Purge & Trap-GC를 이용한 의약품 필름코팅 정제 중 잔류용제에 관한 연구

장준식,이명자,소유섭,문춘선,이주헌,박희라,김진숙,강경모,이선옥,방성연,유미자,유문균,금오성,이병욱 식품의약품안전청 2000 식품의약품안전청 연보 Vol.4 No.-

의약품은 약물을 생체에 적풋하기 위하여 유효성분의 효과가 언제나 일정하게 확보되고 사응에 편리하도록 만들어지는 것이므로 유효썽분 이외에 약효에 영향을 주지 않는 성분이 첨가되는 경운가 많다. 이 때 사용되는 용매들은 제피의 광택 및 건쪼시간의 단축 등을 위하여 휘발점이 낮을 용매들이 주로 사용되어진다. 본 연구는 의약품 필름코팅정제 중 잔류용매 4종(chlorofonr benzen, trichloro ethylen, 1,4-dioxane)에 대한 변형된 pirge & trap-GC 장치를 이용한 동시분석방법을 개발하였으며, 각 표준품의 RSD 값은 chloroform 3.03%, benzen 3.17%, trichloroethylen 3.69% and 1,4-dioxane 3.41%였다. 또한 시중 유통중인 의약품 50종에 대하여 잔류웅매 양을 측정하였으며, 검출되는 잔류용매는 한 건도 없었다. This study nras carried out to develope the analytical method for the mixture of chlorefonn, benzen, trichloroethylen and 1,4-dioxane simultaneously and determine the remainingorgauic solvents in coating tablets by Purge & Trap-GC. The results were as follouFs ; 1. Chloroform, benzen, trio:tloroethylen and 1,4-dioxane separated by tenax #5 trap by HP-624GC column by terrlperature programming. The peaks were separated completely at retentiontime of 6.88min for chloroform, 8.21min for benzen, 10.38miu for trichloroethylen and 11.95minfor 1,4-dioxane. 2. Standard RSD were individually chloroform 3.03%, benzen 3.17%, trichloroethylen 3.69%and 1,4-diorane 3.41%. 3. 60 samples were not detrcted chloroform, benzen, trichloroethylen and 1,4-dioxane.

Analog형 PLL을 사용한 Pull-In Range와 주파수 체배 회로에 관한 연구

李俊模,金聖珞 관동대학교 1984 關大論文集 Vol.12 No.2

In this paper, Lock range, Capture range, frequency stability of the VCO by source voltage variation of the frequency multiplier are experimented and frequency multiplier is composed by the PLL and the frequency divider. Because multiplication rate passes the reference output to the VCO through R and C, it is possible to multiply about ten times the maximum free running frequency of VCO, 500KHz. The capture range has no concern with the multiplication constant and it has about 70KHz to 80KHz bandwidth when the input voltage is 50mV/div but lock range is decreased as much the frequency divider rate as multiplication constant. Though the frequency variation of the VCO has no concern with source voltage, a amplitude varition happened.

Immittance 함수 확장에 의한 고차능동 RC 회로망

李俊模 관동대학교 1986 關大論文集 Vol.14 No.2

In active RC networks, GIC inductor and FDNR is realized as an immittance elements. Using these elements, a new networks design method with high-order elements can be considered. In this paper, the fundamental circuit is designed as unilateral circuits. Immittance function of arbitrary order is realized by expanding the fundamental circuit, and is implemented by active RC networks. Inverse L type circuit using this RC circuit is considered. The network design method in this paper is relatively easy and parameter of circuit is calculated simply. 5th order lowpass filter using this active RC networks is implemented and what its operation characteristic is approximately same that of theory is proved through experiment, and its dynamic range is studied.

전력 송·배전 시스템 상에서 발생하는 이벤트에 대한 데이터 마이닝 가상 트랜잭션과 연관 규칙의 적용

이준섭,이창언,윤상일,김응모 成均館大學校 科學技術硏究所 2002 論文集 Vol.53 No.1

There has been much research on data mining techniques for applying more advanced applications. In this paper, we introduce a approach to convert time series data into virtual transaction data for analysis power electronic transmission and distribution system. However, most of these techniques has focused on transaction data rather than time series data. We present a new way which is discovered and repaired faults of Electric Power system using Data Mining techniques.

스위칭 파형을 사용한 동조 N-Path Filter에 관한 연구

李俊模 관동대학교 1983 關大論文集 Vol.11 No.1

In this paper, a method based on N-Path principle is presented to design bandpass filters tunable over a fairly wide tuning range. The design represents a compromise between the complexity of the switching waveform and that of the auxiliary output filter. Broad tuning range has been made possible by use of switched band-limiting networks. The system transfer function of a switched N-Path Filter with a very general switching waveform is derived and the results are applies to a variety of practical situations. We know that the losses in the shift register degrades the amplitude characteristics and lowers the center frequency gain. The realization of this class N-Path Filter using time-multiplexing of the basic analog network is discussed.

기능성 소화불량증환자에서 Winstal® 투여에 관한 임상경험

이창형,김영탁,금민수,권중구,안병철,윤영미,권영오,김성국,최용환,정준모 慶北大學校 醫科大學 1994 慶北醫大誌 Vol.35 No.3

목적 : 기능성 소화불량증은 소화, 흡수등 장관의 기능적인 이상과 관련되어 있을 것으로 생각되며 복합소화효소제(Winstal®)를 투여하여 그 임상효과를 평가하고자 본 연구를 실시하였다. 대상 및 방법 : 1994년 3월 부터 6월까지 경북대학교병원 내과를 방문한 기능성 소화불량증을 호소하는 환자 20명을 대상으로 Winstal®을 1회 1정씩, 1일 3회 식후 30분내에 경구로 2주간 투여하였다. 결과 : 소화불량증의 증상은 복부불쾌감, 복부팽만감, 식욕부진 및 오심, 복부동통, 공기연하증, 고창 및 구토순이었으며, 증상의 개선은 복부불쾌감이 76.4%(13/17)로 가장 높았으며, 그 다음으로 복부팽만감 및 공기연하증이 66.5%(10/15, 6/9)이었고, 오심 61.5%(8/13), 식욕부진 53.8%(7/13), 복부동통 41.6%(5/12), 고창 37.5%(3/8)이었다. 각 환자별 종합적인 증상의 개선도는 현저한 개선이 2예(10%), 중등도 개선이 3예(15%), 약간개선이 11예(55%), 불변이 4예(20%)이었으며 종합적인 유효율은 80%(16/20)이었다. 부작용은 한 예에서도 관찰되지 않았다. 결론 : 본 제제는 기능성 소화불량증 환자의 증상개선에 추천할 만한 유효한 약제로 생각된다. Dyspepsia is a common symptom in gastroenterologic practice and trigger for numerous consultations with physician. The treatment of chronic functional dyspesia is unsatisfactory. This study was performed to evaluate the efficacy of the digestive compound (Winstal®) on 20 functional dyspepsia patients. On open trial, all patients were given 6 tablets daily for 2 weeks and we evaluated the efficacy of this preparation according to the degree of the improvement. The improvement of symptoms was 76.4%(13/17) in abdominal discomfort, 66.5%(10/15, 6/9) in abdominal distension and aerophagia, 61.5%(8/13) in nausea, 53.8%(7/13) in abdominal pain, and 37.5% (5/12) in flatulence, respectively. Overall effectiveness of subjective symptoms was 80% (16/20) and there were no untoward effects of the preparations during this study. As a result, We think that this preparation is an effective one to relieve symptoms of functional dyspepsia.

낮은 계수감도를 갖는 IIR 디지탈 필터의 제안

李俊模 관동대학교 1994 關大論文集 Vol.22 No.2

The complexity and accuracy of a finite wordlength implementation of an ideal digital filter depends primarily on the chosen filter structure,on the number of multiplications to be performed,and on the size of the multipliers. As the size of the multipliers depends on both the coefficient and state wordlength,any coefficient quantization will lead to a reduction in digital filter complexity at the expense of accuracy in approximating the ideal behaviour. The amount of possible coefficient wordlength reduction depends on the coefficient sensitivity properties of the digital structure. In this paper,a method is proposed for synthesizing very low multiplier coefficient sensitivity in IIR digital filter. The method applies to the case where the poles of the transfer function of the filter are near Z=1.

Bit-slice Devices에 의한 Processor Elements의 평가

李俊模 관동대학교 1993 關大論文集 Vol.21 No.2

Designing with a byte-oriented metal-oxide-semiconductor microprocessor, after all, consists mainly of programming a system made up of components hooked together according to the manufactuer's specifications. But bit-slice processor design involves critical hardware decisions and the creation of an instruction set as well and only then comes the programing. Morever, since bit-slice processor patrs of different manufactures can be mixed in one the same design, consideration must be given individually to each of them. The complexity of bit-slice processor parts, compounded by minimal support from their manufacturers, has won them a poorer welcome than they deserve from designers. Although processors built with bit slices can be extremely powerful, the design flexibility of the parts in both hardware and instruction sets demands an intimate familiarity with a particular family before a designer can be confident of success. In this paper, each slice is illustrated with two diagrams : a diagram of its physical lay out and a diagram of its external connections. The same notation will be used for each slice to ease the transition from slice to slice. However, because of this, these diagrams differ from those used by the manufacturers of the slice. Hence, the manufacturers' diagram are also included to ease the transition to the manufacturer's detailed specifications.

한국인 정신분열병과 도파민 D5 수용체 유전자 연합연구

이민수,조주연,박두병,김준모 大韓神經精神醫學會 1999 신경정신의학 Vol.38 No.2

본 연구는 도파민D5 수용체 유전자와 정신분열병 병인과의 상관성을 밝히기 위하여 한국인 정신분열병 환자군 100명과 정상대조군 100명에서 다형성의 분포를 중합효소연쇄반응을 이용하여 연합연구를 시행하였다. 도파민 D5 수용체 유전자의 대립유전자는(CT/GT/GA)n의 반복으로 구성된 154, 152, 150, 148, 146, 144, 142, 140, 138, 134염기 쌍을 가진 11가지 종류였고 환자군과 정상대조군사이에 대립유전자의 분포는 통계적으로 유의한 차이를 보였다. 각각의 대립유전자 빈도는 환자군에서 대립유전자 A10이 유의하게 감소되어 있었다. 환자군과 정상대조군의 유전자형 분포는 두 군간에 유의한 차이는 없었다. 본 연구의 결과는 도파민 D5 수용체 유전자가 한국인 정신분열병 발생의 취약성에 기여할 가능성이 있다는 것을 제시하지만 본 연구의 결과만으로는 이 유전자부위를 정신분열병의 유전적 결정인자로 결론 내리기는 어려우며 앞으로 더 많은 연구대상을 이용하여 이 도파민 D5 수용체 유전자부위에 대해 본 연구결과를 확인하는 연구가 계속적으로 이루어져야 할 것으로 생각된다. Objective : This study was performed to define the genetic relationship between the microsatellite (CT/GT/GA)n polymorphism for the dopamine D5 receptor gene and schizophrenia. An association study in 100 schizophrenic patients and 100 normal controls of Korean was made by means of using polymerase chain reaction. Results : The microsatellite(D5(CT/GT/GA)n) had 11 alleles. These was a significant difference in the allele distribution between schizophrenic and normal controls(p〈0.05). In schizophrenic patients, the frequency of allele A10 was decreased. As to the genotype distribution, there was no difference in both groups. Conclusions : This finding suggests that dopamine D5 gene is likely to be related to the development of schizophrenia in Korea but with only this result, we cannot come to the conclusion that this genetic locus is the genetic determinant of schizophrenia. Further studies of dopamine D5 receptor genetic locus that can confirm this result should be made.

트랙터 부착용 로더 기구부의 기구학적 시뮬레이션 프로그램 개발

이규승,박원엽,노광모,김준호 성균관대학교 생명공학연구소 1999 生命工學硏究 Vol.5 No.1

A loader mechanism mounted on tractor was modeled for kinematic analysis, and a computer simulation program was developed by using Cartesian coordinate approach, in order to remove the burden of routine derivation and computation from the engineer. The results of kinematic analysis was compared with those of a commercial CAD program. The results of this study was summarized as follows. 1. The results of the simulation showed good agreement with results of the commercial CAD program. This program could be used for predicting the kinematic properties of each links on the loader mechanism. 2. The velocity of bucket which affect the performance of loader increased very quickly just before the finishing point of boom operation, and acceleration also increased sharply at this point. Thus it is concluded that when bucket is rolling, maximum reaction force arises. 3. Velocity and acceleration of each links on the loader mechanism changed very quickly when the bucket cylinder started operation.