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Qing-Qing Dong,Qiu-Tong Wang,Lei Wang,Ya-Xin Jiang,Mei-Ling Liu,Hai-Jie Hu,Yong Liu,Hao Zhou,Hong-Peng He,Tong-Cun Zhang,Xuegang Luo 한국식품과학회 2018 Food Science and Biotechnology Vol.27 No.4
Sulforaphane (SFN), a natural compound derived from cruciferous vegetables, has been proved to possess potent anti-cancer activity. SMYD3 is a histone methyltransferase which is closely related to the proliferation and migration of cancer cells. This study showed that SFN could dose-dependently induce cell cycle arrest, stimulate apoptosis, and inhibit proliferation and migration of gastric carcinoma cells. Accompanied with these anticancer effects, SMYD3 and its downstream genes, myosin regulatory light chain 9, and cysteine-rich angiogenic inducer 61, was downregulated by SFN. Furthermore, overexpression of SMYD3 via transfection could abolish the effects of SFN, suggesting that SMYD3 might be an important mediator of SFN. To the best of our knowledge, this is the first report describing the role of SMYD3 in the anti-cancer of SFN. These findings might throw light on the development of novel anti-cancer drugs and functional food using SFN-rich cruciferous vegetables.
Liu, Yi-Qing,Zhang, Guo-An,Zhang, Bing-Chang,Wang, Yong,Liu, Zheng,Jiao, Yu-Lian,Liu, Ning,Zhao, Yue-Ran Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.3
Background: Prostate cancer is one of the main causes of cancer death, and drug resistance is the leading reason for therapy failure. However, how this occurs is largely unknown. We therrfore aimed to study the response of DU145 cells to cisplatin. Materials and Methods: Du145 prostate cancer cells were treated with a low dose of cisplatin for 24 h and cell viability and number were determined by MTT assay and trypan blue exclusion assay, respectively. The real time polymerase chain reaction (PCR) was used to assess responses to cisplatin treatment. Results: After 24h $2{\mu}g/ml$ treatment did not result in significant reduction in cell viability or number. However, it led to enhanced cancer cell invasiveness. E-cadherin mRNA was reduced, and vimentin, Snail, Slug, metalloproteinase 9 (MMP9) mRNA expression increased significantly, a feature of epithelial-mesenchymal transition (EMT). Conclusions: Short time low concentration cisplatin treatment leads to elevated invasiveness of DU145 cancer cells and this is possibly due to EMT.
Qing-dong Liu,Wen-qing Liu,Shi-jin Zhao 대한금속·재료학회 2013 METALS AND MATERIALS International Vol.19 No.4
3D atom probe (3DAP) combined with TEM is applied to characterize the nanostructure and composition of coarsening carbides that precipitate in a Nb-V micro-alloyed steel tempered at 650 °C for 4 h. The results indicate that high temperature tempering of the as-quenched lath-like martensitic structures leads to the coarsening of alloyed carbide in the recovered ferritic matrix. TEM characterization and EDS analysis show that the alloy carbides are typically spherical or ellipsoidal and are enriched with V, Nb and Mo. Crystallographic lattice overlap and distortion create a distinct optical Moiré pattern at the carbide/matrix boundary, as observed by HRTEM. 3DAP gives the compositional distribution at atomic scale in the coarsening carbide and the surrounding matrix. Non-carbide-forming elements such as Si and Al are depleted in the carbide and are enriched at the carbide/matrix heterophase interface. Carbide-forming elements such as Mn, V, Mo and Nb distribute heterogeneously in the whole carbide, leading to the formation of a Mn-, V- and Mo-enriched core and Mo-enriched external shell.
Overview of aristolochic acid nephropathy: an update
Zhou Qing-Qing,Jiang Lei,Tao Su,Gang Liu,Yang Liu 대한신장학회 2023 Kidney Research and Clinical Practice Vol.42 No.5
Aristolochic acid nephropathy (AAN) is a rapidly progressive renal interstitial fibrosis caused by medical or environmental exposure to aristolochic acid (AA). Since the outbreak of AAN in Belgium was reported nearly 30 years ago, the safety of herbal remedies has drawn considerable attention, and AAN has become a global public health problem. Breakthroughs have been made to better understand the disease, including the toxicity of AAs, the possible mechanisms of AAN, the disease patterns, and the pathological features; however, some critical problems remain unresolved. Because of the insidious onset of the disease, the incidence of AAN and the prevalence of exposure to AAs are unknown and might be largely underestimated. During the past decades, AA-containing herbs have been strictly administrated in many regions and the occurrence of AAN has declined sharply, yet cases of AAN are still sporadically reported. Despite the progress in the understanding of the disease’s pathogenesis, there is no effective treatment for delaying or reversing the renal deterioration caused by AAN. Therefore, the risk of exposure to AAs should be taken seriously by public health workers and clinicians. In this review, we updated the latest data on AAN, summarized the advances throughout these years, and put forward some challenges for future research.
EXAMINING THE INFUENCE OF CULTURAL EXPERIENCE ON CONSUMERS’ AUTHENTICITY EVALUATION OF LUXURY BRANDS
Qing Wang,Martin Liu 글로벌지식마케팅경영학회 2016 Global Marketing Conference Vol.2016 No.7
This research explored how experiencing a country’s cultural heritage influences consumers’ authenticity evaluation of its luxury brands. It showed authenticity was culturally constructed and perception was influenced by marketing means selectively exposing the consumers to different brand attributes. It contributes to transcultural research by linking cultural attributes to brand authenticity attributes.
Qing Liu,Yang Zhao,Shuqi Cai,Shi-lin Dong 한국풍공학회 2020 Wind and Structures, An International Journal (WAS Vol.31 No.6
Large cylindrical floating-roof tanks, constructed as oil containers, are usually distributed regularly in open area and easily exposed to severe wind loads. However, wind pressures around these grouped squat tanks appear to have not been clearly given in design codes or thoroughly studied in existing researches. This paper conducts a detailed investigation on wind loads on the external wall of a four-tank group in square arrangement. To achieve that, wind tunnel tests are carried out on both empty and full tank groups, considering various wind angles and spacing. Results show that 3 regions in elevation can be identified on the tank shell according to the circumferential wind pressure distribution. The upper 2 regions cover a relatively small portion of the shell where excessive negative pressures are spotted, setting an alarm to the design of the top angle and stiffening rings. By comparing results on grouped tanks to those on an isolated tank, grouping effects concerning wind angle, tank position in group and spacing are discussed. Deviations on pressure distributions that will compromise structural safety are outlined, including the increase of negative pressures, the shift of maximum pressure locations as well as the change of positive pressure range. And, several potentially unfavourable wind pressure distributions are selected for further analyses.
Adversarial Attack on DL-based Massive MIMO CSI Feedback
Qing Liu,Jiajia Guo,Chao-Kai Wen,Shi Jin 한국통신학회 2020 Journal of communications and networks Vol.22 No.3
With the increasing application of deep learning (DL) algorithms in wireless communications, the physical layer faces newchallenges caused by adversarial attack. Such attack has significantly affected the neural network in computer vision. We chooseDL-based channel state information (CSI) to show the effect of adversarial attack on DL-based communication system. We presenta practical method to craft white-box adversarial attack on DLbased CSI feedback process. Our simulation results show the destructive effect adversarial attack causes on DL-based CSI feedback by analyzing the performance of normalized mean square error. We also launch a jamming attack for comparison and find thatthe jamming attack could be prevented with certain precautions. As DL algorithm becomes the trend in developing wireless communication, this work raises concerns regarding the security in the useof DL-based algorithms.
Qing Liu,Yang Zhao,Shuqi Cai,Shi-lin Dong 한국풍공학회 2020 Wind and Structures, An International Journal (WAS Vol.31 No.6
To investigate the structural behaviour of grouped tanks under wind loads, 2 problems need to be figured out, wind pressures on tank shells and critical loads of the shell under these pressure distribution patterns. Following the wind tunnel tests described in the companion paper, this paper firstly seeks to obtain wind loads on the external wall in a squarely-arranged cylindrical tank group by numerical simulation, considering various layouts. The outcomes demonstrate that the numerical method can provide similar results on wind pressures and better insights on grouping effects through extracted streamlines. Then, geometrically nonlinear analyses are performed using several selected potentially unfavourable wind pressure distributions. It is found that the critical load is controlled by limit point buckling when the tank is empty while excessive deformations when the tank is full. In particular, significant reductions of wind resistance are found on grouped full tanks compared to the isolated tank, considering both serviceability and ultimate limit state, which should receive special attention if the tank is expected to resist severe wind loads with the increase of liquid level.