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Lee, Min-Soo,Ham, Byung Joo,Kee, Baik Seok,Kim, Jung‐,Bum,Yeon, Byeong Kil,Oh, Kang‐,Seob,Oh, Byoung Hoon,Lee, Chul,Jung, Han Yong,Chee, Ik‐,Seung,Choe, Byeong Moo,Paik, In Ho Informa UK (Librapharm) 2005 Current medical research and opinion Vol.21 No.9
<P>OBJECT: To compare efficacy and safety of milnacipran and fluoxetine in a population of Korean patients with major depression. RESEARCH DESIGN AND METHODS: The design was a multi-centre, randomised, comparative clinical study. Patients with major depression (DSM-IV diagnostic criteria) scoring over 17 points on the 17-item Hamilton Depression Scale (HAM-D) and over 21 points on the Montgomery-Asberg Depression Rating Scale (MADRS) were recruited and randomised to receive milnacipran (50 mg/day increasing after 1 week to 100 mg/day) or fluoxetine (20 mg/day) for 6 weeks. All previous medication was stopped at least 7 days before entry into the study. Patients were evaluated (HAM-D, MADRS and clinical global impression scale, CGI) at baseline and after 1, 2, 4 and 6 weeks of treatment. All adverse events which developed during the study period were recorded. RESULTS: 70 patients (milnacipran 39; fluoxetine 31) were included in the study. Total score on both HAM-D, MADRS and CGI decreased significantly in both groups after 1 week and continued to decrease throughout the study. There was no significant difference between the two groups for any measurement at any time point. Both antidepressants were well tolerated. In the milnacipran group, 13 patients reported 28 adverse reactions, and in the fluoxetine group 11 patients reported 18 adverse reactions. Two patients discontinued due to adverse events in the milnacipran group and three in the fluoxetine group. There were no clinically significant modifications in vital signs, routine blood laboratory tests, biochemistry or ECG throughout the study. Nausea and headache were the most frequently reported adverse events with milnacipran while digestive disturbances, diarrhoea and insomnia were more common with fluoxetine. CONCLUSION: Milnacipran, like fluoxetine, was found to be effective and well tolerated for the treatment of major depression in this population of depressed Korean patients. Principal limitations of the study were its open design, its small sample size and its relatively short duration.</P>
주요우울증에 대한 Milnacipran의 효과 및 안정성 : Fluoxetine과의 비교
이민수,함병주,기백석,김정범,연병길,오강섭,오병훈,이철,정한용,지익성,최병무,백인호 大韓神經精神醫學會 2004 신경정신의학 Vol.43 No.4
Objectives : This 6-week, open label randomized, multicenter study was conducted to evaluate the antidepressant effect and safety of milnacipran and fluoxetine in patients with major depression. Methods : The study was done in patients with major depression diagnosed by DSM-IV who score ≥17 in 17 items Hamilton Rating Scale for Depression (17-item HAM-D) and score ≥25 in Montgomery and Asberg Depression Rating Scale (MADRS). A total of 87 patients were randomized to milnacipran group and fluoxetine group. In cases of the patients taking other antidepressants, 6 weeks of each medication was administered after 7 days of drug excretion period. The evaluation was done using 17 item HAM-D, MADRS, Clinical Global Impression Scale (CGI), and COVI scale after baseline, 1 week, 2 weeks, 4 weeks, and 6 weeks. The side effects that had occurred during the period of our study were put in records by developed/disappeared time, severities, incidences, managements and results. Results : A total of 87 patients were enrolled. 70 (mitnacipran group 39 ; fluoxetine group 31) of them were included for the 6 weeks of research and 17 of them dropped out with in the first week, not due to adverse reactions or deficiency of effects. Total 17 item HAM-D scores, total points of MADRS, and CGI showed significant decrease after 1 week in each treatment group and continued decrease after 2 weeks and 4, 6 weeks. But there was no difference between milnacipran group and fluoxetine group in the antidepressant effect. There were no significant changes in vital sign, CBC, chemistry, and EKG in each treatment group. The commonly reported side elfects of minlacipran were nausea (25.0%), headache (10.7%), vomiting (7.1%),constipation (7.1%), dizziness (7.1%) and those of fluoxetne were GI trouble (11.1%), diarrhea (11.1%), insomnia (11.1%),agitation (5.6%), and dizziness (5.6%). Conclusion : Milnacipran was effective for the improvement of depressive symptoms and was well tolerated and safe in patients with depression.
함승시(Seung-Shi Ham),정차권(Cha-Kwon Chung),이재훈(Jae-Hoon Lee),최근표(Kun-Pyo Choi),정성원(Seung-Won Jung),김은정(Eun-Jeong Kim) 한국식품영양과학회 1998 한국식품영양과학회지 Vol.27 No.1
더위지기의 발암물질 억제효과 실험결과 생즙, 에탄올추출물 및 물 추출물의 경우 Salmonella typhimurium TA100 균주에서 직접 변이원 물질인 MNNG(0.5㎍/plate)에 대하여 시료를 50㎍/plate 첨가시 생즙의 경우는 83%의 높은 억제 효과를 나타내었으며 에탄올 추출물의 경우는 35% 그리고 물 추출물의 경우는 20%의 억제효과를 나타내었다. 한편 간접변이원인 Trp-P-1(5㎍/plate)의 발암물질에 대해서도 생즙 50㎍/plate 첨가시 70%의 높은 억제효과를 나타내었으며 에탄올 추출물에 대해서는 30%, 물 추출물에 대해서는 15%의 낮은 억제효과를 나타내었다. 한편 4종류의 인간 암세포를 이용하여 더위지기의 생즙과 에탄올 추출물 그리고 물 추출물에 대한 세포독성 실험결과 인간 폐암세포인 A549의 경우 50㎍/ml의 농도를 첨가하였을 때 에탄올 추출물 89%, 생즙 80% 그리고 물 추출물이 35%의 사멸효과를 나타내었다. 또한 유방암세포인 MCF7에 대해서는 50㎍/ml 첨가시 에탄올 추출물 91%, 생즙 76%, 물 추출물 30%의 억제효과를 나타내었으며, 섬유육종암세포 HT1080에 대해서는 에탄올 추출물 90%, 생즙 78% 그리고 물 추출물이 30%의 억제효과를 나타내었고 위암세포인 KATOⅢ에 대해서는 에탄올 추출물 68%, 생즙 52% 그리고 물 추출물이 18%의 세포독성효과를 나타내었다. 4종류의 인간 암세포주에 대한 더위지기의 항암효과는 에탄올 추출물에서 강한 효과를 보여주었다. The antimutagenic activity of three kinds of extract such as fresh juice, ethanol extract and water extract of Artemisia iwayomogi against 3-amino-l,4-dimethyl-5H-pyrido[4,3-b]indol(Trp-P-1) and N-methyl-N'-nitro-N-nitrosoguanidine(MNNG) was demonstrated with the Salmonella typhirnurium assay. The numbers of revertants per plate decreased significantly when these extracts(0.5㎍/plate) added to the assay system using S. typhimurium TA100. These extracts also showed prominant cytotoxic activity against four different kinds of human cancer cell such as human lung cancer cell(A549), breast cancer cell(MCF7), fibrosacoma cell(HT1080) and gastric cancer cell(KATOⅢ), respectively.
( Seung Hon Ham ),( Ji Hoon Park ),( Eun Kyo Chung ),( Dong Uk Park ),( Chung Sik Yoon ) 대한보건협회 2011 대한보건협회 보건종합학술대회 Vol.2011 No.-
[Background] Nanoparticles have been concerned due to their potential toxicity to human health. Although task-based sampling is theoretically considered to be a plausible approach for the assessment of nanoparticle exposure, few data on this type of sampling have yet been published. [Purpose] This study characterized and compared, based on task, the nanoparticle exposure profiles of engineered nanoparticle manufacturing workplaces (ENMW) and workplaces that generated welding fumes containing incidental nanoparticles. [Method] Two ENMW and two welding workplaces were investigated for exposure assessments. Real-time devices that utilized a scanning mobility particle sizer (SMPS), surface area monitor, condensation particle counter (CPC) and dust monitor were utilized to characterize the concentration profiles and size distributions of airborne nanoparticles. Filter-based sampling was performed to measure time-weighted average (TWA) concentrations and for off-line analysis using the electron microscope. [Results] This study demonstrated that the exposure profile, in terms of concentration and size distribution, varies greatly according to the task. For example, certain tasks, such as the pouring of liquid-phase titanium dioxide, grinder cover opening during the manufacturing of aluminum nanopowder, opening of the facility to collect produced nanoparticles, welding, and activities/accidents that included tobacco smoking and spilling of nano solution made the concentration of airborne nanoparticles increase by several fold compared with the background. The size distributions during tasks were different from those during periods with no activity and from the background. The size distributions during tasks were different from those during periods with no activity and from the background. The airborne concentration profiles of the nanoparticles varied according to not only the types of nanoparticles but also the concentration metrics. The airborne concentrations in the workplaces that adapted traditional industrial hygiene control methods, such as an adequate ventilation, containment and good housekeeping, were much lower than those in the workplaces where poor control methods were employed. This study suggests that a task-based exposure assessment could provide much information on the exposure profiles of nanoparticles and could thus be used as an exposure assessment tool.
Antimutagenic Effects of Juices from Edible Korean Wild Herbs
Seung-Shi Ham,Deog-Hwan Oh,Jeong-Kee Hong,Jae-Hoon Lee 한국식품영양과학회 1997 Preventive Nutrition and Food Science Vol.2 No.2
The mutagenic and antimutagenic activities of juices from 20 common edible wild herbs found in Korea were investigated using the spore-rec assay and Ames test. The juices of Hemerocallis fulva and Capsella bursapastoris exhibited a little induction or inhibition of mutagenesis in the presence of selected metal ions, but juices of most edible wild herbs did not affect on the mutagenesis in the spore-rec assay. In the other hand, all of the juices strongly inhibited the mutagenesis induced by benzo[a]pyrene, 2-amino-fluorene, and 3-amino-l,4-dimethyl-5H-pyridol tested on Salmonella typhimurium TA98 or TA100 in the presence of S-9 mix. The antimutagenic effects increased as the concentration of the mutagens increase. The results suggest that concentration of samples or types of various mutagen interact to affect the antimutagenic potential of the juices in the TA98 and TA100 strain.
Antimutagenic Effects of Juices from Edible Korean Wild Herbs
Ham, Seung-Shi,Oh, Deog-Hwan,Hong, Jeong-Kee,Lee, Jae-Hoon The Korean Society of Food Science and Nutrition 1997 Preventive Nutrition and Food Science Vol.2 No.2
The mutagenic and antimutagenic activities of juices from 20 common edible wild herbs found in Korea were investigated using the spore-rec assay and Ames test. The juices of Hemerocallis fulva and Capsella bursapastoris exhibited a little induction or inhibition of mutagenesis in the presence of selected metal ions, but juices of most edible wild herbs did not affect on the mutagenesis in the spore-rec assay. In the other hand, all of the juices strongly inhibited the mutagenesis induced by benzo[a]pyrene, 2-amino-fluorene, and 3-amino-1,4-dimethyl-5H-pyridol tested on Salmonella typhimurium TA98 or TA100 in the presence of S-9 mix. The antimutagenic effects increased as the concentration of the mutagens increase. The results suggest that concentration of samples or types of various mutagen interact to affect the antimutagenic potential of the juices in the TA98 and TA100 strain.