생강성분 6-Paradol의 세포 독성 및 병리학적 연구

김옥희,유은숙,정인경,이상섭,Kim, Ok-Hee,Yoo, Eun-Sook,Jung, In-Kyung,Lee, Sang-Sup 한국환경성돌연변이발암원학회 1998 한국환경성돌연변이·발암원학회지 Vol.18 No.1

It is previously reported that 6-paradol can induce prolonged analgesia in experimental animals. In order to investigate the mutagenicity of 6-paradol, Ames Samonella/microsome plate assay was carried out with Salmonella typhimurium strains, TA 98, TA 100, TA 1535 and TA 1538, 6-Paradol was nonmutagenic in Salmonella typhimurium with and without rat liver microsomal activation. The rec assay with Bacillus substilis strains H 17 $rec^+$ and M 45 $rec^+$ was carried out ot test 6-paradol and other compounds (1-3 mg/disc) for DNA damaging activity, 6-Paradol was also nonmutagenic in DNA damaging activity. The relative size of the inhibition zone for 6-paradol was smaller than that of capsaicin. We have also determined the pathological effects of this compound on the various tissues of rats after administrating(i.p.) with increasing doses of 4, 8, 12, 16 mg/kg at 2 hour intervals and found no significant changes in terms of histology.

쑥뜸치료가 암환자의 심박변이도에 미치는 영향

김옥희,최정은,윤정원,유화승,Kim, Ok-Hee,Choi, Jung-Eun,Yoon, Jeung-Won,Yoo, Hwa-Seung 대한암한의학회 2011 大韓癌韓醫學會誌 Vol.16 No.1

Objective : The study aims to investigate the effect of moxibustion treatments on autonomic nervous system function of cancer patients through the evaluation of heart rate variability (HRV) biofeedback testing. Materials and Methods : Six cancer patients from inpatient care unit of Dunsan Oriental Hospital, Daejeon University were given three moxibustion treatment sessions every other day over one week period on five Oriental Medicine meridian points CV4, CV6, CV12, KD1, and PC8. HRV biofeedback was conducted before and after each treatment sessions. Three areas of analyses were done from the test conducted; Time Domain Analysis, Frequency Domain Analysis and Autonomic Nervous System (ANS) balance analysis. Results : Time Domain Analysis has shown increased Standard Deviation of all Normal R-R Intervals (SDNN), and decreased Mean Heart Rate and Physical Stress Index (PSI) levels, with statistical significance (P<0.05). In Frequency Domain Analysis, series of moxa treatments have increased Total Power (TP), Very Low Frequency Oscillation Power (VLF), High Frequency Oscillation Power (HF), normalized HF values while decreasing Low Frequency Oscillation Power (LF), normalized LF and LF/HF ratio with statistical significance (P<0.05). The values of ANS activity, ANS balance, Stress resistance, Stress index, have also shown significant changes. For cardiac stability stroke volume power (SP) and Blood Vessel Tension (BVT) were followed, which were both increased after treatment. All changes were statistically significant (P<0.05). Conclusion : The results have shown a positive correlation between the moxibustion treatments and autonomic nervous system responses on cancer patients through the HRV biofeedback testing. This study suggests possible application of moxibustion treatments for managing ANS functions of cancer patients, although additional studies with larger population are necessary to confirm the data.

Nocardia SP . 에 의한 Δ4 - 3 - Ketosteroid 류의 산화

김옥희,이상섭 ( Ok Hee Kim,Sang Sup Lee ) 생화학분자생물학회 1974 BMB Reports Vol.7 No.1

Rationalizing of conformational or structural modification effect on 9α-hydroxylation of 17-ketosteroids which have Δ⁴-3-keto-system was attempted. When 6-methylandrost-4-ene-3,17-dione was incubated with Nocardia opaca, the rate of 9 a-hydroxylation was much slower than that of androst-4-ene-3,17-dione. In contrast, 9 a-hydroxylation of 6α-methylandrost-4-ene-3, 17-dione was faster than that of 6 ~-isomer. In addition to these two compounds, 19-norandrost-4-ene3,17-dione and 6,19-oxidoandrost-4-ene-3,17-dione were also compared with androst-4-ene-3,17-dione, and it was found that the rate of 9α-hydroxylation and B-ring rupturing of androst-4-ene-3,17-dione was fastest among tested steroids.

교합 유도 형태에 따른 저작근 활성도에 관한 연구

김옥희,계기성,Kim, Ok-Hee,Kay, Kee-Sung 대한치과보철학회 1989 대한치과보철학회지 Vol.27 No.2

The purpose of this study was to investigate the muscle activity of the group function occlusion and the changed canine guided occlusion using EM2. In this study, 13 subjects with group function occlusion and without temporomandibular disorders were selected, each subject was changed to the canine guided occlusion by forming the lingual ramps in the upper canines with light curing composite resin. The muscle activities of the anterior temporal and masseter muscle were recorded in the group function occlusion and immediately, one week, and two weeks after changing to the canine guided occlusion under the condition of maximum voluntary clenching in centric occlusion, lateral excursion, and during gum chewing. The results were as follows: 1. In case of maximum voluntary clenching in centric occlusion, the muscle activities of the anterior temporal and masseter muscle of working and balancing side didn't show any difference immediately after changing to the canine guided occlusion, one week after changing to the canine guided occlusion, one week after changing to it the muscle activities of the anterior temporal masseter muscle of working and balancing side were increased significantly, and two weeks after changing to it the muscle activities of the masseter muscle were increased significantly in comparison with the group function occlusion. 2. In case of maximum voluntary clenching in lateral excursion, the muscle activities of the anterior temporal and masseter muscle of working and balancing side were reduced significantly immediately after changing to the canine guided occlusion, one week after changing to it the muscle activities of the anterior temporal muscle of balancing side and of the anterior temporal and masseter muscle of working side were reduced significantly, and 2 weeks after changing to it the muscle activities of the anterior temporal and masseter muscle of working side were reduced significantly in comparison with the .group function occlusion. 3. During gum chewing, the muscle activities of the anterior temporal and masseter muscle of working and balancing side didn't show any difference immediately after changing to the canine guided occlusion, one week after changing to it the muscle activities of the masseter muscle of working and balancing side were increased significantly, and two weeks after changing to it only the muscle activities of masseter muscle of working side were increased significantly.

Nocardia Sp.에 의한 ${\Delta}^4$-3-Ketosteroid 류의 산화

김옥희,이상섭,Kim, Ok-Hee,Lee, Sang-Sup 생화학분자생물학회 1974 한국생화학회지 Vol.7 No.1

Steroid의 핵구조(ring structure)가 $9{\alpha}$-hydroxylation에 미치는 영향을 검토하기 위하여 $6{\beta}$-methylandrost-4-ene-3, 17-dione, $6{\alpha}$-methylandrost-4-ene-3, 17-dione, 19-norandrost-4-ene-3, 17-dione, androst-4-ene-3, 17-dione과 6, 19-oxidoandrost-4-ene-3, 17-dione 등 ${\Delta}^4$-keto-system을 갖고 있는 steroid를 Nocardia opaca 배양액중에 첨가하여 주고 $9{\alpha}$-hydroxylation 되는 과정을 살폈다. ${\Delta}^4$-keto-system에 $6{\beta}$-methyl group이 존재하면 현저히 hydroxylation의 속도가 느린 것을 발견하였다. Rationalizing of conformational or structural modification effect on $9{\alpha}$-hydroxylation of 17-ketosteroids which have ${\Delta}^4$-3-keto-system was attempted. When $6{\beta}$-methylandrost-4-ene-3, 17-dione was incubated with Nocardia opaca. the rate of $9{\alpha}$-hydroxylation was much slower than that of androst-4-ene-3, 17-dione. In contrast, $9{\alpha}$-hydroxylation of $6{\alpha}$-methylandrost-4-ene-3, 17-dione was faster than that of $6{\beta}$-isomer. In addition to these two compounds, 19-norandrost-4-ene-3, 17-dione and 6.19-oxidoandrost-4-ene-3, 17-dione were also compared with androst-4-ene-3, 17-dione, and it was found that the rate of $9{\alpha}$-hydroxylation and B-ring rupturing of androst-4-ene-3, 17-dione was fastest among tested steroids.

슬로관광 목적지로서의 슬로시티(slow city)의 정체성과 장소마케팅의 가능성

김옥희(Ok Hee Kim),민웅기(Woong Ki Min) 한양대학교 관광연구소 2013 觀光硏究論叢 Vol.25 No.3

슬로시티는 생태지향적 가치와 사회변혁적 운동으로서의 정체성을 지니며, 최 근 급부상하고 있는 슬로관광과도 다음과 같은 관련성이 있다. 첫째, 슬로시티는 특정 공 간의 관광활동에 참여하는 방문객과 지역주민들의 상반되는 가치를 공존이라는 하나의 공유된 가치로 연계시켜준다. 둘째, 슬로시티는 슬로관광과 같은 대안관광을 가능하게 하 여 이를 통해 지역주민의 경제적 편익을 창출하는 지속가능 한 성장모델로서의 관광 매니 지먼트를 가능케 한다. 셋째, 슬로시티는 관광 분야에서 지속적으로 경계하고 있는 환경 오염과 관련한 사회문제에 대해 사회적 책임을 이행할 수 있도록 도와준다. 넷째, 슬로 시 티에서의 관광활동 시 소비산업이라는 정체성을 넘어 광의의 복지관광으로서 기능할 수 있는 토대를 마련해준다. 다섯째, 슬로시티는 슬로관광 과정에서 사회적 자본의 확충을 통한 거버넌스(Governance) 구조의 창출을 가능하게 한다. 이를 통해 관광활동을 둘러싼 생산적 의사결정의 협업구조가 형성될 수 있다. 이처럼 슬로시티는 슬로관광과 관련하여 기존의 사회공간이 지니지 못한 관광목적지로서의 다양한 정체성이 내재해있으며, 장소 마케팅의 수단이자 동시에 목적으로서의 입지를 갖는다. The identity of ‘slow city’ is valued for being ecologically oriented and a movement to reform the society, and the slow city is closely related with slow tourism in perspective of an alternative tourism attraction. First, the different values of residents who live in a slow city and visitors who participate in tourism activities there are converged into a shared value, co-existence through slow tourism. Second, a slow city creates an opportunity for residents to generate economic benefits through community-based slow tourism. Third, a slow city is committed to social responsibility through responding to social issues such as environmental pollution that is one of problems in tourism industry. Forth, slow tourism in a slow city is beyond just consumption activity, and lays a foundation for welfare tourism. Finally, slow tourism in a slow city contributes to promoting social capital expansion supported by local governance, offering the construct of cooperation in decision-making process of tourism industry. As a slow city as a slow tourism destination has various identities different from other society spaces, it can be considered to be a means to create postmodern social values.

제주도(濟州島) 천주교(天主敎)의 수용(受容) 전개과정(展開過程)

김옥희 ( Ok Hee Kim ) 제주대학교 탐라문화연구소 1987 탐라문화 Vol.0 No.6

논문 6 : 복잡계 이론으로 본 생태무용의 내적 경험체계

김옥희 ( Ok Hee Kim ) 한국무용교육학회 2015 韓國舞踊敎育學會誌 Vol.26 No.1

This research intends to discover the meaning of internal creation of individuals through the life preservation experience of eco-dance that connects the value and meaning of ecology with life based on complex systems and find the internal experience system of eco-dance in which mental reasoning as the combination of emotion, thought and value system of individuals and not as an pre-existed dance finds out body and soul as a subject that recognizes itself and comes to realization. Concentration and experience in eco-dance is a way of knowledge and internalization of ecological value, which results in enhancing the life quality through aesthetic experience, and sharing and getting along in eco-dance is the process of perceiving the ecological life that knows how to fulfill life. Therefore eco-dance provides the foundation for a communal awareness that respects life characteristics and negates discrimination and alienation. Also in this regard, eco-dance matches the systematic thought process in which experiencing the wholeness of nature through body and living in harmony with the nature comes to completion by contributing to the Commons.

『 만엽집 (万葉集) 』 에 나탄난 차자연구 - 도래인과 일본인 작품의 비교를 중심으로 -

김옥희(Ok Hee Kim) 한국일본어문학회 1999 日本語文學 Vol.7 No.-

N/A N/A

진로만다라 과제학습이 대학생의 진로정체감과 진로준비행동에 미치는 영향

김옥희(Kim Ok-Hee),이근희(Lee Geun-Hee) 국민대학교 교육연구소 2006 교육논총 Vol.26 No.1

  본 연구의 목적은 만다라를 활용한 진로(진로만다라)과제학습이 진로정체감과 진로준비행동에 미치는 영향에 대해서 알아보는 것이다. 만다라는 깨달음의 성취란 의미로 하나의 원형으로서의 상징을 표현하는 문화적 의미나 치유적이고 교육적인 의미를 가지고 있다. 만다라에 생애발달적 접근으로서의 다양한 진로와 관련된 주제를 주고 그리도록 했다. 연구대상은 교육심리과목을 듣는 대학생으로 실험집단 39명, 통제집단 43명이다. 사전검사를 실시해 동질집단임을 확인하였고 처치 후 사후검사를 실시해 t검증을 하였다. 그 결과 진로정체감에는 유의한 차이가 보이지 않았다. 하위척도 중 안정성, 독특성, 자기주장, 자기존재의식에서는 유의미한 차이를 보이지 않았지만 목표지향성에서만 p<.0l수준에서 유의미한 차이를 보였다. 목표지 향성은 장래에 꼭 하고 싶은 분야, 장래의 인생에 대한 방향 설정, 졸업 후의 진로 결정과 적성 등에 대한 문항 등으로 되어 있다. 진로만다라 과제학습이 자신의 목표를 설정하고 나아갈 방향에 대해서 생각해 볼 수 있는 확신을 갖게 해 주었음을 의미한다고 볼 수 있다.<BR>  진로준비행동에는 p<. 001에서 유의미하게 나타났다. 진로준비행동은 자신의 진로와 관련한 인지나 태도치원이 아닌 실제적이고 구체적인 행위의 치원을 말하는 것이다. 따라서 진로만다라 과제학습이 진로를 준비하기 위한 실제적인 행동을 하도록 동기를 부여하거나 도움을 주는데 효과적임을 알 수 있다.<BR>  진로정체감은 진로준비행동과 상관이 있는 것으로 나타났다. 진로정체감의 하위요인들도 모두 진로준비 행동과 상관이 높은 것으로 나타났다. 이는 정체감이 높을수록 진로준비행동을 잘 하고 있다고 보여진다. 따라서 대학생들이 자신의 진로에 대해서 내면적으로 갚은 탐색을 해 볼 수 있는 다양한 프로그램의 개발과 보급이 필요하다. 또 성별, 연령별, 기간별, 학과별에 따른 진로만다라 과제학습에 대한 추후연구가 필요하다.   The purpose of this study was intended to investigate the effect of career(career mandala) task learning on college students" career identity and preparation activities. The college students were given the subject related to diverse careers as an approach to mandala of lifelong development and asked to draw it. The subjects taking a course in educational psychology comprised 39 college students in the experimental group and 43 college students in the control group. It was confirmed that they were the homogeneous group by conducting the pre-test and the t-test was conducted through the post-test after treatment. As a result, it was found that there was no difference in career identity between both groups. It was found that there was no significant difference in such sub-scales as stability, peculiarity, self-assertiveness, self-existence consciousness but that there was a significant difference in goal-orientedness alone at the level of p<.01. Goal-orientedness comprises the items on the field to want to do in the future, the setting of a direction for their future life, decision on post-graduation career and aptitude, and the like. It can be thought that this study has its significance in that career experience learning activity convinced college students to think about the direction to set and go towards their goal.<BR>  It was found that there was a significant difference in career preparation activity between groups at the level of P<.001. career preparation behavior refers to the dimension of physical and concrete conduct, not that of recognition or attitude related to their career. It can be found that career mandala task learning is effective in motivating and helping college students to actually prepare for their career.<BR>  It was found that career identity correlated with career preparation behavior. And it was shown that the sub-factors of career identity all were highly correlated to career preparation behavior, which indicates that the level of higher career identity leads to better career preparation behavior.<BR>  Accordingly, it is necessary to develop and disseminate diverse programs for enabling college students to make a profound inner exploration of their career. And it is thought that subsequent research will be conducted on career mandala task learning by sex, by age, by period and by department.