Construction of neurospheroids via surface modified concave microwells

이건희,임재호,박지수,이원석,윤대성,김수현,김명기,이상훈,김동휘 한국공업화학회 2018 Journal of Industrial and Engineering Chemistry Vol.62 No.-

Developing a three-dimensional (3D) neural tissue model is important to comprehensively understand neural development and neuronal degeneration associated with various neurological disorders such as axonopathy and neuronopathy. Here, a new microplatform suitable for constructing neuronal spheroids (neurospheroids) was developed by modulating cell–surface interactions. The inner surface of a polydimethylsiloxane (PDMS) concave microwell array extensively used in in vitro cell aggregation was modified with typical extracellular matrix (ECM) molecules or carbon nanotubes to control neural spheroid formation. Modulating neuronal cell–ECM interactions could tune 3D intercellular interactions and spheroidal functionality. Neurite outgrowth, a neuronal marker for complex interneuronal signaling, was found to be tightly regulated by cell–ECM interactions in a confined space. Furthermore, amyloid-β (Aβ)-induced axonopathy representing a pathological feature of neurodegenerative diseases in vivo was examined in this study to monitor the degeneration of neurite outgrowth and alteration of neuronal morphology in these neurospheroids. The proposed neural tissue model could be used to study various neurodegenerative diseases in the future.

Inverse shadowing for expansive flows

이건희,Zoonhee Lee 대한수학회 2003 대한수학회보 Vol.40 No.4

We extend the notion of inverse shadowing defined fordiffeomorphisms to flows, and show that an expansive flow on acompact manifold with the shadowing property has the inverseshadowing property with respect to the classes of continuousmethods. As a corollary we obtain that a hyperbolic flow also hasthe inverse shadowing property with respect to the classes ofcontinuous methods.

BI(brand identity)의 색채감성에서 나타난 한국 전통 색 활용에 관한 연구 - 국내 전통주(국순당, 서울탁주제조협, 진로, 롯데)사례를 중심으로 -

이건희,전양덕 한국정보디자인학회 2011 정보디자인학연구 Vol. No.

전통유물에 사용된 전통 색채에는 우리 민족 고유한 전통의식과 감성을 찾아 볼 수 있다. 역사의 흐름을 통해 전해 내려와 시대와 세대로 전유되는 한 국가의 전통 색은 그 국가의 역사와 전통 속의 뿌리 깊은 정신과 사상이 녹아있으며, 이를 통해 미래의 전통색채를 예측해 볼 수 있다. 따라서 본 연구는 먼저 과거에서 현재까지 한국인의 의식 속에서 자리 잡고 있는 색채를 분석하고, 한국 전통색채에 녹아 있는 색채감성을 이해하고자 한다. 현대사회에서는 색채를 통해 시간과 장소에 대한 제한 없이 시각적 정보를 전달하고 전달 받을 수 있다. 또한 색채는 현대 문명의 발전과 함께 개인에게 있어서 점점 다양해지고 많은 부분에서 활용 되고 있다. 즉, 색채는 사회, 문화, 경제, 정치적 척도로써의 역할을 하며 우리의 생활 속 깊이 간여하여 색채에 대한 선호도를 형성하고 있다. 따라서 본 연구는 전통 색채를 사용하여 우리나라를 연상할 수 한국 색채 감성을 연구하고, 이를 바탕으로 브랜드 아이텐티티에 응용할 수 있도록 하고자 한다. 구매자의 입장에서 기술을 중심으로 한 제품이 아무리 부합 된다 하더라도 디자인이나 색채의 시각적 욕구가 충족되지 못하면 구매 의욕이 저하되므로 경쟁력을 잃게 된다. 따라서 국제 경쟁력을 지닌 상품의 개발에 있어 우선시되는 것은 우리나라를 상징하는 고유의 색채 문화 상품의 개발 전략을 수립하는 일이다. 그것은 제품이 지니는 속성과 소비계층의 색채수요를 동시에 감안한 색채디자인을 완성되도록 연구 개발되어야한다.

古代 會計發展史 硏究 : 이집트ㆍ그리스ㆍ로마時代를 中心으로

李建憙 한국경영사학회 1996 經營史學 Vol.13 No.-

대학기숙사에서 동선공간의 공유성에 관한 연구- 사이공간 개념을 바탕으로 -

이건희,송하엽 한국문화공간건축학회 2022 한국문화공간건축학회논문집 Vol.- No.80

A dormitory is a space where various members of the same group live together. Unlike the past, which has played a role in providing accommodation-oriented services, a number of amenities are planned today to reflect the needs of users and provide a more comfortable life as well as accommodation functions. However, due to the need to accommodate a large number of people and economic problems, the distribution of residential and convenient functions is centered on efficiency. Therefore, in this study, the movement space, which is the space connecting these spaces, was viewed from the perspective of the in-between space, and the movement space was newly sought as a space where special actions and experiences can be achieved beyond simple movement. For this purpose, a literature survey was conducted on the dormitory and in-between space, and based on this, four cases in which the movement space was characterized by the in-between space were selected and compared. After that, the analysis contents were synthesized to derive planning elements and characteristics that allow the movement space to be used in a way beyond movement in the dormitory. As a result, when the movement space is planned to have the characteristics of the in-between space, it becomes a representative characteristic of the dormitory, and a natural social and spatial experience is induced in it. In addition, it was confirmed that the characteristics of the in-between space can be realized by diaonal arrangement of movement space or by insertion of in-between space.

Th1, Th2형 Cytokine이 인간 비점막섬유아세포의 Eotaxin, RANTES 단백과 mRNA 발현에 미치는 영향

이건희,조중생,유영인,노경섭,차창일,조정제 대한이비인후과학회 2002 대한이비인후과학회지 두경부외과학 Vol.45 No.5

Background and Objectives:Fibroblasts interact with eosinophils and play a key role in the pathogenesis of airway dise-ases. The aims of this study were to investigate whether Th1 or Th2 type cytokines can induce mRNA and protein expresion of eotaxin and RANTES in human nasal fibroblast (HNF) and to verify the corelation betwen the stimulation of different cytokines and chemokines in HNF. Materials and Methods:Cultured HNF were stimulated by IL-13, TNF-α, IFN-γ, IL-13 with TNF-α, IL-13 with IFN-γ, TNF-α with IFN-γ >?F??(??(?F)?? (0.2, 2, 20, 200 ng/ml). MRNA expression of eotaxin and RANTES were revealed by RT-PCR and protein of eotaxin and RANTES were revealed by ELISA. Results:TNF-α and IFN-γ induced mRNA and protein expr-esion of RANTES in HNF and they synergisticaly induced protein expresion of RANTES. RANTES expresion increased in a time dependent manner. IL-13 induced mRNA and protein expresion of eotaxin in HNF and it synergisticaly reacted with TNF-α or IFN-γmanner. Conclusion:Th1 or Th2 type cytokines induce mRNA and protein expresion of eotaxin and RANTES in human nasal fibroblasts. TNF-α or IFN-γ induce more RANTES than eotaxin but IL-13 induces more eotaxin than RANTES. There may be some synergic effects of cytokines for mRNA and protein expresion of chemokines. (Korean J Otolaryngol 2002;45:467-72)

니트 제품의 지속가능성에 관한 탐색적 연구

이건희 한국니트디자인학회 2013 패션과 니트 Vol.11 No.3

Today, high expectations are being placed on protection of the environment and economizing natural resources. We are putting a lot of effort into eco-friendly and sustainable fashion design. This is the time to make an effort like this in the knit industry part. The purpose of this study is the contemplation of an eco-friendly and practical method of production, consumption and disposal in the knit industry through case study analysis. I got these results from the research shown here in. First, they natural fibers pollute the environment more than synthetic fibers because it need an enormous quantity of water in the process of producing thread. Second, synthetic fibers pollute the environment because of the release of poisonous gas from discarded products. It is necessary to prepare a way to extend the period of use for knit products to solve these two problems. I think we have to help consumer to reuse or recycle out-of-style or worn-out knitwear like Levi's ‘Forever Blue’ Campaign. On the other hand, most of the fine-gauge products that are produced by cutting & sewing create too much waste at the production stage. So, we’d better transfer to a system of seamless knitwear to reduce garbage. Low-gauge products need physical work when we want to re-use them because they have big thread, but the fine-gauge knits are easy to re-use. I hope that the knit industry will reform to be green industries by realizing sustainability.

비배부에 발생한 혈관평활근종 1예

이건희,조중생,이인영,장명근 대한이비인후과학회 2003 대한이비인후과학회지 두경부외과학 Vol.46 No.1

Angiomyoma is a benign myogenic tumor which can be found wherever smoth muscle is present. They are most commonly found in the alimentary tract, female genito-urinary tract, skin and subcutaneous tissues, but are rare in the area of the head and neck due to the scarcity of smoth muscle tissue. Because of their rarity, these tumors are often clinically misdiagnosed and identified only after histological examination. We present a case of angioleiomyoma which was found in the nasal dorsum and was excised by open rhinoplasty approach. (Korean J Otolaryngol 2003 ;46 :85-7)

지식자원과 네트워크가 다국적 기업 해외 자회사의 자율성에 미치는 영향: 내부 협상력을 중심으로

이건희 한국국제경영관리학회 2009 국제경영리뷰 Vol.13 No.2

본 연구는 다국적기업의 한국 내 자회사가 보유한 지식자원과 네트워크를 중심으로 의사결정 자율성에 영향을 미치는 요인들에 대하여 살펴보았다. 이를 위해 기존 문헌 연구를 통해 12개의 가설을 설정하였다. 설정된 가설의 검증을 위하여 다국적기업의 한국 자회사 표본 211개를 대상으로 신뢰성 검증, 타당성 검증, 상관관계 분석 및 구조방정식모형 분석을 실시하였다. 이를 통해 얻어진 분석 결과는 다음과 같다. 첫째, 해외 자회사의 내부 협상력은 자회사 자율성에 통계적으로 유의한 정(+)의 영향을 미치는 것으로 나타났다. 둘째, 지식자원 보유량, 지식자원의 경쟁우위정도, 외부 네트워크 배태성, 자회사 중요도가 높을수록 자회사의 자율성은 높은 것으로 나타났다. 셋째, 자율성에 영향을 미치는 요인중 지식자원 보유량과 지식자원의 경쟁우위정도는 내부 협상력을 완전매개로 정(+)의 영향을 미쳤다. 넷째, 외부 네트워크와 자회사 중요도는 내부 협상력을 부분매개로 하여 자율성에 정(+)의 영향을 미치는 것으로 나타났다. 본 연구의 이론적 의의는 기존의 자회사의 발전에 관한 연구에 자회사의 내부 협상력이 자율성에 미치는 영향을 분석함으로써 기존의 자회사 자율성 연구의 확장을 시도한 것이다. 실무적으로는 해외 자회사의 자율성을 확대하고자하는 본사 경영자에게 다국적기업 전체 네트워크의 효율성을 저하시킬 가능성이 있는 자회사 내부 협상력과 자율성과의 관계에 대한 이해를 제공하고 있다. The purpose of the study is to learn more about the factors influencing subsidiary autonomy of the MNCs located in Korea by bringing focus into the resources and networks of the subsidiary. Following the qualitative research tradition in the field of international business studies, the study examines twelve hypotheses. To test the hypotheses, the study analyzes two hundred eleven subsidiaries of MNCs in Korea by reliability test, validity test, correlation analysis, and path analysis by structure equation modeling. The key findings of the study are as follows. First, the study reveals bargaining power of overseas subsidiary is related to subsidiary autonomy in a positive direction with statistic significance. Second, knowledge stock, competitiveness of knowledge, external network embeddedness and degree of subsidiary importance are positively related to subsidiary autonomy. Third, The effect of knowledge stock and competitiveness of knowledge on subsidiary autonomy is fully mediated by subsidiary bargaining power. Forth, the bargaining power partially mediates between two independent variables, external network embededness and degree of subsidiary importance, and subsidiary autonomy. Theoretical implication for the study is expansion of traditional view to subsidiary autonomy by analysis of the effect of bargaining power on subsidiary autonomy derived from subsidiary development theory of international business studies. In terms of implication for management practices, the study provides the managers of headquarters who wish to increase the level of subsidiary autonomy with profound understanding of relationship between subsidiary autonomy and bargaining power which may jeopardize the global efficiency of MNCs network.

상악동에 국한된 섬유성 이형성증 1예

이건희,조중생,이인영,김훈 대한이비인후과학회 2002 대한이비인후과학회지 두경부외과학 Vol.45 No.1

Fibrous dysplasia is a developmental disease of the bone, characterized by the replacement of normal spongiosa and filling of the medullary cavity of affected bones by an abnormal fibrous tissue. Fibrous dysplasia arising in the paranasal sinus is are predominant:the monostotic type, in which only one bone is afected;and the polyostotic type, in which multiple bo-nes are affected. Recently, we experienced a case of monostotic fibrous dysplasia which was confined to the maxillary sinus and approached by the Caldwell-Luc method. Hence, we report a case of fibrous dysplasia of the maxillary sinus with a re-view of literature. (Korean J Otolaryngol 2002;45:86-8)