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소아 알레르기 환자에서 혈청 흉선과 활동화 조절 케모카인, 대식세포 유래 케모카인의 상승과 호산구 염증지표와의 연관성
정보현 ( Bo Hyun Chung ),이해성 ( Hae Sung Lee ),서현석 ( Hyeon Seok Seo ),박하늘 ( Ha Neul Park ),지그프리드바우어 ( Siegfried Bauer ),서성철 ( Sung Chul Seo ),윤원석 ( Won Suck Yoon ),정지태 ( Ji Tae Choung ),유영 ( Young Yoo ) 대한천식알레르기학회 2012 천식 및 알레르기 Vol.32 No.4
Background: Thymus and activation-regulated chemokine (CCL17) and macrophage-derived chemokine (CCL22) are known as important mediators in allergic inflammation. Recently many researchers have focused on these mediators, but the role of the serum CCL17 and CCL22 in allergic diseases in children are still controversial. The aims of this study were to compare serum levels of CCL17 and CCL22 between children with different manifestation of allergic diseases, such as bronchial asthma, allergic rhinitis and atopic dermatitis, to analyze relationship with blood eosinophil makers and to find clinical significance of these markers. Methods: A total of 49 children (14 bronchial asthma, 13 allergic rhinitis and 13 atopic dermatitis) and the 9 healthy control subjects were enrolled in this study. Clinical characteristics and serum chemokine (CCL17, CCL22) levels were analyzed. We examined whether serum levels of CCL17 and CCL22 would be related to serum immunoglobulin E levels, blood eosinophils and serum eosinophil cationic protein concentrations. Results: Serum levels of CCL17 and CCL22 were significantly higher in children with bronchial asthma and atopic dermatitis than that in controls. Serum levels of CCL17 and CCL22 were significantly related to serum immunoglobulin E levels, blood eosinophil counts and serum eosinophil cationic protein concentrations with different strength in children with allergic diseases. Conclusion: Serum CCL17 and CCL22 may play a crucial role in the chronic allergic inflammatory process and can be used as inflammatory markers. These suggest that serum CCL17 and CCL22 might be involved in the pathophysiology of allergic diseases in children.
공과대학의 소양교육 현황 분석 - 홍익대학교 과학기술대학을 중심으로 -
박진원,백현덕,심수만,정보현,Park Jin-Won,Baek Hyun-Deok,Sim Soo-Man,Chung Bo-Hyun 한국공학교육학회 2004 공학교육연구 Vol.7 No.3
본 논문은 지방에 소재하고 있는 지역 공과대학의 공학소양교육에 대해 연구한 것이다. 기업의 대학교육에 대한 평가, 대학 및 이공계 지원 학생수의 감소, 고등학교 교과과정의 변화 등 공학교육 전반에 대한 환경 변화에 대응하여, 기초과학, 전산 및 교양 등 공학소양교육에 대한 개선 방안을 모색하기 위해, 현재 진행되고 있는 홍익대학교 과학기술대학의 공학소양교육에 대해 분석해 본 것이다. 이를 위하여 본 대학의 교수, 재학생 및 졸업생을 대상으로 설문조사를 실시하였다. 설문조사 결과와 기업의 공학교육에 대한 요구사항을 분석하여 공학소양교육 개선에 대한 기본 방향을 설정하였다. 즉, 수요자 중심 교육, 산업현장 적응력 제고, 문제 해결 능력 강화 및 공학 설계 능력 배양을 개선된 공학소양교육의 기본 방향으로 정립하였다. This study is for the analysis on the basic engineering education for enhancing the quality of engineers at a local engineering school. Negative appraisal for the engineering education by industry, the decrease on the number of students applying for the colleges of engineering, the changes on the high school education make the engineering schools forced to improve the basic engineering education. For the starting point for the study, we have surveyed on the current engineering education by asking questions to professors, students and alumni of Hongik College of Science and Technology. Analyzing the survey results and considering the needs by industry, we have set the basic educational philosophy as educating practical engineers and have decided the goals of basic engineering education as changing to student oriented education, enhancing the field adaptation capability, improving the problem solving ability and introducing engineering design courses.
천식 소아에서 호기산화질소 농도와 기도 과민성, 혈액 호산구 수, 혈청 호산구 양이온 단백 농도와의 상관관계
서현석 ( Hyeon Seok Seo ),정보현 ( Bo Hyun Chung ),박하늘 ( Ha Neul Park ),서성철 ( Sung Chul Seo ),( Bauer Siegfried ),송대진 ( Dae Jin Song ),정지태 ( Ji Tae Choung ),유영 ( Young Yoo ) 대한소아알레르기호흡기학회(구 대한소아알레르기 및 호흡기학회) 2012 소아알레르기 및 호흡기학회지 Vol.22 No.3
Purpose: The measurement of fraction of nitric oxide (FeNO) is a noticeable tool that reflects airway inflammation in asthmatic patients. We wanted to find out the relationship between pulmonary function, bronchial hyperresponsiveness (AHR), blood eosinophilic inflammatory markers and FeNO level before and after methacholine bronchoprovocation test in asthmatic patients. Methods: Fifty-five children, who visited the Allergy Clinic of Korea University Anam Hospital from March 2011 to February 2012, due to asthmatic symptoms, such as history of episodic wheezing or dyspnea during the previous year and resolved after using bronchodilators, were enrolled. We performed the baseline pulmonary function and methacholine bronchoprovocation test in the enrolled patients. Blood eosinophil counts and blood eosinophil cationic protein (ECP) were measured. FeNO levels were measured before and after the methacholine bronchoprovocation test. Results: The mean FeNO levels (36.3 ppb) fell after methacholine bronchoprovocation test (25.7 ppb). Forced expiratory volume in one second (FEV1) %pred inversely correlated both with FeNO level before (R2=0.07, P =0.029) and after (R2=0.059, P =0.01) methacholine bronchoprovocation test. The provocative concentration, causing a 20% decrease in FEV1 to methacholine (methacholine PC20) inversely correlated both with FeNO levels before (R2=0.086, P =0.001) and after (R2=0.141, P =0.001) the challenge. FeNO level measured at bronchoconstriction state significantly correlated with blood eosinophil counts (R2=0.112, P =0.028). Serum ECP levels correlated FeNO level, neither before nor after bronchoprovocation. Conclusion: The baseline FeNO levels were higher in asthmatic children. However, FeNO levels rather decreased after methacholine induced bronchoconstriction. Repeated spirometry maneuver was considered to have an effect on reducing FeNO levels. FeNO correlated with pulmonary function, airway AHR and blood eosinophil counts.
함동훈(Dong Hun Ham),정우철(Woo Chull Chung),정보현(Bo Hyun Jung),정대웅(Dae Ung Jung),강경록(Kyung Rok Kang) 대한정형외과학회 2017 대한정형외과학회지 Vol.52 No.2
목적: 증상이 있는 환자에서 경도의 이형성증을 관절경적으로 치료했을 때 나타나는 결과를 알아보고자 한다. 대상 및 방법: 2010년 8월부터 2015년 2월 사이에 성가롤로병원에서 비구순 파열에 대해 관절경적 치료를 받은 환자 중 1년 이상 추시가 된 경계성 고관절 이형성증으로 분류되는 29명의 환자(18o<lateral center edge angle [LCEA]<25°)를 대상으로 하여 후향적으로 수술 전, 후의 환자의 임상적 소견 및 환자의 만족도를 분석하였고 재수술 및 합병증을 기록하였다. 결과: 평균 연령은 35.7세(16-63세)였으며 16명의 여자 환자(55.2%)와 13명의 남자 환자(44.8%)의 성비를 보였다. 평균 LCEA는 22.0° (range, 18°-25°), 평균 Tönnis angle은 6.1° (range, 0°-18°) 였다. 평균 20.2개월(12-39개월)의 추시 결과 수술 후 1년째의 환자 설문 지표(modified Harris hip score, the hip outcome score) 및 visual analogue scale은 모든 예에서 유의한 상승소견을 보였으며(p<0.001) 환자의 만족도는 평균 7.7점이었다. 결론: 경계성 고관절 이형성증 환자에서 비구순 파열의 관절경적 치료는 좋은 결과를 나타낸다. 따라서 증상이 심하거나 보존적인 치료에 반응을 보이지 않는 경우 관절경적 치료는 증상을 호전시킬 수 있는 좋은 선택지 중 하나이다. Purpose: The outcome of hip arthroscopy as a treatment of patients with hip dysplasia is variable. In patients with severe hip dysplasia, arthroscopy has the potential to exacerbate instability and unfavorable outcome. To the best of out knowledge, there has not been a report regarding arthroscopic treatment in patients with borderline hip dysplasia in Korea. We favorable outcome with using arthroscopy to treat symptomatic borderline hip dysplasia. Materials and Methods: Between August 2010 and February 2015, 143 patients undergoing hip arthroscopy for intra-articular hip disorder were retrospectively enrolled. From this cohort, a borderline dysplasia group compromising 29 patient with lateral center edge angle (LCEA)>18° and <25° and a minimum of 1 years follow-up, was identified. Patient-reported outcome scores, including modified Harris hip score, the hip outcome score-activity of daily living, the sport-specific subscale, visual analogue scale (VAS) and satisfaction survey were obtained preoperatively and at postoperative 3 months, 6 months, 1 year, 2 years, and 3 years. Revision surgery and complications were recorded for each group. Results: The mean age was 35.7 years (range, 16–63 years) years respectively. There were 16 females (55.2%) and 13 males (44.8%). The mean LCEA was 22.0° (range, 18°-25°) and the mean Tönnis angle was 6.1° (range, 0°-18°). The mean follow-up was 20.2 months (range, 12-39 months), and at the 1 year follow-up, there was significant improvement (p<0.001) in all patient reported outcome scores and VAS. Satisfaction survey showed an average score of 7.7. Conclusion: In patients with borderline hip dysplasia, if there is an occurrence of symptomatic labral tear, arthroscopic labral refixation has a good short-term result. Therefore, if patients have no response to conservative treatment or have severe pain, arthroscopic labral refixation is a useful treatment options to relieve symptom.
Pipkin 분류 I형 대퇴골두 전위 골절에 대한 관절 경하 골절편 절제술: 증례 보고
김채근 ( Che Keun Kim ),정우철 ( Woo Chull Chung ),송지훈 ( Ji Hun Song ),박진영 ( Jin Young Park ),정보현 ( Bo Hyun Jung ) 대한고관절학회 2014 Hip and Pelvis Vol.26 No.1
고관절 탈구와 동반되는 대퇴골두의 골절은 Pipkin의 분류에 따라 다양한 치료방법이 시행되고 있다. 이 중 I형 골절은 전위가 적은 경우에는 보존적 치료를 시행하지만 전위가 있거나 동심원적 정복에 방해를 주는 경우에는 수술적 치료로 관혈적으로 골절편을 제거하거나 정복 후 고정하는 방법이 일반적인 치료 방법이다. 이 증례에서는 Pipkin 분류 I형의 전위된 골절이 발생한 62세 남자 환자에게 관절경적 절제술을 시행하였고, 수술 전 영상학적 검사에서 확인이 어려웠던 작은 골편을 추가로 제거하여 만족할 만한 결과를 얻어 이를 문헌 고찰과 함께 보고하고자 한다. There has been a variety of options for treatment of femoral head fracture with hip dislocation according to the Pipkin classification. Pipkin type I fractures with minimal displacement have been treated conservatively. However, in cases where the fracture was displaced or reduced incongruently, it has been treated by open fragment excision or fixation after reduction. In our case, the patient was a 62-year-old man who sustained a displaced fracture of Pipkin type I. We achieved a satisfactory outcome by arthroscopic excision of a displaced bony fragment and small bony fragments that could not be confirmed by pre-operative imaging study. Therefore, we report on the case with a review of the literature.
Some Properties of Conformal Invariants
Chung, Bo-Hyun 홍익대학교 산업기술연구소 1994 産業技術 Vol.4 No.-
어떤 순수기하학적인 문제나 또는 함수론적인 문제를 해결하는데, 等角不變量의 성질을 이용하면 쉬운 경우가 있다. 이 소고에서는 등각불변량의 유용성을 보여주기 위하여 그 예를 조사, 연구하였다. 일반사변형의 면적 圓環面의 표면적에 대한 예와 extremal distance 와 Dirichlet적분 D(u)의 관계를 이용하여, 조화함수 u가 극한값을 가질 조건을 찾아 보았다.
A Note on Joined Extremal Distance
Chung, Bo-Hyun 홍익대학교 산업기술연구소 1999 産業技術 Vol.9 No.-
어떤 곡선족의 modulus, extremal length, extremal distance 개념과 기본 성질을 소개한 다음, joined extremal distance λ_i 와 minimal extremal distance λ^* 의 관계를 알아 보았다. 그 결과 어떤 특별한 가정 밑에서는 λ_i = λ^* 이다.