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Weng, R.C.,Edwards, S.A.,Hsia, L.C. Asian Australasian Association of Animal Productio 2009 Animal Bioscience Vol.22 No.9
To evaluate different housing systems, 80 gilts were randomly allocated at puberty to four treatments: i) sow stall in gestation followed by farrowing crate (SC), ii) group housing with individual feeding in gestation followed by farrowing crate (GC), iii) ESF (Electronic Sow Feeding) system in gestation followed by farrowing crate (EC), and iv) ESF system followed by group farrowing pen (EG). The results showed that stalled sows had a longer interval between puberty and second estrus (p<0.001). The sows kept in the ESF system gained more body weight (p<0.01) and backfat (p<0.05) prior to service, and more backfat during gestation (p<0.05), but also had greater backfat losses in the subsequent lactation (p<0.01). Sows changing from loose housing to confinement at farrowing had longer gestation length (p<0.001). Total litter size did not differ significantly between gestation treatments, but the number of stillborn piglets was significantly higher in the SC treatment (p<0.01). After weaning, SC sows had the longest interval for rebreeding (p<0.001). Some EG sows came into heat before weaning, giving this treatment the shortest interval. These results indicate that gestation confinement in sow stalls had several detrimental effects on sow performance relative to group housing.
Weng Wenya,Ge Tingwen,Wang Yi,He Lulu,Liu Tinghao,Wang Wanning,Zheng Zongyu,Yu Lechu,Zhang Chi,Lu Xuemian 대한당뇨병학회 2020 Diabetes and Metabolism Journal Vol.44 No.4
Background: Fibroblast growth factor 21 (FGF21) has been only reported to prevent type 1 diabetic nephropathy (DN) in the streptozotocin-induced type 1 diabetes mellitus (T1DM) mouse model. However, the FVB (Cg)-Tg (Cryaa-Tag, Ins2-CALM1) 26OVE/PneJ (OVE26) transgenic mouse is a widely recommended mouse model to recapture the most important features of T1DM nephropathy that often occurs in diabetic patients. In addition, most previous studies focused on exploring the preventive effect of FGF21 on the development of DN. However, in clinic, development of therapeutic strategy has much more realistic value compared with preventive strategy since the onset time of DN is difficult to be accurately predicted. Therefore, in the present study OVE26 mice were used to investigate the potential therapeutic effects of FGF21 on DN. Methods: Four-month-old female OVE26 mice were intraperitoneally treated with recombinant FGF21 at a dose of 100 μg/kg/day for 3 months. The diabetic and non-diabetic control mice were treated with phosphate-buffered saline at the same volume. Renal functions, pathological changes, inflammation, apoptosis, oxidative stress and fibrosis were examined in mice of all groups. Results: The results showed that severe renal dysfunction, morphological changes, inflammation, apoptosis, and fibrosis were observed in OVE26 mice. However, all the renal abnormalities above in OVE26 mice were significantly attenuated by 3-month FGF21 treatment associated with improvement of renal adenosine 5´-monophosphate (AMP)-activated protein kinase (AMPK) activity and sirtuin 1 (SIRT1) expression. Conclusion: Therefore, this study demonstrated that FGF21 might exert therapeutic effects on DN through AMPK-SIRT1 pathway.
Characterization of the B cell receptor repertoire of patients with acute coronary syndrome
Weng Ruiqiang,Liu Sudong,Gu Xiaodong,Zhong Zhixiong 한국유전학회 2022 Genes & Genomics Vol.44 No.1
Background: Acute coronary syndrome (ACS) is a complex cardiovascular disease whose development involves the dysregulation of adaptive immune responses. Though it has been proven that T cells associate with inflammation in the development of ACS, the function of B cells in disease remains unclear. Objective: The aim of this study was to reveal the diversity of the B cell receptor (BCR) repertoire of patients with ACS. Methods: We conducted a pilot study to sequence the immune repertoire of peripheral blood mononuclear cells (PBMCs) from patients with ACS, including acute myocardial infarction (AMI) and unstable angina (UA), and quantitatively characterized BCR repertoires by bioinformatics analysis. Results: We found that patients with AMI and UA had lower BCR repertoire diversity compared with controls with normal coronary arteries (NCA). Lower percentages of productive unique BCR nt sequences and higher percentages of top 200 unique BCR sequences were identified in AMI and UA patients than NCA controls. Patients had various preferential usage of V and J genes from B cell clones in accordance with the disease severity of coronary arteries. AMI patients had distinct CDR3 amino acids, and their frequency differed among patients with ACS. Conclusions: Our results indicate that differential BCR signatures represent an imprint of distinct repertoires among ACS patients. This study thereby opens up the prospect of studying disease-relevant B cells to better understand and treat ACS.
Weng, D.G.,Zhang, C.,Lu, X.L.,Zeng, S.,Zhang, S.M. Techno-Press 2012 Structural Engineering and Mechanics, An Int'l Jou Vol.44 No.5
The passive energy dissipation technology has been proven to be reliable and robust for recent practical applications. Various dampers or energy dissipation devices have been widely used in building structures for enhancing their performances during earthquakes, windstorm and other severe loading scenarios. This paper presents a simplified seismic design procedure for retrofitting earthquake-damaged frames with viscous dampers. With the scheme of designing the main frame and the supplemental viscous dampers respectively, the seismic analysis model of damped structure with viscous dampers and braces was studied. The specific analysis process was described and approach to parameter design of energy dissipation components was also proposed. The expected damping forces for damped frame were first obtained based on storey shear forces; and then they were optimized to meet different storey drift requirements. A retrofit project of a RC frame school building damaged in the 2008 Wenchuan earthquake was introduced as a case study. This building was retrofitted by using viscous dampers designed through the simplified design procedure proposed in this paper. Based on the case study, it is concluded that this simplified design procedure can be effectively used to make seismic retrofit design of earthquake-damaged RC frames with viscous dampers, so as to achieve structural performance objectives under different earthquake risk levels.
Weng, Yuan,Fei, Bojian,He, Ping,Cai, Ming Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.9
Background: Glutathione-S-Transferase T1 (GSTT1) gene has been shown to be involved in the development of esophageal cancer. However, the results have been inconsistent. In this study, the authors performed a meta-analysis to clarify the association between GSTT1 polymorphism and esophageal cancer risk among Chinese Han population. Methods: Published literature from PubMed, the China National Knowledge Infrastructure and Wanfang Data were searched. Pooled odds ratio (OR) and 95% confidence interval (95%CI) was calculated using a fixed- or random-effects model. Results: Eleven studies with a total of 2779 individuals were included in the meta-analysis. The results showed that GSTT1 null genotype was significantly associated with esophageal cancer risk in Chinese (OR = 1.31, 95%CI 1.12 to 1.53, p = 0.001). Further sensitivity analyses confirmed the significant association. The cumulative meta-analysis showed a trend of an obvious association between GSTT1 null genotype and esophageal cancer risk as information accumulated by year. Conclusions: This meta-analysis suggests a significant association of GSTT1 null genotype with esophageal cancer risk in the Chinese Han population.
THE CHARACTERISTICS OF ZINC DIFFUSED NORMALLY ON GaAs AND InP JUNCTION FETs
Weng, Tung H. 대한전자공학회 1989 ICVC : International Conference on VLSI and CAD Vol.1 No.1
In this paper, a new technique using semi-sealed quartz bottle for zinc diffusion in GaAs and InP was employed. The basic requirement for zinc diffusion in these materials is to provide an overpressure ambient 50 that decomposition at the diffusion temperature can be avoided. This was done for the case of InP by placing InP wafer with diffusion charge which contained pure zinc and a small amount of InP powder in a semi-sealed bottle. This small amount of InP powder seemed to have provided the needed overpressure ambient to avoid decomposition. TA e surface showed no degradation after diffusion and maintained its original smooth surface. However, the surface was decomposed if no InP powder was added in the diffusion charge. For the case of GaAs, no GaAs powder was needed in the diffusion charge. Only pure zinc was required for producing heavily doped P-layer. The vapor produced by GaAs in the semi-sealed bottle during diffusion seemed to be sufficient to avoid decomposition. This is in sharp contrast to the behavior of zinc diffusion in InP using the same technique The detailed characteristics of the diffused layer of InP are presented. Similar characteristics for GaAs were also obtained. Junction field effect transistors were fabricated using the P layer formed by semi-sealed diffusion for both InP and GaAs. For InP junction FETs the measured transconductance varies from 80 to 100 ms/mm gate length. GaAs junction FETs show similar results with well behaved I-V characteristics.