http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Chemical inhibition of prometastatic lysyl-tRNA synthetase–laminin receptor interaction
Kim, Dae Gyu,Lee, Jin Young,Kwon, Nam Hoon,Fang, Pengfei,Zhang, Qian,Wang, Jing,Young, Nicolas L,Guo, Min,Cho, Hye Young,Mushtaq, Ameeq Ul,Jeon, Young Ho,Choi, Jin Woo,Han, Jung Min,Kang, Ho Woong,Joo NATURE PUBLISHING GROUP 2014 NATURE CHEMICAL BIOLOGY Vol. No.
Lysyl-tRNA synthetase (KRS), a protein synthesis enzyme in the cytosol, relocates to the plasma membrane after a laminin signal and stabilizes a 67-kDa laminin receptor (67LR) that is implicated in cancer metastasis; however, its potential as an antimetastatic therapeutic target has not been explored. We found that the small compound BC-K-YH16899, which binds KRS, impinged on the interaction of KRS with 67LR and suppressed metastasis in three different mouse models. The compound inhibited the KRS-67LR interaction in two ways. First, it directly blocked the association between KRS and 67LR. Second, it suppressed the dynamic movement of the N-terminal extension of KRS and reduced membrane localization of KRS. However, it did not affect the catalytic activity of KRS. Our results suggest that specific modulation of a cancer-related KRS-67LR interaction may offer a way to control metastasis while avoiding the toxicities associated with inhibition of the normal functions of KRS.
박수영,서희원,왕남웅,김대회,여인환,최동호,Park. Soo Young,Seo. Hee Won,Wang. Nam Woong,Kim. Dae Hoi,Yeo. In Hwan,Choi. Dong Ho 한국방재학회 2014 한국방재학회논문집 Vol.14 No.2
국외에서는 용도 및 창의 크기를 제한하여 방화구획에 비차열 방화유리의 사용을 허용하는데 반해 국내에는 그 사용이 불가능하다. 따라서, 국내의 비차열 방화유리의 내화성능을 확인하고, 화재안전성을 평가해 볼 필요성이 있다. 본 연구에서는 비차열 방화유리에 대하여 면적별로 4가지 실험체를 구성하여 내화실험을 실시하고, 측정된 복사열유량 및 온도를 적용하여 화재안전성을 평가하였다. 그 결과 화재안전성을 확보하면서 사용이 가능한 면적비를 제안하였다. In foreign countries, a non-insulated fire glazed window is permitted in fire compartment restricting the use and size, but on the domestic side, not permitted. So, there is a need to confirm the fire resistance of the domestic non-insulated fire glazed window and to evaluate the fire safety of that. In this study, the fire resistance tests of 4 types of windows were conducted depending on window area, and the measured radiant heat fluxes and temperatures were evaluated in fire safety. As a result, we suggested the window/wall area ratio secured the fire safety.