Effect of Heart Rate and Body Mass Index on the Interscan and Interobserver Variability of Coronary Artery Calcium Scoring at Prospective ECG-Triggered 64-Slice CT

Jun Horiguchi,Noriaki Matsuura,Hideya Yamamoto,Masao Kiguchi,Chikako Fujioka,Toshiro Kitagawa,Katsuhide Ito 대한영상의학회 2009 Korean Journal of Radiology Vol.10 No.4

Objective: To test the effects of heart rate, body mass index (BMI) and noise level on interscan and interobserver variability of coronary artery calcium (CAC) scoring on a prospective electrocardiogram (ECG)-triggered 64-slice CT. Materials and Methods: One hundred and ten patients (76 patients with CAC) were scanned twice on prospective ECG-triggered scans. The scan parameters included 120 kV, 82 mAs, a 2.5 mm thickness, and an acquisition center at 45% of the RR interval. The interscan and interobserver variability on the CAC scores (Agatston, volume, and mass) was calculated. The factors affecting the variability were determined by plotting it against heart rate, BMI, and noise level (defined as the standard deviation: SD). Results: The estimated effective dose was 1.5 ± 0.2 mSv. The mean heart rate was 63 ± 12 bpm (range, 44-101 bpm). The patient BMIs were 24.5 ± 4.5 kg/㎡ (range, 15.5-42.3 kg/㎡). The mean and median interscan variabilities were 11% and 6%, respectively by volume, and 11% and 6%, respectively, by mass. Moreover, the mean and median of the algorithms were lower than the Agatston algorithm (16% and 9%, respectively). The mean and median interobserver variability was 10% and 4%, respectively (average of algorithms). The mean noise levels were 15 ± 4 Hounsfield unit (HU) (range, 8-25 HU). The interscan and interobserver variability was not correlated with heart rate, BMI, or noise level. Conclusion: The interscan and interobserver variability of CAC on a prospective ECG-triggered 64-slice CT with high image quality and 45% of RR acquisition is not significantly affected by heart rate, BMI, or noise level. The volume or mass algorithms show reduced interscan variability compared to the Agatston scoring (p < 0.05). Objective: To test the effects of heart rate, body mass index (BMI) and noise level on interscan and interobserver variability of coronary artery calcium (CAC) scoring on a prospective electrocardiogram (ECG)-triggered 64-slice CT. Materials and Methods: One hundred and ten patients (76 patients with CAC) were scanned twice on prospective ECG-triggered scans. The scan parameters included 120 kV, 82 mAs, a 2.5 mm thickness, and an acquisition center at 45% of the RR interval. The interscan and interobserver variability on the CAC scores (Agatston, volume, and mass) was calculated. The factors affecting the variability were determined by plotting it against heart rate, BMI, and noise level (defined as the standard deviation: SD). Results: The estimated effective dose was 1.5 ± 0.2 mSv. The mean heart rate was 63 ± 12 bpm (range, 44-101 bpm). The patient BMIs were 24.5 ± 4.5 kg/㎡ (range, 15.5-42.3 kg/㎡). The mean and median interscan variabilities were 11% and 6%, respectively by volume, and 11% and 6%, respectively, by mass. Moreover, the mean and median of the algorithms were lower than the Agatston algorithm (16% and 9%, respectively). The mean and median interobserver variability was 10% and 4%, respectively (average of algorithms). The mean noise levels were 15 ± 4 Hounsfield unit (HU) (range, 8-25 HU). The interscan and interobserver variability was not correlated with heart rate, BMI, or noise level. Conclusion: The interscan and interobserver variability of CAC on a prospective ECG-triggered 64-slice CT with high image quality and 45% of RR acquisition is not significantly affected by heart rate, BMI, or noise level. The volume or mass algorithms show reduced interscan variability compared to the Agatston scoring (p < 0.05).

Quadricuspid Aortic Valve Complicated with Severe Aortic Regurgitation and Left-Sided Inferior Vena Cava

Jun Shiraishi,Kazunari Okawa,Kohei Muguruma,Daisuke Ito,Masayoshi Kimura,Eigo Kishita,Yusuke Nakagawa,Masayuki Hyogo,Akiyuki Takahashi,Takahisa Sawada 한국심초음파학회 2017 Journal of Cardiovascular Imaging (J Cardiovasc Im Vol.25 No.1

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Assisting Authors to Convert Raw Products into Polished Prose

( Takumi Ito ),( Tatsuki Kuribayashi ),( Hayato Kobayashi ),( Ana Brassard ),( Masato Hagiwara ),( Jun Suzuki ),( Kentaro Inui ) 서울대학교 인지과학연구소 2020 Journal of Cognitive Science Vol.21 No.1

Being a notoriously complex problem, writing is generally decomposed into a series of subtasks: idea generation, expression, revision, etc. Given some goal, the author generates a set of ideas (brainstorming), which he integrates into some skeleton (outline, text plan, outline). This leads to a first draft which is submitted then for revision possibly yielding changes at various levels (content, structure, form). Having made a draft, authors usually revise, edit, and proofread their documents. We confine ourselves here only to academic writing, focusing on sentence production. While there has been quite some work on this topic, most writing assistance has mainly dealt with grammatical errors, editing and proofreading, the goal being the correction of surface-level problems such as typography, spelling, or grammatical errors. We broaden the scope by also including cases where the entire sentence needs to be rewritten in order to express properly all of the information planned. Hence, Sentence-level Revision (SentRev) becomes part of our writing assistance task. Obviously, systems performing well in this task can be of considerable help for inexperienced authors by producing fluent, well-formed sentences based on the user’s drafts. In order to evaluate our SentRev model, we have built a new, freely available crowdsourced evaluation dataset which consists of a set of incomplete sentences produced by nonnative writers paired with final version sentences extracted from published academic papers. We also used this dataset to establish baseline performance on SentRev.

Central Nervous System Drug Evaluation Using Positron Emission Tomography

Mizuho Sekine,Jun Maeda,Hitoshi Shimada,Tsuyoshi Nogami,Ryosuke Arakawa,Harumasa Takano,Makoto Higuchi,Hiroshi Ito,Yoshiro Okubo,Tetsuya Suhara 대한정신약물학회 2011 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.9 No.1

In conventional pharmacological research in the field of mental disorders, pharmacological effect and dose have been estimated by ethological approach and in vitro data of affinity to the site of action. In addition, the frequency of administration has been estimated from drug kinetics in blood. However, there is a problem regarding an objective index of drug effects in the living body. Furthermore, the possibility that the concentration of drug in blood does not necessarily reflect the drug kinetics in target organs has been pointed out. Positron emission tomography (PET) techniques have made progress for more than 20 years,and made it possible to measure the distribution and kinetics of small molecule components in living brain. In this article, we focused on rational drug dosing using receptor occupancy and proof-of-concept of drugs in the drug development process using PET.

Experimental Study of the Sound Field in Water Generated from a Vibrating Plate with Flexural Traveling Waves

Noritoshi NAKAGAWA,Jun SATONOBU,Takao ITO 한국소음진동공학회 2003 한국소음진동공학회 국제학술대회논문집 Vol.2003 No.8

Warehouse-design Support considering Seasonal Products

Makoto Nikaido,Jun Ota,Toyokazu Kobayashi,Tomio Ito,Toshimitsu Higashi,Hirofumi Tamura 제어로봇시스템학회 2006 제어로봇시스템학회 국제학술대회 논문집 Vol.2006 No.10

PEBP2-β/CBF-β-dependent phosphorylation of RUNX1 and p300 by HIPK2: implications for leukemogenesis

Wee, Hee-Jun,Voon, Dominic Chih-Cheng,Bae, Suk-Chul,Ito, Yoshiaki American Society of Hematology 2008 Blood Vol.112 No.9

<P>The heterodimeric transcription factor RUNX1/PEBP2-β (also known as AML1/CBF-β) is essential for definitive hematopoiesis. Here, we show that interaction with PEBP2-β leads to the phosphorylation of RUNX1, which in turn induces p300 phosphorylation. This is mediated by homeodomain interacting kinase 2 (HIPK2), targeting Ser249, Ser273, and Thr276 in RUNX1, in a manner that is also dependent on the RUNX1 PY motif. Importantly, we observed the in vitro disruption of this phosphorylation cascade by multiple leukemogenic genetic defects targeting RUNX1/CBFB. In particular, the oncogenic protein PEBP2-β-SMMHC prevents RUNX1/p300 phosphorylation by sequestering HIPK2 to mislocalized RUNX1/β-SMMHC complexes. Therefore, phosphorylation of RUNX1 appears a critical step in its association with and phosphorylation of p300, and its disruption may be a common theme in RUNX1-associated leukemogenesis.</P>

Transfer kinetics of perfluorooctane sulfonate from water and sediment to a marine benthic fish, the marbled flounder ( <i>Pseudopleuronectes yokohamae</i> )

Sakurai, Takeo,Kobayashi, Jun,Kinoshita, Kyoko,Ito, Nozomi,Serizawa, Shigeko,Shiraishi, Hiroaki,Lee, Jeong-Hoon,Horiguchi, Toshihiro,Maki, Hideaki,Mizukawa, Kaoruko,Imaizumi, Yoshitaka,Kawai, Toru,Suz Wiley Periodicals 2013 Environmental toxicology and chemistry Vol.32 No.9

<P>The authors investigated the kinetics of transfer of perfluorooctane sulfonate (PFOS) from water, suspended sediment, and bottom sediment to a marine benthic fish, the marbled flounder (<I>Pseudopleuronectes yokohamae</I>). Fish were exposed in 3 treatments to PFOS in combinations of these exposure media for 28 d and then depurated for 84 d. A major part (37–66%) of PFOS in the fish was in the carcass (i.e., whole body minus muscle and internal organs). Three first-order-kinetic models that differed in exposure media, that is, 1) sum of dissolved and particulate phases and sediment; 2) dissolved phase, particulate phase, and sediment; and 3) dissolved phase only, were fitted to the data assuming common rate constants among the treatments. The uptake efficiency of dissolved PFOS at the respiratory surfaces was estimated to be 3.2% that of oxygen, and the half-life of PFOS in the whole body to be 29 d to 31 d. The better fit of models 1 and 2 and the values of the estimated uptake rate constants suggested that the PFOS in suspended and bottom sediments, in addition to that dissolved in water, contributed to the observed body burden of the fish. Based on an evaluation of several possible contributing factors to the uptake of PFOS from suspended and bottom sediments, the authors propose that further investigation is necessary regarding the mechanisms responsible for the uptake. <I>Environ Toxicol Chem</I> 2013;32:2009–2017. © 2013 The Authors. <I>Environmental Toxicology and Chemistry</I> Published by Wiley Periodicals, Inc., on behalf of SETAC. This is an open access article under the terms of the Creative Commons Attribution Non-Commercial License, which permits use, distribution, and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.</P>

The <i>Plasmodium vivax</i> Merozoite Surface Protein 1 Paralog Is a Novel Erythrocyte-Binding Ligand of <i>P. vivax</i>

Cheng, Yang,Wang, Yue,Ito, Daisuke,Kong, Deok-Hoon,Ha, Kwon-Soo,Chen, Jun-Hu,Lu, Feng,Li, Jian,Wang, Bo,Takashima, Eizo,Sattabongkot, Jetsumon,Tsuboi, Takafumi,Han, Eun-Taek American Society for Microbiology 2013 Infection and immunity Vol.81 No.5

<P>Merozoite surface protein 1 of <I>Plasmodium vivax</I> (PvMSP1), a glycosylphosphatidylinositol-anchored protein (GPI-AP), is a malaria vaccine candidate for <I>P. vivax</I>. The paralog of PvMSP1, named <I>P. vivax</I> merozoite surface protein 1 paralog (PvMSP1P; PlasmoDB PVX_099975), was recently identified and predicted as a GPI-AP. The similarities in genetic structural characteristics between PvMSP1 and PvMSP1P (e.g., size of open reading frames, two epidermal growth factor-like domains, and GPI anchor motif in the C terminus) led us to study this protein. In the present study, different regions of the PvMSP1P protein, demarcated based on the processed forms of PvMSP1, were expressed successfully as recombinant proteins [i.e., 83 (A, B, and C), 30, 38, 42, 33, and 19 fragments]. We studied the naturally acquired immune response against each fragment of recombinant PvMSP1P and the potential ability of each fragment to bind erythrocytes. The N-terminal fragment (83A) and two C-terminal fragments (33 and 19) reacted strongly with sera from <I>P. vivax</I>-infected patients, with 50 to 68% sensitivity and 95 to 96% specificity, respectively. Due to colocalization of PvMSP1P with PvMSP1, we supposed that PvMSP1P plays a similar role as PvMSP1 during erythrocyte invasion. An <I>in vitro</I> cytoadherence assay showed that PvMSP1P, especially the 19-kDa C-terminal region, could bind to erythrocytes. We also found that human sera from populations naturally exposed to vivax malaria and antisera obtained by immunization using the recombinant molecule PvMSP1P-19 inhibited <I>in vitro</I> binding of human erythrocytes to PvMSP1P-19. These results provide further evidence that the PvMSP1P might be an essential parasite adhesion molecule in the <I>P. vivax</I> merozoite and is a potential vaccine candidate against <I>P. vivax</I>.</P>

Constitutive Equations Based on Non-associated Flow Rule for the Analysis of Forming of Anisotropic Sheet Metals

Boxun Wu,Koichi Ito,Naomichi Mori,Tetsuo Oya,Tom Taylor,Jun Yanagimoto 한국정밀공학회 2020 International Journal of Precision Engineering and Vol.7 No.2

In this study, an anisotropic constitutive model based on the non-associated flow rule was developed for anisotropic sheet metals. This model was defined in the quadratic form of the Hill’s anisotropic function under a general three-dimensional stress condition. The anisotropic parameters for the yield function were identified using the directional planar yield stresses, bulge yield stress and shear yield stress, while those for the plastic potential function were identified using the directional r-values. A full expression related to the non-associated flow rule was applied and the model was implemented into the finite element code ABAQUS. A static-implicit analysis and the solid element were applied. Capability of the developed model for predicting the anisotropic behavior of sheet metal was investigated by considering two different sheet metal forming processes: cylindrical cup drawing of AA2090-T3, A6061P-T6 and SPCE; and hole expansion forming test of A6016-O. Cup heights and through-thickness strain distributions obtained from the simulations were compared with the experimental data. Results demonstrate that the developed material model considering 3D condition can improve accuracy of predicting the anisotropic behaviors. Furthermore, the simple formulations are efficient and user-friendly for computational analyses and solving the common industrial sheet metal forming problems.