Detection of Dopamine and its Byproducts in Parkinsonian Patients on LDOPA Therapy and Evaluation of Possible Effects on the Treatment

Yin,Yu Mi Kim,Sul Hee Han,Min Hee Kang,Myung Koo Lee 한국임상약학회 2002 학술대회 Vol.2002 No.1

The behavior of exchange market pressure in china : 1980-2005

Yin Yu 인하대학교 정석물류통상연구원 2009 인하대학교 정석물류통상연구원 학술대회 Vol.2009 No.10

In this paper, the exchange market pressure(EMP) was defined as the abnormal values of the weighted average of changes in Fisher’s exchange rates, in interest rates and in international reserves, and developed stylized facts concerning the univariate behavior of a variety of macroeconomic variables. We selected nine macroeconomic indicators of China from Q1/1980 TO Q2/2005, compared their behavioral characteristics among the three exchange rate arrangements (ERAs) and between the two events of calm and pressure, and tried to tie these results to China’s actual economic situation. Results shown that the following characteristics emerged in EMP: sharp letting down of CPI%. depreciation of nominal monetary, and growth of credit.

Antioxidant and Anticancer Activity of Fractions from Picrasma quassioides (D. Don) Benn. Methanolic Extract

Yin, Yu,Wang, Myeong-Hyeon The Korean Society of Medicinal Crop Science 2007 韓國藥用作物學會誌 Vol.15 No.5

The potential antioxidant and anticancer activities of Hexane, EtOAc (Ethyl acetate), BuOH (n-Buthanol) and water fractions from methanolic (MeOH) extract of Picrasma quassioides (D. Don) Benn. were evaluated in vitro. Tested fractions showed strong antioxidant activity, especially EtOAc fraction had the highest activity ($IC_{50}\;=\;114.01\;{\mu}g/mL$), containing high total phenolics and total flavonoids contents, showed $67.59\;Tan\;{\mu}g/mg$ and $64.95\;Que\;{\mu}g/mg$ respectively. Anticancer activity of these fractions was tested by MTT assay on HT-29 (the human colon carcinoma cells) cell line. BuOH fraction not only showed very high anticancer activity, but also had no cytotoxic effect on 293 (the human normal kidney cells) cell line. Considering these results, we used BuOH fraction of MeOH crude extract from P. quassioides (D.Don) Benn. to do assessment of apoptosis by flow cytometry and the mRNA expression levels of widely established apoptotic-related genes on HT-29 cell line. All the experiments showed that BuOH fraction can induce apoptosis on HT-29 cell line strongly. Taken together, methanolic extract of P. quassioides has potential for antioxidant and anticancer activities products.

Biological Activities of Fractions from Methanolic Extract of Picrasma quassioides

Yu Yin,허성일,노광수,왕명현 한국식물학회 2009 Journal of Plant Biology Vol.52 No.4

Antioxidant, antidiabetes, and anticancer activities of fractions (water, hexane, EtOAc, and BuOH) from methanolic (MeOH) extract of Picrasma quassioides were evaluated in vitro. Among the four fractions, BuOH fraction showed cytotoxic activity on the human stomach carcinoma cells (NCI-N87) without cytotoxic effect on the human normal kidney cells (293) by MTT assay. Considering these results, we adapted BuOH fraction of MeOH extract to the assessment of apoptosis by flow cytometry and mRNA expression levels of established apoptotic-related genes on NCI-N87 cells. The experiments showed that BuOH fraction could induce apoptosis on NCI-N87 cells significantly. Take together these results, P. quassioides showed that it could be used for potential pharmaceutical products.

Biological Activities of Water and Ethanol Extracts from Two Varieties of Rubus coreanus Miquel Fruits

Yin, Yu,Wang, Myeong-Hyeon The Korean Society of Food Science and Nutrition 2011 Preventive Nutrition and Food Science Vol.16 No.1

The potential biological activities of water and ethanol extracts from two varieties of Rubus coreanus Miquel fruits produced in the Gochang-gun (GR) and Hoengseong-gun (HR) regions of Korea were examined. The hydroxyl radical ($\cdot$OH) scavenging activity, reducing power, lipid peroxidation inhibitory activity, and antiproliferative activity on cancer cells by these extracts were examined, and $\alpha$-amylase and $\alpha$-glucosidase inhibition assays were also performed. The EtOH extract from GR showed high hydroxyl radical scavenging activity ($EC_{50}=119.47{\pm}5.13\;{\mu}g/mL$), lipid peroxidation inhibitory activity ($EC_{50}=213.45{\pm}3.14\;{\mu}g/mL$) and a concentration dependence, with OD values ranging from 0.15 to 0.56 (50 to 200 ${\mu}g/mL$), for reducing power. The EtOH extract from GR has the highest antiproliferative activities on MDA-MB-231 and HepG2 cancer cells among four extracts. Meanwhile, all extracts showed certain $\alpha$-amylase and $\alpha$-glucosidase inhibition activities. These results indicate that extracts from two varieties of R. coreanus fruits have significant antioxidant, anti-diabetic and anti-tumorigenic activities, which suggest these extracts could be a potential source for pharmaceutical.

Biological Activities of Water and Ethanol Extracts from Two Varieties of Rubus coreanus Miquel Fruits

Yu Yin,Myeong-Hyeon Wang 한국식품영양과학회 2011 Preventive Nutrition and Food Science Vol.16 No.1

The potential biological activities of water and ethanol extracts from two varieties of Rubus coreanus Miquel fruits produced in the Gochang-gun (GR) and Hoengseong-gun (HR) regions of Korea were examined. The hydroxyl radical ( OH) scavenging activity, reducing power, lipid peroxidation inhibitory activity, and antiproliferative activity on cancer cells by these extracts were examined, and α-amylase and α-glucosidase inhibition assays were also performed. The EtOH extract from GR showed high hydroxyl radical scavenging activity (EC50=119.47±5.13 ㎍/mL), lipid peroxidation inhibitory activity (EC50=213.45±3.14 ㎍/mL) and a concentration dependence, with OD values ranging from 0.15 to 0.56 (50 to 200 ㎍/mL), for reducing power. The EtOH extract from GR has the highest antiproliferative activities on MDA-MB-231 and HepG2 cancer cells among four extracts. Meanwhile, all extracts showed certain α-amylase and α-glucosidase inhibition activities. These results indicate that extracts from two varieties of R. coreanus fruits have significant antioxidant, anti-diabetic and anti-tumorigenic activities, which suggest these extracts could be a potential source for pharmaceutical.

Complete ¹H-NMR and <SUP>13</SUP>C-NMR spectral assignment of five malonyl ginsenosides from the fresh flower buds of Panax ginseng

Yu-Shuai Wang,Yin-Ping Jin,Wei Gao,Sheng-Yuan Xiao,Yu-Wei Zhang,Pei-He Zheng,Jia Wang,Jun-Xia Liu,Cheng-He Sun,Ying-Ping Wang 고려인삼학회 2016 Journal of Ginseng Research Vol.40 No.3

Background: Ginsenosides are the major effective ingredients responsible for the pharmacological effects of ginseng. Malonyl ginsenosides are natural ginsenosides that contain a malonyl group attached to a glucose unit of the corresponding neutral ginsenosides. Methods: Medium-pressure liquid chromatography and semipreparative high-performance liquid chromatography were used to isolate purified compounds and their structures determined by extensive one-dimensional- and two-dimensional nuclear magnetic resonance (NMR) experiments. Results: A new saponin, namely malonyl-ginsenoside Re, was isolated from the fresh flower buds of Panax ginseng, along with malonyl-ginsenosides Rb1, Rb2, Rc, Rd. Some assignments for previously published ¹H- and <SUP>13</SUP>C-NMR spectra were found to be inaccurate. Conclusion: This study reports the complete NMR assignment of malonyl-ginsenoside Re, Rb₁, Rb₂, Rc, and Rd for the first time.

Effects of Acarbose Addition on Ruminal Bacterial Microbiota, Lipopolysaccharide Levels and Fermentation Characteristics In vitro

Yin, Yu-Yang,Liu, Yu-Jie,Zhu, Wei-Yun,Mao, Sheng-Yong Asian Australasian Association of Animal Productio 2014 Animal Bioscience Vol.27 No.12

This study investigated the effects of acarbose addition on changes in ruminal fermentation characteristics and the composition of the ruminal bacterial community in vitro using batch cultures. Rumen fluid was collected from the rumens of three cannulated Holstein cattle fed forage ad libitum that was supplemented with 6 kg of concentrate. The batch cultures consisted of 8 mL of strained rumen fluid in 40 mL of an anaerobic buffer containing 0.49 g of corn grain, 0.21 g of soybean meal, 0.15 g of alfalfa and 0.15g of Leymus chinensis. Acarbose was added to incubation bottles to achieve final concentrations of 0.1, 0.2, and 0.4 mg/mL. After incubation for 24 h, the addition of acarbose linearly decreased (p<0.05) the total gas production and the concentrations of acetate, propionate, butyrate, total volatile fatty acids, lactate and lipopolysaccharide (LPS). It also linearly increased (p<0.05) the ratio of acetate to propionate, the concentrations of isovalerate, valerate and ammonia-nitrogen and the pH value compared with the control. Pyrosequencing of the 16S rRNA gene showed that the addition of acarbose decreased (p<0.05) the proportion of Firmicutes and Proteobacteria and increased (p<0.05) the percentage of Bacteroidetes, Fibrobacteres, and Synergistetes compared with the control. A principal coordinates analysis plot based on unweighted UniFrac values and molecular variance analysis revealed that the structure of the ruminal bacterial communities in the control was different to that of the ruminal microbiota in the acarbose group. In conclusion, acarbose addition can affect the composition of the ruminal microbial community and may be potentially useful for preventing the occurrence of ruminal acidosis and the accumulation of LPS in the rumen.

A Factor Analysis of Chinese University EFL Learners’ Foreign Language Classroom Anxiety

Yin Xiaoteng, Wang Yu 부산대학교 과학교육연구소 2017 교사교육연구 Vol.56 No.2

ABSTRACT: The subjects of the present study were 344 college students from China. They responded to a 5-point likert scale questionnaire adapted from Horwitz’s Foreign Language Classroom Anxiety Scale (FLCAS). Their responses to the questionnaire were submitted to exploratory factor analysis and confirmatory factor analysis (with the help of SPSS and AMOS statistical package) for identifying anxiety dimensions. The results showed that there existed four dimensions of the FLCAS and the four-factor model adequately fit the data. The fit indices also suggested that the instrument measuring the dimensions of anxiety specific to college students in China was construct-wise valid and reliable for future use and it may also provide some reference for measuring anxiety dimensions in similar cultural context countries like Korea and Japan

Identifying Creep and Destructuration Related Soil Parameters by Optimization Methods

Yin-Fu Jin,Zhen-Yu Yin,Yvon Riou,Pierre-Yves Hicher 대한토목학회 2017 KSCE JOURNAL OF CIVIL ENGINEERING Vol.21 No.4

The paper aims to construct an efficient optimization method for identifying creep and destructuration related governing parameters of soft structured clay. An elastic viscoplastic model has been developed and adopted. Different optimization processes, by genetic algorithm or particle swarm optimization with uniform or random samplings initialization methods, are carried out to obtain the material parameters from conventional undrained triaxial tests performed on a K0-concolidated natural soft clay. All comparisons demonstrate that the uniqueness of the solution is better guaranteed with the genetic algorithm rather than with the particle swarm optimization method. Furthermore, the efficiency of genetic algorithm has been verified by simulating other tests.