현장 / 불행을 사명으로 승화시킨 유을희전도사

김세미 기독교대한성결교회 활천사 1993 활천 Vol.480 No.-

Separation of Praseodymium and Dysprosium by Solvent Extraction Using Fatty Acid as an Extractant Ⅱ

김세미,김정훈,김영운,허남호,강호철 한국공업화학회 2013 한국공업화학회 연구논문 초록집 Vol.2013 No.1

폐렴을 동반한 간질성폐질환 환자에서 두 차례 FMT 후 호전 된 중증 CDI 1예

김세미,정아론,은서준,문형철,박상욱,홍건영 대한내과학회 2019 대한내과학회 추계학술대회 Vol.2019 No.1

학술연구논문 포스터발표 : 1분과: 산림환경, 산림생태, 수목학, 분류, 조림 ; 가리왕산 일대 천연활엽수림의 군집별 생태적 속성 평가

김세미,황광모,정상훈,이정민,박병배,김지홍 한국임학회 2013 한국임학회 학술발표논문집 Vol.2013 No.-

Antitumor Activity of LB42907, a Potent and Selective Farnesyltransferase Inhibitor: Synergistic Effect in Combination with Other Anticancer Drugs

김세미,Ji Hyun Park,Sun-Young Koo,김동명,Kwihwa Kim,Shin Wu Jeong,Hyun-Ho Chung,Heung-Soo Cho,Joonghoon Park,Hyeon Joo Yim,Jinho Lee,Jong Sung Koh 대한화학회 2008 Bulletin of the Korean Chemical Society Vol.29 No.7

Inhibitors of farnesyltransferase (FT), a key enzyme in the post-translational modifications of Ras proteins, have been extensively studied as novel anticancer agents in the preclinical stages, some of which are currently in clinical development. Previously, it has been reported that a novel FT inhibitor LB42907 inhibits Ras farnesylation in the nanomolar range in vitro. The aim of this study was to assess the antitumor efficacy of LB42907 in vitro and in vivo. Anchorage-independent growth of various human tumor cell lines was potently inhibited by treatment with LB42907, comparable to other FT inhibitors in clinical development. In the nude mouse, oral administration of LB42907 demonstrated potent antitumor activity in several human tumor xenograft models including bladder, lung and pancreas origin. Interestingly, significant tumor regression in EJ (bladder) and A549 (lung) xenografts was induced by LB42907 treatment. The effectiveness of LB42907 was also investigated in simultaneous combination with paclitaxel, vincristine, cisplatin or gemcitabine against NCI-H460, A549, and HCT116 cells in vitro using median-effect analysis. LB42907 markedly synergized with most anticancer drugs tested in this study in NCI-H460 cell. In contrast, LB42907 displayed antagonism or partial synergism with these drugs in A549 and HCT116 cells, depending on the class of combined drugs and/ or the level of cytotoxicity. Our results demonstrate that LB42907 is an effective antitumor agent in vitro and in vivo and combination of LB42907 with other chemotherapeutic drugs results in synergistic or antagonistic effects mainly in a cell line-dependent manner. Further preclinical study is warranted.

레바미피드 100 mg 정제의 생물학적동등성

김세미,조혜영,강현아,이용복 한국임상약학회 2008 한국임상약학회지 Vol.18 No.1

Rebamipide, (±)-2-(4-chlorobenzoylamino)-3-[2(1H)-quinolinon-4-yl] propionic acid, is used for mucosal protection, healing of gastroduodenal ulcers, and treatment of gastritis. It works by enhancing mucosal defense, scavenging free radicals and temporarily activating genes encoding cyclooxygenase-2. The purpose of the present study was to evaluate the bioequivalence of two rebamipide tablets, Mucosta® (Korea Otsuca Pharmaceuticals Co., Ltd.) and Mustar (Korean Drug Co., Ltd.), according to the guidelines of the Korea Food and Drug Administration (KFDA). The release of rebamipide from the two rebamipide formulations in vitro was tested using KP VIII Apparatus II method with pH 6.8 dissolution medium. Twenty six healthy male subjects, 23.46 ± 2.63 years in age and 66.62 ± 8.97 kg in body weight, were divided into two groups and a randomized 2 × 2 cross-over study was employed. After a single tablet containing 100 mg as rebamipide was orally administered, blood samples were taken at predetermined time intervals and the concentrations of rebamipide in serum were determined using HPLC with fluorescence detector. The dissolution profiles of two formulations were similar in the tested dissolution medium. The pharmacokinetic parameters such as AUCt, Cmax and Tmax were calculated, and ANOVA test was utilized for the statistical analysis of the parameters using logarithmically transformed AUCt, Cmax and untransformed Tmax. The results showed that the differences between two formulations based on the reference drug, Mucosta® were -5.08, 3.52 and -9.71% for AUCt, Cmax and Tmax, respectively. There were no sequence effects between two formulations in these parameters. The 90% confidence intervals using logarithmically transformed data were within the acceptance range of log 0.8 to log 1.25 (e.g., log 0.84~log 1.07 and log 0.90~log 1.17 for AUCt and Cmax, respectively). Thus, the criteria of the KFDA bioequivalence guideline were satisfied, indicating Mustar tablet was bioequivalent to Muscota® tablet.

식품 관련 앱(APP) 서비스 품질 속성이 서비스 이용자의 지각된 가치와 구매 후 행동의도에 미치는 영향

김세미,박상현,주나미 대한영양사협회 2020 대한영양사협회 학술지 Vol.26 No.3

In modern society, the online to offline (O2O) market has become an emerging market. Based on social and cultural phenomena, the importance of “FOODTECH” linked with mobile applications is growing in the food and restaurant industry. This study examined subjective food application service quality, perceived value, and post-purchase behavior intentions. According to this study, of foodtech service quality attributes, only information, mobility, and reliability had positive (+) relationships with perceived value. However, foodtech service quality attributes did not have a direct impact on behavior intentions. Perceived values had a positive(+) relationship with behavior intentions and showed full mediation effects between foodtech service quality attributes and behavior intentions. Based on these results, future research on the relationship among food application service quality, perceived value, and post-purchase behavior intentions is needed.

잣나무 조림지에서 확인된 생태적 복원 효과

김세미,안지홍,임윤경,피정훈,김경순,이호영,조용찬,배관호,이창석 경상대학교 농업생명과학연구원 2013 농업생명과학연구 Vol.47 No.5

Developmental process of vegetation over years after afforestation was analyzed in the Korean pine (Pinus koraiensis) plantations with different stand ages. Height and diameter of Korean pine increased rapidly until 27 years after afforestation and tended to be blunted since then. Density of Korean pine tended to be reduced with the increase of stand age. As the result of stand ordination of Korean pine plantations with different ages based on floristic composition, Korean pine plantations showed a changing depending on stand age but a difference from the reference, Mongolian oak (Quercus mongolica) stands. Korean pine plantations showed the trend to be usually succeeded to the native vegetation dominated by ash (Fraxinus rhynchophylla) but partially by Mongolian oak as the results of analysis based on the frequency distribution by diameter class of major tree species. Species richness and diversity of all plantations were higher than those of the reference vegetation. On the other hand, the exotic plants, which no appear in the reference stands, appeared in the Korean pine stands but the percentage was very low as it is below 3%. As were shown in the above mentioned results, the Korean pine plantation did not show restoration effects such as species composition similar to the reference stands, successional trend toward the vegetation dominated by the native oaks and so on. The background of the difference is as follows. The other plantations were created to control erosion in the forest degraded due to excessive uses, whereas the Korean pine plantations were to get seeds as an useful resource. Therefore the former stands are no longer interfered artificially but the latter is dominated continuously by artificial interferences. 조성연도가 다른 잣나무조림지에서 조림 후 시간이 경과함에 따라 식생의 발달과정을 분석하였다. 잣나무의 높이와 직경은 27년생 식분까지 빠르게 생장하였고, 그 이후의 생장은 큰 변화를 보이지 않았다. 밀도는 식분의 연령이 증가함에 따라 감소하는 경향이었다. 식생조성에 기초하여 조성연도가 다른 잣나무조림지의 식분을 대조구 식분과 함께 서열화 한 결과, 잣나무조림지 식분들은 독자적인 변화경향을 보이고 대조구 식분과는 차이를 보였다. 주요 종의 직경급별 빈도분포를 분석한 결과, 잣나무조림지는 대체로 물푸레나무가 우점하는 식생으로의 천이경향을 보였지만 지소에 따라 신갈나무가 우점하는 식생으로의 천이경향도 나타났다. 종 다양성은 모든 지소들이 대조지소보다 높게 나타났다. 잣나무조림지에는 대조구에는 전혀 출현하지 않는 외래종이 출현하였지만 그 비율은 3% 이하로 낮았다. 이러한 결과를 통해서 볼 때, 잣나무조림지는 우리나라의 주요 조림수종인 리기다소나무, 아까시나무, 일본잎갈나무의 조림지에서 일반적으로 나타나는 대조구와 유사한 종 조성, 자생 참나무류가 우점하는 식생으로의 천이 등의 복원효과가 나타나지 않았다. 이러한 차이는 다른 조림지가 과도한 이용에 의해 황폐해진 삼림을 기능적으로 복원하기 위해 시도된 사방조림인 반면에 잣나무조림지는 유용자원으로서 잣을 얻기 위해 조성되어 지속적으로 인위적 간섭이 이루어지는 데서 비롯된 결과로 해석되었다.

Marking the 70th Anniversary of the Korean Armistice Agreement: A Means to Peace

김세미 통일연구원 2023 International journal of korean unification studie Vol.32 No.1

This year marks the 70th anniversary of the signing of the Korean Armistice Agreement that ceased the military hostilities on the Korean peninsula in1953. The Agreement successfully maintainedthe cessation of hostilities on the Korean Peninsula and prevented the resumption of the Korean War. However, tensions remain high. It is time to take the next step to end the Korean War and bring lasting peace to the Korean peninsula through a peace treaty. This article aims to analyze the legal implications of the Korean Armistice Agreement and the temporary nature of the Agreement. This article further argues that with the existence of a peace treaty, a new justification will be needed for any of the parties to use force against another or otherwise, such use of force would be a violation of international law.

영상번역에서 비언어적 요소의 번역화 전략

김세미 새한영어영문학회 2014 새한영어영문학회 학술발표회 논문집 Vol.2014 No.5