급성 근골격병변의 치료에 이용한 국소도포용 PIROXICAM GEL의 효과

김기용,조덕연,김영태 최신의학사 1985 最新醫學 Vol.28 No.6

사과의 열과원인에 관한 조사연구

권병규,강영호,이우승,성민웅,이상윤,조화석 慶北大學校 生産技術硏究所 1970 生産技術 Vol.4 No.-

It is very important to eliminate the immense economic loss caused by cracking in apples through examining the causes of cracking and divising a possible method of prevention of it. Several investigators published their findings on the causes of the cracking of apples which develop on the skin of Ralls apples. However, no definite conclusions or established methods of prevention have been published to this date. Therefore, in this study the causes of the cracking of apples are examined through the use of several methods: (a) the histological and physiological, (b) the microelemental, and (c) the natural environmental. The results are as follows: 1). At the early stage of growth, the thicknesses of the cuticle, as well as of the subepidermis, were the same in Ralls apples without envelopes, Ralls with envelopes, and Jonathan. However. at maturity. the thicknesses differed in the following manner; Ralls apples without envelopes were thickest: Ralls envelopes were less thick than those without envelopes; while Jonathan apples were thinest. 2). Although in the Ralls without envelopes the epidermis is arranged in a brick wall like layer during maturity, in the middle of August the brick wall like epidermis begins to collapse and is surrounded by the cuticle. The process of cracking seems to start with the lenticle and the fruit spot. 3). The rate of cracking was slowed by application of a mixture of IAA and Bordeaux mixture solution, but cracking was not completely halted by this treatment. 4). The stem of a branch laden with apples was put into a solution containing Mn-54, and after absorption took place the distribution of Mn-54 was measured. The results of the measurements were as follows; the bark contained the most Mn-54; the leaves contained the second largest quantitiy; and the apples has the least. 5). The two orchards which were tested tended to have a low soil pH, and a high concentration of soil-solution Mn. 6). The soil with a high rate of cracking tended to have a high pH, which the soil with a low rate had a low pH. 7). In trees with a high rate of cracking, the amount of Mn in the leaves was equal to the amount in the stalk. However, in trees with a low rate of cracking, the amount of Mn in the leaves tended to be high compared with that found in the stalk. 8). The epidermis of the Ralls had a high Ca content than the epidermis of the Johnathan. 9). The epidermis of cracked apples tended to have a higher content of Ca, K,P, Cu and Fe than the epidermis of sound apples. 10). Amoug the apples tested, 11% cracked during the course of the year, with the cracking starting in the middle of Sept. 1969, This low percentage of cracking can be attributed to the small amount of rain during harvest time (late Sept. and October). The total of the added temperature during May, June, and July was 1962℃. 11). Cracking occurred more frequently in apples on the periphery of the tree, in well-colored apples, on the south side of the apples, and on the cheeks of the apples. These occurrances can perhaps be attributed to the amount of sunlight. 12). In the trees tested with newspaper envelops, cracking occurred in 1.9% of the apples with envelopes, and in 11.9% of the apples without envelopes. In the trees tested with Polysteron paper envelopes, cracking occurred in 2.5% of the apples with envelops, and 13.4% of the apples without envelopes. The apples with Polysteron paper envelopes were less infected by insects than the apples with newspaper envelopes. 13). Cracking occurred in 2.4% of the apples covered with vinyl, while in trees not covered with vinyl, 16.6% of the apples crack. The Artificial precipitation produced during harvest time increased the rate of cracking.

증례보고 : Cornelia de Lange Syndrome 환자의 전신마취 경험

조상윤 ( Sang Yun Cho ),전우재 ( Woo Jae Jeon ),조영현 ( Yung Hyun Cho ),심재항 ( Jae Hang Shim ),염종훈 ( Jong Hoon Yeom ),신우종 ( Woo Jong Shin ),김경헌 ( Kyoung Hun Kim ) 대한마취과학회 2008 Korean Journal of Anesthesiology Vol.55 No.6

Cornelia de Lange syndrome (Amsterdam dwarfism) is a congenital disease characterized by mental retardation associated with multiple malformation. A genetic etiology has been proposed, with suggestions of autosomal dominant and recessive inheritance. It affects one in 30,000 to 60,000 live births. Two-thirds of patients with the condition die before the end of their first year; death occurs from pulmonary aspiration in infancy, and from infections and bowel obstruction in later life. One reference to the syndrome highlights problems with seizures, cardiac abnormalities and difficult tracheal intubation but apart from this paper, there is little published information about the anesthetic management. (Korean J Anesthesiol 2008; 55: 769~73)

고농도 Toluene 에서 생육 가능한 Pseudomonas putida 1K1 의 특성

조경연(Kyung - Yun Cho),전효곤(Hyo - Kon Chun),한동초(Dong - Cho Han),고영희(Yung - Hee Kho) 한국미생물생명공학회 1989 한국미생물·생명공학회지 Vol.17 No.3

Melittin has an inhibitory effect on TNF-α-iduced migration of human aortic smooth muscle cells by blocking the MMP-9 expression

( Yun Jeong Jeong ),( Hyun Ji Cho ),( Key Whang ),( In Seon Lee ),( Kwan Kyu Park ),( Jung Yoon Choe ),( Sang Mi Han ),( Cheorl Ho Kim ),( Hyeun Wook Chang ),( Sung Kwon Moon ),( Wun Jea Kim ),( Yung 영남대학교 약품개발연구소 2013 영남대학교 약품개발연구소 연구업적집 Vol.23 No.0

Matrix metalloproteinases-9 (MMP-9) plays an important role in the pathogenesis of atherosclerosis and migration of vascular smooth muscle cells (VSMCs) after an arterial injury. In this study, we investigated the potential molecular mechanisms underlying the anti-atheroscleroic effects ofmelittin, a major component of bee venom, in human aortic smooth muscle cells (HASMCs). Melttin significantly suppressed MMP-9 and MMP-2 secretion, as well as TNF-α-induced MMP-9 expression in the HASMCs. In addition, we found that the inhibitory effects of melittin on TNF-α-induced MMP-9 protein expression are associated with the inhibition of MMP-9 transcription levels. Mechanistically, Melittin suppressed TNF-α-induced MMP-9 activity by inhibiting the phosphorylation of p38 and ERK1/2, but did not affect the phosphorylation of JNK and Akt. Reporter gene and western blotting assays showed that melittin inhibits MMP-9 transcriptional activity by blocking the activation of NF-κB via IκBα signaling pathway. Moreover, the matrigel migration assay showed that melittin reduced TNF-α-induced HASMC migration. These results suggest that melittin suppresses TNF-α-induced HASMC migration through the selective inhibition of MMP-9 expression and provide a novel role of melittin in the anti-atherosclerotic action.ⓒ2012Elsevier Ltd. All rights reserved.

우리나라 질병에 대한 조사

조영선,윤임중 가톨릭대학산업의학센타 산업의학연구소 1981 韓國의 産業醫學 Vol.20 No.4

In order to grasp the nation-wide pattern of diseases, it were collected the 3,368,461 clinical records sended from 11 local branch offices of federation of Korean medical insurance Societies where are located in Seoul city, Busan Cith, Gyong Gi, Gang Weon, Chung Nam, Chung Buc, Jeon Nam, Jeon Buc, Gyeong Nam, Gyeong Buc and Je Ju provinces. This study was carried out from Jan. 1 1980 to June 30 1980. The diseases were classified by morbidity list, International classification of diseases and Korean Standard Classification of Diseases. The results were as follows; 1. There were 1,971,189 persons of insurants (36.6%) and 3,409,779 persons (63.7%) of dependant family. Of these total subjects, male and female were contained each 49.2% and 50.8%. 2. 62.7% of the total subjects were suffered due to some kind of illness within 6months survey period. 3. Ten main diseases in the survey period were influenza, bronchitis, emphysema and asthma, diseases of teeth and supporting structures, directs obstetric conditions, diseases of the circulatory system, intestinal infectious diseases, diseases of urinary system, chronic heart disease and appendicitis. 4. Intestinal infectious diseases observed frequently in the group of under 9 age. 5. Pulmonary tuberculosis were much observed in the group of ower 60 age compared with other groups. 6. Most of malignant neoplasm of female breast and cervix uteri were observed in the group of over 40 age. 7. Diseases of eye and adnexa were in larger number in 30 and 40 aged group. 8. Diseases of the circulatory system and chronic rheumatic heart diseases increased markedly in the over 40 aged group. 9. Acute myocardial infarction were gradually increased according to the age of over 40. 10. Influenza was most frequent disease of all other illnesses. 11. Bronchitis, emphysema and asthma were more frequently observed in the under 9 aged group. 12. Ulcer of stomach and duodenum especially in the age of 40 and diseases of urinary system were much observed in the under 30 aged group. 13. Salphingitis, oophoritis and abortion were especially increased in the 20 and 30 aged group. 14. Venereal diseases and malignant neoplasm were observed more in male than in female. 15. Diseases of eye and adnexa, and diseases of urinary system were more in female than in male. 16. All of malignant neoplasms were 169 cases per 100,0000 population in the under 39 age and 980 cases in the over 40 age.

Risk factors for type-specific persistence of high-risk human papillomavirus and residual/recurrent cervical intraepithelial neoplasia after surgical treatment

( Yung-taek Ouh ),( Hyun Woong Cho ),( Seong Min Kim ),( Kyung-jin Min ),( Sang-hoon Lee ),( Jae-yun Song ),( Jae-kwan Lee ),( Nak Woo Lee ),( Jin Hwa Hong ) 대한산부인과학회 2020 Obstetrics & Gynecology Science Vol.63 No.5

Objective This study aimed to investigate the clinicopathologic risk factors for type-specific persistence of high-risk human papillomavirus (hrHPV) and residual/recurrent cervical intraepithelial neoplasia (CIN) after surgical treatment. Methods Patients with CIN-2/3 who underwent conization or loop electrosurgical excision procedure (LEEP) at Korea University Hospital were enrolled. All patients underwent hrHPV testing and genotyping before conization or LEEP followed by both hrHPV genotyping and cytology. The significance of associations between patient characteristics and persistence of infection were assessed by multivariate logistic regression analyses. Results Among 398 women with pathologically confirmed CIN-2/3, 154 (38.7%) patients showed hrHPV persistence after surgical treatment. In multivariate analysis, high preoperative hrHPV load (P<0.05; odds ratio [OR], 2.063), presence of CIN-2 at treatment (P<0.01; OR, 2.732), and multiple hrHPV infections (P<0.001; OR, 4.752) were associated with hrHPV persistence. HPV 53 was the most likely to persist after treatment (24/43, 55.8%). The risk of residual/recurrent CIN-2/3 was higher in persistent infection with HPV 16 than other types (P<0.05). Menopause (P<0.001; OR, 3.969), preoperative and postoperative hrHPV load (P<0.05; OR, 2.430; P<0.05; OR, 5.351), and infection with multiple hrHPV types (P<0.05; OR, 2.345) were significantly related to residual/recurrent CIN following surgical treatment. Conclusion HPV load before treatment and infection with multiple hrHPV types were predictors of postoperative hrHPV persistence. HPV 53 was the type most likely to persist, but HPV 16 was the type that was most closely associated with residual/recurrent CIN-2/3.

수술중 우연히 발견된 갈색세포종 1례

조원상,송영진,오태근,박희평,장이찬,윤효영 충북대학교 의과대학 충북대학교 의학연구소 1996 忠北醫大學術誌 Vol.6 No.1

갈색세포종은 부신 수질과 교감신경절 또는 친크롬성 조직에서 주로 발생하는 종양으로, 주증상은 고혈압, 두통, 심계항진, 발한이며, 전체 고혈압 환자의 0.1%를 차지할 것으로 추정된다. 이 질환의 진단은 상기 증상과 소변의 생화학적인 검사, 전산화 단층 촬영 등을 이용하여 확진되며 외과적 절제술이 가장 보편화된 치료 방법으로 알려져 있다. 최근에는 영상 진단학의 발전으로 소화기계 질환의 환자에서 전산화단층촬영이 보편적으로 사용되어 종종 부신 종괴가 우연히 발견되며, 이 중 일부분이 수술중 갈색세포종으로 진단된다. 본 증례는 평소 고혈압 등의 갈색세포종을 의심할 만한 소견이 없던 환자가 우상복부 동통과 고열로 내원하여 진단 과정 중 시행된 전산화단층촬영에서 우연히 양측성 부신종양이 발견된 경우이다. 환자는 수술전 소변의 생화학적 검사등에서 갈색세포종을 의심할 만한 소견이 없었으나 수술시 부신 종양을 조작하던 중 혈압의 상승과 빈맥 등의 소견으로 갈색세포증으로 진단되어 양측 부신절제술을 시행하였다. Pheochromocytoma may arise in the adrenal medulla, sympathetic ganglia or chromaffin tissue. The most common symptoms are hypertension, tachycardia, palpitation and headache. About 0.1% of all hypertensive patients are suggested that have underlying Pheocromocytoma. The diagnostic approaches are based on the symptoms, biochemical test of urine and computed tomography. Surgical removal has been known to be the most common treatment modality. Recently, computed tomography has been commonly used in patients who have GI disturbance and incidentally discovered adrenal mass in some of these patients. And a few of these adrenal masses are diagnosed as pheochromocytoma during operation. In this case, patient who had none of the symptoms of pheochromocytoma, admitted because of RUQ pain and high fever, it happened that bilateral adrenal tumor was incidentally discovered on computed tomography in the course of diagnosis. The patient had no doubtful symptom of pheocromocytoma and normal limit of preoperative biochemical test of urine but the adrenal tumor was diagnosed as pheochromocytoma on operation because of hypertension and tachycardia in intraoperative adrenal manipulation. So, bilateral adrenalectomy was done.

Restoration of thermally reduced graphene oxide by atomic-level selenium doping

Yun, Young Soo,Yoon, Gabin,Park, Min,Cho, Se Youn,Lim, Hee-Dae,Kim, Haegyeom,Park, Yung Woo,Kim, Byung Hoon,Kang, Kisuk,Jin, Hyoung-Joon Springer Science and Business Media LLC 2016 NPG Asia Materials Vol.8 No.-

Rg3-enriched red ginseng extracts enhance apoptosis in CoCl 2 -stimulated breast cancer cells by suppressing autophagy

Yun-Jeong Jeong,Mi-Hee Yu,Yuna Cho,Min-Young Jo,Kwon-Ho Song,Yung Hyun Choi,Taeg Kyu Kwon,Jong-Young Kwak,Young-Chae Chang 고려인삼학회 2024 Journal of Ginseng Research Vol.48 No.1

Background: Ginsenoside Rg3, a primary bioactive component of red ginseng, has anti-cancer effects. However, the effects of Rg3-enriched ginseng extract (Rg3RGE) on apoptosis and autophagy in breastcancer have not yet been investigated. In the present study, we explored the anti-tumor effects ofRg3RGE on breast cancer cells stimulated CoCl2, a mimetic of the chronic hypoxic response, and determinedthe operative mechanisms of action. Methods: The inhibitory mechanisms of Rg3RGE on breast cancer cells, such as apoptosis, autophagy andROS levels, were detected both in vitro. To determine the anti-cancer effects of Rg3RGE in vivo, the cancerxenograft model was used. Results: Rg3RGE suppressed CoCl2-induced spheroid formation and cell viability in 3D culture of breastcancer cells. Rg3RGE promoted apoptosis by increasing cleaved caspase 3 and cleaved PARP anddecreasing Bcl2 under the hypoxia mimetic conditions. Further, we identified that Rg3RGE promotedapoptosis by inhibiting lysosomal degradation of autophagosome contents in CoCl2-induced autophagy. We further identified that Rg3RGE-induced apoptotic cell death and autophagy inhibition was mediatedby increased intracellular ROS levels. Similarly, in the in vivo xenograft model, Rg3RGE induced apoptosisand inhibited cell proliferation and autophagy. Conclusion: Rg3RGE-stimulated ROS production promotes apoptosis and inhibits protective autophagyunder hypoxic conditions. Autophagosome accumulation is critical to the apoptotic effects of Rg3RGE. The in vivo findings also demonstrate that Rg3RGE inhibits breast cancer cell growth, suggesting thatRg3RGE has potential as potential as a putative breast cancer therapeutic