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Won, Yubin,Choi, Hyosun,Kim, In Sik,Mun, Ji Young Korean Society of Microscopy 2017 Applied microscopy Vol.47 No.4
Chronic eosinophilic leukemia (CEL) is a myeloproliferative disease with an increased number of mature eosinophils and their precursors, which results in infiltration into organs and organ enlargement. The main cause of this disease is the overexpression of tyrosine kinase. However, there is a need for alternative medication, because some patients are resistant to imatinib, which is a tyrosine kinase inhibitor for leukemia. Many studies have indicated that S100A8 and splicing factor proline and glutamine-rich (SFPQ) function as initiation signals of apoptosis in CEL cells. We reviewed structural studies on CEL cells related to S100A8 and SFPQ. Particularly, this review highlighted microscopic results for the study of S100A8 and SFPQ in CEL cells.
계량적 모델을 통한 지리학 연구의 최신동향 및 토픽 분석
이유빈(Yubin Lee),이영호(Youngho Lee),성정창(Jeongchang Seong),애나 스타네스쿠(Ana Stanescu),지상훈(Sanghoon Ji),황철수(Chul Sue Hwang) 대한지리학회 2020 대한지리학회지 Vol.55 No.6
지리학의 연구 주제와 방법론이 점차 확장되고, 방대한 양의 연구 결과가 도출되면서 과거의 방식으로는 최근 지리학 관련 연구들의 연구 경향을 한 눈에 파악하기 어려워졌다. 따라서 본 연구에서는 토픽 모델링 기반의 LDA 방법론을 활용하여, 2018년부터 2020년까지 AAG 학회에 제출된 초록들을 분석해 최근 지리학의 연구 토픽을 분석하고자 하였다. 이를 통해 기존 지리학 연구동향 분석의 결과와 비교하여 현재의 지리학 연구동향을 파악하고자 하였다. 이를 위하여 초록 내의 모든 단어를 토큰화하고 표제어추출을 한 뒤, 명사와 형용사에 해당하는 단어만 추출하였다. 이후 LDA를 통하여 총 8개의 토픽(정치생태학, 지리공간 과학, 도시 개발, 지리공간 시각화, 토지 피복 변화, 보건 지리학, 도시 공동체, 정치 지리학)을 추출하였다. 본 연구는 지리학 연구자들이 지리학의 전반적인 연구동향을 이해하고 최근에 주목받고 있는 연구 주제를 탐색하는데 기여할 수 있을 것이다. With the gradual expansion of the scope of research in geography and the vast amount of research results being produced, it has become difficult to grasp the trend of research in recent geography studies. In this study, we tried to analyze the recent research trend and topics of geography by analyzing the abstracts submitted to the AAG Conference from 2018 to 2020, using the LDA-based Topic Modeling. All words in the abstract were tokenized and lemmatized to extract only nouns and adjectives. Eight topics; "Political Ecology," "Geospatial Science," "Urban Development," "Geospatial Visualization," "Land Cover Change," "Health Geography," "Urban Community" and "Political Geography" has been generated through the LDA. This study could contribute to geography researchers understanding the overall research trends in geography and exploring research topics that have recently drawn attention.
Yuan Gao,Yubin Ji,Fuling Wang,Wenlan Li,Xiaomeng Zhang,Zhihui Niu,Zhuo Wang 한국식품과학회 2021 Food Science and Biotechnology Vol.30 No.13
Blueberry residue is usually discarded as waste,but has a high anthocyanins content. The extraction methodof anthocyanins from blueberry residue with ultrasonicassisted dual-aqueous phase system was optimized. Interms of the principle of central group and design (CCD)experimental design, three-factor and five-level responsesurface analysis was adopted to optimize the extractionconditions with the extraction rate of anthocyanins. Theoptimum extraction rate of anthocyanin was12.372 ± 0.078 mg/g. Anthocyanin extract could protectthe pBR322 DNA oxidative damage induced by Fentonreagent, increase the superoxide dismutase(SOD) and glutathioneperoxidase (GSH-Px) enzyme activities, anddecrease the H2O2-induced cell apoptosis of human normalliver cell (LO2 cell). The study indicates that the extractionrate of anthocyanin was increased by optimized ultrasonicassisted dual-aqueous phase system. The anthocyaninextract could protect DNA and LO2 cell from oxidativedamage.
Yuan Gao,Yubin Ji,Wenlan Li,Fuling Wang,Fuling Wang,Xiaomeng Zhang,Zhihui Niu,Lulu Zhou,Lijun Yan 한국식품영양과학회 2021 Journal of medicinal food Vol.24 No.2
This study focused on the antibacterial effects of the endophytic fungi producing naringenin from Dalbergia odorifera T. Chen against Staphylococcus aureus. The antibacterial activity was measured by the inhibition diameters, minimum inhibitory concentration (MIC), and minimum bactericidal concentration (MBC). The time-killing curve was also used to evaluate its antibacterial efficacy. The results of antibacterial activity determinations showed that endophytic fungi secondary metabolites can inhibit the growth of five pathogenic bacteria (S. aureus, Escherichia coli, Salmonella enteritidis, Pseudomonas aeruginosa, and Bacillus subtilis) and the most sensitive strain was S. aureus that had the MIC and MBC values of 0.13 and 0.50 mg/mL, respectively. The membrane permeability study was measured by a DNA leakage assay and electrical conductivity assay. Furthermore, the whole-cell protein lysates and DNA fragmentation assay was evaluated. The morphology of S. aureus treated with the endophytic fungi products was observed by scanning electron microscopy (SEM). The probable antibacterial mechanism of endophytic fungi secondary metabolites was the increased membrane permeability that leads to leaks of nucleic acids and proteins. SEM results further confirmed that the extracts can interfere with the integrity of S. aureus cell membrane and further inhibit the growth of bacteria, resulting in the death of bacteria. This study provides a new perspective for the antibacterial functions of endophytic fungi secondary metabolites for biomedical applications.