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RISS 인기검색어
- 검색키워드
- 저자 : Yunfeng Zhang (검색결과 26 건)
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Zhang, Yunfeng,Chen, Lele,Cao, Yifan,Chen, Si,Xu, Chao,Xing, Jun,Zhang, Kaiguang The Korean Gastric Cancer Association 2020 Journal of gastric cancer Vol.20 No.2
Purpose: Globally, there is a high incidence of gastric cancer (GC). Leucine zipper-EF-hand containing transmembrane protein 1 (LETM1) is reported to play a vital role in several human malignancies. However, there is limited understanding of the role of LETM1 in GC. This study aims to investigate the effects of LETM1 on proliferation, migration, and invasion of GC cells. Materials and Methods: The expression levels of LETM1 in the normal gastric mucosal epithelial cells (GES-1) and GC cells were analyzed by quantitative real-time polymerase chain reaction and western blotting. CCK-8, wound healing, and Transwell invasion assays were performed to evaluate the effect of LETM1 knockdown or overexpression on the proliferation, migration, and invasion of the GC cells, respectively. Additionally, the effect of LETM1 knockdown or overexpression on GC cell apoptosis was determined by flow cytometry. Furthermore, the effect of LETM1 knockdown or overexpression on the expression levels of PI3K/Akt signaling pathway-related proteins was evaluated by western blotting. Results: The GC cells exhibited markedly higher mRNA and protein expression levels of LETM1 than the GES-1 cells. Additionally, the knockdown of LETM1 remarkably suppressed the GC cell proliferation, migration, and invasion, and promoted the apoptosis of GC cells, which were reversed upon LETM1 overexpression. Furthermore, the western blotting analysis indicated that LETM1 facilitates GC progression via the PI3K/Akt signaling pathway. Conclusions: LETM1 acts as an oncogenic gene to promote GC cell proliferation, migration, and invasion via the PI3K/Akt signaling pathway. Therefore, LETM1 may be a potential target for GC diagnosis and treatment.
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Yunfeng Zhang,Fangxun Bao,Caiming Zhang,Qiang Guo,Qi Duan (사)한국CDE학회 2013 한국CAD/CAM학회 국제학술발표 논문집 Vol.2010 No.8
Spline surface is a very important part in Computer Aided Geometric Design. A bivariate rational interpolation spline surface based on function values has been constructed in[9]. It can achieve good approximation effect with parameters, but it would also make the surface control difficult. This paper deals with the constraint methods of partial derivative and directional derivative. the sufficient conditions to modified the partial derivative and directional derivative are derived. The partial derivative and directional derivative can be changed by selecting suitable parameters under the condition that the interpolating data are not changed. Numerical example are given to show how the parameters can be chosen and the shape of surface changed.
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Yunfeng Zhang,Lele Chen,Yifan Cao,Si Chen,Chao Xu,Jun Xing,Kaiguang Zhang 대한위암학회 2020 Journal of gastric cancer Vol.20 No.2
Purpose: Globally, there is a high incidence of gastric cancer (GC). Leucine zipper-EF-hand containing transmembrane protein 1 (LETM1) is reported to play a vital role in several human malignancies. However, there is limited understanding of the role of LETM1 in GC. This study aims to investigate the effects of LETM1 on proliferation, migration, and invasion of GC cells. Materials and Methods: The expression levels of LETM1 in the normal gastric mucosal epithelial cells (GES-1) and GC cells were analyzed by quantitative real-time polymerase chain reaction and western blotting. CCK-8, wound healing, and Transwell invasion assays were performed to evaluate the effect of LETM1 knockdown or overexpression on the proliferation, migration, and invasion of the GC cells, respectively. Additionally, the effect of LETM1 knockdown or overexpression on GC cell apoptosis was determined by flow cytometry. Furthermore, the effect of LETM1 knockdown or overexpression on the expression levels of PI3K/Akt signaling pathway-related proteins was evaluated by western blotting. Results: The GC cells exhibited markedly higher mRNA and protein expression levels of LETM1 than the GES-1 cells. Additionally, the knockdown of LETM1 remarkably suppressed the GC cell proliferation, migration, and invasion, and promoted the apoptosis of GC cells, which were reversed upon LETM1 overexpression. Furthermore, the western blotting analysis indicated that LETM1 facilitates GC progression via the PI3K/Akt signaling pathway. Conclusions: LETM1 acts as an oncogenic gene to promote GC cell proliferation, migration, and invasion via the PI3K/Akt signaling pathway. Therefore, LETM1 may be a potential target for GC diagnosis and treatment.
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Interference Cancellation Scheme for Three-hop Cooperative Relay Networks
( Yinghua Zhang ),( Lei Wang ),( Jian Liu ),( Yunfeng Peng ) 한국인터넷정보학회 2019 KSII Transactions on Internet and Information Syst Vol.13 No.9
In this paper, we focus on interference cancellation for three-hop cognitive radio networks (CRNs) over Rayleigh fading channels. In CRNs, secondary users (SUs) are allowed to opportunistically utilize the licensed spectrum during the idle time of primary users (PUs) to achieve spectrum sharing. However, the SUs maybe power constrained to avoid interference and cover a very short transmission range. We here propose an interference cancellation scheme (ICS) for three-hop CRNs to prolong the transmission range of SUs and improve their transmission efficiency. In the proposed scheme, a flexible transmission protocol is adopted to cancel the interference at both secondary relays and destinations at the same time. And a closed-form expression for the secondary outage probability over Rayleigh fading channels is derived to measure the system performance. Simulation results show that the proposed scheme can significantly reduce the secondary outage probability and increase the secondary diversity in comparison with the traditional cases.
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Safety assessment of biological nanofood products via intelligent computer simulation
Zhao, Yunfeng,Zhang, Le Techno-Press 2022 Advances in nano research Vol.13 No.2
Emerge of nanotechnology impacts all aspects of humans' life. One of important aspects of the nanotechnology and nanoparticles (NPs) is in the food production industry. The safety of such foods is not well recognized and producing safe foods using nanoparticles involves delicate experiments. In this study, we aim to incorporate intelligent computer simulation in predicting safety degree of nanofoods. In this regard, the safety concerns on the nano-foods are addressed considering cytotoxicity levels in metal oxides nanoparticles using adaptive neuro-fuzzy inference system (ANFIS) and response surface method (RSM). Three descriptors including chemical bond length, lattice energy and enthalpy of formation gaseous cation of 15 selected NPs are examined to find their influence on the cytotoxicity of NPs. The most effective descriptor is selected using RSM method and dependency of the toxicity of these NPs on the descriptors are presented in 2D and 3D graphs obtained using ANFIS technique. A comprehensive parameters study is conducted to observe effects of different descriptors on cytotoxicity of NPs. The results indicated that combinations of descriptors have the most effects on the cytotoxicity.
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Shen Yunfeng,Li Xiucun,Zhang Chao,Zhong Hai,Dou Weiqiang 대한영상의학회 2022 Korean Journal of Radiology Vol.23 No.8
Objective: To investigate the clinical application of differential subsampling with Cartesian ordering (DISCO) contrastenhanced (CE) magnetic resonance angiography for anterolateral thigh (ALT) flap transplantation, using operative findings as a reference. Materials and Methods: Thirty patients (21 males and nine females; mean age ± standard deviation, 45.5 ± 15.6 years) who were scheduled to undergo reconstruction with ALT flaps between June 2020 and June 2021 were included in the prospective study. Before ALT flap transplantation, patients were scanned using CE-DISCO imaging. All acquired DISCO images of the 60 lower limbs (both sides from each patient) were analyzed using maximum intensity projection and volume rendering methods. Two experienced radiologists were employed to examine the patterns of the lateral circumflex femoral artery (LCFA), its branches, and perforators and their skin termini, which were compared with the operative findings. Results: Using CE-DISCO, the patterns of the LCFA and its branches were clearly identified in all patients. Four different origins of the LCFA were found among the 60 blood vessels: type I (44/60, 73.3%), type II (6/60, 10.0%), type III (8/60, 13.3%), and type IV (2/60, 3.3%). Owing to a lack of perforators entering the skin, two patients did not undergo ALT flap transplantation. For the remaining 28 patients, the ALT flaps in 26 patients were successfully operated without flap reselection during the operation, while the remaining two patients underwent other surgical procedures due to the thin diameter of the perforator or injury of the perforator during the operation. The success rate of flap transplantation was 92.8% (26/28). All transplanted flaps exhibited good blood supply and achieved primary healing without infection or delayed healing. Conclusion: CE-DISCO imaging can be an effective method for preoperative perforator imaging before ALT flap transplantation.
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Li, Wenting,Zhang, Mengmeng,Wang, Kejun,Lu, Yunfeng,Tang, Hui,Wu, Keliang Asian Australasian Association of Animal Productio 2020 Animal Bioscience Vol.33 No.1
Objective: The objective of a conservation program is to maintain maximum genetic diversity and preserve the viability of a breed. However, the efficiency of a program is influenced by the ability to accurately measure and predict genetic diversity. Methods: To examine this question, we conducted a simulation in which common measures (i.e. heterozygosity) and novel measures (identity-by-descent probabilities and parental genomic components) were used to estimate genetic diversity within a conserved population using double-labeled single nucleotide polymorphism markers. Results: The results showed that the accuracy and sensitivity of identity-by-state probabilities and heterozygosity were close to identity by descent (IBD) probabilities, which reflect the true genetic diversity. Expected heterozygosity most closely aligned with IBD. All common measures suggested that practices used in the current Chinese pig conservation program result in a ~5% loss in genetic diversity every 10 generations. Parental genomic components were also analyzed to monitor real-time changes in genomic components for each male and female ancestor. The analysis showed that ~7.5% of male families and ~30% of female families were lost every 5 generations. After 50 generations of simulated conservation, 4 male families lost ~50% of their initial genomic components, and the genomic components for 24.8% of the female families were lost entirely. Conclusion: In summary, compared with the true genetic diversity value obtained using double-labeled markers, expected heterozygosity appears to be the optimal indicator. Parental genomic components analysis provides a more detailed picture of genetic diversity and can be used to guide conservation management practices.
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Image Denoising Using Low-Rank and Sparse Constraints
Qiang Guo,Yunfeng Zhang,Xiaohong Shen (사)한국CDE학회 2013 한국CAD/CAM학회 국제학술발표 논문집 Vol.2010 No.8
In this short paper, the SAIST method recently proposed for image denoising is improved by exploiting the fixed rank and sparsity constraints. Experimental results show that the improved SAIST obtains better performance than the original SAIST and BM3D.
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Feasibility study of wide-band low-profile ultrasonic sensor with flexible piezoelectric paint
Li, Xin,Zhang, Yunfeng Techno-Press 2008 Smart Structures and Systems, An International Jou Vol.4 No.5
This paper presents a feasibility study of flexible piezoelectric paint for use in wide-band low-profile surface-mount or embeddable ultrasonic sensor for in situ structural health monitoring. Piezoelectric paint is a piezoelectric composite with 0-3 connectivity. Because of its ease of application, piezoelectric paint can be readily fabricated into sensing element with complex pattern. This study examines the characteristics of piezoelectric paint in acoustic emission signal and ultrasonic guided wave sensing. A series of ultrasonic tests including pitch catch and pencil break tests were performed to validate the ultrasonic wave sensing capability of piezoelectric paint. The results of finite element simulation of ultrasonic wave propagation, and acoustic emission generated by a pencil lead break on an aluminum plate are also presented in this paper along with corresponding experimental data. Based on the preliminary experimental results, the piezoelectric paint appears to offer a promising sensing material for use in real-time monitoring of crack initiation and propagation in both metallic and composite structures.
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