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방사선조사 시 Squalene이 mice 혈청에 미치는 효과
오병준,동경래,박용순,권대철,정재은,구은회 한국실내환경학회 2010 한국실내환경학회지 Vol.7 No.1
When radiation is irradiated onto biological tissue, the occurrence of biological change has been already demonstrated and the change of blood composition and chromosome abnormality could be suggested as the representative biological markers which can identify the disturbance caused by radiation exposure. Recently, radiation treatment is performed for the treatment of cancer. Since the protection of blood within normal tissue is very important, the development of radioprotective has been made continuously to protect normal tissues. Squalene is a very important precursor in the biosynthesis of cholesterol. It is the hydrocarbon contained in the liver of deep sea sharks and in olive oils, and large quantity of it is contained in skin, abdominal fat tissue, subcutaneous fat tissue, lymphatic gland, pancreas and in heart muscle. Because of 6 double bonds in SQ, it could easily bind with oxygen ions to have the hazardous oxygen removal capacity along with the effects of scar treatment, blood vessel expansion, inhibitory action of arteriosclerosis, and has been reported to have the effects on myocardial infarction and liver disease, treatment for burn. It has been reported to have active effect of fibroblast. Therefore, the current study was conducted to know the change of total protein, albumin, total cholesterol and glucose in serum after the injection of whole body radiation of SQ in mouse.
Treatment of acute carbon monoxide poisoning with induced hypothermia
오병준,임용균,박은정,민영기,최상천 대한응급의학회 2016 Clinical and Experimental Emergency Medicine Vol.3 No.2
Objective The effect of induced hypothermia on severe acute carbon monoxide (CO) poisoning remains to be addressed further. We investigated the effect of induced hypothermia on severe acute CO poisoning. Methods Retrospective chart review was conducted for patients who diagnosed as severe acute CO poisoning in emergency department and underwent induced hypothermia from May 2013 to May 2014. Hospital courses with critical medication and major laboratory results were investigated through the chart review. Results Among total 227 patients with acute CO poisoning during the period of study, patients with severe acute CO poisoning were 15. All patients underwent induced hypothermia with a temperature goal 33°C. Initial and follow-up levels of S100B protein after induced hypothermia were 0.47 μg/L (interquartile range, 0.11 to 0.71) and 0.10 μg/L (interquartile range, 0.06 to 0.37), respectively (P = 0.01). The mean Glasgow Coma Scales at emergency department admission was 6.87±3.36. Except 1 patient who expired after cardiopulmonary resuscitation, Glasgow Coma Scales at 30-day of hospital discharge were 15 in 10 patients (71.4%), 14 in 1 patient (7.1%), 13 in 1 patient (7.1%), and 6 in 2 patients (14.2%). Seven patients (46.7%) developed delayed neurologic sequelae. Four patients showed mild types of delayed neurologic sequelae and 3 showed moderate to severe types of delayed neurologic sequelae. Conclusion Most of patients underwent induced hypothermia had a good recovery from severe acute CO poisoning. Therefore, induced hypothermia may be considered as a possible treatment in severe acute CO poisoning.
오병준,전웅배,김광상,이현화,표병식,김영순,김선민,정수진,조송미 한국식물병리학회 2004 Plant Pathology Journal Vol.20 No.4
Ripe fruit of pepper (Capsicum annuum) showed resistance to Colletotrichum gloeoporioides, but unripe fruit was susceptible. We previously isolated the PepTLP gene that induced in both unripe and ripe fruit by fungal infection and wound, and only in ripe fruit by jasmonic acid (JA) treatment. To examine further regulation of PepTLP, the action of specific agonist and antagonists of known signaling effector on the PepTLP expression by fungal infection, wound, and JA was investigated. A similar dephosphorylation event negatively activated all the PepTLP expression in the ripe fruit by fungal infection, wound, and JA. The induction of PepTLP expression by wound is differentially regulated via phosphorylation and dephosphorylation step during pre- and post-ripening, respectively. In addition, the induction of PepTLP expression in the ripe fruit by wound and JA is differentially regulated via dephosphorylation and phosphorylation step, respectively. Only both wound and JA treatment has synergistic effect on the PepTLP expression in the unripe fruit. Both SA and JA treatments on the unripe fruit, and both wound or JA and SA on the ripe fruit could not do any effect on the expression of PepTLP. These results suggest that the induction of PepTLP expression is differentially regulated via complex regulatory system against fungal infection, wound, and JA treatment during pre- and post-ripening of pepper fruit.