생강성분 6-Paradol의 세포 독성 및 병리학적 연구

김옥희,유은숙,정인경,이상섭,Kim, Ok-Hee,Yoo, Eun-Sook,Jung, In-Kyung,Lee, Sang-Sup 한국환경성돌연변이발암원학회 1998 한국환경성돌연변이·발암원학회지 Vol.18 No.1

It is previously reported that 6-paradol can induce prolonged analgesia in experimental animals. In order to investigate the mutagenicity of 6-paradol, Ames Samonella/microsome plate assay was carried out with Salmonella typhimurium strains, TA 98, TA 100, TA 1535 and TA 1538, 6-Paradol was nonmutagenic in Salmonella typhimurium with and without rat liver microsomal activation. The rec assay with Bacillus substilis strains H 17 $rec^+$ and M 45 $rec^+$ was carried out ot test 6-paradol and other compounds (1-3 mg/disc) for DNA damaging activity, 6-Paradol was also nonmutagenic in DNA damaging activity. The relative size of the inhibition zone for 6-paradol was smaller than that of capsaicin. We have also determined the pathological effects of this compound on the various tissues of rats after administrating(i.p.) with increasing doses of 4, 8, 12, 16 mg/kg at 2 hour intervals and found no significant changes in terms of histology.

Nocardia Sp.에 의한 ${\Delta}^4$-3-Ketosteroid 류의 산화

김옥희,이상섭,Kim, Ok-Hee,Lee, Sang-Sup 생화학분자생물학회 1974 한국생화학회지 Vol.7 No.1

Steroid의 핵구조(ring structure)가 $9{\alpha}$-hydroxylation에 미치는 영향을 검토하기 위하여 $6{\beta}$-methylandrost-4-ene-3, 17-dione, $6{\alpha}$-methylandrost-4-ene-3, 17-dione, 19-norandrost-4-ene-3, 17-dione, androst-4-ene-3, 17-dione과 6, 19-oxidoandrost-4-ene-3, 17-dione 등 ${\Delta}^4$-keto-system을 갖고 있는 steroid를 Nocardia opaca 배양액중에 첨가하여 주고 $9{\alpha}$-hydroxylation 되는 과정을 살폈다. ${\Delta}^4$-keto-system에 $6{\beta}$-methyl group이 존재하면 현저히 hydroxylation의 속도가 느린 것을 발견하였다. Rationalizing of conformational or structural modification effect on $9{\alpha}$-hydroxylation of 17-ketosteroids which have ${\Delta}^4$-3-keto-system was attempted. When $6{\beta}$-methylandrost-4-ene-3, 17-dione was incubated with Nocardia opaca. the rate of $9{\alpha}$-hydroxylation was much slower than that of androst-4-ene-3, 17-dione. In contrast, $9{\alpha}$-hydroxylation of $6{\alpha}$-methylandrost-4-ene-3, 17-dione was faster than that of $6{\beta}$-isomer. In addition to these two compounds, 19-norandrost-4-ene-3, 17-dione and 6.19-oxidoandrost-4-ene-3, 17-dione were also compared with androst-4-ene-3, 17-dione, and it was found that the rate of $9{\alpha}$-hydroxylation and B-ring rupturing of androst-4-ene-3, 17-dione was fastest among tested steroids.

Nocardia SP . 에 의한 Δ4 - 3 - Ketosteroid 류의 산화

김옥희,이상섭 ( Ok Hee Kim,Sang Sup Lee ) 생화학분자생물학회 1974 BMB Reports Vol.7 No.1

Rationalizing of conformational or structural modification effect on 9α-hydroxylation of 17-ketosteroids which have Δ⁴-3-keto-system was attempted. When 6-methylandrost-4-ene-3,17-dione was incubated with Nocardia opaca, the rate of 9 a-hydroxylation was much slower than that of androst-4-ene-3,17-dione. In contrast, 9 a-hydroxylation of 6α-methylandrost-4-ene-3, 17-dione was faster than that of 6 ~-isomer. In addition to these two compounds, 19-norandrost-4-ene3,17-dione and 6,19-oxidoandrost-4-ene-3,17-dione were also compared with androst-4-ene-3,17-dione, and it was found that the rate of 9α-hydroxylation and B-ring rupturing of androst-4-ene-3,17-dione was fastest among tested steroids.

교합 유도 형태에 따른 저작근 활성도에 관한 연구

김옥희,계기성,Kim, Ok-Hee,Kay, Kee-Sung 대한치과보철학회 1989 대한치과보철학회지 Vol.27 No.2

The purpose of this study was to investigate the muscle activity of the group function occlusion and the changed canine guided occlusion using EM2. In this study, 13 subjects with group function occlusion and without temporomandibular disorders were selected, each subject was changed to the canine guided occlusion by forming the lingual ramps in the upper canines with light curing composite resin. The muscle activities of the anterior temporal and masseter muscle were recorded in the group function occlusion and immediately, one week, and two weeks after changing to the canine guided occlusion under the condition of maximum voluntary clenching in centric occlusion, lateral excursion, and during gum chewing. The results were as follows: 1. In case of maximum voluntary clenching in centric occlusion, the muscle activities of the anterior temporal and masseter muscle of working and balancing side didn't show any difference immediately after changing to the canine guided occlusion, one week after changing to the canine guided occlusion, one week after changing to it the muscle activities of the anterior temporal masseter muscle of working and balancing side were increased significantly, and two weeks after changing to it the muscle activities of the masseter muscle were increased significantly in comparison with the group function occlusion. 2. In case of maximum voluntary clenching in lateral excursion, the muscle activities of the anterior temporal and masseter muscle of working and balancing side were reduced significantly immediately after changing to the canine guided occlusion, one week after changing to it the muscle activities of the anterior temporal muscle of balancing side and of the anterior temporal and masseter muscle of working side were reduced significantly, and 2 weeks after changing to it the muscle activities of the anterior temporal and masseter muscle of working side were reduced significantly in comparison with the .group function occlusion. 3. During gum chewing, the muscle activities of the anterior temporal and masseter muscle of working and balancing side didn't show any difference immediately after changing to the canine guided occlusion, one week after changing to it the muscle activities of the masseter muscle of working and balancing side were increased significantly, and two weeks after changing to it only the muscle activities of masseter muscle of working side were increased significantly.

쑥뜸치료가 암환자의 심박변이도에 미치는 영향

김옥희,최정은,윤정원,유화승,Kim, Ok-Hee,Choi, Jung-Eun,Yoon, Jeung-Won,Yoo, Hwa-Seung 대한암한의학회 2011 大韓癌韓醫學會誌 Vol.16 No.1

Objective : The study aims to investigate the effect of moxibustion treatments on autonomic nervous system function of cancer patients through the evaluation of heart rate variability (HRV) biofeedback testing. Materials and Methods : Six cancer patients from inpatient care unit of Dunsan Oriental Hospital, Daejeon University were given three moxibustion treatment sessions every other day over one week period on five Oriental Medicine meridian points CV4, CV6, CV12, KD1, and PC8. HRV biofeedback was conducted before and after each treatment sessions. Three areas of analyses were done from the test conducted; Time Domain Analysis, Frequency Domain Analysis and Autonomic Nervous System (ANS) balance analysis. Results : Time Domain Analysis has shown increased Standard Deviation of all Normal R-R Intervals (SDNN), and decreased Mean Heart Rate and Physical Stress Index (PSI) levels, with statistical significance (P<0.05). In Frequency Domain Analysis, series of moxa treatments have increased Total Power (TP), Very Low Frequency Oscillation Power (VLF), High Frequency Oscillation Power (HF), normalized HF values while decreasing Low Frequency Oscillation Power (LF), normalized LF and LF/HF ratio with statistical significance (P<0.05). The values of ANS activity, ANS balance, Stress resistance, Stress index, have also shown significant changes. For cardiac stability stroke volume power (SP) and Blood Vessel Tension (BVT) were followed, which were both increased after treatment. All changes were statistically significant (P<0.05). Conclusion : The results have shown a positive correlation between the moxibustion treatments and autonomic nervous system responses on cancer patients through the HRV biofeedback testing. This study suggests possible application of moxibustion treatments for managing ANS functions of cancer patients, although additional studies with larger population are necessary to confirm the data.

논문 6 : 복잡계 이론으로 본 생태무용의 내적 경험체계

김옥희 ( Ok Hee Kim ) 한국무용교육학회 2015 韓國舞踊敎育學會誌 Vol.26 No.1

This research intends to discover the meaning of internal creation of individuals through the life preservation experience of eco-dance that connects the value and meaning of ecology with life based on complex systems and find the internal experience system of eco-dance in which mental reasoning as the combination of emotion, thought and value system of individuals and not as an pre-existed dance finds out body and soul as a subject that recognizes itself and comes to realization. Concentration and experience in eco-dance is a way of knowledge and internalization of ecological value, which results in enhancing the life quality through aesthetic experience, and sharing and getting along in eco-dance is the process of perceiving the ecological life that knows how to fulfill life. Therefore eco-dance provides the foundation for a communal awareness that respects life characteristics and negates discrimination and alienation. Also in this regard, eco-dance matches the systematic thought process in which experiencing the wholeness of nature through body and living in harmony with the nature comes to completion by contributing to the Commons.

사회적 지지와 동거여부가 노인의 정신건강에 미치는 영향

김옥희 ( Ok Hee Kim ) 한남대학교 사회과학연구소 2013 사회과학연구 Vol.22 No.-

본 연구에서는 부산시에 거주하는 65세 이상의 노인을 대상으로 동거여부와 사회적 지지가 노인의 정신건강에 미치는 영향을 분석하였다. 나아가 분석 결과를 토대로 하여 노인의 정신건강을 증진시키기 위한 정책적 실천적 함의를 도출하기 위한 기초자료를 마련하고자 하였다. 분석결과는 다음과 같다. 첫째, 독거노인과 동거노인 두 집단 간에 정신건강과 사회적 지지에 대한 차이검증 결과, 동거노인의 정신건강과 사회적 지지가 독거노인에 비해 유의미하게 좋은 것으로 나타났다. 둘째, 노인의 정신건강에 영향을 미치는 변인들의 영향력을 분석한 결과, 경제수준, 신체적 건강, 동거, 사회적 지지가 영향요인으로 나타났다. 즉 경제수준이 높을수록, 신체적 건강상태가 좋을수록, 가족과 동거할수록, 사회적 지지가 높을수록, 노인의 정신건강은 좋아지는 것으로 나타났다. 셋째, 동거 여부와 사회적 지지 유형에 따른 노인의 정신건강 영향요인을 분석한 결과는 다음과 같다. 사회적 지지중 평가적 지지와 동거여부를 투입하여 정신건강을 예측한 모형의 경우, 종교를 가질수록, 경제수준이 높을수록, 건강상태가 좋을수록, 정보적 지지가 클수록, 정신건강이 좋은 것으로 나타났다. 또 사회적 지지중 물질적 지지와 가족 동거 여부를 투입하여 정신건강을 예측한 모형의 경우 종교를 가질수록, 경제수준이 높을수록, 건강상태가 좋을수록, 동거할수록, 물질적 지지가 클수록, 노인의 정신건강이 좋은 것으로 나타났다. This study is to analyze the effects which social supports and cohabiting influence on the elderly`s mental health target at 200 elderly people who are older than 65 in Busan. Furthermore, based on the analysis results, the basic data are provided to deduct the political and practical implications to improve the elderly`s mental health. The analysis results are as follows. First, the results of investigating the differences about the mental health and social supports between the group of elderly people living alone and the group of elderly people living together were that the mental health and the social supports of elderly people living together were more significant than ones of elderly people living alone. Second, the results of analyzing the effects on the variables which influence on elderly people`s mental health were that the economic level, physical health, living together and social supports were the influence factors. That is, it was shown that the higher the economic level was, the better the physical conditions were, the more usual living together with family was and the higher the social supports were, the better elderly people`s mental health was. Third, the analysis results about influence factors on elderly people`s mental health according to the types of living together or not and social supports were as follows. In case of the model which the mental health was predicted by bringing the evaluative support and living together or not among social supports, it was shown that the more usually elderly people had religions, the higher the economic level was, the better the health condition was and the higher the informative support were, the better the mental health was. In case of the model which the mental health was predicted by bringing the material support and living together with family or not among the social supports, it was also shown that the more usually elderly people had religions, the higher the economic level was, the better the health condition was, the more usual living together with family was and the higher the material supports were, the better the mental health of elderly people was.

일본의 지역포괄케어시스템에서의 케어매니저역할에 관한 연구 : 보건ᆞ의료ᆞ복지 연계역할을 중심으로 on the Correlationship Among Welfare, Medicine and Health

김옥희 ( Ok Hee Kim ) 한국사회보장학회 2006 사회보장연구 Vol.22 No.4

연구 논문 : 인공 먼지로서 단분산 Polystyrene Latex Spheres (PLS)의 제조

김옥희 ( Ok Hee Kim ),류동완 ( Dong Wan Ryu ),성동찬 ( Dong Chan Sung ),문희 ( Hee Moon ) 한국공업화학회 2012 공업화학 Vol.23 No.1

potassium persulfate (KPS)와 sodium dodecyl sulfonate (SDS)를 각각 개시제와 안정제로 사용한 유화중합에 의하여 인공 먼지로 사용할 수 있는 polystyrene latex spheres (PLS)를 제조하였다. PLS입자의 크기를 조절하기 위한 변수로 반응온도와 개시제 및 안정제의 농도가 선택되었다. 반응온도의 증가에 따라 입자의 크기는 작아졌으며, KPS와 SDS의 농도를 변화시켜 PLS 입자의 크기 및 분포를 매우 미세하게 조절할 수 있었다. 본 연구에서 제조된 PLS입자는 변동계수(CV) 값이 7% 이하인 단분산이며, 0.1∼0.5 μm 범위에 있어 인조 먼지로 사용하기에 적합한 것으로 밝혀졌다. Polystyrene latex spheres (PLS) were prepared as artificial dusts by the emulsion polymerization with potassium persulfate (KPS) and sodium dodecyl sulfonate (SDS) as an initiator and a stabilizer, respectively. The reaction temperature and the concentration of the initiator and stabilizer were chosen as variables to control the PLS particle size. As temperature increased, the particle size decreased considerably. Furthermore, the PLS particle size and their size distributions can be controlled minutely by adjusting the concentrations of KPS and SDS. It is confirmed that the PLS prepared in this work is monodispersed with the coefficient of variance less than 7% and are in the range of 0.1∼0.5 μm, which are good for using as artificial dusts.

NEO아동성격검사에 따른 초등학생의 성격특성과 스트레스 대처방식의 관계

김옥희(Ok Hee Kim),안현의(Hyun-nie Ahn) 대한스트레스학회 2008 스트레스硏究 Vol.16 No.2

본 연구는 NEO아동성격검사에 따른 초등학생의 성격특성(신경증: N, 외향성: E, 개방성: O, 친화성: A, 성실성: C)이 스트레스 대처방식(적극적 대처, 소극적 대처, 회피적 대처, 공격적 대처, 사회지지 추구적 대처)과 어떠한 관계가 있는지 알아보고자 하였다. 연구 대상은 326명(남 158, 여 168)의 초등학생이고, 안현의, 안창규, 김동일(2006)이 개발한 ‘NEO아동성격검사’와 민하영과 유안진(1998)이 개발한 ‘일상적 생활 스트레스에 대한 아동의 대처행동 척도’를 사용하였다. 대처행동 척도에 대한 타당성 검증을 위해 요인분석을 실시한 결과, 민하영과 유안진(1998)의 다섯 가지 유형의 대처방식은 긍정적 감정과 관련된 요인 1 (적극적 대처, 회피적 대처, 사회지지 추구적 대처방식)과 부정적 감정과 관련된 요인 2 (소극적 대처, 공격적 대처방식)로 묶여 나타났다. 상관관계분석 결과, 아동의 Big Five의 특성요인 중 신경증(N) 요인은 부정적 감정과 관련된 소극적 대처, 공격적 대처방식과 정적 상관관계를 나타내고, 외향성(E), 친화성(A), 성실성(C) 요인은 긍정적 감정과 관련된 적극적 대처, 사회지지 추구적 대처방식과 정적 상관관계를 나타내며, 개방성(O) 요인은 긍정적ㆍ부정적 감정과 관련된 적극적 대처, 사회지지 추구적 대처, 소극적 대처방식과 정적 상관관계를 나타냈다. 그러나 성인 및 청소년을 대상으로 한 Big Five 특성요인과 대처 방식에 대한 선행 연구 결과와는 달리 아동을 대상으로 한 본 연구에서는, 회피적 대처방식이 신경증(N) 요인과 개방성(O) 요인 뿐 아니라 외향성(E), 성실성(C) 요인과도 유의미한 정적 상관관계를 나타냈다. 판별분석결과, 아동의 Big Five 특성요인 중 신경증(N) 특성은 소극적 대처, 공격적 대처와 같은 부정적 대처방식을 주로 사용하는 아동을 분류하고, 나머지 개방성(O), 친화성(A), 성실성(C), 외향성(E)의 성격 특성은 적극적 대처, 회피적 대처, 사회지지 추구적 대처방식과 같은 긍정적 대처방식을 주로 사용하는 아동을 판별하는 의미 있는 변인인 것으로 나타났다. The purpose of this study was to investigate the relation between the Big Five personality traits (Neuroticism, Extraversion, Openness, Agreeableness, Conscientiousness) and stress coping styles (active, passive, aggressive, avoidant or social support seeking) in elementary school students. NEO Personality Assessment System and Daily Hassles Coping Scale were administered to 326 fourth, fifth and sixth graders (male 158, female 168) who consented to the study. Factor analysis results showed that five coping styles were categorized into Factor 1(active, avoidant, social support seeking) and Factor 2(passive, aggressive). Neuroticism positively correlated with passive and aggressive coping styles which were included in the factor 2, Extraversion, Agreeableness, and Conscientiousness significantly correlated with active and social support seeking ones which were classified into the factor 1, and Openness correlated positively with both factor 2 and a part of factor 1 (avoidant). Additional discriminant analysis was conducted to discover that children high in Neuroticism primarily used the passive and aggressive stress coping behaviors, while children high in Extraversion, Openness, Agreeableness and Conscientiousness preferred to use active, avoidant, and social support seeking. Such results indicate that children of elementary school age show different stress coping behaviors from adults according to their Big Five personality traits.