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ADPKD 낭종액에서의 사이토카인 Profile 에 대한 연구
이중건(Jung Geon Lee),안규리(Curie Ahn),윤성철(Sung Chul Yoon),박종훈(Jong Hoon Park),문창숙(Chang Suk Moon),노진주(Jin Ju No),송은경(Eun Kyeung Song),김연수(Yon Su Kim),한진석(Jin Suk Han),김성권(Suhng Gwon Kim),이정상(Jung Sang Lee 대한신장학회 2002 Kidney Research and Clinical Practice Vol.21 No.5
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이중건(Jung Geon Lee),안규리(Gu Rie Ahn),황대연(Dae Yeon Hwang),황영환(Yeong Hwan Hwang),김기원(Ki Won Kim),이서진(Seo Jin Lee),나기영(Ki Young Na),한진석(Jin Suk Han),김성권(Sung Gwon Kim) 대한내과학회 2000 대한내과학회지 Vol.58 No.1
N/A Background : ADPKD is one of the most common hereditary renal disease in adult and is a systemic disorder with a variety of cardiovascular manifestations. To elucidate the clinical characteristics of cerebrovascular complications in Korean ADPKD patients, we reviewed the medical records of ADPKD patients who was registered in ADPKD clinic of Seoul National University Hospital. Methods : A total of 18 adult patients were included and their sex ratio was 8:10. The median age of ADPKD diagnosis was 45.5 year(range 19-85), and age at cerebrovascular accident(CVA) was 52 years(22-82). The median duration from hypertension to CVA was 8 years(0-30). Results : There were 5 cases of infarction, 4 cases of intracerebral hemorrhage, 4 cases of subarachnoid hemorrhage, and 4 cases of transient ischemic attack. Other clinical parameters of ADPKD were not different from patients who were not complicated with CVA. Intracranial aneurysms were detected in 6 patients and their median age at diagnosis was 47.5 years(33-66). Four cases were manifested as subarachnoid hemorrhage. Five cases were diagnosed through TFCA, and two of them were revealed as multiple aneurysms. Five cases received surgical treatment and five of six cases improved without any neurologic sequeale. MR angiography(MRA) were taken in 16 asymptomatic patients, and multiple aneurysms were newly detected in one of them. Conclusion : Cerebrovascular complications in Korean ADPKD patients were not significantly different from western patients. Intracranial aneurysms must be included in differential diagnosis in ADPKD patients who manifest an acute neurologic symptoms, and high-risk group need to be screened selectively with MRA.(Korean J Med 58:75-82, 2000)
이영환 ( Lee Yeong Hwan ),김용범 ( Kim Yong Beom ),정도영 ( Jeong Do Yeong ),이유경 ( Lee Yu Gyeong ),김건영 ( Kim Geon Yeong ),이준승 ( Lee Jun Seung ),이중건 ( Lee Jung Geon ),최덕례 ( Choe Deog Lye ),박미자 ( Park Mi Ja ),이영 대한신장학회 2001 Kidney Research and Clinical Practice Vol.20 No.6
The incidence of Tuberculosis among the patients with end-stage renal disease(ESRD) has increased up to 16 times of that in the general population. The impairment of the cellular immunity in the ESRD patients may have a role in the pathogenesis. Extrapulmonary tuberculous manifestations such as lymph node, peritoneum, and pleura involvement are more frequent in the ESRD patients than in the general population. However, there has been no case of upper gastrointestinal(UGI) bleeding as a result of a gastric tuberculosis in the ESRD patient on hemodialysis. Here we report an unusual case of a hemodialysis patient with UGI bleeding secondary to a tuberculous gastric ulcer. A 31-year-old female on hemodialysis was admitted with melena. Endoscopy revealed a benign gastric ulcer with a visible bleeding vessel at the base, located in the anterior wall of the antrum. An exploratory laparotomy showed multiple, round, small and yellow nodules on the visceral peritoneum as well as a 1-cm sized gastric ulcer. After gastric resection, a histological examination including peritoneal nodules demonstrated chronic granulomatous inflamation with caseous necrosis and giant cells. The patient has been on antituberculosis medication and followed up in the outpatient department without any event for 8 months.