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Youbing Peng,Hai Cheng,Caiming Shen,Ying Xu,Naifang Bei 한국기상학회 2018 Asia-Pacific Journal of Atmospheric Sciences Vol.54 No.3
Widely distributed proxy records show that there were out-of-phase behaviors of moisture change between arid central Asia (ACA) and monsoonal northern China during the Little Ice Age (LIA) and Medieval Climate Anomaly (MCA). We examined spatial pattern differences between the MCA and LIA to identify contrasting patterns of summer precipitation variability, and to diagnose explanatory mechanisms through the analysis of a 1000-year global climate model simulation driven by natural and anthropogenic forcing. The results show that the model was able to roughly produce the general features of MCA-LIA hydroclimatic spatial differences between monsoonal northern China and ACA, with a relatively wet MCA found in monsoonal northern China and a relatively dry MCA found in ACA. A further analysis of associated circulations shows that increased summer precipitation in monsoonal northern China was caused by the strengthening of summer monsoon, while the decline in summer precipitation in ACAwas caused by an anomalous northward displacement of the subtropical westerly jet stream. Our analyses suggest that both effective solar forcing and El-Niño Southern Oscillation (ENSO) may produce these contrasting patterns of precipitation between monsoonal northern China and ACA. Due to a change in the probability of ENSO phases at the centennial time scale found in our experiments may be attributed to solar irradiances, higher effective solar irradiances during the MCA relative to those of the LIA may have been the ultimate forcing mechanism for the simulated precipitation differences between the MCA and LIA.
( Sang Youb Han ),( Kyung Hwan Jeong ),( Chun-gyoo Ihm ),( Young Sun Kang ),( Dae Ryong Cha ) 대한신장학회 2021 Kidney Research and Clinical Practice Vol.40 No.1
Background: Imbalance of T helper (Th) 1/2 cells has been shown to contribute to the development of immunoglobulin A nephropathy (IgAN). To address the inconsistent results on the role of Th1/Th2 polarization, we evaluated the levels of Th1/Th2 cytokines in various samples from patients with IgAN. Methods: Thirty-one patients with biopsy-proven IgAN (age, 34.48 ± 12.10 years) and 25 healthy controls (age, 44.84 ± 13.72 years) were enrolled. We evaluated the relationship between the levels of Th1/Th2 cytokines and the response to glucocorticoid treatment. Results: The levels of serum interferon-gamma (IFNγ) and urinary monocyte chemoattractant peptide (MCP)-1 were higher in the IgAN group than in the control group. The levels of MCP-1 in urine and secreted by peripheral blood mononuclear cells (PBMCs) were significantly different among three groups categorized based on daily proteinuria. The level of urinary MCP-1 was significantly correlated with proteinuria. The levels of urinary MCP-1, serum interleukin (IL)-4, IFNγ, and IL-2 secreted by PBMCs and intrarenal IL-1 messenger RNA (mRNA) were significantly correlated with the ratio of proteinuria at 6 months to baseline proteinuria in patients undergoing glucocorticoid treatment. MCP-1 mRNA and protein levels were significantly upregulated in mesangial cells stimulated with IFNγ among representative Th1/Th2 cytokines. Conclusion: IFNγ was shown to be a key cytokine in the pathogenic processes underlying IgAN, and its upregulation induced an increase in urinary MCP-1 production. These findings suggest that Th1 cytokines may play an important role in the development of IgAN.