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Monitoring of Corrugation Growth on Tracks with Cologne Egg Fastening System
Hengyu Wang,Stuart Grassie,Yongquan Deng,Heji Zhang,Wenjian Wang,Zefeng Wen,Xuesong Jin 한국도시철도학회 2014 IJAR Vol.2 No.2
Corrugation is a serious problem in railway industry. It may be more commonly seen in metro networks for that metro lines usually have more and sharper curves than the main lines. Research has shown that fastening system is an influence factor on corrugation. Server corrugation was found on tracks with Cologne egg fastening system (Cologne egg for short) shortly after the operation of a metro line. To understand the effects of Cologne eggs on the development of corrugation, curved and tangent lines with Cologne eggs were selected for corrugation growth monitoring. In order to compare the effects of different fastening systems on corrugation, monitoring was also conducted on tracks with the same line condition but using ordinary short sleeper fastening system. Monitoring of rail roughness was done during the whole period between two rail grinding operations using a Corrugation Analysis Trolley (CAT). The characteristics of corrugation growth, such as the speed of growth, the wavelength of corrugation, the distribution of corrugation, etc. were analyzed on different track configurations. Corrugation showed a rapid growth in the first a few weeks after grinding and slowed down after that. Monitoring results show that fasting system is a strong influence factor of corrugation growth. The effect of grinding was discussed. Comparison of corrugation growth of different grinding methods shows that proper grinding method would not only reduce the speed of corrugation growth, but also the final rail roughness level.
Liancai Wang,Yingfeng Wu,Liang Chen,Yongquan Gu,Tingfei Xi,Aiying Zhang,Zeng-guo Feng 한국물리학회 2005 Current Applied Physics Vol.5 No.5
As initial step for developing tissue-engineered vascular autografts, a novel series of biodegradable aliphaticaromatic copoly-esters were synthesized and tubular scaolds were fabricated. Cytotoxicity, adhesion and growth of dierent kinds of cells on thepolyester lms and in vivo biocompatibility have been evaluated. The results indicate that these copolyesters possess good biocom-patibility. Canine bone marrow cells were seeded on the scaolds and cultured in a bioreactor for 3 days. A conuent, adherentmonolayer bone marrow cells was observed in the scaold lumen. All the testing results suggest that these copolyesters might ulti-mately nd applications for vascular tissue engineering..
( Qiuke Hou ),( Yongquan Huang ),( Yan Wang ),( Liu Liao ),( Zhaoyang Zhu ),( Wenjie Zhang ),( Yongshang Liu ),( Peiwu Li ),( Xinlin Chen ),( Fengbin Liu ) 한국미생물 · 생명공학회 2020 Journal of microbiology and biotechnology Vol.30 No.10
Our previous report determined that miR-144 is a key regulator of intestinal epithelial permeability in irritable bowel syndrome with diarrhea (IBS-D) rats. Recent evidence has shown that lactobacilli play an important role in the relief of IBS-D symptoms. However, few studies have addressed the mechanisms by which microRNAs and lactobacilli exert their beneficial effects on intestinal epithelial permeability. Hence, to elucidate whether miRNAs and lactobacilli play roles in intestinal epithelial barrier regulation, we compared miRNA expression levels in intestinal epithelial cells (IECs) under Lactobacillus casei (L. casei LC01) treatment. IECs and L. casei LC01 were co-cultured and then subjected to microRNA microarray assay. qRT-PCR, western blot and ELISA were used to detect the expression of occludin (OCLN) and zonula occludens 1 (ZO1/TJP1). The interaction between miRNAs and L. casei LC01 acting in IECs was investigated through transfection of RNA oligoribonucleotides and pcDNA 3.1 plasmid. The results are as follows: 1) L. casei LC01 decreased the expression of miR-144 and FD4 and promoted OCLN and ZO1 expression in IECs; 2) L. casei LC01 enhanced the barrier function of IECs via downregulation of miR-144 and upregulation of OCLN and ZO1; 3) Under L. casei LC01 treatment, OCLN and ZO1 overexpression could partially eliminate the promoting effect of miR-144 on intestinal permeability in IECs. Our results demonstrate that L. casei LC01 regulates intestinal permeability of IECs through miR-144 targeting of OCLN and ZO1. L. casei LC01 can be a possible therapeutic target for managing dysfunction of the intestinal epithelial barrier.
Isobaric vapor-liquid equilibrium for methanol+benzene+1-octyl-3-methylimidazolium tetrafluoroborate
Qunsheng Li,Baohua Wang,Wei Zhu,Yongquan Fu,Magtuf Zuhir,Lun Li 한국화학공학회 2012 Korean Journal of Chemical Engineering Vol.29 No.7
Isobaric vapor-liquid equilibrium (VLE) data for {methanol (1)+benzene (2)+1-octyl-3-methylimidazolium tetrafluoroborate (3)} where 3 is an ionic liquid ([OMIM]+[BF4]−) at atmospheric pressure (101.32 kPa) were measured with a modified Othmer still. The results showed that the ionic liquid studied can transfer the azeotropic point and eliminate the azeotropic phenomena when its concentration is up to x3=0.30. This means that [OMIM]+[BF4]− can be used as a promising entrainer in the application of extractive distillation. The measured ternary data were correlated using the NRTL model.
Qiang Xu,Shengxiang Lei,Yongquan Zhu,Wei Zhao,Cong Wang,Dapeng Wang 대한토목학회 2022 KSCE JOURNAL OF CIVIL ENGINEERING Vol.26 No.9
The deformation pattern of the stratum caused by constructing a new metro tunnel crossing an existing tunnel is different from the deformation pattern caused by general tunnel construction. However, the prediction results by the ordinary surface settlement prediction model often bring significant errors because the complex influence of existing tunnels on the surface settlement caused by the excavation of new tunnels is always neglected. Based on the equivalent layered method and stochastic medium theory, a prediction model for the surface settlement due to excavating a new tunnel under an existing tunnel in the heterogeneous stratum was established. By equating the bending stiffness of an existing tunnel before and after applying the equivalent layered method, the layer index was determined. The critical parameters of the stochastic medium theory were derived based on the relationship between the critical parameters of both the Peck empirical formula and the stochastic medium theory. The surface settlement of some typical projects was predicted and compared by the prediction model in this paper and the ordinary prediction model. The comparison shows that the proposed prediction model and parameter determination method in this paper had high accuracy and applicability. The results of the prediction model in this paper fit the results of numerical calculation. The research of this paper can provide a new method for the theoretical prediction of surface settlement caused by the excavation of a new tunnel under an existing tunnel in the heterogeneous stratum and the determination of critical parameters of the stochastic medium theory.problem in the construction industry, and helps reducing the material waste and budget cost.
A Study on Fracture Behavior and Impact Stability of Sintered Rare-earth Permanent Magnets
Li Wei,Li Anhua,Wang Huijie,Dong Shengzhi,Guo Yongquan 한국분말야금학회 2006 한국분말야금학회 학술대회논문집 Vol.2006 No.1
The fracture behavior and mechanical characteristics of sintered rare-earth magnets were investigated. It shows that the fracture behavior and bending strength of the magnets obviously exhibit anisotropy. Sm-Co magnets tend to cleavage fracture in the close-packed (0001) plane or in the (10 11 ) plane. The fracture mechanism of Nd2Fe14B magnet mainly appears to be intergranular fracture. The anisotropy of fracture behavior and mechanical strength of sintered rare-earth magnets is caused mainly by the strong crystal-structure anisotropy and the grain alignment texture. The effects of Nd content, and Pr, Dy substitution on the impact stability of Nd2Fe14B magnets were also reported.
BMB Reports : Poly(ADP-ribose) protects vascular smooth muscle cells from oxidative DNA damage
( Chao Zhang ),( Tao Luo ),( Shijun Cui ),( Yongquan Gu ),( Chunjing Bian ),( Yibin Chen ),( Xiaochun Yu ),( Zhonggao Wang ) 생화학분자생물학회(구 한국생화학분자생물학회) 2015 BMB Reports Vol.48 No.6
Vascular smooth muscle cells (VSMCs) undergo death during atherosclerosis, a widespread cardiovascular disease. Recent studies suggest that oxidative damage occurs in VSMCs and induces atherosclerosis. Here, we analyzed oxidative damage repair in VSMCs and found that VSMCs are hypersensitive to oxidative damage. Further analysis showed that oxidative damage repair in VSMCs is suppressed by a low level of poly (ADP-ribosyl)ation (PARylation), a key post-translational modification in oxidative damage repair. The low level of PARylation is not caused by the lack of PARP-1, the major poly(ADP-ribose) polymerase activated by oxidative damage. Instead, the expression of poly(ADP-ribose) glycohydrolase, PARG, the enzyme hydrolyzing poly(ADP-ribose), is significantly higher in VSMCs than that in the control cells. Using PARG inhibitor to suppress PARG activity facilitates oxidative damage-induced PARylation as well as DNA damage repair. Thus, our study demonstrates a novel molecular mechanism for oxidative damage-induced VSMCs death. This study also identifies the use of PARG inhibitors as a potential treatment for atherosclerosis. [BMB Reports 2015; 48(6): 354-359]
Fengwei Tian,Feifei Chi,Gang Wang,Xiaoming Liu,Qiuxiang Zhang,Yongquan Chen,Hao Zhang,Wei Chen 한국미생물학회 2015 The journal of microbiology Vol.53 No.12
Lactobacillus rhamnosus CCFM1107 was screened for high antioxidative activity from 55 lactobacilli. The present study attempted to explore the protective properties of L. rhamnosus CCFM1107 in alcoholic liver injury. A mouse model was induced by orally feeding alcohol when simultaneously treated with L. rhamnosus CCFM1107, the drug Hu-Gan- Pian (HGP), L. rhamnosus GG (LGG), and L. plantarum CCFM1112 for 3 months. Biochemical analysis was performed for both serum and liver homogenate. Detailed intestinal flora and histological analyses were also carried out. Our results indicated that the administration of L. rhamnosus CCFM1107 significantly inhibited the increase in the levels of serum aminotransferase and endotoxin, as well as the levels of triglyceride (TG) and cholesterol (CHO) in the serum and in the liver. Glutathione (GSH), glutathione peroxidase (GSH-Px) and superoxide dismutase (SOD) were elevated while the levels of malondialdehyde (MDA) were decreased. The enteric dysbiosis caused by alcohol was restored by increasing the numbers of both lactobacilli and bifidobacteria and decreasing the numbers of both enterococci and enterobacter. Histological analysis confirmed the protective effect of L. rhamnosus CCFM1107. Compared with the other lactobacilli and to the drug Hu-Gan-Pian, there is a high chance that L. rhamnosus CCFM1107 provides protective effects on alcoholic liver injury by reducing oxidative stress and restoring the intestinal flora.