41 mg GAE/g, respectively, and the microbial with Alcalase group was the highest. In DPPH Radical Scavenging, IC50 values were 9.14, 6.83, 8.52, and 8.49 mg/mL, respectively, and in ABTS Radical Scavenging, IC50 values were 10.63, 8.34, 7.86 and 0.51 mg/mL, respectively, showing higher antioxidant activity in the microbial fermentation extraction group than in the control group. In α-glucosidase inhibitory activity, 35.48%, 65.68%, 61.22% and 81.98% were active in each group, fermented extract group showed higher antidiabetic activity. As a result of the above, it was confirmed that the extract obtained by fermenting pumpkin seeds using microbial exhibited a higher physiological function.

The effects of conjugated linoleic acid (CLA) on metabolic syndrome patients: A systematic review and meta-analysis

Kim, Boyeon,Lim, Ha Rae,Lee, Heeyoung,Lee, Hyangki,Kang, Wonku,Kim, Eunyoung ELSEVIER SCIENCE B.V.; AMSTERDAM 2016 JOURNAL OF FUNCTIONAL FOODS Vol.25 No.-

<P><B>Abstract</B></P> <P>The aim of the systematic review and meta-analysis was to evaluate the effects of conjugated linoleic acid (CLA) in metabolic syndrome (MS) patients. Randomized controlled trials (RCTs) conducted from inception to February 2015 were collected from seven databases. Among 1111 potentially relevant articles, nine RCTs (total 334 patients, 90% male) met inclusion criteria. A significant reduction in the CLA group in body weight and BMI (−0.51 kg [95% confidence interval (CI): −0.96, −0.07; p = 0.02] and −0.18 kg/m<SUP>2</SUP> [95% CI: −0.32, −0.04; p = 0.01], respectively) was found compared to control. No effect was seen on blood pressure, insulin resistance, or triacylglycerol, but a reduction in HDL in the CLA group (−0.06 mmol/L [95% CI: −0.09, −0.03; p = 0.0002]) was found to be statistically and clinically significant. In MS patients, CLA was effective on weight loss and BMI, but adversely reduced HDL. Thus, precautions should be taken with CLA use for MS patients.</P> <P><B>Highlights</B></P> <P> <UL> <LI> We aimed to evaluate the effects of CLA in metabolic syndrome patients. </LI> <LI> A significant reduction in the CLA group in body weight and BMI was found. </LI> <LI> A reduction in HDL in the CLA group was found to be statistically and clinically significant. </LI> <LI> Precautions should be taken with CLA use for metabolic syndrome patients with a low HDL. </LI> </UL> </P>

Optimal pH Condition of Protein Extraction of Defatted Rice Bran According to Supercritical Fluid Extraction Condition by Alkaline Method

Boyeon Shin,Jungeun Kim,Sukjung Kim,Jonggi Jung,Boram Jung,Miae Bang 한국식품영양과학회 2018 한국식품영양과학회 학술대회발표집 Vol.2018 No.10