뇌의부분 손상으로 인한 정동행동의 변화에 관한 연구

이순철,T. Yamamoto.S.Ueki 충남대학교 약학대학 의약품개발연구소 1988 藥學論文集 Vol.4 No.-

Nucleus accumbens septi (NAB), one of mesolimbic system, which anatomically related the limbic system. We an attempted to elucidated emotional changes following bilateral NAB lesions in rats. Caudal, rostral and both areas of NAB were lesioned each in separated animal groups. Furthermore, aggressive behavior induced by NAB rats was investigated in comparison with those induced by olfactory bulbectomized rats and raphe nucleus-lesioned rats. 1) At postoperative day 2, locomotor activity were increased in r-NAB rats but not in c-NAB rats. 2) All rats exhibited hyperirritability and muricide including mouse-eating behavior after NAB lesions. 3) Muricide of NAB rats was significantly supressed by L-DOPA, L-5-HTP and antidepressants, muricide of raphe rats was also significantly inhibited by L-DOPA and L-5-HTP, while that in OB rats was not suppressed. These results suggested that the NAB plays an important role in locomotor activity and aggression. The characteristics of aggressive behavior induced by NAB rats resemble to that of raphe-rats.

Short-term Redistribution of Methylmercury by Sulfur-Containing Compounds

Yamamoto, Ryoji,Sumino, Kimiaki,Nakamae, Katsutoshi,Lee, Won Chang 한국수의공중보건학회 1997 예방수의학회지 Vol.21 No.1

Raf kinase inhibitory protein is required for cerebellar long-term synaptic depression by mediating PKC-dependent MAPK activation.

Yamamoto, Yukio,Lee, Dongwon,Kim, Yoonhee,Lee, Bokyoung,Seo, Changwoo,Kawasaki, Hiroshi,Kuroda, Shinya,Tanaka-Yamamoto, Keiko The Society 2012 The Journal of neuroscience Vol.32 No.41

<P>It was demonstrated previously that a positive feedback loop, including protein kinase C (PKC) and mitogen-activated protein kinase (MAPK), is required for the gradual expression of cerebellar long-term depression (LTD). PKC and MAPK are mutually activated in this loop. MAPK-dependent PKC activation is likely to be mediated by phospholipase A2. On the other hand, it is not clear how PKC activates MAPK. Therefore, the entire picture of this loop was not fully understood. We here test the hypothesis that this loop is completed by the PKC substrate, Raf kinase inhibitory protein (RKIP). To test this hypothesis, we used a mutant form of RKIP that is not phosphorylated by PKC and thus constitutively inhibits Raf-1 and MEK, upstream kinases of MAPK. When this RKIP mutant was introduced into Purkinje cells of mouse cerebellar slices through patch-clamp electrodes, LTD was blocked, while wild-type (WT) RKIP had no effect on LTD. Physiological epistasis experiments demonstrated that RKIP works downstream of PKC and upstream of MAPK during LTD induction. Furthermore, biochemical analyses demonstrated that endogenous RKIP dissociates from Raf-1 and MEK during LTD induction in a PKC-dependent manner, suggesting that RKIP binding-dependent inhibition of Raf-1 and MEK is removed upon LTD induction. We therefore conclude that PKC-dependent regulation of RKIP leads to MAPK activation, with RKIP completing the positive feedback loop that is required for LTD.</P>

Association Between Eating Behavior, Frequency of Meals, and Functional Dyspepsia in Young Japanese Population

Yasunori Yamamoto,Shinya Furukawa,Junichi Watanabe,Aki Kato,Katsunori Kusumoto,Teruki Miyake,Eiji Takeshita,Yoshio Ikeda,Naofumi Yamamoto,Katsuhiko Kohara,Syuichi Saheki,Yuka Saeki,Yoichi Hiasa 대한소화기 기능성질환·운동학회 2022 Journal of Neurogastroenterology and Motility (JNM Vol.28 No.3

Background/AimsFunctional dyspepsia (FD) may be a common digestive disease worldwide and reduces the quality of life of patients. However, only a few studies have investigated the association between eating behavior and FD. The purpose of this cross-sectional study is to examine the association between eating behavior and prevalence of FD in a young Japanese cohort. MethodsIn this study, we enrolled 8923 Japanese university students. FD is diagnosed based on the Rome III criteria. Eating habits and frequency of meals were investigated using a self-administered questionnaire. ResultsThe FD subjects had a younger mean age, a lower body mass index, and a lower proportion of men compared to the non-FD subjects. An independent positive association between skipping breakfast and/or lunch and FD was found (adjusted ORs were 1.60 [95% CI, 1.10-2.32] for breakfast and 2.52 [95% CI, 1.04-5.18] for lunch). Skipping dinner, extra meals (snacks) or midnight snacks was not associated with FD. The prevalence of FD in subjects eating 1, 2, and 3 meals per day was 4.8%, 2.2%, and 1.7%, respectively. The frequency of meals was independently inversely associated with prevalence of FD (adjusted ORs were 1 per day: 2.72 [95% CI, 1.19-5.42], and 2 per day: 1.69 [95% CI, 1.16-2.43], P for trend = 0.001). ConclusionsIn the young Japanese people, the frequency of meals may be independently inversely associated with prevalence of FD. In particular, skipping breakfast and/or lunch was associated with the prevalence of FD.

Association Between Body Mass Index and Functional Dyspepsia in Young Japanese People

Yasunori Yamamoto,Shinya Furukawa,Junichi Watanabe,Aki Kato,Katsunori Kusumoto,Eiji Takeshita,Yoshio Ikeda,Naofumi Yamamoto,Katsuhiko Kohara,Yuka Saeki,Yoichi Hiasa 대한소화기 기능성질환∙운동학회 2022 Journal of Neurogastroenterology and Motility (JNM Vol.28 No.2

Background/AimsEvidence regarding the association between body mass index (BMI) and functional dyspepsia (FD) in the Asian population is limited. Further, no study has evaluated this issue in young people in Asian and Western populations. Thus, we aim to investigate this issue among young Japanese people. MethodsThe study subjects comprised of 8923 Japanese university students. BMI was divided into 4 categories (quartiles) on the basis of the study subjects’ distribution (lowest, low, moderate, and high [reference]). The definition of lean, normal, overweight, and obese was BMI < 18.5 kg/m2, 18.5 ≤ BMI < 25 kg/m2 (reference), 25 kg/m2 ≤ BMI < 30 kg/m2, and 30 kg/m2 ≤ BMI, respectively. The definition of FD was based on the Rome III criteria. ResultsThe prevalence of FD was 1.9% in this cohort. The lowest BMI was independently associated with FD after adjustment (adjusted odds ratio [OR], 2.88; 95% confidence interval [CI], 1.46-3.67); P for trend = 0.001). The lowest BMI was independently associated with FD in women but not in men (OR, 2.94; 95% CI, 1.59-5.77; P for trend = 0.001). Leanness was independently associated with FD in total and in women but not in men (total: adjusted OR, 2.01; 95% CI, 1.40-2.86) and women (OR, 2.19; 95% CI, 1.35-3.45). However, interaction analysis showed no significant difference for sex. ConclusionsAmong young Japanese people, BMI may be independently inversely associated with FD. Leanness may be an independent associated factor for FD in the young Japanese women.

Internet Survey of Japanese Patients With Chronic Constipation: Focus on Correlations Between Sleep Quality, Symptom Severity, and Quality of Life

( Sayuri Yamamoto ),( Yurika Kawamura ),( Kazuhiro Yamamoto ),( Yoshiharu Yamaguchi ),( Yasuhiro Tamura ),( Shinya Izawa ),( Hiroaki Nakagawa ),( Yoshinori Wakita ),( Yasutaka Hijikata ),( Masahide Eb 대한소화기기능성질환·운동학회 2021 Journal of Neurogastroenterology and Motility (JNM Vol.27 No.4

Background/Aims Chronic constipation and lifestyle factors can affect sleep quality. We evaluated the relationship between chronic constipation and sleep in the Japanese population. Methods This cross-sectional internet-based survey included 3000 subjects with constipation, classified according to sleep status (good/poor). Primary endpoints were Bristol stool form scale (BSFS) score and correlations between sleep disorder criteria of the Pittsburgh Sleep Quality Index (PSQI) and sleep status (good/poor sleep). Secondary endpoints included correlations between quality of life (QOL) and mood, medical, lifestyle, and sleep factors. Results The proportion of participants with BSFS category 4 (normal stool) was significantly higher in the good sleep group (P < 0.001). Sleep disturbance (P < 0.05), sleep quality, and duration, use of hypnotic medication, and daytime dysfunction of PSQI (all P < 0.001) significantly correlated with poor sleep. In the poor sleep group, QOL was significantly worse and anxiety and depression levels were significantly higher (all P < 0.001) compared with the good sleep group. Anemia and smoking (both P < 0.05), recent body weight increases, and poor eating habits (all P < 0.001) were significantly higher in the poor sleep group. Male sex, onset associated with change in frequency of stools, sensation of incomplete evacuation for at least 25% of defecations, and manual maneuvers to facilitate at least 25% of defecations correlated with poor sleep. Conclusions Subjects with constipation and poor sleep experienced severe symptoms and had poor QOL. These data support the need for a multifocal treatment approach, including lifestyle advice and pharmacotherapy. (J Neurogastroenterol Motil 2021;27:602-611)

타쿠로 야마모토 아키텍츠

타쿠로 야마모토(Takuro Yamamoto) 현대건축사 2016 월간 CONCEPT Vol.- No.205

The Mechanism of Vascular Injury in Diabetes : Lessons from Cells, Organelles and Transgenic Animals

Yamamoto,Hiroshi 한국생명과학회 2001 한국생명과학회 학술발표회 Vol.33 No.-

Microvessels are composed of endothelial cells and pericytes. They show peculiar changes in diabetes. Pericytes decrease (pericyte loss), while endothelial cells proliferate (angiogenesis) but with dysfunction (thrombogenesis). All of these changes were induced in vitro when each cell type was exposed to advanced glycation endproducts (AGE), non- enzymatically glycosylated protein derivatives which are formed at an accelerated rate during prolonged hyperglycemic exposure. And, those vascular cell responses were dependent on the presence of a cell surface receptor for AGE (RAGE). Coculture experiments revealed that loss of proximal interaction between the two cell types augments the microvascular derangement. To evaluate in vivo the functional role of the AGE-RAGE system in diabetes-induced vascular injury, we then created a double transgenic mouse model in which RAGE is overexpressed in vascular cells and insulin-dependent diabetes develops early after birth. The RAGE-overexpressing animals exhibited advanced diabetic nephropathy exemplified by mesangial expansion and glomerulosclerosis, and this was prevented by the treatment with an inhibitor of AGE formation. Retinopathy indices were also exacerbated in the double transgenic model. Lessons from the endothelial cell nucleus revealed that AGE ligands themselves, TNF-alpha and estradiol activate the transcription of RAGE gene, and that NF-kappa B mediates the induction by the former two, while the and estrogen receptor alpha complex mediates the estradiol induction. Analysis of vascular cell-derived polysomal poly(A)+RNA led to the isolation of novel splice variants of RAGE mRRNA coding for an N-terminally truncated protein and for a C-terminally truncated secretable form. The latter protein had an ability to capture AGE and to neutralize their action on endothelial cells, and was detected in human sera. In conclusion, the AGE-RAGE system would seem to be a promising target for overcoming diabetic vascular complications. Circulating soluble RAGE could contribute to resistance against this life-and QOL-threatening disease.

AEGIS: AN ADVANCED LATTICE PHYSICS CODE FOR LIGHT WATER REACTOR ANALYSES

Yamamoto, Akio,Endo, Tomohiro,Tabuchi, Masato,Sugimura, Naoki,Ushio, Tadashi,Mori, Masaaki,Tatsumi, Masahiro,Ohoka, Yasunori Korean Nuclear Society 2010 Nuclear Engineering and Technology Vol.42 No.5

AEGIS is a lattice physics code incorporating the latest advances in lattice physics computation, innovative calculation models and efficient numerical algorithms and is mainly used for light water reactor analyses. Though the primary objective of the AEGIS code is the preparation of a cross section set for SCOPE2 that is a three-dimensional pin-by-pin core analysis code, the AEGIS code can handle not only a fuel assembly but also multi-assemblies and a whole core geometry in two-dimensional geometry. The present paper summarizes the major calculation models and part of the verification/validation efforts related to the AEGIS code.

A new species of Prosolierius rove beetle with highly modified antennae from mid-Cretaceous Kachin amber of northern Myanmar (Coleoptera, Staphylinidae, Solieriinae)

Yamamoto Shûhei 한국응용곤충학회 2023 Journal of Asia-Pacific Entomology Vol.26 No.2

Solieriinae is a small subfamily of rove beetles, with only a monospecific extant genus, Solierius Bernhauer, 1921, from South America restricted to the temperate forests of southern Chile and Argentina, and four additional species in the extinct genus Prosolierius Thayer, Newton & Chatzimanolis, 2012. All fossil records reported to date are limited to Prosolierius, and are known from the Cretaceous of Barremian–Cenomanian amber deposits from Lebanon, Spain, and northern Myanmar (Kachin). Here, a remarkable new species of Solieriinae, Prosolierius thayerae sp. nov., from mid-Cretaceous Kachin amber is described. The new species is externally similar to Prosolierius tenuicornis Thayer, Newton & Chatzimanolis, 2012, from the same amber deposit in having elongate antennomere 10, but it has shorter antennae, and more importantly has highly modified antennomeres 3 and 4 in both antennae. Notably, these modifications are exceptional in typical staphylinids. Together with the four other fossil species of Prosolierius, the discovery also highlights the hidden paleodiversity of solieriine rove beetles in the mid-Cretaceous. https://www.zoobank.org/urn:lsid:zoobank.org:pub:1EC7EEE5-F413-4C5F-BA45-744EB88B7173