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Multi-Objective Design Exploration and its Applications
Obayashi, Shigeru,Jeong, Shin-Kyu,Shimoyama, Koji,Chiba, Kazuhisa,Morino, Hiroyuki The Korean Society for Aeronautical and Space Scie 2010 International Journal of Aeronautical and Space Sc Vol.11 No.4
Multi-objective design exploration (MODE) and its applications are reviewed as an attempt to utilize numerical simulation in aerospace engineering design. MODE reveals the structure of the design space based on trade-off information. A self-organizing map (SOM) is incorporated into MODE as a visual data mining tool for the design space. SOM divides the design space into clusters with specific design features. This article reviews existing visual data mining techniques applied to engineering problems. Then, we discuss three applications of MODE: multidisciplinary design optimization for a regional-jet wing, silent supersonic technology demonstrator and centrifugal diffusers.
Nakanishi, Toshimichi,Hong, Wan,Shimoyama, Shoichi,Sato, Shin’ichi,Park, Gyujun,Lee, Jong-Geol UNIVERSITY OF ARIZONA 2017 RADIOCARBON Vol.59 No.2
<B>Abstract</B><P>To measure chronological changes in the marine reservoir effect in western Japan, 47 marine shells and 35 terrestrial plants from the same horizons in two cores of Holocene sediments were radiocarbon dated by the KIGAM AMS facility. These cores were obtained from the central and northern parts of Hakata Bay using a Geoslicer device. This drilling tool provided us continuous coverage and many samples. In order to determine the species effects on the marine reservoir effect, both filter feeders and a deposit feeder were selected for study. Based on the analysis of lithology, mollusk assemblage, and <SUP>14</SUP>C dating, two sedimentary units were determined: the upper bay floor sediment and lower estuarine sediment. Reservoir ages of 280±150 yr (<I>n</I>=17) and 340±140 yr (<I>n</I>=18) were obtained from the central and northern parts of Hakata Bay during 2000 to 10,000 cal BP, respectively. Based on these results, it is clear that a paleoenvironmental change occurred here as a result of sea-level rise during the deglacial period.</P>
Takeshi Chida,Kazuhito Kawata,Kazuyoshi Ohta,Erika Matsunaga,Jun Ito,Shin Shimoyama,Satoru Yamazaki,Hidenao Noritake,Tetsuro Suzuki,Takafumi Suda,Yoshimasa Kobayashi 거트앤리버 소화기연관학회협의회 2018 Gut and Liver Vol.12 No.2
Background/Aims: Changes in lipid profiles in patients infected with hepatitis C virus (HCV) during direct-acting antiviral therapy have been reported in recent years. However, the clinical aspects of disturbed lipid metabolism in chronic HCV infection have not been fully elucidated. Methods: Dynamic changes in serum total, low-density lipoprotein (LDL), and high-density lipoprotein (HDL) cholesterol and apolipoprotein levels in patients infected with HCV genotype 1b were examined during combination therapy with daclatasvir (DCV) and asunaprevir (ASV). Results: Total, LDL-, and HDL-cholesterol levels increased rapidly and persistently after week 4. Apolipoprotein (apo) A-I, apo B, apo C-II, and apo C-III levels were significantly higher at week 4 than at week 0. In contrast, apo A-II and apo E levels were significantly lower. The differences in LDL- and HDL-cholesterol levels were positively correlated with those of apo B and apo A-I, respectively. Interestingly, in patients with non-sustained virological response, these cholesterol levels decreased rapidly after viral breakthrough or viral relapse. Furthermore, similar changes were observed for apo A-I, apo B and apo C-III levels. Conclusions: Clearance of HCV using combination therapy with DCV and ASV results in rapid changes in serum lipid profiles, suggesting an influence of HCV infection on disturbed lipid metabolism.