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Yasuhiro Takeuchi,Junko Hashimoto,Yosuke Nishida,Chiemi Yamagiwa,Takashi Tamura,Akihide Atsumi 대한골다공증학회 2018 Osteoporosis and Sarcopenia Vol.4 No.1
Objectives: This postmarketing, observational study evaluated the safety and effectiveness of monthly intravenous (IV) ibandronate in Japanese patients with osteoporosis. Methods: Eligible patients received monthly IV ibandronate 1mg for 12 months. Adverse drug reactions (ADRs) were evaluated. Changes in bone mineral density (BMD) and bone turnover markers (BTMs) were assessed using matched t-test analysis. Cumulative fracture rates were analyzed by Kaplan-Meier methodology. Results: In total, 1062 patients were enrolled, of whom 1025 (n= 887 women, n= 138 men) were treated. Mean patient age was 77 years. Seventy-five ADRs were reported in 54 patients (5.26%). Four patients (0.39%) experienced serious ADRs, including one case of osteonecrosis of the jaw. Acute-phase reactions occurred in 21 patients (2.04%), and half of them arose after the first ibandronate injection. No new safety concerns were identified. Significant increases in BMD at 12 months relative to baseline were observed at the lumbar spine (4.84%, n= 187; 95% confidence interval [CI], 3.47%-6.21%), femoral neck (2.73%, n= 166; 95% CI, 1.46%-4.01%), and total hip (1.93%, n= 133; 95% CI, 0.80%-3.07%). Significant reductions were observed in all BTMs at 12 months (n = 174 in tartrate-resistant acid phosphatase-5b, n = 101 in procollagen type 1 N-terminal propeptide at baseline). The cumulative incidence of nontraumatic,new vertebral and nonvertebral fractures was 3.16% (95% CI, 2.12%-4.70%). Analyses in women only showed similar results to the overall population. Conclusions: These findings confirm the favorable safety and consistent effectiveness of ibandronate, and indicate that monthly IV ibandronate would be beneficial in daily practice for the treatment of Japanese patients with osteoporosis.
Kosei Tamura,Tohru Kamiya,Masafumi Oda,Yasuhiro Morimoto 제어로봇시스템학회 2022 제어로봇시스템학회 국제학술대회 논문집 Vol.2022 No.11
Root resorption is a pathological condition which is characterized by the loss of the tooth root. Root resorption is not painful in its early stages. As a result, many people who are potentially affected and the condition are often left untreated until it is detected during regular check-ups. If detected early, good treatment results can be achieved, whereas failure to treat the condition properly can lead to tooth extraction. However, the root resorption is currently difficult to detect on panoramic radiographs and may be treated as caries after it becomes painful. The aim of this paper is to identify root resorption from panoramic X-ray images using a deep metric learning algorithm. As a loss function for distance learning, it is known that the loss function in angle space is consistent. Therefore, a loss function is defined and trained using the cosine value of the angle between the feature and the center position to improve the discrimination performance. We obtained experimental results based on 150 image sets with 0.80 of accuracy, 0.62 of TPR, 0.19 of FPR and 0.78 of AUC, respectively.
Detection of the root resorption from panoramic X-ray images using deep metric learning
Kosei Tamura,Tohru Kamiya,Masashi Oda,Tatsurou Tanaka,Yasuhiro Morimoto 제어로봇시스템학회 2021 제어로봇시스템학회 국제학술대회 논문집 Vol.2021 No.10
Root resorption is a pathological process characterized by the loss of tooth roots because of inflammation induced by bacterial infection, trauma, physical or chemical irritation. As a result, the development of periodontal disease, increased susceptibility to infection and crooked teeth. In the worst case, it can lead to tooth extraction. Root resorption is often caused by pressure during orthodontic treatment. The presence of root resorption should be checked regularly during orthodontic treatment, as it often occurs. It is necessary to check for root resorption periodically during orthodontic treatment. However, it is difficult to detect the root resorption using a panoramic radiograph. As a result, root resorption is often latent and goes undetected. In this paper, we propose an image analysis method based on deep learning technique for detecting the root resorption on panoramic radiograph. We incorporate the EfficientNet for feature extraction in deep learning to the center loss and triplet loss as the loss function for metric learning. Our proposed method performed to 337 images which is obtained by panoramic radiograph. Accuracy of 71%, true positive rate of 77%, false positive rate of 30% were obtained.
TREATMENT OF SOFT TISSUE INFECTIONS WITH HYPERBARIC OXYGEN (HBO) THERAPY
Uchida, Kazuhiro,Kawashima, Mahito,Tamura, Hiroaki,Yamasaki, Yasuhiro,Takao, Katsuhiro 고신대학교 의학부 1986 高神大學校 醫學部 論文集 Vol.2 No.1
Breathing oxygen under high pressure increases the concentration of oxygen in the blood and reduces hypoxia. Hyperbanc oxygen(HBO) is useful in treating many diseases. It is used orthopedics, for example, to treat anaerobic gas gangrene. At our hospital good results were obtained using it adjunctively to the surgical and antibiotic treatment of soft tissue infections (including aerobic infections).
TREATMENT OF SOFT TISSUE INFECTIONS WITH HYPERBARIC OXYGEN(HBO) THERAPY
Kazuhiro Uchida,Mahito Kawashima,Hiroaki Tamura,Yasuhiro Yamasaki,Katsuhiro Takao 고신대학교(의대) 고신대학교 의과대학 학술지 1986 고신대학교 의과대학 학술지 Vol.2 No.1
Brathing oxygen under high pressure increases the concentration of oxygen in the blood and reduces hypoxia. Hyperbaric oxygen(HBO) is useful in treating many diseases. It is used orthopedics, for example, to treat anaerobic gas gangrene. At our hospital good results were obtained using it adjunctively to the surgical and antibiotic treatment of soft tissue infections (including aerobic infections).
Lim, Sung-Hyuk,Yamaguchi, Munehiro,Nishimura, Okio,Mie, Yasuhiro,Tamura, Tomohiro,Kim, Byung-Woo,Suzuki, Masaaki American Scientific Publishers 2009 Journal of Nanoscience and Nanotechnology Vol.9 No.12
<P>We have succeeded to immobilize fluorescent proteins selectively using a micro-structured organosilane self-assembled monolayer as a template. An organosilane layer with amino terminal group was formed on a thermally oxidized Si wafer by liquid-phase method and then was pattern-etched by vacuum ultraviolet light (VUV). The second organosilane layer with thiol terminal group was deposited on the etched area by chemical vapor surface modification method (CVSM). These micro-structured organosilane layer containing two reactive terminal groups were chemically modified using bi-functional linkers. Two kinds of fluorescent protein, Enhanced Cyan Fluorescent Protein (ECFP) and R-phycoerythrin were selectively immobilized on the chemically modified surface.</P>
Naotaka Ogasawara,Yasushi Funaki,Kunio Kasugai,Masahide Ebi,Yasuhiro Tamura,Shinya Izawa,Makoto Sasaki 대한소화기 기능성질환∙운동학회 2022 Journal of Neurogastroenterology and Motility (JNM Vol.28 No.2
Background/AimsDetailed evaluations of overlapping constipation and gastroesophageal reflux disease (GERD) have not been conducted in Japan. The REACTION-J2 study examined the overlap of these diseases in Japan. MethodsThis internet-based survey recruited participants from general public survey panels. Questions included demographic and medical data and assessments based on validated measures for constipation and GERD. Associations between background factors affecting constipation/GERD overlap, disease measures, and treatment were also evaluated. ResultsAmong 10 000 survey responses received, functional constipation (Rome IV diagnostic criteria) was reported by 439 participants; chronic constipation (Japanese guidelines) by 3804 participants; and subjective constipation symptoms by 2563 participants. The number of participants with constipation/GERD overlap ranged from 73 to 1533 depending on the criteria used. Regardless of the definition used, all GERD groups had significantly higher odds of being constipated than non-GERD participants: the OR (95% CI) for all 9 combinations of definitions ranged between 1.56 (1.21, 2.01) and 2.67 (2.44, 2.92) (all P ≤ 0.001). Straining, hard stools, and sensations of incomplete evacuation and anorectal obstruction/blockage, according to chronic constipation criteria, were common. Participants with constipation/GERD overlap had poorer quality of life (P < 0.001) and worse GERD symptom scores (P < 0.001). The frequency of abnormal stools was highest (P < 0.001) in the constipation/GERD overlap group. In the overlap group, 52.4% and 26.0% used gastric and constipation medication, respectively. ConclusionIndividuals with constipation/GERD overlap tend to have worsened symptoms and quality of life.
( Sayuri Yamamoto ),( Yurika Kawamura ),( Kazuhiro Yamamoto ),( Yoshiharu Yamaguchi ),( Yasuhiro Tamura ),( Shinya Izawa ),( Hiroaki Nakagawa ),( Yoshinori Wakita ),( Yasutaka Hijikata ),( Masahide Eb 대한소화기기능성질환·운동학회 2021 Journal of Neurogastroenterology and Motility (JNM Vol.27 No.4
Background/Aims Chronic constipation and lifestyle factors can affect sleep quality. We evaluated the relationship between chronic constipation and sleep in the Japanese population. Methods This cross-sectional internet-based survey included 3000 subjects with constipation, classified according to sleep status (good/poor). Primary endpoints were Bristol stool form scale (BSFS) score and correlations between sleep disorder criteria of the Pittsburgh Sleep Quality Index (PSQI) and sleep status (good/poor sleep). Secondary endpoints included correlations between quality of life (QOL) and mood, medical, lifestyle, and sleep factors. Results The proportion of participants with BSFS category 4 (normal stool) was significantly higher in the good sleep group (P < 0.001). Sleep disturbance (P < 0.05), sleep quality, and duration, use of hypnotic medication, and daytime dysfunction of PSQI (all P < 0.001) significantly correlated with poor sleep. In the poor sleep group, QOL was significantly worse and anxiety and depression levels were significantly higher (all P < 0.001) compared with the good sleep group. Anemia and smoking (both P < 0.05), recent body weight increases, and poor eating habits (all P < 0.001) were significantly higher in the poor sleep group. Male sex, onset associated with change in frequency of stools, sensation of incomplete evacuation for at least 25% of defecations, and manual maneuvers to facilitate at least 25% of defecations correlated with poor sleep. Conclusions Subjects with constipation and poor sleep experienced severe symptoms and had poor QOL. These data support the need for a multifocal treatment approach, including lifestyle advice and pharmacotherapy. (J Neurogastroenterol Motil 2021;27:602-611)