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유성목(Seong-Mok Yu),박준호(Joon-Ho Park),박종태(Jong-Tae Park),유종근(Jong-Gun Yu) 대한전기학회 2010 정보 및 제어 심포지엄 논문집 Vol.2010 No.10
This paper describes a low-voltage high-efficiency DC-DC buck converter. The proposed DC-DC buck converter operate in PWM(Pulse Width Modulation) mode at moderate to heavy loads(100㎃~500㎃), in PFM(Pulse Frequency Modulation)at light loads(1㎃~100㎃), and in LDO(Low Drop Out) mode at the sleep mode(<1㎃) The triple-mode converter can thus achieve high efficiencies over wide load current range. The designed DC-DC converter is fabricated in a CMOS 0.18㎛ technology. It has a maximum power efficiency of 96.4% and maximum output current of 500㎃. The chip size is 1.15㎜ × 1.10㎜ including pads.
Solar Cell Array Connections with PSpice
Yu, Gwon-Jong,Noe, Myong-gun,Lee, Jung-Tae CHOSUN UNIVERSITY 1997 Basic Science and Engineering Vol.1 No.2
A detailed model of a photovoltaic array written in PSpice is presented in this paper. it is likely that solar cell arrays in photovoltaic system is shadowed partly by clouds, buildings. By the effects of partial shadowing cells are reversely biased and damaged in some cases. In this paper, by analyzing the output characteristics of solar cell arrays according to various shadow patterns, We investigated solar cell arrays connections of prevention the shadowing effects to the utmost.
LC : Side Population in LX2 Cells Decreased by TGF-β
( Jong Bin Kim ),( Yeon Hwa Ann ),( Seo Young Park ),( Hyeon Gun Jee ),( Hye Ri Kim ),( Jeong Hoon Lee ),( Su Jong Yu ),( Hyo Suk Lee ),( Yoon Jun Kim ) 대한간학회 2013 춘·추계 학술대회 (KASL) Vol.2013 No.1
Aim: Side population (SP) cells are known to be enriched in stem/progenitor-like cells. Transforming growth factor (TGF)-β signaling is associated with ECM production in hepatic stellate cells. We hypothesized that the SP fraction in LX2 cells is associated with ECM deposition, which is regulated through TGF-β signaling. Methods: We investigated the relationship between SP cells and TGF-β signaling in the hepatic stellate cell line LX2. The effects of TGF-β and SB431542 on the SP fraction and expression of collagen type I and phospho-Smad2 was determined. Results: We identified 0.8.3% SP cells in LX2 cells. The growth rate of sorted SP and non-SP cells was similar to that of the original LX2 population, but population of the G0/G1 phase was increased in SP cells. Treatment of LX2 cells with TGF-β decreased the SP fraction in a dose-dependent manner and increased the production of collagen type I. Treatment of LX2 cells with SB431542 blocked the effect of TGF-β on the SP fraction and the expression of collagen type I. We cultured LX2 cells on collagen-coated dishes to observe the effect of ECM deposition on the SP fraction. The growth rate and cell cycle distribution was similar to that observed on normal tissue culture dishes, but the SP fraction was decreased when LX2 cells were cultured on collagen-coated plates. Conclusions: These results show that LX2 cells contain a SP fraction and that TGF-β signaling is involved in the induction of ECM deposition as well as the number of SP cells.
( Yu Ran Park ),( Yong-man Kim ),( Shin Wha Lee ),( Ha Young Lee ),( Gun Eui Lee ),( Jong-eun Lee ),( Young-tak Kim ) 대한산부인과학회 2018 Obstetrics & Gynecology Science Vol.61 No.3
Objective Circulating cell-free tumor DNA (cfDNA) is the DNA released by apoptotic and necrotic cells of the primary tumor into the blood during the period of tumor development. The cfDNA reflects the genetic and epigenetic alterations of the original tumor. TP53 mutations are a defining feature of high-grade serous ovarian carcinoma. We optimized the methods for detecting TP53 mutations in cfDNA from blood samples. We confirmed the correlation of TP53 mutation in primary ovarian cancer tissue and it in cfDNA using digital polymerase chain reaction (dPCR). Methods We found 12 frequent mutation sites in TP53 using The Cancer Genome Atlas and Catalogue of Somatic Mutations in Cancer data and manufactured 12 primers. The mutations in tissues were evaluated in fresh-frozen tissue (FFT) and formalin-fixed paraffin-embedded tissue (FFPET). We performed a prospective analysis of serial plasma samples collected from 4 patients before debulking surgery. We extracted cfDNA and calculated its concentration in blood. dPCR was used to analyze TP53 mutations in cfDNA, and we compared TP53 mutations in ovarian cancer tissue with those in cfDNA. Results Ten primers out of 12 detected the presence of TP53 mutations in FFT, FFPET, and cfDNA. In FFT and FFPET tissue, there were no significant differences. The average cfDNA concentration was 2.12±0.59 ng/mL. We also confirmed that mutations of cfDNA and those of FFT were all in R282W site. Conclusion This study developed detection methods for TP53 mutations in cfDNA in ovarian cancer patients using dPCR. The results demonstrated that there are the same TP53 mutations in both ovarian cancer tissue and cfDNA.
( Gun Wung Na ),( Sang Goon Shim ),( Kil Jong Yu ),( Dae Hyeon Cho ),( Chang Uk Jeong ),( Ji Eun Oh ),( Hyun Chin Cho ),( Kwang Min Kim ),( Hyoun Soo Lee ),( Man Je Park ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
Background: In men, erectile dysfunction (ED), which is defi ned as the inability to achieve or maintain an erection suffi cient for satisfactory sexual performance, is an important issue. There were extensive investigations in clinical and pathophysiological mechanisms with sexual dysfunction during the last decade. However, ED in patients with chronic viral hepatitis has been investigated in few and limited studies, which are often not comparable because they use different survey and patient-sampling methodologies. Moreover, few have evaluated the association of ED and depression in patients with chronic viral hepatitis. Therefore, we assessed the prevalence of ED, and their association with depression in patients with chronic viral hepatitis. Methods: This cross-sectional study was conducted from August 2013 through January 2014. All outpatients with chronic viral hepatitis between the age of 18 and 80 years were considered eligible. The exclusion criteria included well established causes of erectile dysfunction such as liver cirrhosis and alcohol abuse. Erectile dysfunction was assessed with the International Index of Erectile Function-5 (IIEF-5) scale. The Beck Depression Inventory (BDI) scale was used to assess depression of the patient. Results: The prevalence of erectile dysfunction among the patients with chronic viral hepatitis was 40%. Age, employment, peg-interferon, IIEF-5 scores and BDI scores were statistically associated with erectile dysfunction. And also, IIEF-5 scores correlated negatively with age, employment and BDI scores. In a multiple logistic regression analysis, age and depression were independently associated with erectile dysfunction. Conclusions : Patients with chronic viral hepatitis have a high prevalence of erectile dysfunction. Age and depression are independent factors of erectile dysfunction in male patients with chronic viral hepatitis. Evaluation of depression must be included to properly manage erectile dysfunction.
Yu, Seong-Bin,Lee, Seung-Ho,Mehran, Muhammad Taqi,Hong, Jong-Eun,Lee, Jong-Won,Lee, Seung-Bok,Park, Seok-Joo,Song, Rak-Hyun,Shim, Joon-Hyung,Shul, Yong-Gun,Lim, Tak-Hyoung Elsevier 2018 CHEMICAL ENGINEERING JOURNAL -LAUSANNE- Vol.335 No.-
<P><B>Abstract</B></P> <P>By using electricity from renewable sources, high-temperature solid oxide co-electrolysis cells (SOCs) can perform advantageous conversion of H<SUB>2</SUB>O/CO<SUB>2</SUB> to high-value syngas. In this work, we investigated the performance of tubular solid oxide co-electrolysis cells for the production of syngas by electrochemical conversion of H<SUB>2</SUB>O/CO<SUB>2</SUB>. The tubular solid-oxide electrolysis cells comprise Ni-yttria stabilized zirconia (Ni-YSZ) based fuel-electrode supported cells, a yttria or scandia-stabilized zirconia (YSZ and ScSZ) electrolyte, and a composite air-electrode of (La<SUB>0.85</SUB>Sr<SUB>0.15</SUB>)<SUB>0.9</SUB>MnO<SUB>3</SUB> (LSM) and La<SUB>0.6</SUB>Sr<SUB>0.4</SUB>Co<SUB>0.2</SUB>Fe<SUB>0.8</SUB>O<SUB>3</SUB> (LSCF). The electrochemical performance of the tubular SOCs for various operating conditions was analyzed using I-V curves, EIS analysis, and gas chromatography. From the results, we confirm the correlation between the operating conditions and the electrochemical performance of the co-electrolysis process in the tubular SOCs. Furthermore, we found that the syngas yield of the ScSZ electrolyte-based SOC cell was better than that of the YSZ electrolyte-based SOC. The results show that using a tubular SOC offered highly efficient conversion of H<SUB>2</SUB>O/CO<SUB>2</SUB>, with high yield and good-quality syngas.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Effect of temperature, inlet gas composition on syngas yield investigated. </LI> <LI> In coelectrolysis, ScSZ electrolyte based SOC performs better than YSZ based SOC. </LI> <LI> Higher amount of CO<SUB>2</SUB> in the feed gas produces more CO in syngas. </LI> <LI> It is possible to achieve high syngas yield through optimized the conditions. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
Hot Carrier Effects in Extreme Submicrometer CMOS
Jong Tae Park,Dae Nam Ha,Seoung Jun Jang,Chong Gun Yu,Byung Gook Park,Jong Duk Lee 한국정보과학회 1998 Journal of Electrical Engineering and Information Vol.3 No.4
Hot carrier effects in CMOS with effective gate length down to 0.1㎛ level are investigated. Hot carrier effects in 0.1㎛ level CMOS are observed at low drain voltage and its possible physical mechanisms are explained. Based on the conventional DC lifetime extrapolation technique, the maximum allowable supply voltage under DC and AC stress is extracted. The enhanced AC degradation for ultra-thin SiO₂, PMOS is explained by the hole trapping during device-off. Finally, a new method for characterizing the hot carrier degradation of ultra-thin SiO₂ PMOS is suggested.