갑상샘눈병증 환자의 안와감압술에서 2차원 안와 전산화 단층촬영의 4가지 parameter의 유용성

이종석,이화,장민욱,백세현,이태수,Jong Suk Lee,Hwa Lee,Min Wook Chang,Sehyun Baek,Tae Soo Lee 대한안과학회 2014 대한안과학회지 Vol.55 No.9

Purpose: To present easily measurable 2D orbit computed tomography (CT) reference data that can be used in a preoperative study for orbital decompression and classification of individual orbital morphologies. Methods: The study sample was composed of 77 patients with orbital contusion (42 Asian males + 35 Asian females = 154 orbits) who visited the emergency room of the Korea University Guro Hospital from September 2012 to June 2013. Patients with orbital wall fracture, retrobulbar hemorrhage, or eyeball rupture were excluded. Medical records including 2D orbit or facial bone CT were retrospectively reviewed and 4 orbital parameters (orbital length, OL; globe length, GL; GL/OL ratio and 2D cone angle) were measured. Results: The average OL was 42.53 ± 2.46 mm (35.63-49.09 mm) and average GL was 24.83 ± 1.09 mm (22.75-28.13 mm). The average GL/OL ratio using these 2 parameters was 0.59 ± 0.04 (0.50-0.68). The posterior cone angle was on average, 45.96 ± 5.91° (29.35-60.04°). Conclusions: Simple measurement of 4 parameters using 2D orbit CT and classification of Asian individual orbital morphology may help in the choice of the most effective surgical technique for decompression surgery in thyroid eye disease patients. J Korean Ophthalmol Soc 2014;55(9):1267-1271

수집 ㆍ 선별업체 지원 확대해야...

이종석,Lee, Jong-Seok 한국자원재생재활용연합회 2004 재활용회보 Vol.2 No.-

초임계 이산화탄소 내 추출물의 확산 특성

이종석,전법주,정일현,홍인권 ( Jong Suk Lee,Bup Ju Jeon,Il Hyun Jung,In Kwon Hong ) 한국공업화학회 1995 공업화학 Vol.6 No.2

최근 초임계유체를 이용한 추출공정은 비교적 휘발성이 낮은 생화학 물질의 분리와 고분자 물질의 분획 기술로 많은 분야에 적용되어 활발한 연구가 진행되고 있다. 그러나 공정설계와 scale-up에 필수적으로 요구되는 확산계수와 같은 전달특성에 관한 데이타의 부족은 상업적인 수준의 기술로 발전을 저해하고 있다. 초임계유체 추출공정에서 지배적인 속도 메카니즘이며, 장치설계에 중요한 변수가 확산특성이므로 초임계유체 내에서 추출물의 확산계수를 예견할 수 있는 능력이 추출공정의 설계와 효율적인 조작에 있어 매우 중요하다. 본 연구에서는 초임계유체 크로마토그래피를 이용하여 capillary peak-broadening법으로 초임계 이산화탄소 내에서 naphthalene의 확산계수를 308.15∼328.15K와 175∼275bar의 압력 범위에서 정량적으로 결정하였고, 일정 온도에서 압력이 증가됨에 따라 낮은 압력 범위에서는 확산계수에 미치는 압력의 영향이 크고, 높은 압력범위에서는 압력의존성이 작음을 확인하였다. 또한 초임계유체계의 압력과 온도의 변화는 밀도, 점도 및 몰 부피와 같은 유체의 전체적인 물성을 변화시켜 용질의 확산특성에 영향이 있음을 확인하였고, 기존의 액체계에 대한 확산계수 상관식 중에서 Matthews-Akgerman식의 확장적용이 실험적으로 측정한 데이타와 잘 일치함을 확인 하였다. Supercritical fluid extraction(SFE) has been studied in recent years as a technique for the separation of an available component from the material of low volatility and the fractionation of polymers, but the lack of data for transport characteristics essentially required for the extraction process design and scaleup has hindered development of the technology to a commercial level. Because diffusion is the dominant rate mechanism in extraction process, the ability to predict the diffusion coefficient is of considerable importance in process design and efficient operation. In this study, binary diffusion coefficients of naphthalene in supercritical carbon dioxide were measured by using the capillary peak broadening(CPB) method. Quantitative measurements were obtained by SFC in the temperature range 308.15∼328.15K and at pressures between 175 and 275bar. The experimental values of the diffusion coefficients have a magnitude of 10^(-4)㎠/s and were approximately in the range 0.5598∼1.1914×10^(-4)㎠/s. The influence of pressure on the diffusion coefficients at higher pressure range was less than that at lower pressure. As the pressure and temperature change, it is clear that the physical properties of fluid such as density, viscosity and molar volume determined the diffusion characteristics of the solute in SC-CO₂. Among the various theoretical equations, the Matthews-Akgerman equation provided a more successful correlation for the experimental data.

소흑산도(小黑山島)와 홍도(紅島)의 식물자원(植物資源) 조사(調査)

이종석,김일중,Lee, Jong Suk,Kim, Yil-Joong 충남대학교 농업과학연구소 1978 Korean Journal of Agricultural Science Vol.5 No.2

For the development of natural ornamental plants, an investigation was carried out about the vegetation of Soheuksan-do and Hong-do, islands located far in the southwestesn part of the Korean peninsular. The vegetation of Soheuksan-do was abundant. The dominant species were Machilus thunbergii, Buxus microphylla var. koreana, and Camellia japonica. Regarding the development of natural ornamental plants, 27 families and 54 species were reported in this investigation. Among these species there were 8 species including Calanthe discolor, Epipachs falcata, Dendrobium monniforme, Goodyera maximowiczii, and Lipari's krameri in Orchidaceae. The vegetation of Hong-do was similar to that of Soheuksan-do, but less abundant. Supplementary 10 species were reported in this investigation. Epipactis falcata and Dendrobium moniliforme were almost exterminated in these islands because of indiscriminating gathering. Therefore these species must be protected immediately. 우리나라의 최남서단(最南西端)에 위치(位置)하는 전라남도(全羅南道) 신안군(新案郡) 흑산면(黑山面)에 속(屬)하는 소흑산도(小黑山島)와 홍도(紅島)의 식물자원(植物資源)을 조사(調査)하였다. 소흑산도(小黑山島)의 식물상(植物相)은 매우 다양(多樣)하였으며, 이중 출현빈도(出現頻度)가 많고 관상식물(觀賞植物)로도 개발(開發) 가능(可能)한 27과(科) 54종(種)을 보고(報告)하였다. 그중 난과식물(蘭科植物)은 새우난(Calanthe discolor)등(等) 8종(種)이었다. 홍도(紅島)의 식물상(植物相)은 소흑산도(小黑山島)와 매우 유사(類似)하였으나 덜 풍부(豊富)해 보였으며, 아직 미기록(未記錄)된 1종(種)을 추가보고(追加報告)하였다. 풍란(風蘭), 석곡 등(等) 기호도(嗜好度)가 높은 관상식물(觀賞植物)은 이미 절종상태(絶種狀態)에 이르고 있어 이의 보호(保護)가 절실(切實)히 요청(要請)되었다.

The Impact of Local and Regional Recurrence on Distant Metastasis and Survival in Patients Treated with Breast Conservation Therapy

이종석,김승일,박형석,Jun Sang Lee,Se Ho Park,박병우 한국유방암학회 2011 Journal of breast cancer Vol.14 No.3

Purpose: We evaluated the effect of local recurrence (LR) and regional recurrence (RR) on distant metastasis and survival in patients treated with breast conservation therapy (BCT). Methods: We analyzed 907 patients who were treated for invasive breast cancer between 1993 and 2006. With 53 months of follow-up, 28 patients (3.1%) developed LR in the breast and 12 patients (1.3%) developed RR before distant metastasis. LR and RR were separated into four patterns to determine the prognostic relevance of recurrence site and time to recurrence: LR within 3 years (early LR), LR after 3 years (late LR), RR within 3 years (early RR), and RR after 3 years (late RR). Results: Early LR (hazard ratio [HR], 4.76; p=0.003) and early RR (HR, 18.16; p<0.001) were independent predictors of distant metastasis. In terms of overall survival, early LR (HR, 5.24; p=0.002), and early RR (HR, 18.80; p<0.001) were significantly related with poor survival. Patients with late LR/RR had a similar favorable prognosis compared with patients who never experienced LR/RR. Conclusion: The result suggests that time to LR/RR following BCT is a significant predictor developing a distant metastasis and surviving.

출판저널 칼럼

이종석,Lee, Jong-Seok 대한출판문화협회 1987 출판저널 Vol.8 No.-

시뮬레이션을 이용한 EPCIS의 효율화 방안에 관한 연구

이종석,이창호,Li, Zhong-Shi,Lee, Chang-Ho 대한안전경영과학회 2010 대한안전경영과학회지 Vol.12 No.4

EPCIS(EPC Information Services) system is a core component of EPCglobal Architecture Framework offering information of the freights, the time of awareness and the location of awareness on the EPCglobal Network. The role of EPCIS is to exchange information based on EPC. There are four kinds of event data which are object event data, aggregation event data, quantity event data, and transaction event data. These EPCIS events data are stored and managed in EPCIS repository. This paper deals with the method which diversifies the data flow load of intensive EPCIS events and effectively manages EPCIS repository for exchanging data smoothly. In order to verify a effectiveness, we measure the performance of the system using a simulation by comparing the existing method with the suggested method.

악성 말초신경막 종양의 치료와 생존율

이종석,전대근,조완형,이수용,오정문,김진욱,Lee, Jong-Seok,Jeon, Dae-Geun,Cho, Wan-Hyung,Lee, Soo-Yong,Oh, Jung-Moon,Kim, Jin-Wook 대한근골격종양학회 2003 대한골관절종양학회지 Vol.9 No.2

Purpose: We analyzed our malignant peripheral nerve sheath tumor (MPNST) cases to find out their oncologic results following by each treatment modalities. Materials and Methods: Thirty four patients with MPNST were registered in Korea Cancer Center Hospital from Feb. 1986 to Nov. 1996. Seventeen cases were male and 17, female. Average age was 41 years (range 18 to 74). Location of the tumor was as follows; 17 in lower extremity, 11 upper extremity, 4 trunk, and 2 retroperitoneum. Following the AJC classification, stage IA were 2 cases, stage IIA 2, stage IIB 6, stage III 16 and stage IV 8. Twenty six patients took operations and adjuvant chemotherapy and/or radiation therapy, 3 operation only and 3 adjuvant chemotherapy or radiation therapy. Average follow up period was 33.5 months (5.6 to 146.1). Kaplan-Meiyer method was done for survival curve, and log rank test for comparison analysis. Results: Fourteen cases were continuous disease free, 2 no evidence of disease, 2 alive with disease and 14 dead of disease states at final follow up. Actual 5-year and 10-year survival rates were 53.5%, 35.7%. Local recurrence rate after operation was 24.1%. 5-year survival rates of stage I/II/III were 100/85.7/55.9% and 2-year survival rate of stage IV was 14.3% (p=0.04). In 21 cases operated with stage II-III, wide margin (15cases) had 76.0% 5-year survival rate, and marginal or intralesional marigin (6cases) had 40.0%. The actual 5-year survival rate of the group which were done 4 or more cycles chemotherapy (8cases) was 71.4% and the actual 3-year survival rate less than 4cycles chemotherapy (6cases) was 83.3% (p=0.96). In 19 cases operated with stage II-III and which had no radiotherapy, marginal or intralesional margin (5cases) had 3 cases of local recurrences (60.0%), though wide margin (14cases) had 4 cases recurrences (28.6%). There was no local recurrence in 8cases which had pre-or post-operative radiotherapy. Conclusions: Surgical margin is an important factor in local recurrence. Resection margin has a tendency to influence the survival despite insufficient statistical significance. Conventional chemotherapy has no defnite statistical sigficance in the effect on local control and survival. Preoperative and postoperative radiotherapy has some positive effect on local control. 서론: 악성 말초 신경막 종양(Malignant peripheral nerve sheath tumor, MPNST)에 대하여 수술, 항암제 투여, 방사선 치료 등을 시행하고 이에 따른 종양학적 결과를 분석하여 보다 합리적인 치료 방법을 알아보고자 하였다. 재료 및 방법: 1986년 2월부터 1996년 11월까지 본원에 등록된 MPNST 환자 34례를 대상으로 하였다. 남자가 17례, 여자가 17례였고 평균연령은 41세(18세~74세)였다. 종양의 위치는 하지가 17례, 상지 11례, 체간부 4례, 후복막 2례였다. AJC(American Joint Committee on Cancer) 분류에 의한 종양의 병기는 stage IA가 2례, stage IIA 2례, stage IIB 6례, stage III 16례, 그리고 stage IV가 8례였다. 치료 방법으로는 26례에서 수술과 항암제 투여 그리고 때에 따라서 방사선치료를 시행하였고 3례에서는 수술만, 3례에서는 항암제 투여나 방사선 치료만 시행하였다. 평균 추시 기간은 33.5개월(5.6개월~141.1개월)이었다. Kaplan-Meiyer 법으로 생존율을 구하였고, log rank test로 비교 분석 하였다. 결과: 최종 추시상 질병 상태는 14례에서 CDF(continuous disease free)였고, 2례가 NED(no evidence of disease), 2례 AWD(alive with disease), 그리고 14례가 DOD(died of disease)였다. 실제(actuarial) 5년 생존율과 10년 생존율 은 53.5 %와, 35.7%였다. 수술 후의 국소 재발율은 24.1%였다. 병기별 5년 실질 생존율은 stage I이 100%, stage II 85.7%, stage III 55.9%였고 stage IV의 경우 2년 실질 생존율이 14.3%였다(p=0.04). Stage II, III에서 수술한 경우 21례에서, 광범위 이상의 절제연을 얻었던 경우가 15례로 5년 실질생존율이 76.0%였고 병소내이거나 변연부 절제연의 경우는 6례로 40.0%였다(p=0.26). 4회차 이상의 항암화학요법제를 투여한 군(8례)의 5년 실질생존율은 71.4%였고 3회차 이하의 불충분한 항암제투여를 시행한 군(6례)의 3년 실질생존율은 83.3%였다(p=0.96). Stage II, III 중 방사선 치료 없이 수술 받은 19례에서 병소내 절제나 변연부 절제를 시행했던 5례는 3례가 국소 재발하였고(60.0%) 광범위 절제를 시행한 14례는 4례가 국소 재발하였다(28.6%). 수술 전 또는 후에 방사선치료를 시행하였던 8례에서는 국소재발이한 예도 없었다. 결론: 외과적 절제연(surgical margin)이 국소 재발에는 중요한 요인이었고, 통계적으로 의미있는 수치는 아니었지만 생존율에도 영향을 주는 경향이 있는 것으로 생각된다. 기존의 항암제 투여는 국소 재발이나 생존율상에 통계적으로 의미있는 차이를 보이지 못하였다. 수술전과 수술후 시행하였던 방사선치료는 국소 재발을 줄이는데 어느 정도의 효과를 보였다.

원전 해체를 고려한 저방사화 결합재 개발

이종석,민지영,이장화,Lee, Jong Suk,Min, Jiyoung,Lee, Jang Hwa 한국콘크리트학회 2016 콘크리트학회지 Vol.28 No.5

약침용(藥鍼用) 봉독액(蜂毒液)의 국소독성시험(局所毒性試驗)에 관(關)한 연구(硏究)

이종석,고형균,김창환,Lee, Jong-Seok,Koh, Hyung-Kyun,Kim, Chang-Hwan 대한한의학회 1995 대한한의학회지 Vol.16 No.1

Pursuant to the Medical Product Safety Administration Guidelines for safety assessment of Korean bee vonom for herb-acupuncture, rabbits were used for skin, eye balls, subcutaneous and muscle irritation test. The results were as follows; 1. The skin irritation test of bee venom for herb-acupuncture did not produce any irritation reactions, when the skin was covered with bee venom. 2. The eye irritation test produced moderate to severe stimulating reactions, once the eye mucous membrane was contacted with bee venom. 3. The subcutaneous and muscle irritation test of bee venom showed such local inflammatory reactions as death of cells, infiltration of inflamed cells, dropsical swelling, and congestion, once injected under the skin and in the muscle. As the results of the study on bee venom for herb-acupuncture indicate that severe reactions in such tests as eye balls, subcutancous and muscle irritation exist in the laboratory, more professional caution should be taken in clinical application of the therapy. In addition, further study on subacute, chronic toxicity and allergy reactions should be pursued.