관상피판술 : 해부학, 수술시 고려사항, 병적인 상태

김영균,이기혁,여환호,김수관,박노승 大韓顎顔面成形再建外科學會 1996 Maxillofacial Plastic Reconstructive Surgery Vol.18 No.4

The coronal approach is a versatile surgical technique. This methos becomes particulary useful for exposure and internal fixation of midfacial fractures and the harvest of calvarial bone graft to manage the complex facial bone fractures. The rectrospective clinical study on the use of this technique in 10 patients was performes. The result shows that this technique provides the excellent exposure of fractures site, the ability to reduce the fragment accurately and good cosmetic results in incision area. We discussed with literatures review that anatomy, technique, indications, and potential complications of the coronal approach.

상악골에서 IMPLANT 매식을 위한 치조제 확대 골절단술

김수관,김영균,여환호,이기혁 大韓顎顔面成形再建外科學會 1997 Maxillofacial Plastic Reconstructive Surgery Vol.19 No.2

Ridge expansion osteotomy(REO) technique is a simple and more conservation method to widen a narrow alveolar ridge in the maxilla. This method is superior to drilling method in soft and narrow maxillary alveolar ridge and allows the surgeon to widen the ridge in routine office procedure. Therefore, it is the treatment of choice to implant the maxilla with narrow alveolar ridge. This article presents clinical cases and discusses the advantages, rationale and surgical protocol of REO technique.

악골결손 재건을 위한 탈회 및 비탈회 동결건조 동종골의 이용

이기혁,박인순,김영균,김수관,엄인웅,여환호,이병준 大韓顎顔面成形再建外科學會 1996 Maxillofacial Plastic Reconstructive Surgery Vol.18 No.3

Bone graft has been used to repair one defect caused by disease and trauma, congenital and acquired deformities. Graft materials are autogenous bone, allogenic bone, xenogenic bone, synthetics. Autogenous bone graft is the most superior to other materials for immunologic reaction, compatibility to host tissue, and revascularization. However, autogenous bone graft is required for additional operation and the amount of taking is limited. Autografts are obtained at own expense and also limited in size, shape. In order to compensate these problems, allogenic bone graft has been used increasingly. But allogenic bone graft encounters immunologic complications. Therefore, it has been used after freezing, lyophilization, or demineralization. Allogenic bone processed by only lyophilization includes potential antigenic properties on its surface, therefore it is demineralized to deplete immunologic reaction. Demineralized bone releases BMP and helps the mesenchymal cells transform to the chondroblast to produce cartilage and bone. This reaction is called osteoinducation. Many authors have reported that mineralized lyophilized bone had less antigenicity clinically and favorable bony consideration with host bone. In our department from 1995 to now, we have used banked allogenic bone graft that has been prepared from Wonkwang Bone Bank in 5 cases and mineralized lyophilized bone graft in 2 cases to reconstruct the maxillofacial bone defect after tumor resection and cyst enucleation and cleft alveolus. We will report with literature review that the result is favorable functionally and esthetically.

일차 양측성 구순열의 일단계 재건에 대한 증례보고

임석균,이기혁,김영균,김수관,이병준,여환호,서재훈 大韓顎顔面成形再建外科學會 1996 Maxillofacial Plastic Reconstructive Surgery Vol.18 No.3

Bilateral cleft lip reconstruction can be performed in one-or two-stages. The choice depends on the surgeon's proficiency and experience. However the type and severity of the cleft must be considered. Complete or incomplete symmetric, bilateral clefts in which the premaxilla is within the alveolar arch or slightly protruded can be successfully treated with simultaneous lip reconstruction on both sides. There are some advantages that one-stage lip reconstruction facilitates creation of a symmetric and balanced lip, retraction of protruding premaxilla and the parent's psychologic satisfaction. However, there are some disadvantages such as micrognathia of the upper jaw by severe scar formation and poor adaptation of flap margins by severe tension. The surgeon must be able to judge and exploit the advantages offered by one-stage approach. We present the case report of one-stage reconstruction of primary bilateral cleft lip with literature reviews.

특이한 악관절 강직증 : 진성 악관절 강직증과 상악골과 하악골 사이의 골성 유합

서재훈,조세인,여환호,이기혁,김영균 大韓顎顔面成形再建外科學會 1995 Maxillofacial Plastic Reconstructive Surgery Vol.17 No.2

TMJ ankylosis is classified with true and false type. A true ankylosis is defined as any condition that produces fibrous or bony adhesions between the articular surfaces of the temporomandibular joint. The main causes of true ankylosis are trauma or infection. A false ankylosis results from pathologic conditions outside the joint that limit mobility of the mandible such as myogenic disorders, coronoid impingement or rare direct bony fusion between maxilla and mandible. The treatment of choice of TMJ ankylosis is surgical intervention. We experienced the male patient with complete mouth opening limitation since 45 years before. This patient has true TMJ ankylosis and rare bony synostosis between maxilla and mandible in the right posterior region. We performed surgical intervention and had a favorable result.

Simultaneous determination of chromones and coumarins in Radix Saposhnikoviae by high performance liquid chromatography with diode array and tandem mass detectors

Kim, Min Kyung,Yang, Dong-Hyug,Jung, Mihye,Jung, Eun Ha,Eom, Han Young,Suh, Joon Hyuk,Min, Jung Won,Kim, Unyong,Min, Hyeyoung,Kim, Jinwoong,Han, Sang Beom Elsevier 2011 Journal of chromatography A Vol.1218 No.37

<P><B>Abstract</B></P><P>Methods using high performance liquid chromatography with diode array detection (HPLC-DAD) and tandem mass spectrometry (HPLC–MS/MS) were developed and validated for the simultaneous determination of 5 chromones and 6 coumarins: prim-<I>O</I>-glucosylcimifugin (1), cimifugin (2), nodakenin (3), 4′-<I>O</I>-β-<SMALL>D</SMALL>-glucosyl-5-<I>O</I>-methylvisamminol (4), sec-<I>O</I>-glucosylhamaudol (5), psoralen (6), bergapten (7), imperatorin (8), phellopterin (9), 3′-<I>O</I>-angeloylhamaudol (10) and anomalin (11), in Radix Saposhnikoviae. The separation conditions for HPLC-DAD were optimized using an Ascentis Express C18 (4.6mm×100mm, 2.7μm particle size) fused-core column. The mobile phase was composed of 10% aqueous acetonitrile (A) and 90% acetonitrile (B) and the elution was performed under a gradient mode at a flow rate of 1.0mL/min. The detection wavelength was set at 300nm. The HPLC-DAD method yielded a base line separation of the 11 components in 50% methanol extract of Radix Saposhnikoviae with no interfering peaks detected. The HPLC-DAD method was validated in terms of linearity, accuracy and precision (intra- and inter-day), limit of quantification (LOQ), recovery, and robustness. Specific determination of the 11 components was also accomplished by a triple quadrupole tandem mass spectrometer equipped with an electrospray ionization (ESI) source. This HPLC–MS/MS method was also validated by determining the linearity, limit of quantification, accuracy, and precision. Quantification of the 11 components in 51 commercial Radix Saposhnikoviae samples was successfully performed using the developed HPLC-DAD method. The identity, batch-to-batch consistency, and authenticity of Radix Saposhnikoviae were successfully monitored by the proposed HPLC-DAD and HPLC–MS/MS methods.</P>

Optical Performance Degradation Effects by Fabrication Errors of Circular-type Computer Generated Holograms

Young-Gwang Kim,Hyug-Gyo Rhee,Young-Sik Ghim 한국물리학회 2018 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.73 No.11

A null test method which relies on a computer generated hologram (CGH) is widely used to measure a large aspheric surface. For precise measurements of the surface shape of an aspheric optics, the CGH must precisely generate a wavefront that can fit on the ideal surface shape of the aspheric optics. If fabrication errors arise in the CGH, an unwanted wavefront will be generated and the measuring result will lack trustworthiness. Thus far, there has been limited research on wavefronts generated by CGH using only linear-type binary grating models. In this study, a theoretical error model of a circular-type zone plate, the most commonly used types for CGH patterns, is suggested. The proposed error model is checked by simulations and experiments.

The Y153H Variant of the STOX1 Gene in Korean Patients with Preeclampsia

Kim, Shin-Young,Park, So-Yeon,Lim, Ji-Hyae,Yang, Jae-Hyug,Kim, Moon-Young,Park, Hyun-Young,Lee, Kwang-Soo,Kim, Young-Ju,Ryu, Hyun-Mee Korean Society of Medical Genetics 2009 대한의학유전학회지 Vol.6 No.1

목 적: 자간전증은 유전적 환경적 요인에 의해 발생하는 다요인성 질환이다. 최근 네덜란드 산모에서의 자간전증 후보 유전자로 확인된 STOX1 유전자는 태반에서 발현되며 모계 대립유전자의 선택적 유전에 의해 각인된다. 본 연구에서는 STOX1 유전자의 단일염기변이형 부위인 Y153H와 한국인 자간전증의 연관성에 대하여 알아보고자 하였다. 대상 및 방법: 자간전증 산모 202과 임신기간 동안 자간전증이 발생하지 않은 정상 산모 204명의 혈액으로부터STOX1 유전자의 Y153H 변이 양상을 SNapShot assay kit와 ABI Prism 3730 DNA analyzer를 사용하여 분석하였다. 결과: STOX1 Y153H 변이의 유전자형 빈도는 자간전증환자군과 정상 대조군 간에 유의한 차이가 없었다(P>0.05). 또한 자간전증 환자군(87.1%)에서 대립유전자형인 H의 빈도도 정상 대조군(86.5%)과 유사하였다. 다중회귀분석결과 YH, HH, YH/HH 유전자형들은 자간전증 발생 위험에 있어서 연관성이 없었다. 결 론: 본 연구진은 처음으로 한국인 자간전증 환자에서 STOX1 유전자의 Y153H 변이형의 특징을 파악 하였다. 연구결과 자간전증 산모와 정상 산모 간의 유전자형과 대립유전자형의 빈도는 차이가 없었다. 비록 실험 대상군의 수적인 제한이 있지만, 이상의 결과를 통해서 한국인에서 STOX1 유전자의 Y153H 변이형은 자간전증과 연관성이 없는 것으로 사료된다. Purpose: Preeclampsia is a multifactorial disorder with genetic and environmental components. Recently, the STOX1 gene, identified as a candidate gene for preeclampsia in Dutch women, has been shown to be placentally expressed and subject to imprinting with preferential transmission of the maternal allele. The purpose of this study is to investigate whether there is an association between the STOX1 Y153H variation and preeclampsia in Korean pregnant women. Materials and Methods: This study involved 202 preeclamptic and 204 healthy pregnant women who were genotyped for the Y153H variant of the STOX1 gene using a commercially available SNapShot assay kit and an ABI Prism 3730 DNA Analyzer. Results: There were no significant differences in genotype frequencies of the Y153H variant of the STOX1 gene between preeclamptic patients and normal controls (P>0.05). The H allele frequency of the STOX1 Y153H variation was similar in patients with preeclampsia (87.1%) and in normal controls (86.5%). In addition, multiple logistic regression analysis showed that the YH, HH, and YH/HH genotypes were not associated with an increased risk of preeclampsia when compared to the YY genotype. Conclusion: This is the first study to characterize the Y153H variant of the STOX1 gene in Korean patients with preeclampsia. We found no differences in the genotype and allele frequencies between preeclamptic and normal pregnancies. Although limited by a relatively small sample size, our study suggests that the STOX1 Y153H variation is not associated with the development of preeclampsia in Korean pregnant women.

후외방 - 후내방 도달법을 이용한 후반 구획 유리체의 관절경하 제거술

김진영,김정만,김창기,한창환,김원유,권중혁 대한슬관절학회 2000 대한슬관절학회지 Vol.12 No.1

Purpose: To report the advantages and the results of arthroscopic removal of loose bodies by posterior-posterior triangulation, using the posteromedial and posterolateral portal. Material and Methods: Sixteen cases in this study had loose bodies in the posterior compartment of the knee joint; nine cases in the posteromedial, three cases in the posterolateral and four cases in the both compartments. Under the supine position, the knee is flexed to a 90 angle, and an obturator was inserted in the posterolateral compartment through the fat areolar tissue eliminating the loose bodies in the posterior compartment. Result: In sixteen cases we eliminated all loose bodies under arthroscopy which were in the posterior compartment of the knee joint and there was no complication such as saphenous nerve palsy, common peroneal nerve palsy, or the rupture of popliteal artery. Conclusion: Arthroscopic removal of loose body in the posterior compartment of the knee joint using posterior-posterior triangulation was considered as one of the useful methods in terms of safety and good visualization.

No association between endothelin-1 gene polymorphisms and preeclampsia in Korean population

Kim, Shin-Young,Park, So-Yeon,Lim, Ji-Hyae,Yang, Jae-Hyug,Kim, Moon-Young,Park, Hyun-Young,Lee, Kwang-Soo,Ryu, Hyun-Mee Korean Society of Medical Genetics 2008 대한의학유전학회지 Vol.5 No.1

목 적 : 자간전증은 임신부와 신생아의 사망 및 이환의 주된 원인으로 유전적 소질과 환경적 요인에 의해 발생하는 다요인성 질환이다. ET-1은 강력한 혈관수축 펩티드로 ET-1 시스템 내의 변경이 자간전증에서의 혈관수축을 자극하는 것으로 생각되고 있다. 본 연구에서는 정상 임신부와 자간전증 임신부에서 ET-1 유전자의 4가지 단일염기다형성들(c.1370T>G, c.137_139delinsA, c.3539+2T>C, and c.5665G >T)의 양상을 조사하여 비교함으로써 이러한 유전자 다형성들과 한국인 자간전증의 연관성에 대하여 알아보고자 하였다. 방 법 : 자간전증 임신부 206명과 임신기간 동안 자간전증이 발생하지 않은 정상 임신부 216명의 혈액으로부터 DNA를 추출하고 ET-1 유전자 다형성들의 양상을 SNapShot kit와 ABI Prism 3100 Genetic analyzer를 사용하여 분석하였다. 결 과 : 자간전증 환자군에서 ET-1 유전자의 4가지 단일 염기다형성 각각의 유전자형 및 대립유전자의 빈도는 대조군과 유의한 차이가 없었다. 또한 자간전증 환자군에서 3가지 일배체형(TDTG, GDCT, and TICT)의 빈도도 대조군과 유의한 차이가 없었다: 61%(TDTG), 13%(GDCT), 13%(TICT) vs. 62%, 14%, 12%. 나이, 미산부률, 분만주수, 신체질량지수 등의 자간전증 발생요인을 공변량으로 하여 유전자형과 자간전증 발생의 위험도 사이의 연관성을 확인하기 위해 다중회귀분석을 시행한 결과 열성모델과 우성모델에서 모두 ET-1 유전자의 단일염기다형성들에 대한 자간전증 발생의 위험도가 증가하지 않았다. 결 론 : 한국인 임신부에서 ET-1 유전자의 4가지 단일염기 다형성들은 자간전증 발생과 연관이 없는 것으로 사료된다. Purpose : Preeclampsia is a major cause of maternal and perinatal mortality and morbidity and is considered to be a multifactorial disorder involving a genetic predisposition and environmental factors. Endothelin-1 (ET-1) is a potent vasoconstrictor peptide, and alterations in the ET-1 system are thought to play a role in triggering the vasoconstriction seen with preeclampsia. The aim of this study was to examine the frequency of the 4 common single-nucleotide polymorphisms (SNPs) (c.1370T>G, c.137_139delinsA, c.3539+2T>C, and c.5665G>T) of the ET-1 gene in normotensive and preeclamptic pregnancies and to investigate whether these SNPs are associated with preeclampsia in pregnant Korean women. Methods : We analyzed blood samples from 206 preeclamptic and 216 normotensive pregnancies using a commercially available SNapShot kit and an ABI Prism 3100 Genetic analyzer. Results : There were no significant differences in genotype or allele frequencies of the 4 SNPs in the ET-1 gene between preeclamptic and normotensive pregnancies. The respective frequencies of the 3 haplotypes (TDTG, GDCT, and TICT; >10% haplotype frequency) were 61%, 13% and 13%, respectively, in preeclampsic pregnancies and 62%, 14% and 12%, respectively, in normotensive pregnancies. The frequencies of these haplotypes were similar for both groups. Using multiple logistic regression analysis, we did not observe an increase in the risk of preeclampsia for the 4 SNPs of the ET-1 gene under either a recessive or dominant model. Conclusion : This study suggests that the 4 SNPs of the ET-1 gene are not associated with an increased risk for preeclampsia in pregnant Korean women.