팔진탕가감방(八珍湯加減方)이 항종양(抗腫瘍) 면역반응(免疫反應)과 항암제(抗癌劑)로 유발(誘發)한 부작용(副作用)에 미치는 영향(影響)

오정진,원진희,이언정,문석재,Oh Jeung-Jean,Won Jin-Hee,Lee Eon-Jeong,Moon Seok-Jae 대한한방내과학회 1998 大韓韓方內科學會誌 Vol.19 No.2

Paljintanggagmbang has been used for cure of tumor as a traditional medicine without any experimental evidence to support the rational basis for its clinical use. This study was carried out to evaluate. the possible therapeutic or antitumoral effects of Paljintanggagmbang extract against tumor, and to carry out some mechanisms responsible for its effect. Experimental studis were performed for measurement of Humoral and Cellular Immune Response and Phagocytosis in Mice treated with mitomytion C(MMC) and Paljintanggagmbang alone and combination. The results obtained in this study were as follows 1. The adminstration of Paljintanggagmbang extract decresed size of tumors cell which MCA induced. 2. The adminstration of Paljintanggagmbang extract decresed growth of the tumors which S 180 transplant. 3. The adminstration of Paljintanggagmbang extract decresed reproduction of A549, Hep3b, 3LL cell and S 180 in vivo. 4. The adminstration of Paljintanggagmbang extract incresed activity of the NK cell. These results also suggested that effect of Paljintanggagmbang might be chiefly due to nonspecific enhancement of Humoral and Cellular Immune Response and Phagocytosis in Mice treated with MMC and Paljintanggagmbang alone and combination.

국내 경도인지장애 노인의 인지기능 향상을 위한 운동재활 프로그램 효과: 체계적 문헌고찰 및 메타분석

문우림,오정하 대한체육학회 2024 대한스포츠융합학회지 (jcses) Vol.22 No.1

This study conducted a systematic review and meta-analysis to determine the effect of exercise rehabilitation programs on improving cognitive function in older adults with mild cognitive impairment (MCI) in Korea. Data sources were collected from RISS, KISS, e-article, DBpia, and Korea Med in January 2024. The PRISMA guideline was used to select the studies to be included in the results. Cochrane risk of bias was used to evaluate the quality literature, and RStudio 2023.12.0+369 version was used for meta-analysis. Finally, 18 studies were analyzed in systematic review and 14 studies were included in meta-analysis. The results of the meta-analysis showed that the exercise rehabilitation program had a medium effect size (SMD = 0.62, 95% CI = 0.14; 1.09, I2 = 80%) on cognitive function of older adults with mild cognitive impairment. It is expected that the methods and effects of the exercise rehabilitation program for improving cognitive function in older adults with mild cognitive impairment presented in the results of this study will be as a basis for field application.

토양피복에 따른 잡초발생과 안개초의 생육 및 개화에 미치는 영향

정동춘,오정문,임회춘,송영주,김정만 한국화훼산업육성협회 2011 화훼연구 Vol.19 No.1

안개초 절화 재배시 토양피복재료 및 피복방법에 따른 잡초 발생량 및 안개초 개화특성 등을 조사하였다. 잡초 발생량은 무피복 146.2 g·m-2(건물중)인 반면 흑색과 녹색 폴리프로필렌 부직포 전면피복은 4.1~4.2 g·m-2으로 거의 발생되지 않았으며, 제초 소요인원도 무피복은 27.9명/10a/년인데 반해 전면피복은 2.4명/10a/년이었다. 여름 절화작형시 개화는 무피복과 골 피복이 늦었으며, 화경장, 측지수, 절화장, 화수폭 및 화경 강도는 흑색과 녹색 부직포 전면피복이 우수하였고, 절화량은 흑색 PE필름, 녹색과 흑색 부직포 전면피복에서 많았다. 월하 후 안개초 고사주율은 흑색 부직포 골 피복처리에서 12.4% 로 가장 낮았고, 녹색 부직포 피복처리가 19.0% 정도 였으며, 흑색 PE 필름 전면 피복처리가 39.0%로 가장 높았다. 가을 절화작형 역시 화경장, 측지수, 절화장 및 화경 강도는 흑색과 녹색 부직포 전면피복이 우수하였고, 절화량은 녹색 부직포가 가장 많았다. 로젯트 발생률은 골피복보다 전면피복이 낮았으며, 피복재료별로는 녹색 부직포 전면피복이 가장 낮았고, 다음은 흑색 부직포, 흑 색 PE 필름 전면피복이 낮았다. 따라서 안개초 절화재배 시 녹색 부직포 전면 피복처리가 잡초 발생억제와 절화 품질 향상 및 절화량 증가에 효과적이라고 생각된다. This study investigated the effect of soil mulching materials and methods on weed occurring for the growth and flowering characteristics in Gypsophila plants cultivation. For mulching materials were used black polyethylene (PE) film, black polypropylene (PP), and green polypropylene, and these were mulched in both ridge and furrow (BRF) or only furrow, respectively. The weed was occurred total 146.2 g/m2/yr as dry weight in non-mulching, but 4.1~4.2 g/m2/yr in BRF mulching by black or green PP. Also weed control were yearly required 27.9 persons/10a in non-mulching, whereas 2.4 persons/10a in BRF mulching by black or green PP. Flower budding and blooming were roughly delayed in non-mulching and furrow mulching. Flowering characteristics such as flower stalk length, primary branches number, and stem firmness were remarkably improved in BRF mulching of black or green PP. Cut flower yield was increased on black BRF mulching or green PP in summer cultivation, while green PP BRF mulching showed better yield in in autumn cultivation. Mortality rate of Gypsophila plants after summer season was lowest as 12.4% in furrow mulching with black PP, followed by about 19.0% in green PP mulching, but highest as 39.0% in BRF mulching with black PE film. Rosette formation rate was lower in furrow than BRF mulching, and was lowest as 13.1% in BRF mulching with green PP, followed by 15.2~15.8% in BRF mulching with black PE film or black PP. So it was thought that BRF mulching with green PP was highly effective in weed control and improvement of yield and cut flower quality in Gypsophila plants cultivation.

근위 경골에 발생한 악성종양 절제 후 슬관절 신전력 재건술 -증례 보고-

박종훈,오정문,김진욱,이수용,Park, Jong-Hoon,Oh, Jung-Moon,Kim, Jin-Wook,Lee, Soo-Yong 대한근골격종양학회 2004 대한골관절종양학회지 Vol.10 No.2

근위 경골부에 발생한 악성종양의 사지구제술은 화학요법의 발달로 인해 대표적인 치료 방법이 되었다. 다양한 술식의 보고에도 불구하고, 종양 절제 후 종양 대치물을 이용한 사지구제술에 있어 슬개건의 부착 부위가 상실되어 슬관절의 신전력을 재건 하기가 어려운 것이 공통적인 문제로 지적 되고있다. 본 연구는 경골 근위부의 종양을 절제한 후 저온열처리 한 다음 원위 대퇴골을 절제하여 저온열처리 자가경골 및 종양대치물과 결합하고, 슬개골을 자가경골과 결합된 원위 대퇴골에 고정하여 슬관절 신전력을 재건 한 2례를 보고하고자 한다. Benign and malignant bone tumors occur most commonly around the knee. The proximal tibia is the most technically demanding site for limb salvage surgery. The most difficult problem using an endoprothesis for proximal tibial resection has been reconstruction of the extensor mechanism. After excision of proximal tibia, we resected distal femur and made a composite with resected distal femur, low heat treated autogenous proximal tibia and endoprothesis. Patella was fixed into the resected down-loaded distal femur. This article shows the new technique and the results of reconstruction of extensor mechanism after prosthetic replacement of the proximal tibia.

원위 요골에 발생한 거대 세포종의 일괄 절제 후 초고분자량 폴리에틸렌 삽입물을 이용한 재건술 - 증례보고 -

전대근,송원석,오정문,Jeon, Dae-Geun,Song, Won-Seok,Oh, Jung-Moon 대한근골격종양학회 2004 대한골관절종양학회지 Vol.10 No.1

원위 요골의 거대 세포종은 빈도가 많지는 않다. 통상적으로 골 소파술 및 골 시멘트 충전술로 치료하지만, 재발한 경우나 처음부터 골피질 파괴가 심하고 관절 침범이 있을 경우에는 일괄 절제(en bloc resection) 후 근위 비골을 이용하여 재건하는 술 식이 많이 이용되어 왔다. 본 연구는 고식적 술 식으로 치료한 후 국소 재발한 원위 요골의 거대 세포종 환자에서, 근위 비골을 이용한 재건술을 시행하여도 일차 술 식 시 오염의 범위가 심하여 다시 재발할 가능성이 높아 초고분자량 폴리에틸렌(ultrahigh molecular weight polyethylene, UHMWPE)과 골수강내 고정물 및 골 시멘트를 조합하여 원위 요골을 재건한 1례를 보고 하고자 한다. A giant cell tumor (GCT) of the distal radius is not common. Curettage with bone cementation is considered as a treatment of choice but, in the case of recurrence, marked cortical disruption, or articular invasion, en bloc excision and reconstruction with proximal fibular bone graft is usual procedure. In reconstruction of en bloc resected distal radius which had recurred GCT after conservative operation, we used the ultrahigh molecular weight polyethylene (UHMWPE) liner with intramedullary rod and bone cement, because the contamination was extent in previous operation and recurrence after fibular bone graft was fearful. This article introduce our new surgical procedure.

잔류성 유기물질(POPs)이 없는 친환경 잉크의 개발 및 인쇄 품질에 관한 연구(제2보): 실 인쇄 시험에 의한 인쇄품질

하영백,정종식,오정문 한국펄프·종이공학회 2019 펄프.종이기술 Vol.51 No.4

Printing inks contain various chemicals, some of which are toxic to humans. These inks are commonly used in baby books, magazines, and packaging materials, including those for food and medicines. Because of the prevalence of printing inks, efforts have been made to manufacture ecofriendly inks containing no harmful substances. In previous studies, we have prepared ecofriendly inks that remove persistent organic pollutants from a pigment. In this study, we investigated their printed quality in terms of the color density, dry down, dot gain, trapping, and L*a*b* values. The results comply with the ISO 12647-2 specifications and demonstrate that these ecofriendly inks exhibit the same print quality as that exhibited by the existing printing inks. Therefore, future research will focus on quality stabilization of the inks for mass production.

잔류성 유기물질(POPs)이 없는 친환경 잉크의 개발 및 인쇄 품질에 관한 연구(제1보): 인쇄적성 시험에 의한 인쇄품질

하영백,정종식,오정문 한국펄프·종이공학회 2019 펄프.종이기술 Vol.51 No.3

Environmental issues in the printing industry have long been recognized by developed countries. This global trend can function as a technological barrier in international business. Therefore, domestic printing industries must prepare sustainable materials, such as inks and dampening solutions, for eco-friendly printing. In this study, we removed phenoxyacetic acid and polychlorinated biphenyls, which are persistent organic pollutants, through pigment synthesis conditions and microwave filtering process changes. Further, the formed pigment was used to produce ink. Eco-friendly inks were made using Ce instead of drying promoters, such as Co and Mn. These inks exhibit the same world-class performance as existing inks in terms of printing quality including transition properties and color density (ISO 12647-2).

토양 피복이 잡초발생과 안개초 생육 및 개화에 미치는 영향

정동춘(Dong-Chun Cheong),오정문(Jeong-Moon Oh),임회춘(Hoi-Chun Lim),최창학(Chang-Hak Choi),김갑철(Kab-Cheol Kim),김정만(Jeong-Man Kim) 한국원예학회 2010 한국원예학회 학술발표요지 Vol.2010 No.5

Stomach Ca에서의 Neoadjuvant Chemotherapy 후 Complete Remission 1예

정인오,신석환,허윤석,오정아,문연회,우제홍,김경래,홍기천,안승익,조영업,김세중,이건영,최선근,최윤미 대한외과학회 2007 대한외과학회 학술대회 초록집 Vol.2007 No.5

생분해성 고형물에 흡착시켜 실험동물에 국소 투여한 홀미움- 166-키토산 복합체의 투여량, 기간 및 부위에 따른 조직의 괴사 정도와 양상

이종석,전대근,조완형,이수용,오정문,김진욱,Lee, Jong-Seok,Jeon, Dae-Geun,Cho, Wan-Hyung,Lee, Soo-Yong,Oh, Jung-Moon,Kim, Jin-Wook 대한근골격종양학회 2003 대한골관절종양학회지 Vol.9 No.2

목적: Holmium-166은 류마티스성 관절염 및 간암 치료에서 이미 임상적으로 사용이 보고된 방사성 동위원소이다. 본 연구는 holmium-166-chitosan 복합체를 외과적으로 생체에 투입하여 임상에 적용 가능한 방법을 연구하고, 투여량과 기간, 투여 부위에 따른 조직학적 반응 정도를 정성 및 정량 분석하여 임상적용의 기초로 활용하는 것이다. 재료 및 방법: Absorbable gelatin sponge에 액체상태의 holmium-166-chitosan 복합체를 50 ${\mu}l}$ 도포하여 고형제로 만들었다. 최종 삽입전에 caliberator로 측정한 방사선량은 약 1.5 mCi였다. Wistar종 흰쥐에 외과적 시술을 통하여 대퇴근육 내부와, 그리고 대퇴골에 접하게 holmium-166-chitosan 복합체가 부착된 gelatin sponge를 삽입 후 봉합하였다. 대퇴 근육내와 대퇴골에 투여한 후 2주, 4주, 6주에 육안 및 현미경 소견하에서 조직 괴사의 깊이, 조직 변화의 양상, 삽입된 gelatin sponge의 변화 등을 관찰하였다. 결과: 2주후의 현미경 소견상 holmium-166과의 접촉면에서는 정상 근육세포의 모양을 찾아 볼 수 없을 만큼 심한 괴사 소견을 보였고 근육세포의 퇴화 및 재생, 근육간 부종, 염증세포의 침윤 소견을 보였으며 유발된 괴사의 깊이는 평균 3.3 mm 였다. 대퇴골에서는 holmium-166과의 접촉면에 있는 골피질은 골소강내 골세포의 소실이 관찰되었고 골수강내의 골수 세포도 파괴되고 섬유화 또는 염증성 반응을 보였다. 괴사의 깊이는 평균 2.9 mm 였다. 4주 때 근육에서는 석회화와 보다 심해진 섬유화 소견이 추가 되었고 괴사의 깊이는 평균 3.3 mm 였다. 골조직에서도 골수강의 섬유화가 더 증가되었고 괴사의 깊이는 평균 3.3 mm였다. 경과 관찰 6주 군에는 연부 조직의 위축과 섬유화의 증가, 육아조직의 형성, 염증 소견의 소실 등이 관찰되었다. 결론: Holmium-166-chitosan 복합체를 생체 흡수 가능한 gelatin sponge에 부착시킨 후 실험동물에 삽입한 결과, 실험동물의 사망을 유발하지도 않았으며 상처의 괴사, 염증, 감염 등의 부작용이 전혀 없어, 생체에 외과적 적용이 가능하였다. 유발된 조직 괴사의 범위는 약 3 mm로 미리 예측한 정도에 근접하는 것으로 악성종양 치료에 임상적 적용이 가능할 것으로 생각한다. Purpose: The aim of this study was to find out a clinically appliable method to insert a biodegradable solid material containing holmium-166-chitosan complex into the surgical field, and to evaluate the histological changes in the normal tissues after ${\beta}$ -ray irradiation from holmium-166 according to the dose, period and type of tissues. Materials and Methods: 3.0 mCi, 50 ${\mu}l$ of the liquid state $^{166}$Ho-chitosan complex was attached to the absorbable gelatin sponge. The radiation activity measured by dose caliberator was 1.5 mCi. These $^{166}$Ho-chitosan complex containing absorbable gelatin sponges were inserted into the thigh muscles and over the femur bones of the Wistar rats. The cases were evaluated at 2 weeks after insertion, and 4, 6 weeks with respect to the histological changes of the soft tissues and bone, the depth of the tissue necrosis, and the changes of the $^{166}$Ho-chitosan complex containing absorbable gelatin sponges. Results: At 2 weeks, the muscles showed coagulation necrosis, degenerating myocytes, regenerating myocytes, intermuscular edema, and inflammatory cells. The necrosis depth was 3.3 mm. In the bones, there was no osteocyte in the lacuna of cortex (empty lacuna), marrow fibrosis, inflammation. The necrosis depth was 2.9 mm. At 4 weeks, in the muscle, calcification and increased fibrosis with necrosis depth by 3.3 mm were the additional findings. In the bone, marrow fibrosis with necrosis depth by 3.3 mm were detected. At 6 weeks, soft tissue shrinkage, increased fibrosis and granulation tissue formation, and nearly resolving inflammatory reaction were the findings. Conclusion: The local application of the $^{166}$Ho-chitosan complex attached to biodegradable gelatin material with surgery in the laboratory animals resulted in no mortality and morbidity, and satisfactory tissue necrosis. Holmium-166 can be applied to the treatment of the malignant tumor patients.