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Computational Fluid Dynamics of Cavitating Flow in Mixed Flow Pump with Closed Type Impeller
Kobayashi, Katsutoshi,Chiba, Yoshimasa Korean Society for Fluid machinery 2010 International journal of fluid machinery and syste Vol.3 No.2
LES(Large Eddy Simulation) with a cavitation model was performed to calculate an unsteady flow for a mixed flow pump with a closed type impeller. First, the comparison between the numerical and experimental results was done to evaluate a computational accuracy. Second, the torque acting on the blade was calculated by simulation to investigate how the cavitation caused the fluctuation of torque. The absolute pressure around the leading edge on the suction side of blade surface had positive impulsive peaks in both the numerical and experimental results. The simulation showed that those peaks were caused by the cavitaion which contracted and vanished around the leading edge. The absolute pressure was predicted by simulation with -10% error. The absolute pressure around the trailing edge on the suction side of blade surface had no impulsive peaks in both the numerical and experimental results, because the absolute pressure was 100 times higher than the saturated vapor pressure. The simulation results showed that the cavitation was generated around the throat, then contracted and finally vanished. The simulated pump had five throats and cavitation behaviors such as contraction and vanishing around five throats were different from each other. For instance, the cavitations around those five throats were not vanished at the same time. When the cavitation was contracted and finally vanished, the absolute pressure on the blade surface was increased. When the cavitation was contracted around the throat located on the pressure side of blade surface, the pressure became high on the pressure side of blade surface. It caused the 1.4 times higher impulsive peak in the torque than the averaged value. On the other hand, when the cavitation was contracted around the throat located on the suction side of blade surface, the pressure became high on the suction side of blade surface. It caused the 0.4 times lower impulsive peak in the torque than the averaged value. The cavitation around the throat caused the large fluctuation in torque acting on the blade.
Akira Mitsuhashi,Yuji Habu,Tatsuya Kobayashi,Yoshimasa Kawarai,Hiroshi Ishikawa,Hirokazu Usui,Makio Shozu 대한부인종양학회 2019 Journal of Gynecologic Oncology Vol.30 No.6
Objective: The present study investigated long-term outcomes of medroxyprogesteroneacetate (MPA) plus metformin therapy in terms of control of atypical endometrial hyperplasia(AEH) and endometrial cancer (EC), and post-treatment conception. Methods: We retrospectively analyzed 63 patients (42 with EC; 21 with AEH) who underwentfertility-sparing management using MPA plus metformin. MPA (400 mg/day) and metformin(750–2,250 mg/day) were administered to achieve complete response (CR). Metformin wasadministered until conception, even after MPA discontinuation. Results: Of the total patients, 48 (76%) had a body mass index (BMI) ≥25 kg/m2 and 43 (68%)showed insulin resistance. Sixty-one patients (97%) achieved CR within 18 months. CR ratesat 6, 8–9, and 12 months were 60%, 84%, and 90%, respectively. During a median followupperiod of 57 months (range, 13–115 months), relapse occurred in 8 of 61 patients (13.1%)who had achieved CR. Relapse-free survival (RFS) in all patients at 5 years was 84.8%. Uponunivariate analysis, patients with BMI ≥25 kg/m2 had significantly better prognoses than didthose with BMI <25 kg/m2 (odds ratio=0.19; 95% confidence interval=0.05–0.66; p=0.009). Overall pregnancy and live birth rates per patient were 61% (19/31) and 45% (14/31), respectively. Conclusions: MPA plus metformin is efficacious in terms of RFS and post treatmentconception. Moreover, metformin may be more efficacious for patients with BMI ≥25 kg/m2.
Takeshi Chida,Kazuhito Kawata,Kazuyoshi Ohta,Erika Matsunaga,Jun Ito,Shin Shimoyama,Satoru Yamazaki,Hidenao Noritake,Tetsuro Suzuki,Takafumi Suda,Yoshimasa Kobayashi 거트앤리버 소화기연관학회협의회 2018 Gut and Liver Vol.12 No.2
Background/Aims: Changes in lipid profiles in patients infected with hepatitis C virus (HCV) during direct-acting antiviral therapy have been reported in recent years. However, the clinical aspects of disturbed lipid metabolism in chronic HCV infection have not been fully elucidated. Methods: Dynamic changes in serum total, low-density lipoprotein (LDL), and high-density lipoprotein (HDL) cholesterol and apolipoprotein levels in patients infected with HCV genotype 1b were examined during combination therapy with daclatasvir (DCV) and asunaprevir (ASV). Results: Total, LDL-, and HDL-cholesterol levels increased rapidly and persistently after week 4. Apolipoprotein (apo) A-I, apo B, apo C-II, and apo C-III levels were significantly higher at week 4 than at week 0. In contrast, apo A-II and apo E levels were significantly lower. The differences in LDL- and HDL-cholesterol levels were positively correlated with those of apo B and apo A-I, respectively. Interestingly, in patients with non-sustained virological response, these cholesterol levels decreased rapidly after viral breakthrough or viral relapse. Furthermore, similar changes were observed for apo A-I, apo B and apo C-III levels. Conclusions: Clearance of HCV using combination therapy with DCV and ASV results in rapid changes in serum lipid profiles, suggesting an influence of HCV infection on disturbed lipid metabolism.