하나님의 형상 비혼지체들

심경미 새가정사 2018 새가정 Vol.712 No.-

Effect of Treatment with Transdermal Ketoprofen on Adjuvant-Induced Arthritis

심경미,Se Eun Kim,배춘식,Seok Hwa Choi,강성수 한국임상수의학회 2006 한국임상수의학회지 Vol.23 No.4

This study demonstrates the anti-arthritic effect of topical application of ketoprofen gel containing N-methyl-2-pyrrolidone (NMP) in adjuvant arthritis therapy. Adjuvant arthritis was induced by a single injection ofFreund's complete adjuvant (FCA). Mature female Sprague-Dawley rats were designated to 3 groups such as controlgroup, K10 group (ketoprofen 10 mg/rat), and NK10 group (ketoprofen 10 mg/rat containing NMP). The anti-arthriticbut also bone damage (X-ray score and regional bone uptake) of the hind paw in arthritis-induced rats. These resultsshowed a higher efficacy of ketoprofen containing NMP than ketoprofen treatment in the adjuvant-induced arthritis.Ketoprofen containing NMP has good intrinsic characteristics for formulation in an efficacious anti-inflammatorytopical application.

랫드 두개골 결손부에서 단삼 수용성 추출물의 골형성 효과

심경미,김세은,강성수,Shim, Kyung Mi,Kim, Se Eun,Kang, Seong Soo 대한수의학회 2010 大韓獸醫學會誌 Vol.50 No.3

The purpose of this study was to evaluate the osteogenic capacity of water extract of danshen (Salvia miltiorrhiza Bunge). We have established in rat critical-sized calvarial defect model using the combination with collagen scaffold and danshen hydrophilic extract. All rats were extinguished at 8 weeks after bone graft surgery, and the bone regeneration ability of bone grafting sides was evaluated by plain radiography and micro-CT. These results revealed water extract of danshen had the potential to promote osteogenesis especially continuous oral administration with local treatment compared to one-shot local treatment. This compound may provide a new alternative agent for growth factors to promote bone healing and bone regeneration. In conclusion, these results suggest that danshen hydrophilic extract have the potential to promote osteogenesis in bone defects. Further studies about fusion technology with salvianolic acid B, peptides, growth factors, and scaffolds using of the combination of tissue engineering, cell engineering and mechanical engineering are needed.

고도보존 및 육성사업의 성과와 발전방향

심경미 국토연구원 2021 국토 : planning and policy Vol.481 No.-

집단미술치료가 아동의 행복감에 미치는 효과

심경미,공마리아 한국아동발달지원연구소 2020 임상미술심리연구 Vol.10 No.3

본 연구의 목적은 집단미술치료가 아동의 행복감에 미치는 효과를 알아보고자 하 였다. 연구대상은 A시의 B지역아동센터의 센터장이 아동의 행복감 향상에 필요하다 고 추천한 초등학교 4-6학년 학생들 가운데 본 연구의 목적에 보호자가 동의한 아동 16명이다. 그들 가운데서 프로그램 참여 동의서를 제출한 아동 8명은 실험집단, 그 외 아동 8명은 통제집단에 배치하였다. 프로그램은 2017년 2월 6일부터 3월 16일까지 주 2회, 회기 당 90분씩 총 12회기 실시되었다. 연구도구는 강영하(2008)가 개발한 행복 감 검사를 사용하였다. 프로그램은 초기에는 친밀감 형성 및 관계형성, 중기는 자기존 중감, 낙관성, 친구관계를 중심으로 후기에는 행복감 다지기로 구성되었다. 자료처리 는 첫째, 실험집단과 통제집단의 행복감 사전검사 점수를 이용하여 독립표본 t-test를 실시하여 두 집단 간의 동질성 여부를 살펴보았다. 둘째, 프로그램의 효과성을 살펴보 기 위해 실험 및 통제집단의 사전-사후검사 점수를 사용하여 반복측정 분산분석 (Repeated Measure ANOVA)을 실시하였다. 연구의 결과, 집단미술치료가 아동의 전 체 행복감 증진에 긍정적 효과를 미치는 것으로 나타났으며, 행복감의 하위영역에서 긍정적인 효과가 나타났다. The purpose of this study is to examine the effects of group art therapy on the happiness of children. The subject of this study was 16 children who were agreed to the program test from their parents among 4th to 6th grade of elementary school children recommended to enhance the happiness from the manager of B community child center in A city. Among them, the experimental group consisted of 8 children who submitted a consent form in the program and the rest of them was control group. The program was organized a total of twelve sessions, for 90 minutes per each session, twice a week from February 6 to March 16, 2017. Research tool used Happiness Test developed by Kang(2008). The program consisted of the intimate formation and relationship formation in the early stage, then self-respect, optimism, and relationship with friends in the middle stage, and then strengthening happiness in the later parts. For processing the data, first, the homogeneity between the two group confirmed that an independent t-test was conducted using the scores of the test for happiness of the experimental group and control one. Second, in order to verify the effectiveness of the program, the repeated measure ANOVA was carried out using the pre-and post-test scores of the experimental group and control one. As a result, group art therapy was effective for increasing the overall happiness of children. It was effective for increasing the happiness of children in low-rank scope.

미니돼지에서 ^99mTc-Tin colloid와 ^99mTc-DISIDA를 사용한 간신티그라피의 비교 연구

심경미,김세은,이원국,궁성수,배춘식,이재영,최석화,한호재,강성수,박수현,Shim, Kyung-Mi,Kim, Se-Eun,Lee, Won-Guk,Koong, Sung-Soo,Bae, Chun-Sik,Lee, Jae-Yeong,Choi, Seok-Hwa,Han, Ho-Jae,Kang, Seong-Soo,Park, Soo-Hyun 한국생명과학회 2006 생명과학회지 Vol.16 No.6

동물 모델에서의 간기능의 비침습적 평가는 하나의 과제로 남아있다. 간신티그라피는 간의 크기 및 모양의 변화에 대한 정보를 제공할 뿐 아니라 간의 전체적인 기능을 파악할 수 있게 해 주며 간이식의 주요 합병증인 간염, 거부반응 및 담도계 합병증의 진단에도 편리하게 사용될 수 있다. 이에 본 연구에서는 미니돼지의 간 기능을 평가하기 위해 사람에서 주로 사용되는 방사성의약품인 $^{99m}Tc-Tin$ colloid와 $^{99m}Tc-DISIDA$를 이용하여 간 및 간담도 신티그라피를 시행하였다. 그 결과, 사람의 간신티그라피와 달리 미니돼지에서는 $^{99m}Tc-Tin$ colloid가 폐, 간, 위벽 및 신장에 섭취되고 폐와 간의 영상이 겹쳐져 간의 관심영역을 설정할 수 없었다. 그러나 $^{99m}Tc-DISIDA$를 사용한 간담도 신티그라피에서는 심장, 폐, 간, 담낭 및 십이지장으로의 연속적 방사능섭취를 관찰할 수 있었다. 따라서 미니돼지에서의 $^{99m}Tc-Tin$ colloid의 사용은 비특이적 결합력으로 인해 간 기능 평가를 위한 영상에는 적합하지 않으나 $^{99m}Tc-DISIDA$는 간담도 기능을 파악하는데 있어 좋은 수단이 될 수 있을 것으로 생각된다. Non-invasive evaluation of liver function in animal models remains a challenge. Hepatoscintigraphy provides information about changes in liver size and shape, and enables to understand general liver function. Futhermore it is readily used to diagnosis complications of liver transplantation like hepatitis, rejections and biliary complications. In this study, we investigated the usefulness of evaluating the liver function in miniature pigs with $^{99m}Tc-Tin$ colloid and $^{99m}Tc-DISIDA$ which are the most commonly used radiopharmaceuticals in human medicine. In result, $^{99m}Tc-Tin$ colloid was uptaked in lung, liver, gastric wall and kidney in miniature pigs. And $^{99m}Tc-DISIDA$ showed continuous uptake images of heart, lung, liver, gallbladder and duodenum, and it was similar to human's. Therefore we could conclude $^{99m}Tc-Tin$ colloid would not be suitable for evaluating hepatic function because of it's nonspecific affinity, however $^{99m}Tc-DISIDA$ scintigraphy would be an effective method for detecting hepatobiliary function in miniature pigs.

新羅 中代 對日關係에 관한 硏究

沈京美 백산학회 1999 白山學報 Vol.- No.52

[책 이야기, 가정 이야기] 가던 길을 멈추고, 삶의 소리에 귀 기울이다

심경미 새가정사 2019 새가정 Vol.724 No.-

Case Study of Diagnosis and Treatment of Thoracic Gunshot Trauma in a Dog by Computed Tomography

심경미,김세은,유경훈,박현정,배춘식,최석화,강성수 한국임상수의학회 2007 한국임상수의학회지 Vol.24 No.1

A 7-year-old female, Jindo dog was referred to the Veterinary Teaching Hospital with mild dyspnea and anorexia due to a gunshot trauma. The dog was wounded in the thoracic region 3 days ago. Plain radiographs showed the left 8 th rib fracture, interstitial pattern in the left caudal lung field and pleural effusion. Abdominal radiographs showed the lead bullet. Computed tomographs (CT) showed the size of pulmonary contusion, laceration, lung parenchymal injuries, hemothorax and perforation of abdominal wall. The therapeutic plan was based on abnormalities seen on CT scans but not clearly seen in survey radiographs. Thoracic CT significantly provides even more informations compared with the corresponding radiographs in thoracic gunshot trauma. Although thoracic survey radiographs are useful as a screening tool, CT is highly sensitive in detecting thoracic injuries after thoracic trauma and is superior to routine thoracic survey radiographs in visualizing lung contusion, pneumothorax and hemothorax. Therefore, we recommend CT in the initial diagnostic work-up of patients with thoracic injuries and with suspected chest trauma because early and exact diagnosis of all thoracic injuries along with sufficient therapeutic consequences may reduce complications.

개에서 치주질환과 연관된 하악골절의 치료

심경미,김세은,유경훈,배춘식,최석화,강성수 한국임상수의학회 2007 한국임상수의학회지 Vol.24 No.4

A 12-year-old, intact female Toy Poodle and a 10-year-old, intact male Yorkshire terrier were referred with bilateral mandibular fractures, severe periodontal disease and teeth loss. In the second case, mandibular fractures were repaired with periodontal disease treatment. After a follow-up period of 1 year, fracture healing was successful in the second case, however in the first case, bone healing was not satisfactory because mandibular fractures were repaired without the treatment of diseased teeth within the fracture line. Nonunion and inflammation of fracture sites, oral malodor confirmed in the first case and normal union of fracture sites observed in the second case. It suggests that the treatment of diseased teeth within the fracture line is mandatory for successful fracture healing.