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기관내관 소독방법 개선에 따른 간호업무 시간단축 및 비용 절감 효과
이행선,김해리나,김은숙,김보람,성선숙 한국의료QA학회 2008 한국의료질향상학회지 Vol.14 No.1
Background: The purposeof innercannula is to protect the upperair wayand permitair to pass freely, in addition, to provideendotrachealsuction, artificial respiration and to maintain adequate oxygensaturation. The tubeneeds to be sterilizedformaintenanceand cleannessof air wayand forprevention of bronchospasm. However, it has been reportedthat there is no guideline forsterilization and manyhospitalsconducttheirown sterilization methods, forexample, oncea day(13's generalhospital), three timesa day(TheCatholic University of Korea STMary's hospital) or evenno cleansing. Consequently, the QI team of our hospitalsuggested the SOP(standard operatingprocedure) of sterilization and evaluate cost and timeeffect in nursing. Method: 1) Benchmarking of 13's neurosurgery departmentof generalhospital in Seoul 2) Investigation of test recordsof sputumculture from patientswith intubation for tracheotomy 3) Checkof resultsof 02 Sat. monitoring to confirm of maintainingopenedair way Result : 1) Improvement of process: decrease of excess sterilization of inner cannula (from 3 timesa day to oncea day) 2) Costeffects: saving over10 million wonper oneyear 3) Providing better nursing: time effects (30 mina day) permit to conductmorenursing activities Conclusion: Itcan get Costand timeeffectsin nursing withimproved sterilization methodof innercannula It needs to do researchon improvement of the monthly exchangeprotocol of outercannula and providesupportingdata forthe properexchangeschedule. The resultof additionalmicroorganism detection frompatients withnewprocessneeds to be evaluated furthermore.
김선태,박상보 大田工業大學 1990 한밭대학교 논문집 Vol.7 No.1
A systematic investigation on diffusion of Zn into InP has been performed using elemental Zn and P as source materials in sealed ampoule at temperature range of 550℃ to 700℃. Under well-defined diffusion conditions, the relation between diffusion depth with the amount of Zn and P in source and the diffusion time gives the good control of the diffusion depth. A high P-pressure source resulted in more desirable diffusion properties allowing a high planar fronts and diffusion-induced dislocation free layers.
멕시코와 네팔에서 도입한 고추 유전자원의 풋마름병 및 역병 저항성
고보환,김정훈,전수경,이지선,김병수 慶北大學校 農業科學技術硏究所 2005 慶北大農學誌 Vol.23 No.-
Above 130 accessions of pepper consisting of 50 introductions from Mexico and Nepal, and resistant and susceptible controls were tested for resistance to bacterial wilt and to Phytophthora root rot at seedling stage by artificial inoculation. As the results, KC897, KC939, KC936 were newly found resistant to bacterial wilt in addition to already known resistance sources such as KC126, KC350, KC351, KC353. No new sources of resistance to Phytophthora root rot were found among the introductions from Mexico and Nepal.
혈액 투석 환자에서 중심정맥 협착에 대한 스텐트 삽입술 : Wallstent Placement
임대승,노상필,이유선,정승현,김보영,이정우,강정아,김정희,이민수,정준용,최시완,정진옥,성인환,이강욱,신영태 충남대학교 의과대학 의학연구소 2002 충남의대잡지 Vol.29 No.1
Stenosis of central vein is a common complication arising after percutaneous subclavian vein catheter insertion performed for temporary vascular access in chronic renal failure patients undergoing hemodialysis. There are several treatment methods for the condition like percutaneous angioplasty(PTA), stent insertion, and surgery, but recent trend is toward PTA and stents. Among the patients diagnosed with chronic renal failure from March 1993 to May 2002 and undergoing hemodialysis through AV fistula, the 14 Patients in whom central vein stenosis arose were selected for the study. A total of 28 percutaneous interventions(5 PTA and 23 stent placement) were performed, and restenosis rate and the time taken till the restenosis in de novo lesions and instant lesions were compared. All 28 cases were operated successfully. The 14 cases that received both anigioplasty and stent placement initially. (de novo lesion : 14 cases), Among the 10 cases with de novo lesion that followed up more than 1 year, 3 cases are currently undergoing hemodialysis without restenosis, and the remaining 7 cases have recurred stenosis with the mean time to restenosis of 10.9 months. In the 7 cases in whom stenosis recurred, 11 interventions were done(instent lesion: 11 cases). 4 of these were using only ballon angioplasty with 100% restenosis rate and the mean time of 3 months until restenosis. The remaining 7 cases were using both balloon angioplasty and stent placement, also with 100% restenosis rate but with the mean time of 12 months until restenosis, which was later than the group receiving only balloon angioplasty. In treating the patients with central vein stenosis, stent placement seems to be more advantageous over PTA in terms of restenosis rate and the mean duration of patency. In the case of instent lesion, inserting the stent for the second time after stenosis recurred lengthened the duration of patency compared to performing balloon angioplasty alone.
최원선,이창호,박보선,김태형 한국공작기계학회 2002 한국공작기계학회 추계학술대회논문집 Vol.2002 No.-
In order to manufacture a precision mold/die by machining, users need high speed & precision mold/die machining center. So, for development of this machine, we intend to use linear motor that is instead of ball-screw, servo-motor and coupling, high-speed spindle of pressurized air journal bearing and composite materials. In this paper we research column moving type and table moving type. The former is mainly piling 3 axes on one moving body, the latter is consist of two independent carriages. Both types are available to high speed & precision machine, but we finally draw a conclusion column moving type due to an advantage of high-speed control of linear motor.
Im Joo-Young,Kim Soo Jin,Park Jong-Lyul,Han Tae-Hee,Kim Woo-il,Kim Inhyub,Ko Bomin,Chun So-Young,Kang Mi-Jung,Kim Bo-Kyung,Jeon Sol A.,Kim Seon-Kyu,Ryu Incheol,Kim Seon-Young,Nam Ki-Hoan,Hwang Inah,Ba 생화학분자생물학회 2024 Experimental and molecular medicine Vol.56 No.-
Cytochrome b5 reductase 3 (CYB5R3) is involved in various cellular metabolic processes, including fatty acid synthesis and drug metabolism. However, the role of CYB5R3 in cancer development remains poorly understood. Here, we show that CYB5R3 expression is downregulated in human lung cancer cell lines and tissues. Adenoviral overexpression of CYB5R3 suppresses lung cancer cell growth in vitro and in vivo. However, CYB5R3 deficiency promotes tumorigenesis and metastasis in mouse models. Transcriptome analysis revealed that apoptosis- and endoplasmic reticulum (ER) stress-related genes are upregulated in CYB5R3-overexpressing lung cancer cells. Metabolomic analysis revealed that CYB5R3 overexpression increased the production of nicotinamide adenine dinucleotide (NAD+) and oxidized glutathione (GSSG). Ectopic CYB5R3 is mainly localized in the ER, where CYB5R3-dependent ER stress signaling is induced via activation of protein kinase RNA-like ER kinase (PERK) and inositol-requiring enzyme 1 alpha (IRE1α). Moreover, NAD+ activates poly (ADP-ribose) polymerase16 (PARP16), an ER-resident protein, to promote ADP-ribosylation of PERK and IRE1α and induce ER stress. In addition, CYB5R3 induces the generation of reactive oxygen species and caspase-9-dependent intrinsic cell death. Our findings highlight the importance of CYB5R3 as a tumor suppressor for the development of CYB5R3-based therapeutics for lung cancer.
Bo-Young Kim,Do-Wan Kim,박은국,Jeonghyun Kim,이창근,Hyun-Seok Jin,Seon-Yong Jeong 대한의학유전학회 2022 대한의학유전학회지 Vol.19 No.2
Purpose: Osteoporosis is a common calcium and metabolic skeletal disease which is characterized by decreased bone mass, microarchitectural deterioration of bone tissue and impaired bone strength, thereby leading to enhanced risk of bone fragility. In this study, we aimed to identify novel genes for susceptibility to osteoporosis and/or bone density. Materials and Methods: To identify differentially expressed genes (DEGs) between control and osteoporosis-induced cells, annealing control primer-based differential display reverse-transcription polymerase chain reaction (RT-PCR) was carried out in pre-osteoblast MC3T3-E1 cells. Expression levels of the identified DEGs were evaluated by quantitative RT-PCR. Associa-tion studies for the quantitative bone density analysis and osteoporosis case-control analysis of single nucleotide polymor-phism (SNPs) were performed in Korean women (3,570 subjects) from the Korean Association REsource (KARE) study cohort. Results: Comparison analysis of expression levels of the identified DEGs by quantitative RT-PCR found seven genes, Anxa6, Col5a1, Col6a2, Eno1, Myof, Nfib, and Scara5, that showed significantly different expression between the dexamethason-treated and untreated MC3T3-E1 cells and between the ovariectomized osteoporosis-induced mice and sham mice. Associa-tion studies revealed that there was a significant association between the SNPs in the five genes, ANXA6, COL5A1, ENO1, MYOF, and SCARA5, and bone density and/or osteoporosis. Conclusion: Using a whole-genome comparative expression analysis, gene expression evaluation analysis, and association analysis, we found five genes that were significantly associated with bone density and/or osteoporosis. Notably, the associa-tion P-values of the SNPs in the ANXA6 and COL5A1 genes were below the Bonferroni-corrected significance level.
Kim, Jae-Min,Bae, Kyung-Yeol,Stewart, Robert,Jung, Bo-Ok,Kang, Hee-Ju,Kim, Sung-Wan,Shin, Il-Seon,Hong, Young Joon,Kim, Ju Han,Shin, Hee-Young,Kang, Gaeun,Ahn, Youngkeun,Kim, Jong-Keun,Jeong, Myung Ho Physicians Postgraduate Press, Inc. 2015 The Journal of clinical psychiatry Vol.76 No.1
<P>Depression is common after acute coronary syndrome (ACS) and has adverse effects on prognosis. There are few evidence-based interventions for treating depression in ACS. This study investigated the efficacy and safety of escitalopram in treating depressive disorders identified 2-14 weeks after a confirmed ACS episode.</P>