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Pulsed γ-ray emission from magnetar 1E 2259+586
Wu, Jason Hung Kit,Hui, Chung Yue,Huang, Regina Hsiu Hui,Kong, Albert Kwok Hing,Cheng, Kwong Sang,Takata, Jumpei,Tam, Pak Hin Thomas,Wu, Eric Man Ho,Liu, Joe 한국우주과학회 2013 Journal of Astronomy and Space Sciences Vol.30 No.2
Anomalous X-ray pulsars (AXPs) are thought to be magnetars which are young isolated neutron stars with extremely strongmagnetic fields of >1014 Gauss. Their tremendous magnetic fields inferred from the spin parameters provide a huge energyreservoir to power the observed X-ray emission. High-energy emission above 0.3 MeV has never been detected despiteintensive search. Here, we present the possible Fermi Large Area Telescope (LAT) detection of γ-ray pulsations above 200MeV from the AXP, 1E 2259+586, which puts the current theoretical models of γ-ray emission mechanisms of magnetars intochallenge. We speculate that the high-energy γ-rays originate from the outer magnetosphere of the magnetar.
Pulsed γ-ray emission from magnetar 1E 2259+586
Jason Hung Kit Wu,허종우,Regina Hsiu Hui Huang,Albert Kwok Hing Kong,Kwong Sang Cheng,Jumpei Takata,Pak Hin Thomas Tam,Eric Man Ho Wu,Joe Liu 한국우주과학회 2013 Journal of Astronomy and Space Sciences Vol.30 No.2
Anomalous X-ray pulsars (AXPs) are thought to be magnetars which are young isolated neutron stars with extremely strong magnetic fields of >1014 Gauss. Their tremendous magnetic fields inferred from the spin parameters provide a huge energy reservoir to power the observed X-ray emission. High-energy emission above 0.3 MeV has never been detected despite intensive search. Here, we present the possible Fermi Large Area Telescope (LAT) detection of γ-ray pulsations above 200MeV from the AXP, 1E 2259+586, which puts the current theoretical models of γ-ray emission mechanisms of magnetars into challenge. We speculate that the high-energy γ-rays originate from the outer magnetosphere of the magnetar.
Wu, Xiangguo,Kang, Thomas H.-K.,Lin, Yang,Hwang, Hyeon-Jong Elsevier 2018 Composite structures Vol.200 No.-
<P><B>Abstract</B></P> <P>As a structural and constructional element, a thin-walled U-shaped precast permanent form consisting of High-Performance Fiber-Reinforced Cementitious Composites (HPFRCC) and steel wire mesh is considered. Prior to casting, transverse steel threaded bars are installed, as well as longitudinal reinforcing bars, connecting two sides of the U-shaped form for shear transfer between the precast and in-filled concrete sections and for fresh concrete pressure resistance. The present study investigated the effect of precast U-shaped HPFRCC section on the shear strength of the composite beams. As parameters for full-scale three-point bending tests, the type or materials of precast section, spacing of shear reinforcement, and shear span-to-depth ratio were considered. The test results showed that the precast U-shaped HPFRCC permanent form increased the shear contributions of in-filled concrete and shear reinforcement in the composite beam substantially. From the experimental and analytical assessment, the coefficients related to the composite action between precast HPFRCC and in-filled concrete sections, shear reinforcement along diagonal cracks, and shear span-to-depth ratio were proposed, which were applied to a previous shear strength model for the simplified shear design of proposed precast U-shaped HPFRCC-in filled concrete composite beams.</P>
Behavior of UHPC-RW-RC wall panel under various temperature and humidity conditions
Wu, Xiangguo,Yu, Shiyuan,Tao, Xiaokun,Chen, Baochun,Liu, Hui,Yang, Ming,Kang, Thomas H.K. Techno-Press 2020 Advances in concrete construction Vol.9 No.5
Mechanical and thermal properties of composite sandwich wall panels are affected by changes in their external environment. Humidity and temperature changes induce stress on wall panels and their core connectors. Under the action of ambient temperature, temperature on the outer layer of the wall panel changes greatly, while that on the inner layer only changes slightly. As a result, stress concentration exists at the intersection of the connector and the wall blade. In this paper, temperature field and stress field distribution of UHPC-RW-RC (Ultra-High Performance Concrete - Rock Wool - Reinforced Concrete) wall panel under high temperature-sprinkling and heating-freezing conditions were investigated by using the general finite element software ABAQUS. Additionally, design of the connection between the wall panel and the main structure is proposed. Findings may serve as a scientific reference for design of high performance composite sandwich wall panels.
Punching shear strength of UHPFRC-RC composite flat plates
Wu, Xiangguo,Yu, Shiyan,Xue, Shicheng,Kang, Thomas H.-K.,Hwang, Hyeon-Jong Elsevier 2019 Engineering structures Vol.184 No.-
<P><B>Abstract</B></P> <P>Reinforced concrete (RC) flat plates are vulnerable to punching shear failure due to small effective area for shear resistance. To strengthen the behavior of existing flat plates, use of ultra high performance fiber reinforced concrete (UHPFRC) as a laminate has been pursued. This study focuses on punching shear behavior of RC flat plates retrofitted with UHPFRC overlay (i.e., UHPFRC-RC composite flat plates). To model the axisymmetric UHPFRC-RC composite flat plate, use of the unified strength theory-based punching shear strength model was proposed. Predictions using the proposed model, when compared to existing test results of UHPFRC-RC composite flat plates under concentric load and nonlinear analysis results using ABAQUS, agreed well with the results. Additionally, from the parametric analysis results using the proposed model and nonlinear analysis, the effects of UHPFRC overlay thickness and tensile strength on the punching shear strength were identified.</P> <P><B>Highlights</B></P> <P> <UL> <LI> A punching shear strength model was proposed for UHPFRC-RC composite flat plates. </LI> <LI> UHPFRC overlay increases the load-carrying capacity, but it is limited at a certain point. </LI> <LI> The punching shear strength can be defined as a function of the thickness and strength of UHPFRC overlay. </LI> </UL> </P>
Meizhu Wu,Aling Shen,Youqin Chen,Liya Liu,Li Li,Senthilkumar Sankararaman,Hongwei Chen,Bin Guan,Zhixue Zhan,Shuhua Nan,Thomas J. Sferra,Jun Peng 한국식품영양과학회 2021 Journal of medicinal food Vol.24 No.1
Intestinal mucosal barrier dysfunction is involved in the pathogenesis of inflammatory bowel disease, including ulcerative colitis (UC). Xinhuang tablets (XHTs) have been prescribed for several kinds of inflammatory diseases, including UC, whereas its possible underlying molecular mechanisms had never been explored. Mouse model of UC was constructed by DSS treatment and followed by XHT treatment. Disease activity index, histopathological of colonic tissue, tumor necrosis factor-alpha (TNF-α), and serum amyloid A (SAA) levels in serum were further assessed. The underlying mechanism was further explored by determination of the expression of epithelial tight junction-related protein. XHT administration ameliorated dextran sulfate sodium (DSS)-induced clinical symptoms, colonic histological injury, and decreased the circulating levels of TNF-α and SAA. Moreover, XHT treatment significantly increased the protein levels of zona occludens (ZO)-1, whereas decreased the levels of phosphorylation of Elk-1. In conclusion, this study confirmed the therapeutic effects of XHT treatment on UC in a DSS-induced mouse model, and indicated that by increasing expression of epithelial tight junctions and decreasing phosphorylation of Elk-1 might be one of the underlying mechanisms of XHT treatment on UC.
Mantle cell lymphoma relapsed after autologous stem cell transplantation: a single-center experience
Aaron Wu,Solomon A. Graf,Nicholas Burwick,Jonathan E. Grim,Zhao Ming Dong,Robert E. Richard,Thomas R. Chauncey 대한혈액학회 2020 Blood Research Vol.55 No.1
BackgroundAutologous stem cell transplantation (autoSCT) can extend remission of mantle cell lym-phoma (MCL), but the management of subsequent relapse is challenging.MethodsWe examined consecutive patients with MCL who underwent autoSCT at Veterans Affairs Puget Sound Health Care System between 2009 and 2017 (N=37).ResultsTen patients experienced disease progression after autoSCT and were included in this analysis. Median progression free survival after autoSCT was 1.8 years (range, 0.3‒7.1) and median overall survival after progression was only 0.7 years (range, 0.1 to not reached). The 3 patients who survived more than 1 year after progression were treated with ibrutinib.ConclusionOur findings suggest that ibrutinib can achieve relatively prolonged control of MCL pro-gressing after autoSCT.
Design and behavior of 160 m-tall post-tensioned precast concrete-steel hybrid wind turbine tower
Xiangguo Wu,Xuesen Zhang,Qingtan Zhang,Dong Zhang,Xiaojing Yang,Faqiang Qiu,Suhyun Park,Thomas H.-K. Kang 국제구조공학회 2022 Steel and Composite Structures, An International J Vol.44 No.3
Prefabricated hybrid wind turbine towers (WTTs) are promising due to height increase. This study proposes the use of ultra-high performance concrete (UHPC) to develop a new type of WTT without the need to use reinforcement. It is demonstrated that the UHPC WTT structure without reinforcing bars could achieve performance similar to that of reinforced concrete WTTs. To simplify the design of WTT, a design approach for the calculation of stresses at the horizontal joints of a WTT is proposed. The stress distribution near the region of the horizontal joint of the WTT structure under normal operating conditions and different load actions is studied using the proposed approach, which is validated by the finite element method. A further parametric study shows that the degree of prestressing and the bending moment both significantly affect the principal stress. The shear-to-torsion ratio also shows a significant influence on the principal tensile stress.