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- 저자 : Liu Sudong (검색결과 2 건)
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Characterization of the B cell receptor repertoire of patients with acute coronary syndrome
Weng Ruiqiang,Liu Sudong,Gu Xiaodong,Zhong Zhixiong 한국유전학회 2022 Genes & Genomics Vol.44 No.1
Background: Acute coronary syndrome (ACS) is a complex cardiovascular disease whose development involves the dysregulation of adaptive immune responses. Though it has been proven that T cells associate with inflammation in the development of ACS, the function of B cells in disease remains unclear. Objective: The aim of this study was to reveal the diversity of the B cell receptor (BCR) repertoire of patients with ACS. Methods: We conducted a pilot study to sequence the immune repertoire of peripheral blood mononuclear cells (PBMCs) from patients with ACS, including acute myocardial infarction (AMI) and unstable angina (UA), and quantitatively characterized BCR repertoires by bioinformatics analysis. Results: We found that patients with AMI and UA had lower BCR repertoire diversity compared with controls with normal coronary arteries (NCA). Lower percentages of productive unique BCR nt sequences and higher percentages of top 200 unique BCR sequences were identified in AMI and UA patients than NCA controls. Patients had various preferential usage of V and J genes from B cell clones in accordance with the disease severity of coronary arteries. AMI patients had distinct CDR3 amino acids, and their frequency differed among patients with ACS. Conclusions: Our results indicate that differential BCR signatures represent an imprint of distinct repertoires among ACS patients. This study thereby opens up the prospect of studying disease-relevant B cells to better understand and treat ACS.
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Oh, Seungbae,Chae, Sudong,Choi, Kyung Hwan,Kim, Bum Jun,Lee, Sang Hoon,Wang, Cong,Liu, Zhixiang,Jeon, Jiho,Lee, Jae-Hyun,Yu, Hak Ki,Choi, Jae-Young Elsevier 2019 JOURNAL OF ALLOYS AND COMPOUNDS Vol.803 No.-
<P><B>Abstract</B></P> <P>By using a MoI<SUB>2</SUB> precursor, a one-dimensional linear chain material, Mo<SUB>6</SUB>S<SUB>3</SUB>I<SUB>6</SUB>, was synthesized on a centimeter scale. As MoI<SUB>2</SUB> can be used to form Mo<SUB>6</SUB>S<SUB>3</SUB>I<SUB>6</SUB> through a gas-phase reaction, a larger amount of single crystals can be synthesized; moreover, these crystals are significantly longer than those synthesized by using Mo, S, and I powder. The synthesized Mo<SUB>6</SUB>S<SUB>3</SUB>I<SUB>6</SUB> exhibited the characteristics of paramagnetic semiconductors with excellent thermal stability and a low bandgap. Furthermore, Mo<SUB>6</SUB>S<SUB>3</SUB>I<SUB>6</SUB> can be separated into long nanometer-scale chains by a solution dispersion process.</P> <P><B>Highlights</B></P> <P> <UL> <LI> First synthesis of cm scale synthesize of vdW 1D material Mo<SUB>6</SUB>S<SUB>3</SUB>I<SUB>6</SUB>. </LI> <LI> Superior material properties based on high crystallinity. </LI> <LI> Atomic level (nm) dispersion for ideal 1D materials. </LI> </UL> </P>
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