소아에서 외상 후 발생한 양안 장액망막박리 1예

김상준,김진영,박성표,Sang Joon Kim,Jin Young Kim,Sung Pyo Park 대한안과학회 2008 대한안과학회지 Vol.49 No.6

Purpose: We report a case of post‐traumatic bilateral serous retinal detachment that resolved spontaneously within a month. Case summary: An 8-year-old male patient presented with post-traumatic bilateral serous retinal detachment and decreased visual acuity. We did not perform any specific treatment. Best corrected visual acuity (BCVA), fluorescein angiography (FA), optical coherence tomography (OCT), and slit lamp examination were used. Conclusions: After 1 month, the patient’s BCVA improved to 1.0 in both eyes, and serous retinal detachment resolved; FA findings and OCT findings were nearly normal. J Korean Ophthalmol Soc 49(6):1018-1021, 2008

토양 내의 Atrazine의 생물학적 분해 촉진을 위한 활성토의 이용

김상준,Kim, Sang-Jun 한국지하수토양환경학회 2006 지하수토양환경 Vol.11 No.6

토양내 atrazine 분해촉진을 위한 생물적 증진제로서의 토양내에서 직접증식된 Atrazine 분해 미생물을 함유하는 활성토의 효용성을 조사하였다. Atrazine 분해미생물을 증식시키기 위하여 Wooster silt loam을 4 mg/kg 농도의 atrazine으로 3회 연속처리하며 atrazine 분해 미생물 수와 atrazine 분해속도를 관찰한 결과, 1회 처리 후 atrazine 분해속도가 현저하게 증가하였고, 2회 처리 후 atrazine을 탄소원과 질소원으로 이용하는 미생물의 수가 각각 103, 101배 증가하였다. 증식된 미생물을 함유하는 이 활성토를 atrazine에 오염(초기농도4 mg/kg)된 Ohio의 전형적인 농지 토양에 0.5%비율로 접종하였을 때, 토양내atrazine 농도가 4일만에 초기농도의 2% 이하로 감소하였다. 비전형적인 토양(pH 4.5 또는 유기물함량 43%)에서 같은 효과를 얻기 위해서는 더 높은 비율의 접종이 필요하였다. 활성토는 저온($10^{\circ}C$ 이하) 습윤(수분함량 15%)한 상태에서 최소한 6개월간 안정하였다. 본 연구결과는 atrazine 분해미생물이 토양내에서 비교적 쉽게 증식되며, 이를 함유하는 활성토가 토양내에서의 atrazine 분해 촉진을 위한 접종제로 유용하게 이용될 수 있음을 보여준다. Effectiveness of activated soil containing directly enriched atrazine-degrading soil microorganisms as an inoculant to bioaugment degradation of atrazine in soils was investigated. A Wooster silt loam (Typic Fragiudalf) was spiked with atrazine at a rate of 4 mg/kg soil three successive times to create activated soil. Atrazine degradation was significantly enhanced (p < 0.05) after the first treatment. After the second treatment, there was an increase in the number, based on MPN, of microorganisms utilizing atrazine as a C- and N-source by 3 logs and 1 log of magnitude, respectively. Inoculation of typical agricultural soils collected from Ohio with activated soil at a rate as low as 0.5% reduced the extractable atrazine remaining in soils to the level below 2% of that initially recovered (initially added at a rate of 4 mg/kg soil) after 4 days. Inoculation at a higher rate was required to achieve the same result in soils with non-typical properties (pH of 4.5 or organic matter of 43% w/w). Activated soil was stable, in terms of atrazine degradation activity, at least up to 6 months when it was kept at low temperature (< $10^{\circ}C$) and moistened (water content above 15%). The results of this study indicate that microorganisms capable of degrading atrazine are relatively easily enriched in soil to create activated soil. Use of activated soil can be a practical option for bioremediation of contaminated soils.

저용량 독시싸이클린 투여가 만성 치주염에 미치는 임상적 미생물학적 효과

김상준,엄흥식,장범석,이재관,Kim, Sang-Jun,Um, Heung-Sik,Chang, Beom-Seok,Lee, Jae-Kwan 대한치주과학회 2009 Journal of Periodontal & Implant Science Vol.39 No.1

Purpose: Tetracycline and its chemically modified non-antibacterial analogues can inhibit certain host-derived tissue destructive collagenases such as matrix metalloproteinases. The purpose of this study was to evaluate clinical and microbiologic effects of the subantimicrobial dose of doxycycline(SDD) in conjunction with scaling and root planing. Materials and methods: A total of 30 patients with chronic periodontitis who were going to receive scaling and root planing were randomly allocated to receive either a doxycycline hyclate for 3 months or nothing. Clinical probing depth, clinical attachment level, gingival recession, and bleeding on probing were measured by one periodontist. After a periodontal examination, microbial samples were collected using sterile paper points. The effect of SDD in conjunction with scaling and root planing on alterations of the periodontal pathogens (Aggregatibacter actinomycetemcomitans, Tannerella forsythia, Porphyromonas gingivalis) were also assessed using l6S rRNA polymerase chain reaction. Results: During the treatment period, clinical parameters for both treatment group and control group were improved. After 3 months, reductions in probing depth and gains in clinical attachment level were significantly greater for the SDD group than control group. Microbial analysis showed that there was no alteration of the periodontal pathogens and no difference between the groups. Conclusion: This study suggested that the subantimicrobial dose of doxycycline as an adjunct therapy with scaling and root planing might be effective and safe in the management of chronic periodontitis.

Effects of MR Parameter Changes on the Quantification of Diffusion Anisotropy and Apparent Diffusion Coefficient in Diffusion Tensor Imaging: Evaluation Using a Diffusional Anisotropic Phantom

김상준,최충곤,김정곤,윤성철,장건호,Ha-Kyu Jeong,Eun Ju Kim 대한영상의학회 2015 Korean Journal of Radiology Vol.16 No.2

To validate the usefulness of a diffusional anisotropic capillary array phantom and to investigate the effects of diffusion tensor imaging (DTI) parameter changes on diffusion fractional anisotropy (FA) and apparent diffusion coefficient (ADC) using the phantom. Diffusion tensor imaging of a capillary array phantom was performed with imaging parameter changes, including voxel size, number of sensitivity encoding (SENSE) factor, echo time (TE), number of signal acquisitions, b-value, and number of diffusion gradient directions (NDGD), one-at-a-time in a stepwise-incremental fashion. We repeated the entire series of DTI scans thrice. The coefficients of variation (CoV) were evaluated for FA and ADC, and the correlation between each MR imaging parameter and the corresponding FA and ADC was evaluated using Spearman’s correlation analysis. The capillary array phantom CoVs of FA and ADC were 7.1% and 2.4%, respectively. There were significant correlations between FA and SENSE factor, TE, b-value, and NDGD, as well as significant correlations between ADC and SENSE factor, TE, and b-value. A capillary array phantom enables repeated measurements of FA and ADC. Both FA and ADC can vary when certain parameters are changed during diffusion experiments. We suggest that the capillary array phantom can be used for quality control in longitudinal or multicenter clinical studies.

장결핵 (腸結核 ) 34예에 대한 임상적 (臨床的) 고찰

김상준,김우길,이수석,라성균,장선택 ( Sang Jhoon Kim,Woo Kil Kim,Su Suk Lee,Rha Sung Kyun,Sun Taik Chang ) 대한소화기학회 1974 대한소화기학회지 Vol.6 No.2

Levy and Granmark had introduced double contrast study in 1896 for the first time. Since Daval and Beclere had human experiment of double contrast air study, so many methods for diagnosis of ge.stric diseases are discovered and improved. 'Aiain valuable purpcses for double contrast study of stomach and duodenum are early diagncsis of stomach cBilcer and differectial diagncsis of ulcer forming malignancy frcm benigncy. In ='d ticn to t4ese, differentiation of gastroauoe.al defects, intrin-ic or extrins!c, is also v'orthwlii!e by tl;e metho3 of doub!e cc,ntrast air study of stomach and duodenum. Hvpotonic duodenography is exclusive of misinterpretation of duocenal non lesion in conventi,.nal barium study, as it attributes in cor firmation of nature, extention of lesion, and differer..iation betv;een intrinsic or extrinsic, cr duodenal or papillary lesion in origin, Hypotonic 3uodenogrzphy is helpful in carly diagnosis of disease and avoid misleading unneccessary fv.rther study or explorat- ory laparotomy.

Ester 및 Ether 형 Polyol Polyurethane lonomer 의 Emulsion 블렌드

김상준,김병규 ( Sang June Kim,Byung Kyu Kim ) 한국공업화학회 1992 공업화학 Vol.3 No.4

Soft segment가 각각 ester 및 ether형 polyol로된 2종의 polyurethane(PU) ionomer를 emulsion 블렌딩하여, 블렌드의 분산점도, 및 emulsion cast film의 접촉각, 기계적 특성을 조성의 함수로 측정하였다. 블렌드의 기계물성은 혼합법칙으로부터 심한scattering이나, negative deviation을 보였으며, 이는 ester 및 ether형 polyol간의 상용성의 결여에 기인하는 것으로 보았다. 접촉각 측정 결과로부터 유화입경이 작은 PPG PU 입자가 주로 도막표면층을 형성하는 것을 확인 할 수 있었다. Two types of polyurethane(PU) ionomer dispersion having different type of soft segment, viz. poly (tetramethylene adipate) glycol(PTAd), and polypropylene glycol (PPG) were emulsion blended. Viscosity of emulsion blend, mechanical, and surface properties of the emulsion cast films were determined as a function of blend composition. Mechanical properties showed a large scatter of data or negative deviation from the additivity rule, and this was attributed to the incompatibility of soft segments. Contact angle measurement indicated that air facing surface of emulsion cast film contained more of PPG PU, due probably to its smaller particle diameter compared to PTAd PU.

병적 근시가 황반 원공 수술 결과에 미치는 영향

김상준,김하경,Sang Joon Kim,MD,Ha Kyoung Kim,MD,PhD 대한안과학회 2013 대한안과학회지 Vol.54 No.6

Purpose: To evaluate if the presence of pathologic myopia could affect the result of macular hole surgery. Methods: This study was a retrospective comparison of the results of macular hole surgery between a pathologic myopia group (11 eyes) and a non-pathologic myopia group (14 eyes). All patients had undergone PPV, ILM peeling and C3F8 (20%) gas temponade. BCVA, IOP and OCT findings were evaluated preoperatively and at 6 months after surgery. Postoperative BCVA, IOP and macular hole closure were compared between each groups. Results: The only statistically significant preoperative parameter between the groups was axial length (p < 0.001). Postoperative BCVA was lower in the pathologic myopia group, but the difference was not statistically significant. The rate of macular hole closure was statistically significant higher in the non-pathologic myopia group (p < 0.001). Conclusions: The presence of pathologic myopia may negatively affect the result of macular hole surgery.

MarSel : 대용량 SNP 일배체형 데이터에 대한 연관불균형기반의 tagSNP 선택 시스템

김상준,여상수,김성권,Kim Sang-Jun,Yeo Sang-Soo,Kim Sung-Kwon 한국정보처리학회 2006 정보처리학회논문지 A Vol.13 No.1

최근 인간의 다양성과 SNP과의 연관연구에 드는 비용을 줄이기 위해서, 최소의 tagSNP을 선택하는 문제를 해결하기 위한 연구가 이루어지고 있다. 일반적으로 많은 수의 SNP들을 여러 블록으로 분할하여 각 블록 내에서 tagSNP을 선택하는 접근방법이 사용되고 있다. 본 논문에서 구현된 MarSel은 기존의 블록분할 접근 방법의 문제로 볼 수 있는 생물학적 의미의 부족을 해결하고자, 연관불균형(Linkage Disequilibrium, LD)의 개념을 도입한 시스템이다. 기존의 접근방법에서는 생물학적으로 재조합(recombination)이 일어나지 않는 연속된 구간에서도 여러 블록으로 나누어지는 문제가 생겼던 반면, MarSel에서는 연관불균형 계수 |D'|에 의해서 연속된 구간이 하나의 블록으로 유지된 상태에서 tagSNP을 선택하게 된다. 또한 MarSel에서는 각 블록 내에서 tagSNP을 선택 할 때에 엔트로피(entropy) 기반의 최적해 알고리즘을 이용함으로써 최소한의 tagSNP 선택을 보장하게 되며, 기존의 구현된 시스템들보다 더 많은 양의 데이터를 효율적으로 처리할 수 있도록 구현되었기 때문에 염색체 레벨의 연관 연구도 가능하게 해준다. Recently the tagSNP selection problem has been researched for reducing the cost of association studies between human's diversities and SNPs. General approach for this problem is that all of SNPs are separated into appropriate blocks and then tagSNPs are chosen in each block. Marsel in this paper is the system that involved the concept of linkage disequilibrium for overcoming the problem that the existing block partitioning approaches have short of biological meanings. In most approaches, the contiguous regions, which recombinations have LD coefficient |D'| and then tagSNP selection step is performed. And MarSel guarantees the minimum tagSNP selection using entropy-based optimal selection algorithm when tagSNPs are chosen in each block, and enables chromosome-level association studies using efficient memory management technique when input is very large-scale dataset that is impossible to be processed in the existing systems.

학술 웹 데이터베이스의 품질 비교 평가 : NDSL, P ubMed, Scopus와 Web of Science를 중심으로

김상준,Kim, Sang-Jun 한국과학기술정보연구원 과학기술정보센터 2005 Journal of Information Science Theory and Practice Vol.36 No.3

NDSL과 PubMed와 같이 연구현장에서 무료로 서비스되는 DB가 있는 주제분야에 Scopus와 WoS DB와 같은 상용 DB를 도입하기 위한 검토과정에 DB의 품질평가를 위한 연구가 필요하다. 본 연구는 선행연구 분석을 통해 품질평가기준을 추출하여 짧은 시간에 객관적으로 측정하기 쉬운 평가항목을 중심으로 발견적 실무적 비교평가를 실시한 것이다. 그 결과 NDSL은 최신성과 저널 및 주제의 포괄성과 망라성에서 우수하며, PubMed는 최신성과 MeSH 색인에서 전통을 자랑하는 의학 및 생명과학 전문 DB인 반면, Scopus는 사회 및 자연과학 분야에서 현재 1996년 이후의 인용정보를 이용자 중심 인터페이스로 쉽게 이용할 수 있고, WoS는 인용색인을 탄생시킨 전통과 명성을 자랑하지만 구독료가 고가인 관계로 폭넓은 접근이 어렵다. 따라서 인용정보가 포함된 상용 Web DB 도입의 타당성 검토와 이용자교육 및 도서관정보 서비스는 이러한 Web DB의 품질평가 결과를 바탕으로 이루어져야 보다 효율적이고 생산적인 정보 서비스가 가능하다. This study is focused on the quality of the Web databases which has been produced in science. For the quality evaluation of NDSL, PubMed, Scopus, and WoS, 10 evaluating criteria are developed on the basis of literature review. The evaluation results show that NDSL and PubMed are superior in the currentness and cost. Scopus and WoS are superior in the information of citing and the analysis tool. It is needed for purchasing, user training, and library service based on the above evaluation results.

중합효소연결반응에 의한 자연 수계에서의 mer 유전자 함유 세균 탐색

김상준,진주영,이현환,조기성 ( Sang Jun Kim,Joo Young Jin,Hyun Hwan Lee,Ki Seong Joh ) 한국환경생물학회 1995 환경생물 : 환경생물학회지 Vol.13 No.1

The distribution of bacteria resistant to mercury (Hg^r-bacteria) was investigated from the coastal water sample of Kwangyang bay and freshwater samples of Taeback area, mer gene was also detected from the isolated Hg^r-bacteria by PCR and colony hybridization using the probes which correspond to the conserved sequence of the reported Tn 21, Tn 501 and pMJ 100. The distribution of Hg^r-bacteria at Kwangyang bay among the total number of heterotrophic bacteria grown on agar media was 0 - 0.15% and 0.05 - 0.084% in Feb. and Apr. respectively. The distribution of those bacteria at Taeback area was 94. 55% in the upstream and 17.78% in the downstream of the valley. From the Hg^r-bacteria, about 1Kb of mer gene was amplified by PCR using the amplified mer gene as probe, the interrelationship between the Hg^r-bacteria and the existence of mer gene was investigated by colony hybridization. As a result, 82% and 70% of the Hg^r-bacteria have mer gene at Kwangyang and Taeback area, respectively.