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      • Monitoring of Corrugation Growth on Tracks with Cologne Egg Fastening System

        Hengyu Wang,Stuart Grassie,Yongquan Deng,Heji Zhang,Wenjian Wang,Zefeng Wen,Xuesong Jin 한국도시철도학회 2014 IJAR Vol.2 No.2

        Corrugation is a serious problem in railway industry. It may be more commonly seen in metro networks for that metro lines usually have more and sharper curves than the main lines. Research has shown that fastening system is an influence factor on corrugation. Server corrugation was found on tracks with Cologne egg fastening system (Cologne egg for short) shortly after the operation of a metro line. To understand the effects of Cologne eggs on the development of corrugation, curved and tangent lines with Cologne eggs were selected for corrugation growth monitoring. In order to compare the effects of different fastening systems on corrugation, monitoring was also conducted on tracks with the same line condition but using ordinary short sleeper fastening system. Monitoring of rail roughness was done during the whole period between two rail grinding operations using a Corrugation Analysis Trolley (CAT). The characteristics of corrugation growth, such as the speed of growth, the wavelength of corrugation, the distribution of corrugation, etc. were analyzed on different track configurations. Corrugation showed a rapid growth in the first a few weeks after grinding and slowed down after that. Monitoring results show that fasting system is a strong influence factor of corrugation growth. The effect of grinding was discussed. Comparison of corrugation growth of different grinding methods shows that proper grinding method would not only reduce the speed of corrugation growth, but also the final rail roughness level.

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        Restoration of dysregulated intestinal barrier and inflammatory regulation through synergistically ameliorating hypoxia and scavenging reactive oxygen species using ceria nanozymes in ulcerative colitis

        Ying Zhang,Hengyu Lei,Pengchong Wang,Qinyuan Zhou,Jie Yu,Xue Leng,Ruirui Ma,Danyang Wang,Kai Dong,Jianfeng Xing,Yalin Dong 한국생체재료학회 2023 생체재료학회지 Vol.27 No.00

        Background Reactive oxygen species (ROS) overproduction and excessive hypoxia play pivotal roles in the initiation and progression of ulcerative colitis (UC). Synergistic ROS scavenging and generating O2 could be a promising strategy for UC treatment. Methods Ceria nanozymes (PEG-CNPs) are fabricated using a modified reverse micelle method. We investigate hypoxia attenuating and ROS scavenging of PEG-CNPs in intestinal epithelial cells and RAW 264.7 macrophages and their effects on pro-inflammatory macrophages activation. Subsequently, we investigate the biodistribution, pharmacokinetic properties and long-term toxicity of PEG-CNPs in mice. PEG-CNPs are administered intravenously to mice with 2,4,6-trinitrobenzenesulfonic acid-induced colitis to test their colonic tissue targeting and assess their anti-inflammatory activity and mucosal healing properties in UC. Results PEG-CNPs exhibit multi-enzymatic activity that can scavenge ROS and generate O2, promote intestinal epithelial cell healing and inhibit pro-inflammatory macrophage activation, and have good biocompatibility. After intravenous administration of PEG-CNPs to colitis mice, they can enrich at the site of colonic inflammation, and reduce hypoxia-induced factor-1α expression in intestinal epithelial cells by scavenging ROS to generate O2, thus further promoting disrupted intestinal mucosal barrier restoration. Meanwhile, PEG-CNPs can effectively scavenge ROS in impaired colon tissues and relieve colonic macrophage hypoxia to suppress the pro-inflammatory macrophages activation, thereby preventing UC occurrence and development. Conclusion This study has provided a paradigm to utilize metallic nanozymes, and suggests that further materials engineering investigations could yield a facile method based on the pathological characteristics of UC for clinically managing UC.

      • Monitoring and Cause Analysis of Tread Abnormal Wear in a Metro Line

        Heji Zhang,Guiming Mei,Hengyu Wang,Wenjian Wang,Zefeng Wen,Xuesong Jin 한국도시철도학회 2014 IJAR Vol.2 No.2

        Abnormal wera of tread is a commonly seen problem in the operation of metro systems. It was found that abnormal wear of tread widely exists on vehicles in a line of Beijing metro. The two main types of abnormal wear are “w” shape wear and narrow grooves on tread. It was found that hardness of the tread is strongly correlated with abnormal wear. Monitoring was conducted to watch the growth of abnormal wear on tread surface. Monitoring results show that abnormal wear of tread disappeared after changing brake shoes. Analysis showed that hardness of brake shoes have a great effect on tread wear. The competition between the wear of wheel tread caused by brake shoes and rail head was discussed to explain the reason of commonly seen abnormal wear of tread in metro systems.

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        Low noise optimization of two-stage gearbox housing structure based on acoustic contribution analysis and topology optimization

        Le Qi,Jianxing Zhou,Pengcheng Jin,Mingming Wang,Yongzheng Su,Hengyu Zhou,Guochun Liu,Lirui Song 대한기계학회 2023 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.37 No.9

        In this paper, a rib layout optimization method that can efficiently reduce the radiated noise of gearboxes is proposed. Taking the secondary gearbox as the research object, the radiated noise of the housing is calculated using the FEM/BEM method, the process of determining the region with the maximum acoustic contribution is illustrated, and a topology optimization model that can reduce the air noise on the field points of the gearbox is established with the surface normal velocity of the region as the optimization target. The method is applied to add new noise reduction ribs on the surface of the gearbox. The results show that after combining the topology optimization with the acoustic contribution analysis, the sound pressure in the area with the highest sound pressure on the gearbox sound field is significantly reduced by adding new noise reduction ribs according to the optimization results.

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