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권현구(Hyun-Gu Kwon),김정진(Jung-Jin Kim),오호석(Ho-Suk Oh) 한국엔터테인먼트산업학회 2012 한국엔터테인먼트산업학회 학술대회 논문집 Vol.2012 No.5
본고에서는 Contextual and User Experience 개념을 기반으로 한 Dynamic Scheduler 어플리케이션의 설계구조와 가치에 대해 분석하였으며, Dynamic Scheduler의 사용자가 필요한 정보를 동적으로 검색 가능한 Architecture에 대해 기술한다. 또한 사용자 요구에 맞추기 위한 유용한 데이터 검색에 있어서 발생하는 많은 리소스를 줄이며, 성능을 제고할 수 있도록 고려하였다. 한편 Contextual and User Experience를 기반으로 한 Dynamic Scheduler 서비스 제공시 문제점으로 개인정보의 노출과 상업적인 활용 등이 예상될 수 있다
위암에서 새롭게 개정된 제7판 UICC/AJCC N병기에 대한 제6판 N병기와의 비교평가
김지훈(Ji Hoon Kim),김찬욱(Chan Wook Kim),최남규(Nam Kyu Choi),곽진호(Jin Ho Kwak),최건무(Kun Moo Choi),장혁재(Hyuk Jae Jang),한명식(Myung Sik Han),이상진(Sang Jin Lee),오호석(Ho Suk Oh),최종수(Jong Soo Choi) 대한외과학회 2010 Annals of Surgical Treatment and Research(ASRT) Vol.79 No.3
Purpose: The 7th edition UICC/AJCC TNM classification for gastric cancer has several changes from the previous edition. Especially, the classification of the number of lymph node metastases (LNM) is reorganized. According to the new TNM system, N stage was categorized to N0 (no LNM), N1 (1∼2 LNM), N2 (3∼6 LNM), N3 (7 or more LNM). The aim of our study was to compare the prognostic significance of the new (7th) UICC/AJCC N stage with the old (6th). Methods: From 2000 to 2005 a total of 425 patients who underwent curative resections with D2 and with 15 or more lymph nodes retrieved were studied retrospectively. Results: According to the 7th UICC/AJCC N stage, the 5-year cumulative survival rates (5YSR) of N0, N1, N2, N3 were 96.0%, 79.2%, 58.5% and 24.3%, respectively (P<0.001). Using univariate analysis, the N stage of 7th and 6th UICC/AJCC TNM classification, 7th UICC/AJCC T stage, differentiation of tumor, type of gastrectomy (subtotal and total gastrectomy), size of primary tumor (≤5, 5<≤10, 10<) were associated with 5YSR. However, Cox regression multivariate analysis showed the 7th UICC/AJCC N stage to bean independent factor for predicting the 5YSR instead of the 6th UICC/AJCC N stage (P<0.001, hazard ratio (HR) 1.859, 95% confidence interval (CI) 1.576∼2.194), including depth of tumor invasion (P<0.001, HR 1.673, 95% CI 1.351∼2.073). Conclusion: The new (7th) UICC/AJCC N stage is a more reliable prognostic factor of gastric cancer than the old (6th) N stage.
Gitelman 씨 증후군으로 오진된 Pseudo - Bartter 씨 증후군 1 예
이동규(Dong Kyu Lee),정재면(Jae Myun Jung),강준구(Jun Goo Kang),김태엽(Tae Yeob Kim),김태종(Tae Jong Kim),오호석(Ho Suk Oh),최창렬(Chang Youl Choi),한상웅(Sang Woong Han),김호중(Ho Jung Kim) 대한신장학회 2002 Kidney Research and Clinical Practice Vol.21 No.3
A 31-year-old woman had a history of fatigue and hypokalemia and metabolic alkalosis and hypocalciuria. The patient had a subtotal thyroidectomy and denied ingestion of diuretic medication. Her clinical and laboratory findings were consistent with Gitelman`s syndrome. Normal blood pressure, hypokalemic metabolic alkalosis, hypocalciuria were present. She confessed to us that she had been taking a pill due to constipation for 7 years. She was afraid that her husband know it. But we don`t know the reason why she had concealed it Surreptious ingestion of diuretics must be excluded in any adult patient in whom a diagnosis of Bartter`s or Gitelman`s syndrome is considered.
증례 : 혈액종양 ; 전립선암에서 발생한 수막암종증 1예
서현웅 ( Hyun Woong Seo ),유승훈 ( Seung Hoon You ),장경희 ( Kyeong Hee Jang ),이정화 ( Joung Hwa Lee ),최종수 ( Jong Soo Choi ),강길현 ( Gil Hyun Kang ),오호석 ( Ho Suk Oh ) 대한내과학회 2011 대한내과학회지 Vol.81 No.2
수막암종증은 암세포가 뇌수막에 침윤한 상태로 정의하는데 자기공명영상이 진단방법으로 쓰이기 전까지 진단이 용이하지 않았다. 또한 전립선암 환자에서 수막암종증이 생긴 경우는 매우 희귀하여 증례보고 형식으로 소수에서 보고 되고 있는 실정이다. 내원 11년 전 전립선암으로 근치적 전립선 절제술을 받고 내원 4년 전 골전이로 항암치료를 받은 병력이 있는 환자로 경련을 주소로 내원하여 시행한 반복적인 뇌척수액 검사에서 세포진을 발견하지 못했지만 뇌척수 액 전립선 특이항원 양성소견과 뇌 자기공명영상 소견으로 수막암종증을 진단하고 조직검사를 통해 확진하여 적극적인 치료로 생명연장을 할 수 있었던 사례를 경험하였기에 문헌 고찰과 함께 보고한다. Meningeal carcinomatosis in patients with prostate cancer is very rare. Recently, we experienced a case of meningeal carcinomatosis in a patient with prostate cancer. He had undergone a radical prostatectomy 11 years before presentation and had undergone chemotherapy 4 years before presentation due to bone metastases. This time, he visited the emergency department because of a seizure. Although cerebrospinal fluid (CSF) examinations did not reveal malignant cells, we diagnosed meningeal carcinomatosis based on positive CSF prostate-specific antigen and magnetic resonance imaging (MRI) findings. The diagnosis was confirmed pathologically. We treated the patient with whole brain radiotherapy and intrathecal chemotherapy. We report a case of prostate cancer with meningeal carcinomatosis with a literature review. (Korean J Med 2011;81:262-265)
윤준영 ( June Young Yoon ),정형정 ( Hyoung Jung Chung ),최혜영 ( Hye Young Choi ),최종수 ( Jong Su Choi ),엄대운 ( Dae Woon Eom ),오호석 ( Ho Suk Oh ) 대한내과학회 2010 대한내과학회지 Vol.79 No.1
Extrapulmonary small cell carcinoma is a highly malignant and poorly differentiated neuroendocrine tumor. The overall incidence in the United States is approximately 0.1~0.4%. Moreover, small cell carcinoma of the liver is extremely rare and few cases have been reported in the literature. We experienced a 65-year-old woman with a 15 cm hepatic mass, which was localized in the left lobe of a noncirrhotic liver. The mass was confirmed as small cell carcinoma by immunohistochemical staining of a biopsy specimen. Other possible primary sites were excluded by radiologic and endoscopic evaluations. The patient was treated with combination chemotherapy. She was in partial response on the last follow-up visit.
증례 : 형액종양 ; 주기적 고용량 부신피질 호르몬제 투여로 치료된 Castleman 병 1예
조성원 ( Sung Won Cho ),정형정 ( Hyoung Jung Chung ),김수희 ( Su Hee Kim ),최종수 ( Jong Su Choi ),강길현 ( Gil Hyun Kang ),오호석 ( Ho Suk Oh ) 대한내과학회 2010 대한내과학회지 Vol.79 No.1
Castleman`s disease is rare, and its cause is unknown. Although various treatments have been attempted, no standard treatment has been established for it. A 51-year-old male on hemodialysis with end-stage renal disease was admitted to our hospital with fever and myalgia. He was diagnosed with multicentric Castleman`s disease (MCD) of the hyaline vascular type. Considering his underlying disease and general condition, cyclic high-dose steroid therapy (prednisolone 1 mg/kg/day for 5 days) was administered every 4 weeks, eight times in total. After this, no symptomatic manifestations of MCD or signs on computed tomography were observed. We report an immunocompromised patient diagnosed with MCD of the hyaline vascular type, who was successfully treated with cyclic high-dose steroid therapy. (Korean J Med 79:72-76, 2010)
악성 질환에서의 고용량 화학요법과 자가말초혈액 조혈모세포이식술 : 단일기관 치료 경험
최정혜,안명주,오호석,이웅수,오석중,이영열,최일영,김인순 대한조혈모세포이식학회 2003 대한조혈모세포이식학회지 Vol.8 No.2
연구배경: 고용량 화학요법은 항암제의 투여 용량에 따라 항암효과가 비례하는 용량반응 관계가 있는 악성종양에서 효과를 기대할 수 있으며 현재 급성백혈병, 악성림프종, 다발성골수종 등의 혈액 종양과 유방암, 고환암, 난소암, 신경아세포종 등의 고형암 환자에서 시행되고 있다. 저자들은 고용량화학요법에 이어 자가조혈모세포이식을 시행 받은 악성 종양 환자를 대상으로 치료효과 및 부작용 등의 임상상을 알아보고자 하였다. 방법: 1997년부터 2003년까지 한양대학교 병원에서 자가조혈모세포이식을 시행 받은 악성 종양 환자 31예(남서 : 여성 15 : 16, 중앙연령: 50세, 다발성골수종 14예, 비호지킨림프종 9예, 유방암 4예, 호지킨림프종 3예, 급성골수성백혈병 1예)를 대상으로 후향적 분석을 시행하였다. 결과: 채집된 단핵구의 중앙값은 5.1×10^(8)/kg (범위 1.6~189.3)이었고 CD34양성세포수의 중앙값은 12.0×10^(6)/kg (범위 1.3~75.1)이었다. 말초혈액 과립구가 500/μL 에 도달하는 중앙값은 11일(범위 8~27)이었고 혈소판이 20,000/μL에 도달하는 중앙값은 11일(범위 0~32)이었다. 고용량 항암화학요법 후 21예가 완전관해, 5예가 부분관해에 도달하였다. 생존한 환자의 중앙추적기간은 29.5개월이었고 전체 환자의 2년 무병생존기간은 55.7%이었고 중앙값은 48.2개월이었다. 2년 생존기간은 62.9%이었으며 중앙값에는 도달하지 않았다. 10예의 사망환자 중 7예가 질병의 진행으로 사망하였고, 조기사망 3예(심부전과 신부전 1예, 장파열 1예, 패혈증 1예)가 있었다. 결론: 이 연구는 포함된 환자의 수가 적고 추적기간이 짧은 단점이 있으나, 다발성골수종, 악성림프종 등의 악성 질환에서 고용량 항암화학요법과 자가조혈모세포이식은 안전하고 효과적인 치료임을 추정할 수 있었다. Background: We performed the current study to evaluate the safety and efficacy of high-dose chemotherapy (HDC) with autologous peripheral blood stem cell transplantation (ASCT) in malignant diseases. Methods: Between January 1997 and March 2003, 31 patients (14 multiple myeloma, 9 Non-Hodgkin's lymphoma, 3 Hodgkin's disease, 4 breast cancer, and 1 acute myelogenous leukemia) underwent HDC with ASCT. Stem cells were collected by CS-3000 after mobilization treatment with chemotherapy and granulocyte colony-stimulating factor. The conditioning regimens included high-dose melphalan, BEAM (BCNU, etoposide, cytosine arabinoside, melphalan), BEAC (BCNU, etoposide, cytosine arabinoside, cyclophosphamide), CPB (cyclophosphamide, cisplatin, BCNU) and others. Results: There were 15 male and 16 female patients and median age was 50 years (range: 29~77). The median number of mononuclear and CD34+ cells was 5.1×10^(8)/kg (1.6~189.3) and 12.0×10^(6)/kg (1.3~75.1), respectively. The median time of neutrophil (>500/μL) and platelet (>20,000/μL) engraftment was 11 (8~27) and 11 (0~32) days after ASCT, respectively. Twenty-two patients experienced neutropenic fever. Twenty-one patients achieved complete remission and 5 patients achieved partial remission after HDC with ASCT. The median follow-up duration for surviving patients was 29.5 months. Causes of death included disease progression (7), sepsis (1), bowel perforation (1), and renal failure (1). Median progression free survival (PFS) was 48.2 months and median overall survival (OS) was not reached. Two-year PFS and OS was 55.7% and 62.9%, respectively. Conclusion: Our results suggest that HDC with ASCT was safe and effective modality in patients with various malignant diseases.
관해유도 항암화학요법에 실패한 호지킨병 환자에서 2회의 자가 말초혈액 조혈모세포이식 후 지연되어 완전 관해된 1예
정성진,김일,박환철,오호석,최정혜,이영열,김인순,최일영,안명주 대한조혈모세포이식학회 2003 대한조혈모세포이식학회지 Vol.8 No.1
관해유도 항암화학요법에 실패한 호지킨병 환자에서 2회의 연속된 자가 조혈모세포이식은 하나의 치료 대안으로서 고려될 수 있다. 저자들은 진행된 호지킨병으로 진단된 뒤 기존 항암화학요법에 저항을 보여 자가 말초혈액 조혈모세포이식을 시행하였으나 여전히 부분 관해를 보였고, 재차 자가 말초혈액 조혈모세포이식을 시행하였으나 영상학적 검사에서 부분 관해에 머물렀던 환자가 조혈모세포 이식 3년 후 추적 검사에서는 완전 관해 소견을 보인 1예를 경험하여 이를 보고하는 바이다. The double autologous stem cell transplantation after high-dose therapy has been considered as a therapeutic chance for patients with refractory or relapsing Hodgkin's disease. We report here a 29-year-old patient with Hodgkin's disease (nodular sclerosis, Stage IVB), who was partially responsive to 6 cycles of conventional chemotherapy, achieved only partial remission despite double autologous peripheral blood stem cell transplantation. However, long- term follow-up with 3 years after second stem cell transplantation, the persistently remained tumors on spleen, left ilium, and right scapular area disappeared spontaneously and now the patient has no evidence of disease. Compared with previously reported cases of long-lasting persistent evidences of unresolved disease after allogeneic bone marrow transplantation with subsequent complete response in other hematologic malignancies, an atypical pattern in this case with delayed complete response after autologous hematopoietic stem cell transplantation has not been reported.