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      • Clinical Observation and Therapeutic Evaluation of Rh-endostatin Combined with DP Regimen in Treating Patients with Advanced Esophageal Cancer

        Deng, Wen-Ying,Song, Tao,Li, Ning,Luo, Su-Xia,Li, Xiang Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.16

        Objective: To observe the curative effects of rh-endostatin combined with DP regimen in treating patients with advanced esophageal cancer and analyze the correlation of CT perfusion (CTP) parameters and the expression of vascular endothelial growth factor (VEGF). Methods: Twenty patients with esophageal cancer confirmed pathologically were randomly divided into combined treatment (rh-endostatin+DP regimen) group and single chemotherapy group, 10 patients in each group, respectively. All patients were given conventional CT examination and CTP imaging for primary tumor. The level of VEGF, the size of tumor and CTP parameters (BF, BV, PS and MTT) before treatment and after 2 cycles of treatment were determined for the comparison and the correlation between CTP parameters and VEGF expression was analyzed. Results: the therapeutic effect of rh-endostatin+DP regimen group was superior to single chemotherapy group. VEGF level after treatment in rh-endostatin+DP regimen group was obviously lower than single chemotherapy group (P<0.01). The expression of VEGF had positive correlation with BF and BV but negative correlation with MTT. Compared with treatment before for rh-endostatin+DP regimen group, BF, BV and PS decreased while MTT increased after treatment (P<0.05). However, there were no significant differences between treatment before and after treatment in single chemotherapy (P>0.05). Conclusions: Rh-endostatin can down-regulate the expression of VEGF in esophageal cancer, change the state of hypertransfusion and high permeability of tumor vessels and had the better curative effect and slighter adverse reactions when combined with chemotherapy.

      • KCI등재
      • KCI등재

        Facile Fabrication of Extremely Small CoNi/C Core/Shell Nanoparticles for Efficient Microwave Absorber

        Xiang Wen,Lizhen Hou,Lianwen Deng,Daitao Kuang,Heng Luo,Shiliang Wang 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2019 NANO Vol.14 No.7

        CoNi magnetic nanoparticles (NPs) and hybrid architectures have attracted tremendous attention from numerous applications. In this study, a facile approach based on one-step metal-organic chemical vapor deposition (MOCVD) was developed to fabricate CoNi/C core/shell NPs with an extremely small core size of ~3.7 nm and an ultrathin shell thickness of 1–3 nm. Only 10 wt.% CoNi/C core/shell NP-filled composites with thickness of 1.6 mm exhibit an optimal reflection loss value of -25.7 dB and an absorbing bandwidth value up to 6.2 GHz. The extremely small core/shell NPs are demonstrated to have enhanced electromagnetic parameters (i.e., complex permittivity and permeability), reflection loss and broadened effective absorption bandwidth, as compared to the relatively larger NPs. The superior microwave absorbing performance should be attributed to the increased specific area with enriched interfacial polarization. The as-synthesized extremely small CoNi/C core/shell NPs are expected to be a fascinating candidate for efficient microwave absorption material with lightweight and thin thickness.

      • KCI등재
      • KCI등재

        Numerical analysis of a dual-wave band guided-mode resonance filter with embedded bilayer asymmetric metallic gratings

        Ma Wen-Zhuang,Liu Jing,Yu Gao-Xiang,Chen Wei,Chen Yu-Shan,Deng Xu-Chu 한국물리학회 2021 Current Applied Physics Vol.27 No.-

        In this paper, a novel guided-mode resonances (GMRs) based embedded dual-wavelength filter, which had the bilayer gratings located at the two sides of dielectric substrate and arranged at asymmetric position, was investigated and studied theoretically. As compared to symmetric structures that usually provided single wavelength of transmission resonance, as one normal incidence was used for transverse magnetic polarized light, the designed asymmetric structure could generate two remarkable narrow band wavelengths of transmission resonance. The parameters to affect the resonance wavelengths and the transmission resonance Q value (Q = λ/Δλ) of two bands were the distance between the two metallic gratings, the relatively lateral positions of the upper and lower gratings, the number of structure period, the thicknesses of metallic gratings, and the thickness of dielectric film. By optimizing the designed parameters, a GMR device with two resonance wavelengths located at 1239 and 1302 nm showed relative optimal performance because they had high transmission depth (99.9% and 90%) and ultra-narrow transmission bandwidth (2.8 and 1.8 nm) at the two resonance wavelengths. The presented structure can offer a potential route towards dual-band narrow-band filters and refractive index sensors in the near infrared.

      • An Improved PSO Algorithm Based on Mutation Operator and Simulated Annealing

        Xiaojun Deng,Zhiqiang Wen,Yu Wang,Pingan Xiang 보안공학연구지원센터 2015 International Journal of Multimedia and Ubiquitous Vol.10 No.10

        Particle swarm optimization (PSO) algorithm is simple stochastic global optimization technique, but it exists unbalanced global and local search ability, slow convergence speed and solving accuracy. An improved simulated annealing (ISAM) algorithm is introduced into the PSO algorithm with crossover and Gauss mutation to propose an improved PSO (ISAMPSO) algorithm based on the mutation operator and simulated annealing in this paper. In the ISAMPSO algorithm, the mutation operator of genetic algorithm is introduced into the SA algorithm as a generation mechanism of new solution in order to propose an improved simulated annealing algorithm with mutation (ISAM). Then the ISAM algorithm is introduced into the PSO algorithm to jump out the local optimum, effectively achieve the global optimum adjust and optimize the population, maintain the diversity of the population, improve the local search ability and convergence speed. Six classical functions are selected to test the performance of the proposed ISAMPSO algorithm. The simulation experiments results show that the proposed ISAMPSO algorithm can effectively overcomes the stagnation phenomenon and enhance the global search ability. The convergence speed and accuracy were better than the PSO algorithm.

      • KCI등재

        A prospective randomized multicenter trial for lymphadenectomy in early- stage ovarian cancer: LOVE study

        Ting Deng,Kaijiang Liu,Liang Chen,Xiao-jun Chen,Hua Wen Li,Hongyan Guo,Huijiao Zhang,Libing Xiang,Xin Feng,Xiaoyu Wang,Hextan Y. S. Ngan,Jianguo Zhao,Dongling Zou,Qing Liu,Jihong Liu 대한부인종양학회 2023 Journal of Gynecologic Oncology Vol.34 No.3

        Background: The Lymphadenectomy in Ovarian Neoplasms (LION) study revealed that systemic lymphadenectomy did not bring survival benefit for advanced ovarian cancer patients with clinically normal lymph nodes and was associated with a higher incidence of operative complications. However, there is no consensus on whether lymphadenectomy has survival benefit or not in early epithelial ovarian cancer (EOC). Methods: We designed the LOVE study, a multicenter, randomized controlled, phase III trial to compare the efficacy and safety of comprehensive staging surgery with or without lymphadenectomy in stages IA-IIB EOC and fallopian tube carcinomas (FTC). The hypothesis is that the oncological outcomes provided by comprehensive staging surgery without lymphadenectomy are non-inferior to those of conventional completion staging surgery in early-stage EOC and FTC patients who have indications for post-operative adjuvant chemotherapy. Patients assigned to experimental group will undergo comprehensive staging surgery, but lymphadenectomy. Patients assigned to comparative group will undergo completion staging surgery including systematic pelvic and para-aortic lymphadenectomy. All subjects will receive 3–6 cycles of standard adjuvant chemotherapy. Major inclusion criteria are pathologic confirmed stage IA-IIB EOC or FTC, and patients have indications for adjuvant chemotherapy either confirmed by intraoperative fast frozen section or previous pathology after an incomplete staging surgery. Major exclusion criteria are non-epithelial tumors and low-grade serous carcinoma. Patients with severe rectum involvement which lead to partial rectum resection will be excluded. The sample size is 656 subjects. Primary endpoint is disease-free survival.

      • KCI등재

        Robust Control for Bidirectional Stabilization System With Time Delay Estimation

        Shu-sen Yuan,Wen-xiang Deng,Jian-yong Yao,Guo-lai Yang 제어·로봇·시스템학회 2024 International Journal of Control, Automation, and Vol.22 No.4

        In this paper, to address the problem of high precision tracking control for bidirectional stabilization system of marching all-electric tank, a continuous nonsingular terminal sliding mode (CNTSM) control method combined with time delay estimation (TDE) technique is presented. First, the nonlinear mathematical model of the bidirectional stabilization system with consideration of actuator dynamics is established. Second, the TDE method is invoked to estimate the unknown system dynamics and provide fascinating model-free structures. Then, a CNTSM surface and a fast TSM reaching law are constructed to guarantee finite-time convergence. The proposed controller no longer requires system dynamics benefiting from TDE, while ensuring high accuracy, fast convergence and good robustness against lumped uncertainty due to the CNTSM manifold and the fast TSM reaching law. The stability and finite-time convergence of the closed-loop system are analyzed applying Lyapunov theory. Extensive comparative results verify the superiority with the proposed controller.

      • KCI등재

        Parameter design of active damping‑based shunt hybrid active power filters

        Jianhang Lu,Miao Zhang,Junming Wen,Dali Zheng,Shaoli Deng,Xiang Shi,Ling Yang 전력전자학회 2023 JOURNAL OF POWER ELECTRONICS Vol.23 No.5

        This paper presents the parameter design of a new topology of hybrid active power filter (HAPF), which makes the system capacity smaller. Based on the main topological circuit, the passive LC single-tuned circuit shunted into the HAPF effectively reduces the capacity of the system. By introducing the grid voltage feedforward method, the DC-side voltage control becomes relatively stable, and the fundamental reactive current flowing through the converter is effectively reduced. Meanwhile, to suppress the resonance of the HAPF, the state variable feedback method is adopted. According to theoretical analysis, a simulation model of the system is built in the MATLAB environment. Then a low-voltage experimental HAPF platform is built to validate the result of the simulations.

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