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疎水性 環境이 Spermine에 의하여 誘發되는 凝縮된 DNA의 異例的 吸光度-溫度樣相에 미치는 影響
高東成,李天培,崔宇永,李璨容 충남대학교 1985 忠南科學硏究誌 Vol.12 No.2
We have investigated the effect of hydrophobic environmental reagents (urea and DMSO) on the anomalous absorbance-temperature profile of condensed DNA, induced by spermine. The cooperativity of the phase transition to the trough region in the anomalous absorbance-temperature profile is more sensitive to the hydrophobic environmental reagents than that of the melting region, and the trough peak size can be decreased by increased concentration of the hydrophobic reagents. The present data indicate the importance of hydrophobic interaction in the stabilization of the condensed state of DNA induced by spermine, and that the anomalous absorbance-temperature profile is due to the thermal stabilization of the tertiary structure of the spermine-induced collapsed state of the DNA.
高東成,李天培,崔宇永,李璨容 충남대학교 기초과학연구소 1986 연구논문집 Vol.6 No.-
We have investigated the effect of hydrophobic environmental reagents (urea and DMSO) on the anomalous absorbance-temperature profile of condensed DNA, induced by spermine. The cooperativity of the phase transition to the trough region in the anomalous absorbance-temperature profile is more sensitive to the hydrophobic environmental reagents than that of the melting region, and the trough peak size can be decreased by increased concentration of the hydrophobic reagents. The present data indicate the importance of hydrophobic interaction in the stabilization of the condensed state of DNA induced by spermine, and that the anomalous absorbance-temperature profile is due to the thermal stabilization of the tertiary structure of the spermine-induced collapsed state of the DNA.
Aminopeptidase M 저해제인 Valistatin과 des-Asp^4-Amastatin을 생산하는 방선균 SL20209의 특성 및 동정
고학룡,전효곤,정명철,서현효,김홍중,박용하,고영희 한국미생물생명공학회 ( 구 한국산업미생물학회 ) 1996 한국미생물·생명공학회지 Vol.24 No.1
Aminopeptidase M 저해제인 valistatin과 des-asp^4-amastatin을 생산하는 방선균 분리주 SL20209의 특성을 조사하고 수리동정을 실시하였다. 형태적, 배양학적 및 생리적 특성으로 부터 SL20209는 방성균 중에서도 Streptomyces 속에 속하는 것으로 나타났으며, 43개의 분류단위 특성으로 TAXON program을 이용하여 수리동정한 결과, 주군집 29의 Streptomyces 중 Streptomyces griseoplanus와 가장 근접한 것으로 나타났다. 따라서, 분리주 SL20209를 S. griseoplanus SL20209로 동정하였다. Characterization and numerical identification were carried out for an actionmycetes SL20209. Morphological, cultural and physiological properties of SL20209 which produced valistatin and des-asp^4-amastatin as inhibitors of aminopeptidase M were evaluated. The isolate was identified to be the genus of Streptomyces. Fourty-three taxonomic units were analysed by using a TAXON program. The isolate was classified into the major cluster 29 of Streptomyces and best-matched to Streptomyces griseoplanus.
( Yong-hyun Ko ),( Seung-hwan Kwon ),( Ji-young Hwang ),( Kyung-in Kim ),( Jee-yeon Seo ),( Thi-lien Nguyen ),( Seok-yong Lee ),( Hyoung-chun Kim ),( Choon-gon Jang ) 한국응용약물학회 2018 Biomolecules & Therapeutics(구 응용약물학회지) Vol.26 No.2
Liquiritigenin (LQ) is a flavonoid that can be isolated from Glycyrrhiza radix. It is frequently used as a tranditional oriental medicine herbal treatment for swelling and injury and for detoxification. However, the effects of LQ on cognitive function have not been fully explored. In this study, we evaluated the memory-enhancing effects of LQ and the underlying mechanisms with a focus on the N-methyl-D-aspartic acid receptor (NMDAR) in mice. Learning and memory ability were evaluated with the Y-maze and passive avoidance tests following administration of LQ. In addition, the expression of NMDAR subunits 1, 2A, and 2B; postsynaptic density-95 (PSD-95); phosphorylation of Ca<sup>2+</sup>/calmodulin-dependent protein kinase II (CaMKII); phosphorylation of extracellular signal-regulated kinase 1/2 (ERK 1/2); and phosphorylation of cAMP response element binding (CREB) proteins were examined by Western blot. In vivo, we found that treatment with LQ significantly improved memory performance in both behavioral tests. In vitro, LQ significantly increased NMDARs in the hippocampus. Furthermore, LQ significantly increased PSD-95 expression as well as CaMKII, ERK, and CREB phosphorylation in the hippocampus. Taken together, our results suggest that LQ has cognition enhancing activities and that these effects are mediated, in part, by activation of the NMDAR and CREB signaling pathways.
Ko, Yong-Hyun,Kwon, Seung-Hwan,Hwang, Ji-Young,Kim, Kyung-In,Seo, Jee-Yeon,Nguyen, Thi-Lien,Lee, Seok-Yong,Kim, Hyoung-Chun,Jang, Choon-Gon The Korean Society of Applied Pharmacology 2018 Biomolecules & Therapeutics(구 응용약물학회지) Vol.26 No.2
Liquiritigenin (LQ) is a flavonoid that can be isolated from Glycyrrhiza radix. It is frequently used as a tranditional oriental medicine herbal treatment for swelling and injury and for detoxification. However, the effects of LQ on cognitive function have not been fully explored. In this study, we evaluated the memory-enhancing effects of LQ and the underlying mechanisms with a focus on the N-methyl-D-aspartic acid receptor (NMDAR) in mice. Learning and memory ability were evaluated with the Y-maze and passive avoidance tests following administration of LQ. In addition, the expression of NMDAR subunits 1, 2A, and 2B; postsynaptic density-95 (PSD-95); phosphorylation of $Ca^{2+}$/calmodulin-dependent protein kinase II (CaMKII); phosphorylation of extracellular signal-regulated kinase 1/2 (ERK 1/2); and phosphorylation of cAMP response element binding (CREB) proteins were examined by Western blot. In vivo, we found that treatment with LQ significantly improved memory performance in both behavioral tests. In vitro, LQ significantly increased NMDARs in the hippocampus. Furthermore, LQ significantly increased PSD-95 expression as well as CaMKII, ERK, and CREB phosphorylation in the hippocampus. Taken together, our results suggest that LQ has cognition enhancing activities and that these effects are mediated, in part, by activation of the NMDAR and CREB signaling pathways.
Challenge to Future Displays: Transparent AM-OLED driven by PEALD grown ZnO TFT
Ko Park, Sang-Hee,Hwang, Chi-Sun,Byun, Chun-Won,Ryu, Min-Ki,Lee, Jeong-Ik,Chu, Hye-Yong,Cho, Kyoung-Ik,Chae, Jang-Youl,Han, Se-Jin The Korean Infomation Display Society 2007 建設技術情報 Vol.2007 No.8
We have fabricated 3.5” transparent AM-OLED panel driven by PEALD grown ZnO TFT. The performance of ZnO thin film transistor was improved by adapting top gate structure, protection layer for ZnO from photolithography process, optimizing temperature and plasma power of ZnO growth process. The ZnO-TFT has a mobility of <TEX>$8.9cm^2/V.s$</TEX>, a subthreshold swing of 0.95V, and an on/off ratio of <TEX>$10^7$</TEX>.
Ko, Young Gun,Chun, Yong Jin,Kim, Choong Hyun,Choi, Ung Su Elsevier 2011 Journal of hazardous materials Vol.194 No.-
<P><B>Graphical abstract</B></P><P><ce:figure id='fig0005'></ce:figure></P><P><B>Highlights</B></P><P>► The crystal growth of Cu(II) ions on the novel chelating fiber. ► Adsorption capacity of Cu(II) and Cr(VI) ions in the chelating fiber packed column. ► This work demonstrates the adsorption process system with the chelating fiber for the removal of Cu(II) and Cr(VI) ions in the aqueous solution.</P> <P><B>Abstract</B></P><P>Herein, we demonstrate the adsorption process system with the diethylenetriamne coupled polyacrylonitrile fiber for the removal of Cu(II) and Cr(VI) ions in the aqueous solution. The synthesized chelating fiber showed a high adsorption capacity of 11.4mequiv/g. Interestingly, the crystal growth of copper ions on the chelating fiber was observed during the adsorption process. The chelating fiber packed column showed the high performance of the removal of Cu(II) in the aqueous solution due to the distinct characteristic of the crystal growth of metal ions on the chelating fiber. After Cu(II) adsorption on the chelating fiber, the color of the fiber changed to light blue from yellow. The isotherm parameter <I>n</I> of 1.991 was obtained with Freundlich isotherm model for the adsorption equilibrium study which indicates that Cu(II) adsorption on the chelating fiber is very favorable due to <I>n</I>>1. The pseudo-first-order and pseudo-second-order model equations were used for the kinetic study.</P>