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Interrelation of Cyclin D1, Cyclin E, and p27Kip1 Expression on Tissue Arrays of Breast Cancer
Sehwan Han,Young-Duck Kim,Hong-Yong Kim,Hong-Joo Kim,Kyeongmee Park,Byung-Noe Bae,Suk Yong Ryu,Ki Hwan Kim 대한암학회 2002 Cancer Research and Treatment Vol.34 No.5
Purpose: To evaluate the clinical impact of the alteredexpression of cell cycle regulators in stage I and II breastcancers.Materials and Methods: The interaction between cyclinD1/E and p27Kip1 expressions were analyzed usingtissue microarray (TMA) technology in 133 breast cancers.Data from the immunohistochemical assays of 3molecules were merged, and analyzed, with a Ki67labeling index of the same tumors.Results: Cyclin D1 was expressed in 72 breast carcinomas(54.1%) and cyclin E in 60 (45.1%) out of the 133breast carcinomas. Expressions of cyclin D1 and cyclinE were inversely related to each other, and significantlyassociated with the estrogen receptor (ER) expressionand differentiation of the breast carcinoma. The expressionof cyclin E was significantly decreased in tumorsexpressing cyclin D1 (p=0.022). There was a trend forcyclin D1 expression to increase in tumors expressingp27Kip1 (p=0.053), but the expression of cyclin E didnot correlate with p27Kip1 expression. The Ki67 labelingindex was markedly increased in tumors expressing cyclinE, whereas it was significantly decreased in the cyclin D1or p27Kip1 expressing-tumors. From survival analysis,cyclin E expression was the only significant variable forthe prediction of poor survival.Conclusion: The abnormal expressions of cell cycleregulatory molecules are prevalent, and interrelated witheach other in breast cancer. Integration of TMA technologyallowed a high-throughput analysis for correlating molecularthe in situ findings, with the clinico-pathologicinformation. Among the three molecules studied, thecyclin E had a prognostic implication for stage I and IIbreast cancer. (Cancer Res Treat. 2002;34:388-393)
IN REMEMBRANCE OF THE MAY THAT RETURNED
( Noe Young-ki ) 대한민국역사박물관 2020 Public History & Museum Vol.3 No.-
The special exhibition May, when the day comes again, launched at the National Museum of Korean Contemporary History in commemoration of the 40th anniversary of the May 18 Democratization Movement (also known as the Gwangju Uprising), demonstrates the process of “historicizing” a 40-year-old event. Exhibits included the military uniforms, riot sticks, and ammunition of martial law troops; government records; police logs; reporters’ notebooks; flyers and leaflets, such as Tusa Heobo, an alternative newsletter produced by citizens; photographs and videos; diaries; hamjibak, nickel silver bowls used for serving rice balls to protesters; and hospital medicine cabinets. May, when the day comes again did justice to the particularities of the exhibits and events reproduced. Although there were no central figures in this exhibition, main characters do appear. Individuals are portrayed as protagonists of the May 18 Democratization Movement. A wealth of individual material, such as diaries and letters, aluminum bowls, doctor’s gowns, and various records kept by citizens bring another genre of history to the fore. These exhibits demonstrate that a multitude of individuals from all walks of life joined the May 18 Democratization Movement. Since the significance of this exhibition is its “discovery of individuals,” more material must be found and exhibited in the future, thus giving greater meaning to the May 18 Democratization Movement and contributing to the continuous development of human rights and democracy in Korean society.
노찬숙(Noe, Chan-Sook),김기영(Kim, Ki-Young) 한국산학기술학회 2009 한국산학기술학회논문지 Vol.10 No.11
본 논문에서는 최근 정보통신의 다양한 분야에서 응용되고 있는 USN과 LBS 기술을 이용하여 사회복지 인 프라를 위한 서비스 체계화, 상대적 소외계층을 위한 안전체계 구축, 첨단 IT 기술 접목의 복지통신정책 실현, 공공 u-Wellbeing 서비스 시스템 구축을 목적으로 u-Care 서비스 시스템을 설계 구현하였다. 이 서비스는 독거 또는 치매노 인, 장애인을 위한 사회복지 서비스로 거주지 실내 활동 현황 모니터링이 가능하며, 실외 활동의 모니터링을 위해서 는 초소형 GPS 기반의 위치추적 단말기를 이용하여 보호대상자의 위치정보 및 이동경로를 확인할 수 있다. 또한 보 호대상자의 실내 움직임이 감지되지 않거나 위치 및 상태 정보에 이상이 생겼을 시에 사회복지 관련 기관, 경찰, 119, 가족 등에게 SMS로 자동 발송하는 서비스 방식이다. In this paper, we developed u-Care service system using technologies of USN and LBS to help construct social welfare infrastructure and social safety net for lone seniors and handicapped people. This service not only monitors the in-house and outdoor activities of those disabled people but also sends the messages, whenever abnormal behaviors are detected, to the people related to them as well as the social welfare organizations and public safety institutions such as police and emergency services and etc in order to alert them.
노찬숙(Noe, Chan-Sook),김기영(Kim, Ki-Young) 한국산학기술학회 2009 한국산학기술학회 학술대회 Vol.- No.-
본 논문에서는 최근 정보통신의 다양한 분야에서 응용되고 있는 USN과 LBS 기술을 이용하여 사회복지 인프라를 위한 서비스 체계화, 상대적 소외계층을 위한 안전체계 구축, 첨단 IT 기술 접목의 복지통신정책 실현, 공공 u-Wellbeing 서비스 시스템 구축을 목적으로 u-Care 서비스 시스템을 설계 구현하였다. 이 서비스는 독거 또는 치매노인, 장애인을 위한 사회복지 서비스로 거주지 실내 활동 현황 모니터링이 가능하며, 초소형 GPS 기반의 위치추적 단말기를 이용하여 실시간 위치정보 및 상태 정보에 이상이 생겼을 시에는 사회복지 관련 기관, 경찰, 119, 가족 등에게 SMS로 자동 발송하는 서비스 방식이다.
식도정맥류 출혈의 치료에 대한 비용 대비 효과 - Modified Sugiura Procedure와 내시경적 치료의 비교 -
배병노 ( Byung Noe Bae ),양근호 ( Keun Ho Yang ),김홍용 ( Hong Yong Kim ),김기환 ( Ki Hwan Kim ),한세환 ( Se Hwan Han ),김홍주 ( Hong Joo Kim ),김영덕 ( Young Duck Kim ),신원창 ( Won Chang Shin ) 대한소화기학회 2003 대한소화기학회지 Vol.41 No.4
Background/Aims: According to current studies, the patients treated with modified Sugiura procedure show lower rebleeding rates compared with endoscopic therapy. The aim of this case-control study was to compare modified Sugiura procedure (transabdominal esophageal transection plus esophagogastric devascularization plus splenectomy) with endoscopic therapy for the prevention of recurrent variceal bleeding. Methods: Twenty patients were treated with surgery and 22 patients were treated with endoscopic therapy. We compared their outcomes. Measured main outcomes were mortality, variceal rebleeding, post-interventional changes of liver function, total hospital days, and total hospital charges. Results: Overall mortality in this series was not different. Bleeding related mortality and encephalopathy in the endoscopic therapy group were slightly higher than those in the surgery therapy group. However, these differences were not statistically significant. In patients treated with the modified Sugiura procedure, the liver function was remarkably improved after the operation. Rates of rebleeding (p<0.001), requiring additional endoscopy (p=0.016) and rehospitlalizations (p=0.008) were higher in endoscopic therapy group. In spite of initial lower cost, the overall costs of endoscopic therapy were higher than those of surgery if the costs for the prevention of variceal rebleeding was included. Conclusions: These results indicate that modified Sugiura procedure for esophageal variceal bleeding could improve therapeutic efficiency and quality of life of the patient, especially in the patients with good liver reservoir function. (Korean J Gastroenterol 2003;41:302-308)
Space-Time Diversity Relaying Strategy using Cooperative Communication Technique
김은기(Eun-Ki Kim),박노윤(Noe-Yoon Park),이관섭(Kwan-Seob Lee),김영주(Young-Ju Kim) 한국콘텐츠학회 2009 한국콘텐츠학회논문지 Vol.9 No.4
본 논문에서는 협력 통신 기법을 이용한 새로운 시공간 다이버시티 중계 시스템을 제안한다. 하나의 협동 그룹에 1개 이상의 중계 단말을 추가하여 프레임 에러 여부 및 채널 상태 정보 등의 상태정보를 서로 공유한다. 채널 상태 정보가 좋은 단말만을 선택하여 다중안테나를 이용한 시공간 다이버시티 중계전송을 시작한다. 또한 제안하는 중계전송을 위해 협동그룹 내의 새로운 중계단말 간의 교신 프로토콜을 제안한다. 이 방식에 대해 수신신호 대 송신신호 비(Er/Es)를 측정하여 성능이 개선됨을 증명하였으며, 플랫페이딩(flat-fading) 채널에서의 시뮬레이션을 통해 기존의 협동다이버시티에 비해 혁신적으로 성능이 향상됨을 보인다. In this paper a new space-time diversity relaying strategy using cooperative communication technique is proposed. More than one relaying terminals are included in one cooperative group to share their state information, such as frame error rate and channel state information. The best terminals are selected to send bit information using space-time diversity relay system. An implementation for the proposed scheme is also presented using the TDMA cooperative protocol. The resulting receive signal to transmit signal ratio and computer simulation demonstrate that the proposed strategy outperforms the conventional cooperative system.