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Jong-Wook Lee(Jong-Wook Lee),Hyeon-Soo Ahn(Hyeon-Soo Ahn),Jinho Chang(Jinho Chang),Hye-Young Kang(Hye-Young Kang),Dong-Jin Chang(Dong-Jin Chang),Jae Kyung Suh(Jae Kyung Suh),Hankil Lee(Hankil Lee) 대한안과학회 2022 Korean Journal of Ophthalmology Vol.36 No.5
Purpose: Netarsudil is a Rho kinase inhibitor and the first new class of clinically useful ocular hypotensive agents. In this study, we conducted a systematic literature review and meta-analysis to summarize and synthesize the available evidence on the efficacy and safety of fixed-dose combination (FDC) therapy with netarsudil/latanoprost in patients with glaucoma. Methods: We identified relevant studies in PubMed, Ovid Medline, Embase, and Cochrane Central until April 2021. The quality of the studies and the level of evidence were assessed using the Risk of Bias tool. Efficacy was measured as the mean difference in reducing intraocular pressure (IOP), and safety was assessed by the risk of conjunctival hyperemia (CH) due to FDC therapy, netarsudil monotherapy, or latanoprost monotherapy. Results: Four studies met the predefined eligibility criteria and were included in the meta-analysis. The mean difference in the reduction in IOP after 2 weeks and 4 to 6 weeks of drug administration was -2.41 mmHg (95% confidence interval [CI], -2.95 to -1.87) and -1.77 mmHg (95% CI, -2.31 to -1.87), respectively, in patients receiving FDC therapy versus those receiving latanoprost monotherapy. On the other hand, latanoprost monotherapy had a greater effect in reducing IOP than netarsudil monotherapy after 4 to 6 weeks of administration (mean difference, 0.95 mmHg; 95% CI, 0.43 to 1.47). The risk of CH was significantly higher with both FDC therapy and netarsudil monotherapy compared to latanoprost monotherapy in week 12, where the relative ratio was 3.01 (95% CI, 1.95 to 4.66) and 2.33 (95% CI, 1.54 to 3.54), each. Conclusions: Netarsudil/latanoprost FDC therapy has a significantly greater effect on reducing IOP than latanoprost alone. The symptoms of CH were mostly mild, and only a few glaucoma patients discontinued the medication owing to CH in earlier clinical trials. Therefore, it would be beneficial to consider the administration of netarsudil/latanoprost FDC therapy in patients with glaucoma.
Lee, Jinho,Kang, Hongkyu,Kee, Seyoung,Lee, Seoung Ho,Jeong, Song Yi,Kim, Geunjin,Kim, Junghwan,Hong, Soonil,Back, Hyungcheol,Lee, Kwanghee American Chemical Society 2016 ACS APPLIED MATERIALS & INTERFACES Vol.8 No.9
<P>Recently, the most efficient tandem polymer solar cells (PSCs) have used poly(3,4-ethylene-dioxythiophene):poly(styrenesulfonate) (PEDOT:PSS) as a p-type component of recombination layer (RL). However, its undesirable acidic nature, originating from insulating PSS, of PEDOT:PSS drastically reduces the lifetime of PSCs. Here, we demonstrate the efficient and stable tandem PSCs by introducing acid-free self-doped conducting polymer (SCP), combined with zinc oxide nanoparticles (ZnO NPs), as RL for PEDOT:PSS-free tandem PSCs. Moreover, we introduce an innovative and versatile nanocomposite system containing photoactive and p-type conjugated polyelectrolyte (p-CPE) into the tandem fabrication of an ideal self-organized recombination layer. In our new RL, highly conductive SCP facilitates charge transport and recombination process, and p-CPE helps to achieve nearly loss-free charge collection by increasing effective work function of indium tin oxide (ITO) and SCP. Because of the synergistic effect of extremely low electrical resistance, ohmic contact, and pH neutrality, tandem devices with our novel RL performed well, exhibiting a high power conversion efficiency of 10.2% and a prolonged lifetime. These findings provide a new insight for strategic design of RLs using SCPs to achieve efficient and stable tandem PSCs and enable us to review and extend the usefulness of SCPs in various electronics research fields.</P>
Lee, Youngjoo,Kim, Jiyeon,An, Jinho,Lee, Sungwon,Lee, Heetae,Kong, Hyunseok,Song, Youngcheon,Choi, Hye Ran,Kwon, Ji-Wung,Shin, Daekeun,Lee, Chong-Kil,Kim, Kyungjae The Korean Society of Applied Pharmacology 2017 Biomolecules & Therapeutics(구 응용약물학회지) Vol.25 No.2
Hyperlipidemia, which is closely associated with a fatty diet and aging, is commonly observed in the western and aged society. Therefore, a novel therapeutic approach for this disease is critical, and an immunological view has been suggested as a novel strategy, because hyperlipidemia is closely associated with inflammation and immune dysfunction. In this study, the effects of an aqueous extract of Rubus occidentalis (RO) in obese mice were investigated using immunological indexes. The mice were fed a high-fat diet (HFD) to induce hyperlipidemia, which was confirmed by biochemical analysis and examination of the mouse physiology. Two different doses of RO and rosuvastatin, a cholesterol synthesis inhibitor used as a control, were orally administered. Disturbances in immune cellularity as well as lymphocyte proliferation and cytokine production were significantly normalized by oral administration of RO, which also decreased the elevated serum tumor necrosis factor $(TNF)-{\alpha}$ level and total cholesterol. The specific immune-related actions of RO comprised considerable improvement in cytotoxic T cell killing functions and regulation of antibody production to within the normal range. The immunological evidence confirms the significant cholesterol-lowering effect of RO, suggesting its potential as a novel therapeutic agent for hyperlipidemia and associated immune decline.
Effectiveness of pharmacopuncture for cervical spondylosis: A systematic review and meta-analysis
Lee, Sungyub,Shin, Joon-Shik,Lee, Jinho,Ha, In-Hyuk,Kim, Me-riong,Koh, Wonil,Lee, Sook-Hyun,Kim, Seoyoun,Cha, Yun-Yeop,Lee, Jun-Hwan,Jang, Bo-Hyoung,Lee, Yoon Jae ELSEVIER SCIENCE B.V. 2018 European journal of integrative medicine Vol.20 No.-
Introducing paired electric dipole layers for efficient and reproducible perovskite solar cells
Lee, Jong-Hoon,Kim, Junghwan,Kim, Geunjin,Shin, Dongguen,Jeong, Song Yi,Lee, Jinho,Hong, Soonil,Choi, Jin Woo,Lee, Chang-Lyoul,Kim, Heejoo,Yi, Yeonjin,Lee, Kwanghee The Royal Society of Chemistry 2018 ENERGY AND ENVIRONMENTAL SCIENCE Vol.11 No.7
<P>Elimination of charge trapping at defects is highly challenging for poly-crystalline organometal halide perovskites. Here, we report a new architecture for reinforcing the built-in electric field (<I>E</I>in) across the photoactive layer with a pair of strong electric dipole layers (EDLs). The paired EDLs significantly intensify the <I>E</I>in across the perovskite layer, resulting in suppressed charge trapping of photogenerated charges. As a result, our low-temperature processed P-I-N planar PeSC devices using the paired EDLs exhibit a higher power conversion efficiency (<I>η</I>max ∼ 19.4%) and a smaller device-to-device variation with a standard deviation (S.D.) of 0.70%, which far surpass those (<I>η</I>max ∼ 17.8%, S.D. ∼ 1.1%) of the devices with typical charge transport layers.</P>