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Determinants of Exercise Capacity in Patients With Hypertrophic Cardiomyopathy
Hwang Ji-won,Lee Sang-Chol,Kim Darae,Kim Jihoon,Kim Eun Kyoung,Chang Sung-A,Park Sung-Ji,Kim Sung Mok,Choe Yeon Hyeon,Ahn Joong Hyun,Park Seung Woo 대한의학회 2022 Journal of Korean medical science Vol.37 No.8
Background: Reduced exercise capacity reflects symptom severity and clinical outcomes in patients with hypertrophic cardiomyopathy (HCM). The present study aimed to identify factors that may affect exercise capacity in patients with HCM. Methods: In 294 patients with HCM and preserved left ventricular (LV) ejection fraction, we compared peak oxygen consumption (peak VO2) evaluated by cardiopulmonary exercise testing as a representative parameter of exercise tolerance with clinical and laboratory data, including N-terminal pro-hormone of brain natriuretic peptide (NT-proBNP), diastolic parameters on echocardiography, and the grade of myocardial fibrosis on cardiac magnetic resonance imaging (CMR). Results: Median peak VO2, was 29.0 mL/kg/min (interquartile range [IQR], 25.0–34.0). Age (estimated β = −0.140, P < 0.001), female sex (β = −5.362, P < 0.001), NT-proBNP (β = −1.256, P < 0.001), and E/e′ ratio on echocardiography (β = −0.209, P = 0.019) were significantly associated with exercise capacity. Peak VO2 was not associated with the amount of myocardial fibrosis on CMR (mean of late gadolinium enhancement 12.25 ± 9.67%LV). Conclusion: Decreased exercise capacity was associated with age, female sex, increased NTproBNP level, and E/e′ ratio on echocardiography. Hemodynamic changes and increased filling pressure on echocardiography should be monitored in this population for improved outcomes.
Kim, Ha-Na,Kim, Jun-Yeon,Park, Kyeong-Ju,Hwang, Ji-Min,Jang, Jun-Yeong,Jo, Min-Gi,Ko, Min-Jung,Chae, Sang-Yeup,Kim, Jung-Hyun,Goo, Bonhyuk,Park, Yeon-Cheol,Seo, Byung-Kwan,Baek, Yong-Hyeon,Nam, Sang-S Korean AcupunctureMoxibustion Medicine Society 2021 대한침구의학회지 Vol.38 No.4
Background: Lumbar herniated intervertebral disc (LHIVD) is a frequently presented condition/disease in Korean medical institutions. In this study, the economics of thread embedding acupuncture (TEA) was evaluated in a randomized controlled trial comparing TEA with sham TEA (STEA). Methods: This economic evaluation was analyzed from a limited social perspective, and the per-protocol set was from a basic analysis perspective. The cost-effectiveness analysis was based on the change in visual analog scale score, and the cost-utility analysis was based on the quality-adjusted life years. The final results were expressed as the average cost-effectiveness ratio and incremental cost-effectiveness ratio, and furthermore sensitivity analysis was performed to confirm the robustness of the results observed. Results: The cost-effectiveness analysis showed that TEA was 9,908 won lower than STEA, while the decrease in 100 mm visual analog scale score was 8.5 mm greater in the TEA group compared with the STEA group (p > 0.05). The cost-utility analysis showed that TEA was 9,908 won lower than STEA, while the quality-adjusted life years of TEA was 0.0026 years higher than STEA (p > 0.05). These results were robust in the sensitivity analysis, but were not statistically significant. Conclusion: In treating LHIVD, TEA appeared to have cost-effectiveness and cost-utility compared with STEA. However, there were no significant differences between the groups in terms of cost, effectiveness, and utility indicators. Therefore, results must be interpreted prudently; this study was the 1<sup>st</sup> to conduct an economic evaluation of TEA for LHIVD.
Hyeon, Ji-Yeon,Hwang, Seoyeon,Kim, Hyejin,Song, Jaehyoung,Ahn, Jeongbae,Kang, Byunghak,Kim, Kisoon,Choi, Wooyoung,Chung, Jae Keun,Kim, Cheon-Hyun,Cho, Kyungsoon,Jee, Youngmee,Kim, Jonghyun,Kim, Kisang Centers for Disease Control and Prevention 2013 Emerging infectious diseases Vol.19 No.8
<P>The epidemiology of enteroviral infection in South Korea during 1999–2011 chronicles nationwide outbreaks and changing detection and subtyping methods used over the 13-year period. Of 14,657 patients whose samples were tested, 4,762 (32.5%) samples were positive for human enterovirus (human EV); as diagnostic methods improved, the rate of positive results increased. A seasonal trend of outbreaks was documented. Genotypes enterovirus 71, echovirus 30, coxsackievirus B5, enterovirus 6, and coxsackievirus B2 were the most common genotypes identified. Accurate test results correlated clinical syndromes to enterovirus genotypes: aseptic meningitis to echovirus 30, enterovirus 6, and coxsackievirus B5; hand, foot and mouth disease to coxsackievirus A16; and hand, foot and mouth disease with neurologic complications to enterovirus 71. There are currently no treatments specific to human EV infections; surveillance of enterovirus infections such as this study provides may assist with evaluating the need to research and develop treatments for infections caused by virulent human EV genotypes.</P>
Hwang, Ji-Hyeon,Shin, Yong-Keol,Park, So-Yeon,Kim, Jeesoo,Kim, Su-Mi,Kim, Byounghan,Park, Jong-Hyeon,Lee, Jong-Soo,Lee, Kwang-Nyeong American Society for Microbiology 2016 Journal of clinical microbiology Vol.54 No.1
<P>During an outbreak of foot-and-mouth disease (FMD), real-time reverse transcription-PCR (rRT-PCR) is the most commonly used diagnostic method to detect viral RNA. However, while this assay is often conducted during the outbreak period, there is an inevitable risk of carryover contamination. This study shows that the carryover contamination can be prevented by the use of target-specific restriction endonuclease in that assay.</P>
HWANG, IN,LEE, HYEON,YOO, KI-YEON,KIM, DAE,KIM, JUNG,KIM, CHANG,LIM, BEONG,KANG, TAE-CHEON,BANG, KYUNG,SEONG, NAK,LEE, HAK,KIM, JONG,WON, MOO Taylor Francis 2006 International journal of neuroscience Vol.116 No.8
<P>The present study examined ischemia-related changes in tyrosine kinase A (trkA) immunoreactivity and its protein content in the dentate gyrus after 5 min of transient forebrain ischemia in gerbils. One day after ischemic insult, cresyl violet-positive polymorphic cells showed ischemic degeneration. The ischemia-induced changes in trkA immunoreactivity were found in the polymorphic layer (PL) and granule cell layer (GCL) of the dentate gyrus. In the sham-operated group, trkA immunoreactivity in the dentate gyrus was very weak. From 30 min after ischemia, trkA immunoreactivity was increased in the dentate gyrus and peaked in the dentate gyrus at 12 h after ischemia-reperfusion. Thereafter, trkA immunoreactivity was decreased time-dependently after ischemia-reperfusion. Four days after ischemic insult, trkA immunoreactivity was similar to that of the sham-operated group. In addition, it was found that ischemia-related changes in trkA protein content were similar to the immunohistochemical changes. These results suggest that the chronological changes of trkA in the dentate gyrus after transient forebrain ischemia may be associated with ischemic damage in polymorphic cells of the dentate gyrus.</P>
뇌졸중 후 상지기능 개선을 위한 스마트폰 어플리케이션 개발
김황용(Hwang-Yong Kim),허명(Myoung Heo),김다운(Da-Woon Kim),김정환(Jeong-Hwan Kim),곽연상(Yeon-Sang Kwak),손재광(Jae-Kwang Son),장환석(Hwan-Seok Jang),최경현(Kyeong-Hyeon Choi),이제성(Je-Seong Lee) 한국엔터테인먼트산업학회 2015 한국엔터테인먼트산업학회논문지 Vol.9 No.2
스마트폰 무선인터넷 사용량이 늘어나면서 스마트폰 어플리케이션에 대한 수요와 공급이 급속히 증가한 반면에 뇌졸중 재활분야에서의 어플리케이션은 국내에 거의 미비한 실정이다. 그러므로 본 연구는 뇌졸중 상지기능 개선에 효과가 검증된 단계별 반복적 팔 보조 프로그램(Graded Repetitive Arm Supplementary Program ; GRASP)을 한국 실정에 맞게 수정 보완 하여 뇌졸중 환자들의 본인 상태에 맞게 3단계로 구성하여 동영상으로 제작한 후 스마트폰 어플리케이션을 개발하여 구글 플레이에 등록하였다. 본 연구에서 개발한 모바일 어플리케이션을 통해 병원에서는 재활치료 후 남은 시간에 자가 운동 할 수 있도록 가이드를 제공할 수 있고, 퇴원 후 가정에서는 뇌졸중 환자들이 쉽게 따라 운동 할 수 있는 자조관리 재활훈련 서비스를 제공할 수 있어서 뇌졸중 후 상지기능 회복에 도움을 줄 것으로 기대한다. Smartphone application programs for stroke rehabilitation are few, if any, in Korea while wireless internet access is getting much easier and general smartphone application programs are rapidly increasing. The purpose of this study was to develop a smartphone application program for upper extremity rehabilitation of individuals with stroke, and to register it in the Google play. This study used the Graded Repetitive Arm Supplementary Program (GRASP) as the basic rehabilitation program and modified it for the Korean culture. GRASP has been proven to be effective on improving the function of upper extremity of the individuals with stroke. The smartphone application program of this study consists of three levels of video segments which were made by the researchers for the study. The application program is expected to provide stroke patients with an useful guide to exercise by themselves at home or in hospitals.
P629 : Generalized Lichen planus in childhood with nail involvement
( Sang Hyeon Hwang ),( Ju Yeon Choi ),( Han Saem Kim ),( Jung In Kim ),( Jung Min ),( Hyun Min Seo ),( Heun Joo Lee ),( Yoon Hwan Kim ),( Ho Joo Jung ),( Ji Hye Park ),( Ga Young Lee ),( Won Serk Kim 대한피부과학회 2014 대한피부과학회 학술발표대회집 Vol.66 No.1