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Zhang, Peng,Jin, Yue-Fei,Zhang, Qiao,Wu, Yi-Ming,Wu, Wei-Dong,Yao, Wu,Wu, Yong-Jun,Li, Zhi-Tao,Zhao, Yong,Liu, Yu,Feng, Fei-Fei Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.12
Background: We sought to evaluate the role of tumor associated macrophages (TAMs) on the promotion of coal tar pitch extract (CTPE)-induced tumorigenesis of human bronchial epithelial cells (BEAS-2B) and tumor metastasis in nude mice, and related mechanisms. Materials and Methods: BEAS-2B cells were first treated with 2.4 mg/mL CTPE for 72 hours. After removal of CTPE, the cells were continuously cultured and passaged using trypsin-EDTA. THP-1 cells were used as macrophage-like cells. BEAS-2B cells under different conditions (n=6/group) were injected into the back necks of nude mice, and alterations of tumor xenograft growth, indicative of tumorigenicity, and tumor metastasis were determined. Pathological changes (tumor nests and microvascular lesions) of HE-stained tumor tissues were also evaluated. The expression of AP-1(c-Jun) in xenografts and metastatic tumors was determined using immunohistochemistry. Results: Tumor size and weight in nude mice transplanted with the mixture of CTPE-induced passage 30 BEAS-2B and THP-1 cells (2:1) were increased compared to those from the CTPE-treated BEAS-2B cells at passage 30 alone at different observation time points. Tumor metastasis to lymph nodes and liver was only detected after transplantation of a mixture the two kinds of cells. The numbers of tumor nests and microvascular lesions, and the expression levels of AP-1 (c-Jun) in tumors from the mixture of two kinds of cells were increased apparently in contrast to those in tumor from the CTPE-treated BEAS-2B cells of passage 30 alone. In addition, there was positive correlation between AP-1 (c-Jun) expression level and the number of microvascular lesions, or between AP-1 (c-Jun) expression level and tumor metastasis in these two groups. Conclusions: TAMs not only facilitate tumorigenesis transformation of CTPE-induced BEAS-2B cells, but also promote tumor growth, angiogenesis and metastasis in nude mice in vivo, which may be mediated by AP-1.
My Opinion on Traditionalism in Modern Chuanqi Zaju
( Peng Jun Zuo ) 성균관대학교 동아시아학술원 2004 Sungkyun Journal of East Asian Studies Vol.4 No.1
There existed a creative tendency called traditionalism during the development of modern chuanqi (poetic dramas of the Ming and Qing dynasties) zaju (poetic drama set to music, flourishing in the Yuan dynasty, usually consisting of four acts called zhe, with one character having the singing role in each zhe). This tendency, which was obviously observed in its theme, artistic structure, literary style, etc., showed its adherence as well as adequate modification to tradition. Its ideology, artistic quality and style were characterized by complexity, variety and profundity. The traditionalism in modern chuanqi originated from the unique drama, literature and culture of modern China, and it also made significant contribution to the development of drama. This cultural psychology and creative pursuit also reflected certain cultural symbolism. Its significance and value was not only of dramatic and literary history, but also of history of culture and ideology.
Dynamic Allocation of Random Access Opportunity for Machine-Type Communication in LTE-Advanced
Peng Li,Yun-jian Jia,Ming-jun Feng,Fei Chen,Pei-hua He,Guo-jun Li 보안공학연구지원센터 2015 International Journal of Smart Home Vol.9 No.2
With the rapid growth of machine-type communications (MTC) devices, the radio access network (RAN) will be overloaded when a large number of MTC devices try to access the radio networks in a short time. In this paper, a combination of a dynamic resource allocation and a random access check mechanism is proposed to solve the overload problems for MTC in LTE-Advanced. An analytical model is presented with the derivation of three metrics, the collision probability, the success probability, and the idle probability to evaluate the method. Simulation and analysis results show the superior performance of the method we proposed to solve the RAN overload problem.